Cleft lip and palate associated transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Cleft lip and palate transmembrane protein 1 (CLPTM1), putative

Species:

Leishmania braziliensis

UniProt:

A4HAD0_LEIBR

TriTrypDb:

LbrM.20.0130 , LBRM2903_200008100

Length:

584

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A4HAD0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAD0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	562	566	PF00656	0.667
CLV_NRD_NRD_1	330	332	PF00675	0.271
CLV_NRD_NRD_1	408	410	PF00675	0.271
CLV_PCSK_KEX2_1	289	291	PF00082	0.429
CLV_PCSK_PC1ET2_1	289	291	PF00082	0.429
CLV_PCSK_SKI1_1	110	114	PF00082	0.489
CLV_PCSK_SKI1_1	159	163	PF00082	0.500
CLV_PCSK_SKI1_1	21	25	PF00082	0.286
CLV_PCSK_SKI1_1	260	264	PF00082	0.480
CLV_PCSK_SKI1_1	289	293	PF00082	0.454
CLV_PCSK_SKI1_1	380	384	PF00082	0.314
CLV_PCSK_SKI1_1	386	390	PF00082	0.299
DEG_SPOP_SBC_1	61	65	PF00917	0.163
DOC_CDC14_PxL_1	444	452	PF14671	0.307
DOC_CKS1_1	485	490	PF01111	0.368
DOC_CYCLIN_RxL_1	156	165	PF00134	0.320
DOC_CYCLIN_RxL_1	257	265	PF00134	0.344
DOC_CYCLIN_RxL_1	287	297	PF00134	0.344
DOC_CYCLIN_yCln2_LP_2	89	95	PF00134	0.320
DOC_MAPK_FxFP_2	197	200	PF00069	0.344
DOC_MAPK_gen_1	289	295	PF00069	0.344
DOC_MAPK_gen_1	329	339	PF00069	0.454
DOC_MAPK_gen_1	380	390	PF00069	0.544
DOC_MAPK_gen_1	430	439	PF00069	0.457
DOC_MAPK_MEF2A_6	110	118	PF00069	0.237
DOC_MAPK_MEF2A_6	182	191	PF00069	0.240
DOC_MAPK_MEF2A_6	298	305	PF00069	0.344
DOC_PP1_RVXF_1	129	135	PF00149	0.316
DOC_PP2B_PxIxI_1	487	493	PF00149	0.486
DOC_PP4_FxxP_1	197	200	PF00568	0.254
DOC_PP4_FxxP_1	218	221	PF00568	0.344
DOC_SPAK_OSR1_1	78	82	PF12202	0.320
DOC_USP7_MATH_1	108	112	PF00917	0.318
DOC_USP7_MATH_1	176	180	PF00917	0.308
DOC_USP7_MATH_1	404	408	PF00917	0.544
DOC_USP7_MATH_1	48	52	PF00917	0.331
DOC_USP7_MATH_1	61	65	PF00917	0.207
DOC_WW_Pin1_4	189	194	PF00397	0.249
DOC_WW_Pin1_4	206	211	PF00397	0.240
DOC_WW_Pin1_4	251	256	PF00397	0.269
DOC_WW_Pin1_4	3	8	PF00397	0.673
DOC_WW_Pin1_4	484	489	PF00397	0.355
LIG_14-3-3_CanoR_1	131	137	PF00244	0.326
LIG_14-3-3_CanoR_1	335	340	PF00244	0.483
LIG_14-3-3_CanoR_1	464	470	PF00244	0.311
LIG_14-3-3_CanoR_1	53	62	PF00244	0.221
LIG_BRCT_BRCA1_1	349	353	PF00533	0.408
LIG_BRCT_BRCA1_1	479	483	PF00533	0.403
