LeishMANIAdb
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Glucose-6-phosphate 1-dehydrogenase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Glucose-6-phosphate 1-dehydrogenase
Gene product:
glucose-6-phosphate 1-dehydrogenase, putative
Species:
Leishmania braziliensis
UniProt:
A4HAD3_LEIBR
TriTrypDb:
LbrM.20.0160 , LBRM2903_200008500 *
Length:
561

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 4
Forrest at al. (procyclic) no yes: 4
Silverman et al. no yes: 0
Pissara et al. yes yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 12
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0005654 nucleoplasm 2 1
GO:0005777 peroxisome 6 1
GO:0020015 glycosome 7 1
GO:0042579 microbody 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HAD3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAD3

Function

Biological processes
Term Name Level Count
GO:0005975 carbohydrate metabolic process 3 13
GO:0005996 monosaccharide metabolic process 3 13
GO:0006006 glucose metabolic process 5 13
GO:0006091 generation of precursor metabolites and energy 3 13
GO:0006098 pentose-phosphate shunt 5 12
GO:0006139 nucleobase-containing compound metabolic process 3 13
GO:0006725 cellular aromatic compound metabolic process 3 13
GO:0006739 NADP metabolic process 7 13
GO:0006740 NADPH regeneration 4 13
GO:0006753 nucleoside phosphate metabolic process 4 13
GO:0006793 phosphorus metabolic process 3 13
GO:0006796 phosphate-containing compound metabolic process 4 13
GO:0006807 nitrogen compound metabolic process 2 13
GO:0008152 metabolic process 1 13
GO:0009117 nucleotide metabolic process 5 13
GO:0009987 cellular process 1 13
GO:0019318 hexose metabolic process 4 13
GO:0019362 pyridine nucleotide metabolic process 5 13
GO:0019637 organophosphate metabolic process 3 13
GO:0034641 cellular nitrogen compound metabolic process 3 13
GO:0044237 cellular metabolic process 2 13
GO:0044238 primary metabolic process 2 13
GO:0044281 small molecule metabolic process 2 13
GO:0046483 heterocycle metabolic process 3 13
GO:0046496 nicotinamide nucleotide metabolic process 6 13
GO:0051156 glucose 6-phosphate metabolic process 4 13
GO:0055086 nucleobase-containing small molecule metabolic process 3 13
GO:0071704 organic substance metabolic process 2 13
GO:0072524 pyridine-containing compound metabolic process 4 13
GO:1901135 carbohydrate derivative metabolic process 3 13
GO:1901360 organic cyclic compound metabolic process 3 13
GO:1901564 organonitrogen compound metabolic process 3 13
GO:0000302 response to reactive oxygen species 4 1
GO:0006950 response to stress 2 1
GO:0006979 response to oxidative stress 3 1
GO:0008283 cell population proliferation 2 1
GO:0009051 pentose-phosphate shunt, oxidative branch 5 1
GO:0042221 response to chemical 2 1
