Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PrimPol-like protein 2, putative

Species:

Leishmania braziliensis

UniProt:

A4HAC4_LEIBR

TriTrypDb:

LbrM.20.0070 , LBRM2903_200007600

Length:

761

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HAC4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAC4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0003887	DNA-directed DNA polymerase activity	5	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1
GO:0016779	nucleotidyltransferase activity	4	1
GO:0034061	DNA polymerase activity	4	1
GO:0140097	catalytic activity, acting on DNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	32	36	PF00656	0.513
CLV_NRD_NRD_1	162	164	PF00675	0.571
CLV_NRD_NRD_1	281	283	PF00675	0.568
CLV_NRD_NRD_1	377	379	PF00675	0.435
CLV_NRD_NRD_1	607	609	PF00675	0.437
CLV_NRD_NRD_1	751	753	PF00675	0.537
CLV_PCSK_KEX2_1	162	164	PF00082	0.620
CLV_PCSK_KEX2_1	281	283	PF00082	0.568
CLV_PCSK_KEX2_1	607	609	PF00082	0.533
CLV_PCSK_KEX2_1	751	753	PF00082	0.537
CLV_PCSK_SKI1_1	153	157	PF00082	0.621
CLV_PCSK_SKI1_1	256	260	PF00082	0.549
CLV_PCSK_SKI1_1	271	275	PF00082	0.399
CLV_PCSK_SKI1_1	476	480	PF00082	0.402
CLV_PCSK_SKI1_1	494	498	PF00082	0.384
CLV_PCSK_SKI1_1	607	611	PF00082	0.487
CLV_PCSK_SKI1_1	737	741	PF00082	0.450
CLV_Separin_Metazoa	748	752	PF03568	0.557
DEG_APCC_DBOX_1	475	483	PF00400	0.382
DEG_APCC_DBOX_1	606	614	PF00400	0.342
DEG_SCF_FBW7_2	627	634	PF00400	0.474
DEG_SPOP_SBC_1	297	301	PF00917	0.422
DEG_SPOP_SBC_1	556	560	PF00917	0.617
DEG_SPOP_SBC_1	579	583	PF00917	0.488
DOC_CKS1_1	628	633	PF01111	0.473
DOC_CKS1_1	645	650	PF01111	0.303
DOC_CYCLIN_RxL_1	268	278	PF00134	0.482
DOC_CYCLIN_yCln2_LP_2	500	503	PF00134	0.457
DOC_MAPK_gen_1	378	385	PF00069	0.356
DOC_MAPK_gen_1	562	570	PF00069	0.471
DOC_MAPK_gen_1	667	675	PF00069	0.552
DOC_MAPK_MEF2A_6	153	160	PF00069	0.555
DOC_MAPK_NFAT4_5	153	161	PF00069	0.497
DOC_PP1_RVXF_1	319	325	PF00149	0.391
DOC_PP1_RVXF_1	384	391	PF00149	0.498
DOC_PP2B_LxvP_1	124	127	PF13499	0.648
DOC_PP2B_LxvP_1	500	503	PF13499	0.457
DOC_PP2B_LxvP_1	740	743	PF13499	0.468
DOC_PP4_FxxP_1	399	402	PF00568	0.391
DOC_PP4_FxxP_1	477	480	PF00568	0.397
DOC_PP4_FxxP_1	496	499	PF00568	0.510
DOC_PP4_FxxP_1	586	589	PF00568	0.615
DOC_USP7_MATH_1	16	20	PF00917	0.518
DOC_USP7_MATH_1	335	339	PF00917	0.440
DOC_USP7_MATH_1	360	364	PF00917	0.550
DOC_USP7_MATH_1	410	414	PF00917	0.686
DOC_USP7_MATH_1	415	419	PF00917	0.678
DOC_USP7_MATH_1	456	460	PF00917	0.321
DOC_USP7_MATH_1	510	514	PF00917	0.573
DOC_USP7_MATH_1	518	522	PF00917	0.489
DOC_USP7_MATH_1	556	560	PF00917	0.746
DOC_USP7_MATH_1	575	579	PF00917	0.649
DOC_USP7_MATH_1	58	62	PF00917	0.698
DOC_USP7_MATH_1	589	593	PF00917	0.508