LIG_CaM_NSCaTE_8	466	473	PF13499	0.289
LIG_CtBP_PxDLS_1	552	556	PF00389	0.634
LIG_eIF4E_1	30	36	PF01652	0.373
LIG_eIF4E_1	444	450	PF01652	0.307
LIG_FHA_1	111	117	PF00498	0.269
LIG_FHA_1	125	131	PF00498	0.233
LIG_FHA_1	142	148	PF00498	0.245
LIG_FHA_1	207	213	PF00498	0.320
LIG_FHA_1	248	254	PF00498	0.271
LIG_FHA_1	304	310	PF00498	0.293
LIG_FHA_1	382	388	PF00498	0.471
LIG_FHA_1	4	10	PF00498	0.767
LIG_FHA_1	485	491	PF00498	0.353
LIG_FHA_1	50	56	PF00498	0.330
LIG_FHA_1	61	67	PF00498	0.328
LIG_FHA_2	263	269	PF00498	0.320
LIG_FHA_2	394	400	PF00498	0.531
LIG_FHA_2	512	518	PF00498	0.481
LIG_GBD_Chelix_1	304	312	PF00786	0.438
LIG_LIR_Apic_2	198	202	PF02991	0.272
LIG_LIR_Gen_1	314	321	PF02991	0.296
LIG_LIR_Gen_1	350	357	PF02991	0.272
LIG_LIR_Gen_1	361	372	PF02991	0.191
LIG_LIR_Gen_1	480	491	PF02991	0.403
LIG_LIR_Gen_1	517	527	PF02991	0.508
LIG_LIR_Gen_1	538	546	PF02991	0.491
LIG_LIR_Gen_1	77	87	PF02991	0.271
LIG_LIR_Nem_3	178	184	PF02991	0.268
LIG_LIR_Nem_3	207	211	PF02991	0.263
LIG_LIR_Nem_3	314	319	PF02991	0.309
LIG_LIR_Nem_3	333	337	PF02991	0.437
LIG_LIR_Nem_3	350	356	PF02991	0.248
LIG_LIR_Nem_3	361	367	PF02991	0.191
LIG_LIR_Nem_3	377	381	PF02991	0.274
LIG_LIR_Nem_3	451	456	PF02991	0.318
LIG_LIR_Nem_3	506	512	PF02991	0.487
LIG_LIR_Nem_3	517	523	PF02991	0.498
LIG_LIR_Nem_3	538	544	PF02991	0.487
LIG_LIR_Nem_3	77	82	PF02991	0.279
LIG_PCNA_PIPBox_1	17	26	PF02747	0.587
LIG_PCNA_PIPBox_1	372	381	PF02747	0.307
LIG_PCNA_yPIPBox_3	10	24	PF02747	0.674
LIG_PCNA_yPIPBox_3	510	520	PF02747	0.483
LIG_Pex14_2	477	481	PF04695	0.282
LIG_Pex14_2	95	99	PF04695	0.191
LIG_PTB_Apo_2	135	142	PF02174	0.292
LIG_PTB_Apo_2	342	349	PF02174	0.247
LIG_PTB_Apo_2	94	101	PF02174	0.304
LIG_SH2_CRK	444	448	PF00017	0.360
LIG_SH2_CRK	456	460	PF00017	0.237
LIG_SH2_CRK	467	471	PF00017	0.216
LIG_SH2_CRK	509	513	PF00017	0.485
LIG_SH2_GRB2like	224	227	PF00017	0.240
LIG_SH2_NCK_1	444	448	PF00017	0.307
LIG_SH2_PTP2	30	33	PF00017	0.341
LIG_SH2_SRC	419	422	PF00017	0.544
LIG_SH2_STAP1	456	460	PF00017	0.243
LIG_SH2_STAP1	467	471	PF00017	0.245
LIG_SH2_STAT5	139	142	PF00017	0.268
LIG_SH2_STAT5	160	163	PF00017	0.307
LIG_SH2_STAT5	184	187	PF00017	0.229
LIG_SH2_STAT5	224	227	PF00017	0.291
LIG_SH2_STAT5	264	267	PF00017	0.247
LIG_SH2_STAT5	30	33	PF00017	0.341