GO:0050896 response to stimulus 1 1
GO:1901700 response to oxygen-containing compound 3 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 13
GO:0003824 catalytic activity 1 13
GO:0004345 glucose-6-phosphate dehydrogenase activity 5 13
GO:0005488 binding 1 13
GO:0016491 oxidoreductase activity 2 13
GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 3 13
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 4 13
GO:0036094 small molecule binding 2 13
GO:0050661 NADP binding 4 13
GO:0097159 organic cyclic compound binding 2 13
GO:1901265 nucleoside phosphate binding 3 13
GO:1901363 heterocyclic compound binding 2 13

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 201 203 PF00675 0.211
CLV_NRD_NRD_1 500 502 PF00675 0.320
CLV_PCSK_KEX2_1 121 123 PF00082 0.378
CLV_PCSK_KEX2_1 160 162 PF00082 0.363
CLV_PCSK_KEX2_1 201 203 PF00082 0.200
CLV_PCSK_KEX2_1 430 432 PF00082 0.211
CLV_PCSK_KEX2_1 500 502 PF00082 0.334
CLV_PCSK_PC1ET2_1 121 123 PF00082 0.378
CLV_PCSK_PC1ET2_1 160 162 PF00082 0.363
CLV_PCSK_PC1ET2_1 430 432 PF00082 0.211
CLV_PCSK_SKI1_1 127 131 PF00082 0.247
CLV_PCSK_SKI1_1 41 45 PF00082 0.511
CLV_PCSK_SKI1_1 509 513 PF00082 0.363
CLV_PCSK_SKI1_1 69 73 PF00082 0.410
DEG_APCC_KENBOX_2 347 351 PF00400 0.363
DOC_CKS1_1 510 515 PF01111 0.291
DOC_CYCLIN_yClb1_LxF_4 33 39 PF00134 0.332
DOC_MAPK_gen_1 430 436 PF00069 0.211
DOC_MAPK_gen_1 500 506 PF00069 0.363
DOC_MAPK_gen_1 67 76 PF00069 0.435
DOC_MAPK_MEF2A_6 410 418 PF00069 0.293
DOC_MAPK_MEF2A_6 67 75 PF00069 0.381
DOC_MAPK_RevD_3 71 86 PF00069 0.304
DOC_PP1_RVXF_1 413 419 PF00149 0.304
DOC_PP1_RVXF_1 55 61 PF00149 0.369
DOC_PP2B_LxvP_1 186 189 PF13499 0.291
DOC_PP4_FxxP_1 173 176 PF00568 0.364
DOC_PP4_FxxP_1 99 102 PF00568 0.211
DOC_USP7_MATH_1 360 364 PF00917 0.364
DOC_USP7_MATH_1 374 378 PF00917 0.286
DOC_USP7_MATH_1 438 442 PF00917 0.320
DOC_USP7_MATH_1 453 457 PF00917 0.346
DOC_USP7_MATH_1 482 486 PF00917 0.291
DOC_USP7_UBL2_3 160 164 PF12436 0.429
DOC_USP7_UBL2_3 447 451 PF12436 0.364
DOC_USP7_UBL2_3 63 67 PF12436 0.420
DOC_WW_Pin1_4 509 514 PF00397 0.291
LIG_14-3-3_CanoR_1 267 273 PF00244 0.359
LIG_14-3-3_CanoR_1 460 467 PF00244 0.383
LIG_14-3-3_CanoR_1 474 478 PF00244 0.221
LIG_14-3-3_CanoR_1 57 61 PF00244 0.357
LIG_Actin_WH2_2 128 146 PF00022 0.211
LIG_Actin_WH2_2 445 462 PF00022 0.353
LIG_APCC_ABBA_1 235 240 PF00400 0.444
LIG_APCC_ABBA_1 422 427 PF00400 0.361
LIG_APCC_ABBA_1 92 97 PF00400 0.248
LIG_BIR_II_1 1 5 PF00653 0.662
LIG_BRCT_BRCA1_1 494 498 PF00533 0.291
LIG_Clathr_ClatBox_1 318 322 PF01394 0.291
LIG_deltaCOP1_diTrp_1 392 399 PF00928 0.291
LIG_deltaCOP1_diTrp_1 505 511 PF00928 0.397
LIG_EVH1_2 189 193 PF00568 0.291
LIG_FHA_1 311 317 PF00498 0.291
LIG_FHA_1 379 385 PF00498 0.304
LIG_FHA_1 447 453 PF00498 0.349
LIG_FHA_1 494 500 PF00498 0.310