DOC_WW_Pin1_4	114	119	PF00397	0.723
DOC_WW_Pin1_4	307	312	PF00397	0.671
DOC_WW_Pin1_4	495	500	PF00397	0.521
DOC_WW_Pin1_4	514	519	PF00397	0.554
DOC_WW_Pin1_4	581	586	PF00397	0.644
DOC_WW_Pin1_4	627	632	PF00397	0.684
DOC_WW_Pin1_4	644	649	PF00397	0.381
DOC_WW_Pin1_4	94	99	PF00397	0.699
LIG_14-3-3_CanoR_1	102	110	PF00244	0.679
LIG_14-3-3_CanoR_1	131	137	PF00244	0.483
LIG_14-3-3_CanoR_1	176	184	PF00244	0.653
LIG_14-3-3_CanoR_1	306	314	PF00244	0.412
LIG_14-3-3_CanoR_1	59	65	PF00244	0.709
LIG_14-3-3_CanoR_1	674	683	PF00244	0.571
LIG_Actin_WH2_2	273	291	PF00022	0.536
LIG_APCC_ABBA_1	226	231	PF00400	0.392
LIG_BIR_II_1	1	5	PF00653	0.667
LIG_BRCT_BRCA1_1	167	171	PF00533	0.564
LIG_BRCT_BRCA1_1	557	561	PF00533	0.755
LIG_BRCT_BRCA1_1	582	586	PF00533	0.741
LIG_eIF4E_1	63	69	PF01652	0.426
LIG_FHA_1	18	24	PF00498	0.700
LIG_FHA_1	297	303	PF00498	0.397
LIG_FHA_1	569	575	PF00498	0.606
LIG_FHA_1	604	610	PF00498	0.546
LIG_FHA_1	628	634	PF00498	0.617
LIG_FHA_1	641	647	PF00498	0.410
LIG_FHA_1	744	750	PF00498	0.630
LIG_FHA_1	753	759	PF00498	0.569
LIG_FHA_2	137	143	PF00498	0.476
LIG_FHA_2	289	295	PF00498	0.535
LIG_LIR_Apic_2	495	499	PF02991	0.520
LIG_LIR_Apic_2	583	589	PF02991	0.634
LIG_LIR_Apic_2	92	98	PF02991	0.609
LIG_LIR_Gen_1	168	179	PF02991	0.548
LIG_LIR_Gen_1	634	645	PF02991	0.650
LIG_LIR_Gen_1	682	690	PF02991	0.527
LIG_LIR_Gen_1	74	85	PF02991	0.600
LIG_LIR_Nem_3	168	174	PF02991	0.534
LIG_LIR_Nem_3	227	232	PF02991	0.394
LIG_LIR_Nem_3	389	393	PF02991	0.429
LIG_LIR_Nem_3	394	399	PF02991	0.486
LIG_LIR_Nem_3	558	564	PF02991	0.673
LIG_LIR_Nem_3	612	617	PF02991	0.406
LIG_LIR_Nem_3	634	640	PF02991	0.668
LIG_LIR_Nem_3	682	686	PF02991	0.470
LIG_LIR_Nem_3	689	693	PF02991	0.454
LIG_LIR_Nem_3	81	87	PF02991	0.561
LIG_Pex14_2	230	234	PF04695	0.516
LIG_Pex14_2	324	328	PF04695	0.373
LIG_PTAP_UEV_1	190	195	PF05743	0.477
LIG_PTB_Apo_2	40	47	PF02174	0.644
LIG_PTB_Apo_2	735	742	PF02174	0.591
LIG_RPA_C_Fungi	158	170	PF08784	0.615
LIG_SH2_CRK	730	734	PF00017	0.442
LIG_SH2_GRB2like	698	701	PF00017	0.529
LIG_SH2_NCK_1	217	221	PF00017	0.578
LIG_SH2_SRC	655	658	PF00017	0.505
LIG_SH2_STAP1	133	137	PF00017	0.391
LIG_SH2_STAP1	655	659	PF00017	0.588
LIG_SH2_STAP1	730	734	PF00017	0.546
LIG_SH2_STAT3	466	469	PF00017	0.317
LIG_SH2_STAT3	663	666	PF00017	0.436
LIG_SH2_STAT5	229	232	PF00017	0.471
LIG_SH2_STAT5	393	396	PF00017	0.539
LIG_SH2_STAT5	466	469	PF00017	0.508
LIG_SH2_STAT5	663	666	PF00017	0.487
LIG_SH2_STAT5	671	674	PF00017	0.512
LIG_SH2_STAT5	687	690	PF00017	0.337
LIG_SH3_2	645	650	PF14604	0.377
LIG_SH3_3	123	129	PF00018	0.565
LIG_SH3_3	188	194	PF00018	0.725
LIG_SH3_3	222	228	PF00018	0.515
LIG_SH3_3	308	314	PF00018	0.637
LIG_SH3_3	477	483	PF00018	0.371
LIG_SH3_3	496	502	PF00018	0.471
