Malate dehydrogenase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial malate dehydrogenase

Species:

Leishmania braziliensis

UniProt:

A4HAB8_LEIBR

TriTrypDb:

LbrM.20.0010 , LBRM2903_200007100

Length:

325

Annotations

LeishMANIAdb annotations

A group of metabolic enzymes without any likely TM segment. Very conserved in Eukaryota.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 36

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 21

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

A4HAB8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAB8

Function

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Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	18
GO:0006099	tricarboxylic acid cycle	3	18
GO:0006108	malate metabolic process	7	17
GO:0008152	metabolic process	1	18
GO:0009987	cellular process	1	18
GO:0019752	carboxylic acid metabolic process	5	18
GO:0043436	oxoacid metabolic process	4	18
GO:0043648	dicarboxylic acid metabolic process	6	17
GO:0044237	cellular metabolic process	2	18
GO:0044238	primary metabolic process	2	18

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	18
GO:0016491	oxidoreductase activity	2	18
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	18
GO:0016615	malate dehydrogenase activity	4	18
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4	18
GO:0030060	L-malate dehydrogenase activity	5	18

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	309	311	PF00675	0.245
CLV_NRD_NRD_1	86	88	PF00675	0.273
CLV_PCSK_SKI1_1	71	75	PF00082	0.380
DEG_Nend_UBRbox_1	1	4	PF02207	0.619
DOC_MAPK_gen_1	71	81	PF00069	0.417
DOC_MAPK_MEF2A_6	170	179	PF00069	0.212
DOC_PP1_RVXF_1	207	213	PF00149	0.422
DOC_PP1_RVXF_1	309	316	PF00149	0.322
DOC_PP1_SILK_1	240	245	PF00149	0.219
DOC_PP2B_LxvP_1	285	288	PF13499	0.376

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6H7	Leptomonas seymouri	49%	100%
A0A0N0P6W7	Leptomonas seymouri	65%	100%
A0A0N1HYD1	Leptomonas seymouri	45%	100%
A0A0N1I818	Leptomonas seymouri	40%	95%
A0A0N1ILF3	Leptomonas seymouri	75%	100%
A0A0S3QTC6	Thermosulfidibacter takaii (strain DSM 17441 / JCM 13301 / NBRC 103674 / ABI70S6)	31%	100%
A0A0S4IRQ1	Bodo saltans	59%	80%
A0A0S4ITJ4	Bodo saltans	45%	98%
A0A1X0P752	Trypanosomatidae	47%	100%
A0A1X0P9G5	Trypanosomatidae	40%	90%

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