LIG_FHA_1 510 516 PF00498 0.291
LIG_FHA_1 57 63 PF00498 0.477
LIG_FHA_1 70 76 PF00498 0.304
LIG_FHA_2 110 116 PF00498 0.444
LIG_FHA_2 282 288 PF00498 0.304
LIG_FHA_2 463 469 PF00498 0.291
LIG_LIR_Apic_2 170 176 PF02991 0.364
LIG_LIR_Apic_2 97 102 PF02991 0.211
LIG_LIR_Gen_1 150 159 PF02991 0.369
LIG_LIR_Gen_1 191 200 PF02991 0.363
LIG_LIR_Gen_1 381 389 PF02991 0.291
LIG_LIR_Gen_1 408 418 PF02991 0.444
LIG_LIR_Gen_1 442 453 PF02991 0.291
LIG_LIR_Gen_1 481 491 PF02991 0.291
LIG_LIR_Nem_3 150 156 PF02991 0.336
LIG_LIR_Nem_3 157 162 PF02991 0.267
LIG_LIR_Nem_3 191 196 PF02991 0.468
LIG_LIR_Nem_3 381 385 PF02991 0.270
LIG_LIR_Nem_3 392 397 PF02991 0.311
LIG_LIR_Nem_3 408 414 PF02991 0.291
LIG_LIR_Nem_3 442 448 PF02991 0.291
LIG_LIR_Nem_3 481 486 PF02991 0.333
LIG_LIR_Nem_3 505 511 PF02991 0.294
LIG_LIR_Nem_3 87 91 PF02991 0.306
LIG_Pex14_2 269 273 PF04695 0.291
LIG_Pex14_2 88 92 PF04695 0.304
LIG_PTB_Apo_2 263 270 PF02174 0.291
LIG_Rb_LxCxE_1 335 349 PF01857 0.397
LIG_SH2_NCK_1 153 157 PF00017 0.320
LIG_SH2_PTP2 411 414 PF00017 0.444
LIG_SH2_STAP1 12 16 PF00017 0.521
LIG_SH2_STAP1 356 360 PF00017 0.397
LIG_SH2_STAP1 475 479 PF00017 0.308
LIG_SH2_STAP1 483 487 PF00017 0.299
LIG_SH2_STAT5 128 131 PF00017 0.402
LIG_SH2_STAT5 148 151 PF00017 0.304
LIG_SH2_STAT5 185 188 PF00017 0.357
LIG_SH2_STAT5 250 253 PF00017 0.342
LIG_SH2_STAT5 297 300 PF00017 0.317
LIG_SH2_STAT5 356 359 PF00017 0.310
LIG_SH2_STAT5 367 370 PF00017 0.291
LIG_SH2_STAT5 411 414 PF00017 0.381
LIG_SH2_STAT5 445 448 PF00017 0.337
LIG_SH2_STAT5 95 98 PF00017 0.339
LIG_SH3_3 474 480 PF00018 0.320
LIG_SUMO_SIM_anti_2 334 341 PF11976 0.364
LIG_SUMO_SIM_anti_2 72 77 PF11976 0.212
LIG_TYR_ITIM 183 188 PF00017 0.291
LIG_UBA3_1 315 323 PF00899 0.291
MOD_CK1_1 147 153 PF00069 0.257
MOD_CK1_1 2 8 PF00069 0.681
MOD_CK1_1 473 479 PF00069 0.291
MOD_CK2_1 224 230 PF00069 0.364
MOD_CK2_1 281 287 PF00069 0.347
MOD_GlcNHglycan 132 135 PF01048 0.466
MOD_GlcNHglycan 149 152 PF01048 0.183
MOD_GlcNHglycan 177 180 PF01048 0.419
MOD_GlcNHglycan 227 230 PF01048 0.352
MOD_GlcNHglycan 3 8 PF01048 0.539
MOD_GlcNHglycan 358 361 PF01048 0.427
MOD_GlcNHglycan 394 397 PF01048 0.211
MOD_GlcNHglycan 41 44 PF01048 0.578
MOD_GlcNHglycan 78 81 PF01048 0.320
MOD_GSK3_1 225 232 PF00069 0.291
MOD_GSK3_1 268 275 PF00069 0.338
MOD_GSK3_1 281 288 PF00069 0.303
MOD_GSK3_1 356 363 PF00069 0.334
MOD_GSK3_1 374 381 PF00069 0.333
MOD_N-GLC_1 130 135 PF02516 0.281
MOD_N-GLC_1 225 230 PF02516 0.314
MOD_N-GLC_1 273 278 PF02516 0.369
MOD_N-GLC_1 493 498 PF02516 0.320
MOD_NEK2_1 130 135 PF00069 0.334
MOD_NEK2_1 239 244 PF00069 0.369
MOD_NEK2_1 272 277 PF00069 0.280
MOD_NEK2_1 285 290 PF00069 0.323
MOD_NEK2_1 446 451 PF00069 0.287
MOD_NEK2_1 459 464 PF00069 0.330
MOD_NEK2_1 467 472 PF00069 0.284
MOD_NEK2_1 492 497 PF00069 0.331