LIG_SH3_3	512	518	PF00018	0.501
LIG_SH3_3	585	591	PF00018	0.615
LIG_SH3_3	625	631	PF00018	0.690
LIG_SH3_3	642	648	PF00018	0.337
LIG_SH3_3	711	717	PF00018	0.560
LIG_SH3_3	84	90	PF00018	0.593
LIG_SUMO_SIM_anti_2	19	25	PF11976	0.534
LIG_SUMO_SIM_par_1	156	161	PF11976	0.524
LIG_SUMO_SIM_par_1	180	187	PF11976	0.454
LIG_SUMO_SIM_par_1	272	278	PF11976	0.380
LIG_SUMO_SIM_par_1	312	318	PF11976	0.383
LIG_SUMO_SIM_par_1	445	451	PF11976	0.284
LIG_SUMO_SIM_par_1	67	75	PF11976	0.420
LIG_TRAF2_1	632	635	PF00917	0.725
LIG_TRAF2_1	745	748	PF00917	0.545
LIG_WRC_WIRS_1	133	138	PF05994	0.329
LIG_WRC_WIRS_1	342	347	PF05994	0.330
LIG_WRC_WIRS_1	687	692	PF05994	0.551
MOD_CDC14_SPxK_1	117	120	PF00782	0.523
MOD_CDK_SPxK_1	114	120	PF00069	0.530
MOD_CDK_SPxK_1	644	650	PF00069	0.553
MOD_CK1_1	111	117	PF00069	0.684
MOD_CK1_1	19	25	PF00069	0.593
MOD_CK1_1	301	307	PF00069	0.490
MOD_CK1_1	513	519	PF00069	0.649
MOD_CK1_1	578	584	PF00069	0.592
MOD_CK1_1	638	644	PF00069	0.618
MOD_CK2_1	136	142	PF00069	0.550
MOD_CK2_1	184	190	PF00069	0.640
MOD_CK2_1	248	254	PF00069	0.576
MOD_CK2_1	288	294	PF00069	0.555
MOD_CK2_1	307	313	PF00069	0.357
MOD_CK2_1	335	341	PF00069	0.556
MOD_CK2_1	742	748	PF00069	0.568
MOD_GlcNHglycan	1	4	PF01048	0.547
MOD_GlcNHglycan	10	14	PF01048	0.547
MOD_GlcNHglycan	165	168	PF01048	0.546
MOD_GlcNHglycan	177	180	PF01048	0.531
MOD_GlcNHglycan	185	189	PF01048	0.743
MOD_GlcNHglycan	190	194	PF01048	0.684
MOD_GlcNHglycan	198	201	PF01048	0.427
MOD_GlcNHglycan	264	267	PF01048	0.570
MOD_GlcNHglycan	413	416	PF01048	0.673
MOD_GlcNHglycan	417	420	PF01048	0.610
MOD_GlcNHglycan	442	445	PF01048	0.378
MOD_GlcNHglycan	48	51	PF01048	0.514
MOD_GlcNHglycan	512	515	PF01048	0.613
MOD_GlcNHglycan	520	523	PF01048	0.481
MOD_GlcNHglycan	526	529	PF01048	0.407
MOD_GlcNHglycan	576	580	PF01048	0.628
MOD_GlcNHglycan	637	640	PF01048	0.716
MOD_GlcNHglycan	718	721	PF01048	0.704
MOD_GSK3_1	104	111	PF00069	0.669
MOD_GSK3_1	114	121	PF00069	0.676
MOD_GSK3_1	132	139	PF00069	0.286
MOD_GSK3_1	24	31	PF00069	0.711
MOD_GSK3_1	283	290	PF00069	0.553
MOD_GSK3_1	297	304	PF00069	0.403
MOD_GSK3_1	305	312	PF00069	0.555
MOD_GSK3_1	344	351	PF00069	0.572
MOD_GSK3_1	411	418	PF00069	0.683
MOD_GSK3_1	436	443	PF00069	0.516
MOD_GSK3_1	456	463	PF00069	0.499
MOD_GSK3_1	483	490	PF00069	0.501
MOD_GSK3_1	510	517	PF00069	0.607
MOD_GSK3_1	539	546	PF00069	0.590
MOD_GSK3_1	552	559	PF00069	0.609
MOD_GSK3_1	575	582	PF00069	0.700
MOD_GSK3_1	589	596	PF00069	0.481
MOD_GSK3_1	623	630	PF00069	0.618
MOD_GSK3_1	640	647	PF00069	0.472
MOD_GSK3_1	675	682	PF00069	0.419
MOD_LATS_1	100	106	PF00433	0.741
MOD_N-GLC_2	700	702	PF02516	0.527
MOD_NEK2_1	132	137	PF00069	0.463
MOD_NEK2_1	248	253	PF00069	0.574
MOD_NEK2_1	288	293	PF00069	0.492
