Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HAC5_LEIBR

TriTrypDb:

LbrM.20.0080 , LBRM2903_200007700

Length:

595

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HAC5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAC5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	446	450	PF00656	0.434
CLV_NRD_NRD_1	120	122	PF00675	0.485
CLV_NRD_NRD_1	252	254	PF00675	0.570
CLV_NRD_NRD_1	490	492	PF00675	0.452
CLV_NRD_NRD_1	501	503	PF00675	0.415
CLV_NRD_NRD_1	58	60	PF00675	0.510
CLV_NRD_NRD_1	80	82	PF00675	0.586
CLV_PCSK_FUR_1	499	503	PF00082	0.525
CLV_PCSK_KEX2_1	122	124	PF00082	0.465
CLV_PCSK_KEX2_1	252	254	PF00082	0.594
CLV_PCSK_KEX2_1	490	492	PF00082	0.410
CLV_PCSK_KEX2_1	501	503	PF00082	0.459
CLV_PCSK_KEX2_1	79	81	PF00082	0.592
CLV_PCSK_PC1ET2_1	122	124	PF00082	0.465
CLV_PCSK_PC1ET2_1	79	81	PF00082	0.555
CLV_PCSK_SKI1_1	166	170	PF00082	0.562
CLV_PCSK_SKI1_1	315	319	PF00082	0.485
CLV_PCSK_SKI1_1	469	473	PF00082	0.449
CLV_PCSK_SKI1_1	483	487	PF00082	0.589
CLV_PCSK_SKI1_1	80	84	PF00082	0.535
DEG_APCC_DBOX_1	165	173	PF00400	0.457
DEG_ODPH_VHL_1	401	413	PF01847	0.364
DOC_CYCLIN_RxL_1	312	325	PF00134	0.517
DOC_MAPK_MEF2A_6	208	215	PF00069	0.514
DOC_MAPK_MEF2A_6	222	229	PF00069	0.397
DOC_MAPK_NFAT4_5	222	230	PF00069	0.506
DOC_MAPK_RevD_3	107	122	PF00069	0.494
DOC_PP1_RVXF_1	489	496	PF00149	0.373
DOC_PP1_RVXF_1	574	580	PF00149	0.542
DOC_SPAK_OSR1_1	193	197	PF12202	0.371
DOC_USP7_MATH_1	145	149	PF00917	0.618
DOC_USP7_MATH_1	241	245	PF00917	0.435
DOC_USP7_MATH_1	280	284	PF00917	0.557
DOC_USP7_MATH_1	375	379	PF00917	0.569
DOC_USP7_MATH_1	383	387	PF00917	0.517
DOC_USP7_MATH_1	403	407	PF00917	0.567
DOC_USP7_MATH_1	544	548	PF00917	0.402
LIG_14-3-3_CanoR_1	16	22	PF00244	0.641
LIG_14-3-3_CanoR_1	290	296	PF00244	0.513
LIG_14-3-3_CanoR_1	382	390	PF00244	0.622
LIG_14-3-3_CanoR_1	43	51	PF00244	0.452
LIG_14-3-3_CanoR_1	490	494	PF00244	0.458
LIG_14-3-3_CanoR_1	501	506	PF00244	0.388
LIG_14-3-3_CanoR_1	80	89	PF00244	0.691
LIG_AP2alpha_2	139	141	PF02296	0.620
LIG_APCC_ABBA_1	172	177	PF00400	0.642
LIG_BRCT_BRCA1_1	191	195	PF00533	0.491
LIG_BRCT_BRCA1_1	295	299	PF00533	0.420
LIG_BRCT_BRCA1_1	370	374	PF00533	0.458
LIG_BRCT_BRCA1_1	491	495	PF00533	0.462
LIG_deltaCOP1_diTrp_1	137	143	PF00928	0.634
LIG_deltaCOP1_diTrp_1	187	195	PF00928	0.497
LIG_FHA_1	124	130	PF00498	0.602
LIG_FHA_1	396	402	PF00498	0.445
LIG_FHA_1	407	413	PF00498	0.350
LIG_FHA_1	416	422	PF00498	0.417
LIG_FHA_1	443	449	PF00498	0.452
LIG_FHA_1	466	472	PF00498	0.387
LIG_FHA_1	524	530	PF00498	0.432
LIG_FHA_2	266	272	PF00498	0.489