MOD_PIKK_1 239 245 PF00454 0.324
MOD_PIKK_1 310 316 PF00454 0.321
MOD_PKA_1 121 127 PF00069 0.402
MOD_PKA_1 84 90 PF00069 0.304
MOD_PKA_2 121 127 PF00069 0.442
MOD_PKA_2 392 398 PF00069 0.211
MOD_PKA_2 459 465 PF00069 0.373
MOD_PKA_2 473 479 PF00069 0.288
MOD_PKA_2 56 62 PF00069 0.499
MOD_Plk_1 130 136 PF00069 0.211
MOD_Plk_1 239 245 PF00069 0.364
MOD_Plk_1 369 375 PF00069 0.453
MOD_Plk_1 467 473 PF00069 0.304
MOD_Plk_2-3 8 14 PF00069 0.624
MOD_Plk_4 121 127 PF00069 0.363
MOD_Plk_4 188 194 PF00069 0.397
MOD_Plk_4 268 274 PF00069 0.372
MOD_Plk_4 335 341 PF00069 0.363
MOD_Plk_4 482 488 PF00069 0.291
MOD_Plk_4 69 75 PF00069 0.325
MOD_ProDKin_1 509 515 PF00069 0.291
MOD_SUMO_for_1 547 550 PF00179 0.317
MOD_SUMO_for_1 62 65 PF00179 0.425
MOD_SUMO_rev_2 154 162 PF00179 0.448
MOD_SUMO_rev_2 328 338 PF00179 0.336
TRG_DiLeu_BaEn_1 335 340 PF01217 0.211
TRG_DiLeu_BaEn_2 536 542 PF01217 0.320
TRG_DiLeu_BaLyEn_6 211 216 PF01217 0.334
TRG_DiLeu_BaLyEn_6 510 515 PF01217 0.304
TRG_ENDOCYTIC_2 153 156 PF00928 0.444
TRG_ENDOCYTIC_2 185 188 PF00928 0.327
TRG_ENDOCYTIC_2 411 414 PF00928 0.397
TRG_ENDOCYTIC_2 445 448 PF00928 0.308
TRG_ENDOCYTIC_2 483 486 PF00928 0.297
TRG_ER_diArg_1 200 202 PF00400 0.200
TRG_ER_diArg_1 499 501 PF00400 0.334
TRG_NES_CRM1_1 306 322 PF08389 0.364
TRG_Pf-PMV_PEXEL_1 214 218 PF00026 0.291

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HY68 Leptomonas seymouri 77% 100%
A0A0S4IKV7 Bodo saltans 59% 100%
A0A0S4JKV9 Bodo saltans 61% 91%
A0A1X0P8S6 Trypanosomatidae 65% 99%
A0A1X0P9F7 Trypanosomatidae 65% 99%
A0A3R7JXC4 Trypanosoma rangeli 65% 100%
A0QP90 Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) 36% 100%
A2CIJ8 Leishmania infantum 86% 100%
A2CIK6 Leishmania donovani 86% 100%
D0A1T2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 61% 100%
E9B4H4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 84% 100%
O00091 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 49% 100%
O14137 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 39% 100%
O24357 Spinacia oleracea 47% 98%
O51581 Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31) 31% 100%
O54537 Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) 35% 100%
O55044 Cricetulus griseus 50% 100%
O59812 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 40% 100%
O68282 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 38% 100%
O83491 Treponema pallidum (strain Nichols) 36% 100%
O84188 Chlamydia trachomatis (strain D/UW-3/Cx) 38% 100%
O95479 Homo sapiens 32% 71%
P05370 Rattus norvegicus 51% 100%
P0A585 Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) 38% 100%
P0A587 Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) 31% 100%
P0AC53 Escherichia coli (strain K12) 37% 100%
P0AC54 Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) 37% 100%