LIG_SH2_STAT5	347	350	PF00017	0.300
LIG_SH2_STAT5	355	358	PF00017	0.274
LIG_SH2_STAT5	441	444	PF00017	0.288
LIG_SH3_3	109	115	PF00018	0.344
LIG_SH3_3	170	176	PF00018	0.221
LIG_SH3_3	363	369	PF00018	0.405
LIG_SH3_3	42	48	PF00018	0.298
LIG_SUMO_SIM_par_1	291	297	PF11976	0.347
LIG_SUMO_SIM_par_1	300	306	PF11976	0.268
LIG_TRAF2_1	566	569	PF00917	0.699
LIG_TYR_ITIM	28	33	PF00017	0.380
LIG_TYR_ITIM	442	447	PF00017	0.405
LIG_UBA3_1	89	94	PF00899	0.344
LIG_WRC_WIRS_1	20	25	PF05994	0.541
LIG_WRC_WIRS_1	478	483	PF05994	0.405
MOD_CDK_SPxxK_3	251	258	PF00069	0.344
MOD_CDK_SPxxK_3	3	10	PF00069	0.586
MOD_CK1_1	22	28	PF00069	0.355
MOD_CK1_1	241	247	PF00069	0.343
MOD_CK1_1	270	276	PF00069	0.273
MOD_CK1_1	280	286	PF00069	0.253
MOD_CK1_1	338	344	PF00069	0.293
MOD_CK1_1	360	366	PF00069	0.320
MOD_CK1_1	426	432	PF00069	0.520
MOD_CK1_1	51	57	PF00069	0.233
MOD_CK1_1	511	517	PF00069	0.560
MOD_CK1_1	64	70	PF00069	0.286
MOD_CK2_1	262	268	PF00069	0.306
MOD_CK2_1	280	286	PF00069	0.203
MOD_CK2_1	311	317	PF00069	0.405
MOD_CK2_1	393	399	PF00069	0.509
MOD_Cter_Amidation	329	332	PF01082	0.320
MOD_GlcNHglycan	169	172	PF01048	0.522
MOD_GlcNHglycan	178	181	PF01048	0.499
MOD_GlcNHglycan	241	244	PF01048	0.412
MOD_GlcNHglycan	369	372	PF01048	0.293
MOD_GlcNHglycan	406	409	PF01048	0.344
MOD_GlcNHglycan	416	419	PF01048	0.226
MOD_GlcNHglycan	450	453	PF01048	0.300
MOD_GlcNHglycan	456	459	PF01048	0.288
MOD_GlcNHglycan	561	564	PF01048	0.493
MOD_GSK3_1	137	144	PF00069	0.308
MOD_GSK3_1	247	254	PF00069	0.278
MOD_GSK3_1	280	287	PF00069	0.293
MOD_GSK3_1	303	310	PF00069	0.293
MOD_GSK3_1	389	396	PF00069	0.480
MOD_GSK3_1	465	472	PF00069	0.291
MOD_GSK3_1	60	67	PF00069	0.252
MOD_N-GLC_1	108	113	PF02516	0.473
MOD_N-GLC_1	124	129	PF02516	0.360
MOD_N-GLC_1	137	142	PF02516	0.429
MOD_N-GLC_1	176	181	PF02516	0.391
MOD_N-GLC_1	238	243	PF02516	0.440
MOD_N-GLC_1	247	252	PF02516	0.440
MOD_N-GLC_1	423	428	PF02516	0.274
MOD_NEK2_1	141	146	PF00069	0.336
MOD_NEK2_1	238	243	PF00069	0.252
MOD_NEK2_1	247	252	PF00069	0.203
MOD_NEK2_1	262	267	PF00069	0.227
MOD_NEK2_1	277	282	PF00069	0.183
MOD_NEK2_1	293	298	PF00069	0.256
MOD_NEK2_1	303	308	PF00069	0.262
MOD_NEK2_1	311	316	PF00069	0.307
MOD_NEK2_1	381	386	PF00069	0.438
MOD_NEK2_1	459	464	PF00069	0.408
MOD_NEK2_1	469	474	PF00069	0.287