LIG_FHA_2	345	351	PF00498	0.518
LIG_FHA_2	382	388	PF00498	0.501
LIG_FHA_2	428	434	PF00498	0.511
LIG_KLC1_Yacidic_2	387	391	PF13176	0.422
LIG_LIR_Gen_1	13	22	PF02991	0.380
LIG_LIR_Gen_1	2	11	PF02991	0.533
LIG_LIR_Gen_1	292	303	PF02991	0.419
LIG_LIR_Gen_1	405	415	PF02991	0.363
LIG_LIR_Gen_1	492	500	PF02991	0.477
LIG_LIR_Gen_1	569	579	PF02991	0.657
LIG_LIR_LC3C_4	408	412	PF02991	0.426
LIG_LIR_Nem_3	13	17	PF02991	0.375
LIG_LIR_Nem_3	155	160	PF02991	0.571
LIG_LIR_Nem_3	185	191	PF02991	0.537
LIG_LIR_Nem_3	2	7	PF02991	0.556
LIG_LIR_Nem_3	292	298	PF02991	0.450
LIG_LIR_Nem_3	391	396	PF02991	0.473
LIG_LIR_Nem_3	405	410	PF02991	0.365
LIG_LIR_Nem_3	433	437	PF02991	0.462
LIG_LIR_Nem_3	492	498	PF02991	0.552
LIG_LIR_Nem_3	569	575	PF02991	0.651
LIG_LYPXL_yS_3	337	340	PF13949	0.593
LIG_MLH1_MIPbox_1	191	195	PF16413	0.358
LIG_MLH1_MIPbox_1	295	299	PF16413	0.420
LIG_NRBOX	33	39	PF00104	0.477
LIG_NRBOX	443	449	PF00104	0.349
LIG_PTB_Apo_2	336	343	PF02174	0.520
LIG_SH2_CRK	14	18	PF00017	0.527
LIG_SH2_CRK	160	164	PF00017	0.596
LIG_SH2_CRK	4	8	PF00017	0.546
LIG_SH2_SRC	305	308	PF00017	0.385
LIG_SH2_SRC	533	536	PF00017	0.453
LIG_SH2_STAP1	295	299	PF00017	0.420
LIG_SH2_STAP1	4	8	PF00017	0.468
LIG_SH2_STAT5	175	178	PF00017	0.605
LIG_SH2_STAT5	305	308	PF00017	0.385
LIG_SH2_STAT5	389	392	PF00017	0.487
LIG_SH2_STAT5	4	7	PF00017	0.480
LIG_SH2_STAT5	40	43	PF00017	0.444
LIG_SH2_STAT5	488	491	PF00017	0.438
LIG_SH2_STAT5	497	500	PF00017	0.383
LIG_SH2_STAT5	533	536	PF00017	0.437
LIG_SH3_3	397	403	PF00018	0.466
LIG_SUMO_SIM_anti_2	167	173	PF11976	0.520
LIG_SUMO_SIM_anti_2	408	414	PF11976	0.359
LIG_SUMO_SIM_par_1	408	414	PF11976	0.350
LIG_SUMO_SIM_par_1	587	594	PF11976	0.472
LIG_TRAF2_1	517	520	PF00917	0.408
LIG_UBA3_1	257	264	PF00899	0.518
LIG_WRC_WIRS_1	226	231	PF05994	0.360
MOD_CK1_1	260	266	PF00069	0.492
MOD_CK1_1	278	284	PF00069	0.529
MOD_CK1_1	368	374	PF00069	0.579
MOD_CK1_1	405	411	PF00069	0.521
MOD_CK1_1	42	48	PF00069	0.572
MOD_CK2_1	265	271	PF00069	0.523
MOD_CK2_1	427	433	PF00069	0.514
MOD_CK2_1	46	52	PF00069	0.666
MOD_CK2_1	514	520	PF00069	0.412
MOD_Cter_Amidation	57	60	PF01082	0.388
MOD_GlcNHglycan	123	126	PF01048	0.655
MOD_GlcNHglycan	17	20	PF01048	0.540
MOD_GlcNHglycan	276	280	PF01048	0.584
MOD_GlcNHglycan	295	298	PF01048	0.337
MOD_GlcNHglycan	363	366	PF01048	0.637
MOD_GlcNHglycan	370	373	PF01048	0.724
MOD_GlcNHglycan	413	416	PF01048	0.367
MOD_GlcNHglycan	529	532	PF01048	0.455
MOD_GlcNHglycan	572	575	PF01048	0.560
MOD_GlcNHglycan	582	585	PF01048	0.452
MOD_GSK3_1	121	128	PF00069	0.693
MOD_GSK3_1	141	148	PF00069	0.480