MOD_NEK2_1	296	301	PF00069	0.354
MOD_NEK2_1	320	325	PF00069	0.503
MOD_NEK2_1	38	43	PF00069	0.573
MOD_NEK2_1	46	51	PF00069	0.497
MOD_NEK2_1	640	645	PF00069	0.579
MOD_NEK2_1	675	680	PF00069	0.558
MOD_NEK2_1	686	691	PF00069	0.437
MOD_NEK2_2	335	340	PF00069	0.448
MOD_NEK2_2	557	562	PF00069	0.504
MOD_NEK2_2	655	660	PF00069	0.583
MOD_PIKK_1	460	466	PF00454	0.314
MOD_PIKK_1	549	555	PF00454	0.513
MOD_PKA_1	378	384	PF00069	0.304
MOD_PKA_2	175	181	PF00069	0.481
MOD_PKA_2	196	202	PF00069	0.436
MOD_PKA_2	24	30	PF00069	0.587
MOD_PKA_2	305	311	PF00069	0.389
MOD_PKA_2	58	64	PF00069	0.496
MOD_Plk_1	184	190	PF00069	0.518
MOD_Plk_1	232	238	PF00069	0.555
MOD_Plk_1	256	262	PF00069	0.468
MOD_Plk_1	28	34	PF00069	0.514
MOD_Plk_1	486	492	PF00069	0.308
MOD_Plk_1	538	544	PF00069	0.628
MOD_Plk_1	655	661	PF00069	0.546
MOD_Plk_1	72	78	PF00069	0.553
MOD_Plk_2-3	29	35	PF00069	0.627
MOD_Plk_2-3	313	319	PF00069	0.482
MOD_Plk_4	104	110	PF00069	0.639
MOD_Plk_4	132	138	PF00069	0.425
MOD_Plk_4	19	25	PF00069	0.677
MOD_Plk_4	272	278	PF00069	0.485
MOD_Plk_4	341	347	PF00069	0.335
MOD_Plk_4	448	454	PF00069	0.431
MOD_Plk_4	623	629	PF00069	0.566
MOD_Plk_4	72	78	PF00069	0.596
MOD_ProDKin_1	114	120	PF00069	0.723
MOD_ProDKin_1	307	313	PF00069	0.671
MOD_ProDKin_1	495	501	PF00069	0.517
MOD_ProDKin_1	514	520	PF00069	0.551
MOD_ProDKin_1	581	587	PF00069	0.646
MOD_ProDKin_1	627	633	PF00069	0.682
MOD_ProDKin_1	644	650	PF00069	0.386
MOD_ProDKin_1	94	100	PF00069	0.699
MOD_SUMO_rev_2	251	258	PF00179	0.588
MOD_SUMO_rev_2	283	291	PF00179	0.525
TRG_DiLeu_BaEn_1	605	610	PF01217	0.532
TRG_DiLeu_BaEn_2	340	346	PF01217	0.449
TRG_DiLeu_BaLyEn_6	559	564	PF01217	0.710
TRG_DiLeu_LyEn_5	605	610	PF01217	0.541
TRG_ENDOCYTIC_2	133	136	PF00928	0.331
TRG_ENDOCYTIC_2	217	220	PF00928	0.427
TRG_ENDOCYTIC_2	229	232	PF00928	0.399
TRG_ENDOCYTIC_2	662	665	PF00928	0.530
TRG_ENDOCYTIC_2	687	690	PF00928	0.462
TRG_ENDOCYTIC_2	730	733	PF00928	0.451
TRG_ER_diArg_1	280	282	PF00400	0.560
TRG_ER_diArg_1	349	352	PF00400	0.512
TRG_ER_diArg_1	597	600	PF00400	0.652
TRG_ER_diArg_1	607	609	PF00400	0.537
TRG_ER_diArg_1	750	752	PF00400	0.526
TRG_NES_CRM1_1	318	332	PF08389	0.540
TRG_NES_CRM1_1	423	438	PF08389	0.551
TRG_Pf-PMV_PEXEL_1	465	469	PF00026	0.422
TRG_Pf-PMV_PEXEL_1	562	566	PF00026	0.740
TRG_Pf-PMV_PEXEL_1	607	612	PF00026	0.496

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZS4	Leptomonas seymouri	55%	97%
A0A1X0P8G3	Trypanosomatidae	33%	100%
A0A3R7N6P4	Trypanosoma rangeli	35%	100%
A0A3S7X7B7	Leishmania donovani	82%	100%
A4I9H9	Leishmania infantum	82%	100%
D0A1T6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9B4H7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4Q3J8	Leishmania major	80%	100%