MOD_NEK2_1	477	482	PF00069	0.195
MOD_NEK2_1	62	67	PF00069	0.276
MOD_NEK2_2	126	131	PF00069	0.266
MOD_PIKK_1	211	217	PF00454	0.190
MOD_PIKK_1	241	247	PF00454	0.344
MOD_PIKK_1	262	268	PF00454	0.320
MOD_PIKK_1	270	276	PF00454	0.320
MOD_PIKK_1	389	395	PF00454	0.450
MOD_PIKK_1	428	434	PF00454	0.520
MOD_PIKK_1	470	476	PF00454	0.293
MOD_PIKK_1	54	60	PF00454	0.289
MOD_PIKK_1	82	88	PF00454	0.337
MOD_PK_1	335	341	PF00069	0.492
MOD_PK_1	495	501	PF00069	0.525
MOD_PKA_2	404	410	PF00069	0.527
MOD_PKA_2	414	420	PF00069	0.517
MOD_PKA_2	77	83	PF00069	0.314
MOD_Plk_1	108	114	PF00069	0.275
MOD_Plk_1	124	130	PF00069	0.166
MOD_Plk_1	137	143	PF00069	0.254
MOD_Plk_1	176	182	PF00069	0.281
MOD_Plk_1	187	193	PF00069	0.296
MOD_Plk_1	247	253	PF00069	0.253
MOD_Plk_1	267	273	PF00069	0.108
MOD_Plk_1	360	366	PF00069	0.243
MOD_Plk_1	423	429	PF00069	0.474
MOD_Plk_1	553	559	PF00069	0.647
MOD_Plk_4	219	225	PF00069	0.347
MOD_Plk_4	307	313	PF00069	0.349
MOD_Plk_4	347	353	PF00069	0.293
MOD_Plk_4	465	471	PF00069	0.244
MOD_Plk_4	511	517	PF00069	0.476
MOD_ProDKin_1	189	195	PF00069	0.249
MOD_ProDKin_1	206	212	PF00069	0.240
MOD_ProDKin_1	251	257	PF00069	0.269
MOD_ProDKin_1	3	9	PF00069	0.673
MOD_ProDKin_1	484	490	PF00069	0.352
MOD_SUMO_for_1	388	391	PF00179	0.544
MOD_SUMO_for_1	93	96	PF00179	0.344
MOD_SUMO_rev_2	322	327	PF00179	0.454
TRG_AP2beta_CARGO_1	538	548	PF09066	0.491
TRG_DiLeu_BaLyEn_6	297	302	PF01217	0.163
TRG_DiLeu_BaLyEn_6	445	450	PF01217	0.307
TRG_ENDOCYTIC_2	264	267	PF00928	0.254
TRG_ENDOCYTIC_2	30	33	PF00928	0.347
TRG_ENDOCYTIC_2	378	381	PF00928	0.190
TRG_ENDOCYTIC_2	444	447	PF00928	0.343
TRG_ENDOCYTIC_2	456	459	PF00928	0.227
TRG_ENDOCYTIC_2	467	470	PF00928	0.240
TRG_ENDOCYTIC_2	509	512	PF00928	0.487
TRG_ER_diLys_1	581	584	PF00400	0.748
TRG_Pf-PMV_PEXEL_1	290	294	PF00026	0.520

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6I8	Leptomonas seymouri	66%	97%
A0A1X0P8S5	Trypanosomatidae	49%	100%
A0A3S7X7A7	Leishmania donovani	84%	100%
A0A422MZT4	Trypanosoma rangeli	47%	99%
A4I9H3	Leishmania infantum	84%	100%
D0A1S8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9B4H1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q3K4	Leishmania major	84%	100%
Q54RJ1	Dictyostelium discoideum	42%	94%
V5DIK4	Trypanosoma cruzi	45%	99%