MOD_GSK3_1	17	24	PF00069	0.587
MOD_GSK3_1	214	221	PF00069	0.594
MOD_GSK3_1	271	278	PF00069	0.563
MOD_GSK3_1	289	296	PF00069	0.594
MOD_GSK3_1	357	364	PF00069	0.648
MOD_GSK3_1	402	409	PF00069	0.544
MOD_GSK3_1	411	418	PF00069	0.400
MOD_GSK3_1	42	49	PF00069	0.559
MOD_GSK3_1	423	430	PF00069	0.496
MOD_GSK3_1	465	472	PF00069	0.370
MOD_GSK3_1	523	530	PF00069	0.448
MOD_GSK3_1	566	573	PF00069	0.420
MOD_LATS_1	380	386	PF00433	0.480
MOD_NEK2_1	17	22	PF00069	0.584
MOD_NEK2_1	218	223	PF00069	0.458
MOD_NEK2_1	225	230	PF00069	0.469
MOD_NEK2_1	242	247	PF00069	0.401
MOD_NEK2_1	291	296	PF00069	0.436
MOD_NEK2_1	298	303	PF00069	0.401
MOD_NEK2_1	570	575	PF00069	0.538
MOD_PIKK_1	27	33	PF00454	0.623
MOD_PIKK_1	423	429	PF00454	0.437
MOD_PIKK_1	80	86	PF00454	0.562
MOD_PKA_1	121	127	PF00069	0.454
MOD_PKA_1	501	507	PF00069	0.326
MOD_PKA_1	80	86	PF00069	0.562
MOD_PKA_2	15	21	PF00069	0.650
MOD_PKA_2	265	271	PF00069	0.639
MOD_PKA_2	289	295	PF00069	0.357
MOD_PKA_2	381	387	PF00069	0.633
MOD_PKA_2	42	48	PF00069	0.391
MOD_PKA_2	489	495	PF00069	0.455
MOD_PKA_2	500	506	PF00069	0.378
MOD_PKA_2	80	86	PF00069	0.601
MOD_PKB_1	121	129	PF00069	0.455
MOD_PKB_1	499	507	PF00069	0.339
MOD_PKB_1	85	93	PF00069	0.584
MOD_Plk_1	218	224	PF00069	0.488
MOD_Plk_1	442	448	PF00069	0.504
MOD_Plk_2-3	443	449	PF00069	0.428
MOD_Plk_4	125	131	PF00069	0.525
MOD_Plk_4	17	23	PF00069	0.509
MOD_Plk_4	2	8	PF00069	0.575
MOD_Plk_4	32	38	PF00069	0.421
MOD_Plk_4	327	333	PF00069	0.419
MOD_Plk_4	365	371	PF00069	0.629
MOD_Plk_4	406	412	PF00069	0.429
MOD_Plk_4	443	449	PF00069	0.376
MOD_Plk_4	501	507	PF00069	0.369
MOD_SUMO_for_1	560	563	PF00179	0.613
MOD_SUMO_rev_2	117	124	PF00179	0.486
MOD_SUMO_rev_2	553	562	PF00179	0.613
TRG_DiLeu_BaEn_1	167	172	PF01217	0.520
TRG_DiLeu_BaEn_1	443	448	PF01217	0.343
TRG_ENDOCYTIC_2	14	17	PF00928	0.529
TRG_ENDOCYTIC_2	160	163	PF00928	0.709
TRG_ENDOCYTIC_2	175	178	PF00928	0.428
TRG_ENDOCYTIC_2	288	291	PF00928	0.448
TRG_ENDOCYTIC_2	295	298	PF00928	0.424
TRG_ENDOCYTIC_2	337	340	PF00928	0.593
TRG_ENDOCYTIC_2	4	7	PF00928	0.559
TRG_ENDOCYTIC_2	497	500	PF00928	0.492
TRG_ER_diArg_1	251	253	PF00400	0.647
TRG_ER_diArg_1	489	491	PF00400	0.470
TRG_ER_diArg_1	498	501	PF00400	0.434
TRG_ER_diArg_1	80	82	PF00400	0.553
TRG_Pf-PMV_PEXEL_1	469	474	PF00026	0.501
TRG_Pf-PMV_PEXEL_1	87	91	PF00026	0.597

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEU5	Leptomonas seymouri	42%	99%
A0A3Q8IF64	Leishmania donovani	78%	100%
A4I9H8	Leishmania infantum	78%	100%
E9B4H6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4Q3J9	Leishmania major	79%	100%