P11410 Cyberlindnera jadinii 49% 100%
P11411 Leuconostoc mesenteroides 34% 100%
P11412 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 51% 100%
P11413 Homo sapiens 51% 100%
P12646 Drosophila melanogaster 51% 100%
P21907 Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4) 34% 100%
P29686 Synechococcus elongatus (strain PCC 7942 / FACHB-805) 37% 100%
P37830 Solanum tuberosum 54% 100%
P37986 Dickeya dadantii (strain 3937) 36% 100%
P41571 Ceratitis capitata 50% 100%
P41764 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 50% 100%
P44311 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) 36% 100%
P48826 Aspergillus niger 51% 100%
P48828 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 48% 100%
P48848 Nostoc punctiforme (strain ATCC 29133 / PCC 73102) 36% 100%
P48992 Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576) 36% 100%
P54547 Bacillus subtilis (strain 168) 37% 100%
P54996 Takifugu rubripes 48% 100%
P56110 Helicobacter pylori (strain ATCC 700392 / 26695) 31% 100%
P56201 Oryctolagus cuniculus 31% 70%
P57405 Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) 31% 100%
P73411 Synechocystis sp. (strain PCC 6803 / Kazusa) 37% 100%
P77809 Aggregatibacter actinomycetemcomitans 38% 100%
P97324 Mus musculus 48% 100%
P9WN70 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) 31% 100%
P9WN71 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 31% 100%
P9WN72 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) 38% 100%
P9WN73 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 38% 100%
Q00612 Mus musculus 50% 100%
Q27464 Caenorhabditis elegans 48% 100%
Q27638 Drosophila yakuba 51% 100%
Q29492 Osphranter robustus 50% 100%
Q42919 Medicago sativa 52% 100%
Q43727 Arabidopsis thaliana 47% 97%
Q43793 Nicotiana tabacum 47% 95%
Q43839 Solanum tuberosum 47% 97%
Q4Q3K1 Leishmania major 84% 100%
Q557D2 Dictyostelium discoideum 50% 100%
Q5FUK8 Gluconobacter oxydans (strain 621H) 33% 100%
Q7YS37 Bos indicus 45% 100%
Q89AI7 Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp) 33% 100%
Q8CFX1 Mus musculus 32% 71%
Q8K9M2 Buchnera aphidicola subsp. Schizaphis graminum (strain Sg) 31% 100%
Q8L743 Arabidopsis thaliana 47% 94%
Q8SR89 Encephalitozoon cuniculi (strain GB-M1) 26% 100%
Q8XCJ6 Escherichia coli O157:H7 37% 100%
Q93ZW0 Arabidopsis thaliana 37% 90%
Q9FJI5 Arabidopsis thaliana 55% 100%
Q9FY99 Arabidopsis thaliana 47% 94%
Q9LK23 Arabidopsis thaliana 54% 100%
Q9PKK8 Chlamydia muridarum (strain MoPn / Nigg) 36% 100%
Q9X0N9 Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) 40% 100%
Q9Z3S2 Rhizobium meliloti (strain 1021) 35% 100%
Q9Z8U6 Chlamydia pneumoniae 37% 100%
Q9ZKB2 Helicobacter pylori (strain J99 / ATCC 700824) 30% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS