Receptor-type protein kinase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HAB3_LEIBR

TriTrypDb:

LbrM.19.1900 , LBRM2903_190026200

Length:

212

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	5
GO:0042995	cell projection	2	5
GO:0043226	organelle	2	5
GO:0043227	membrane-bounded organelle	3	5
GO:0110165	cellular anatomical entity	1	5
GO:0120025	plasma membrane bounded cell projection	3	5

Expansion

Sequence features

A4HAB3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAB3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	21	25	PF00656	0.450
CLV_NRD_NRD_1	189	191	PF00675	0.575
CLV_PCSK_KEX2_1	189	191	PF00082	0.575
CLV_PCSK_SKI1_1	50	54	PF00082	0.490
DEG_APCC_DBOX_1	30	38	PF00400	0.510
DEG_Nend_UBRbox_2	1	3	PF02207	0.659
DOC_CDC14_PxL_1	4	12	PF14671	0.515
DOC_CYCLIN_yClb5_NLxxxL_5	77	86	PF00134	0.502
DOC_MAPK_gen_1	118	128	PF00069	0.448
DOC_MAPK_gen_1	189	196	PF00069	0.569
DOC_MAPK_gen_1	50	60	PF00069	0.532
DOC_USP7_MATH_1	184	188	PF00917	0.553
DOC_USP7_MATH_1	208	212	PF00917	0.657
DOC_WW_Pin1_4	51	56	PF00397	0.521
LIG_14-3-3_CanoR_1	178	185	PF00244	0.544
LIG_14-3-3_CanoR_1	19	24	PF00244	0.552
LIG_14-3-3_CanoR_1	87	92	PF00244	0.481
LIG_Actin_WH2_2	119	137	PF00022	0.493
LIG_BRCT_BRCA1_1	93	97	PF00533	0.514
LIG_DLG_GKlike_1	19	26	PF00625	0.540
LIG_DLG_GKlike_1	87	95	PF00625	0.516
LIG_FHA_1	135	141	PF00498	0.479
LIG_FHA_1	200	206	PF00498	0.533
LIG_FHA_2	107	113	PF00498	0.492
LIG_FHA_2	73	79	PF00498	0.457
LIG_IRF3_LxIS_1	55	61	PF10401	0.518
LIG_LIR_Gen_1	152	159	PF02991	0.470
LIG_LIR_Gen_1	54	65	PF02991	0.405
LIG_LIR_Nem_3	152	156	PF02991	0.459
LIG_LIR_Nem_3	54	60	PF02991	0.405
LIG_Pex14_1	93	97	PF04695	0.514
LIG_SH2_SRC	57	60	PF00017	0.513
LIG_SH2_STAT5	57	60	PF00017	0.513
LIG_SUMO_SIM_par_1	192	197	PF11976	0.569
MOD_CDK_SPK_2	51	56	PF00069	0.423
MOD_CK1_1	129	135	PF00069	0.475
MOD_CK1_1	144	150	PF00069	0.353
MOD_CK1_1	180	186	PF00069	0.526
MOD_CK1_1	61	67	PF00069	0.524
MOD_CK1_1	72	78	PF00069	0.463
MOD_CK2_1	106	112	PF00069	0.476
MOD_CK2_1	163	169	PF00069	0.474
MOD_CK2_1	72	78	PF00069	0.457
MOD_GlcNHglycan	128	131	PF01048	0.448
MOD_GlcNHglycan	165	168	PF01048	0.448
MOD_GlcNHglycan	181	185	PF01048	0.528
MOD_GlcNHglycan	186	189	PF01048	0.525
MOD_GlcNHglycan	4	7	PF01048	0.541
MOD_GSK3_1	106	113	PF00069	0.229
MOD_GSK3_1	15	22	PF00069	0.553
MOD_GSK3_1	180	187	PF00069	0.467
MOD_GSK3_1	87	94	PF00069	0.511
MOD_N-GLC_1	126	131	PF02516	0.416
MOD_N-GLC_1	149	154	PF02516	0.501
MOD_N-GLC_1	61	66	PF02516	0.512
MOD_N-GLC_2	83	85	PF02516	0.494
MOD_NEK2_1	104	109	PF00069	0.368
MOD_NEK2_1	134	139	PF00069	0.535
MOD_NEK2_1	149	154	PF00069	0.243
MOD_NEK2_1	196	201	PF00069	0.499
MOD_NEK2_1	58	63	PF00069	0.435
MOD_NEK2_1	91	96	PF00069	0.481
MOD_PIKK_1	141	147	PF00454	0.538
MOD_PIKK_1	69	75	PF00454	0.522
MOD_PKA_2	134	140	PF00069	0.514
MOD_PKA_2	177	183	PF00069	0.552
MOD_PKA_2	18	24	PF00069	0.442
MOD_PKA_2	199	205	PF00069	0.602
MOD_Plk_1	149	155	PF00069	0.460
MOD_Plk_1	157	163	PF00069	0.434
MOD_Plk_1	180	186	PF00069	0.554
MOD_Plk_1	61	67	PF00069	0.458
MOD_Plk_4	110	116	PF00069	0.468
MOD_ProDKin_1	51	57	PF00069	0.521
TRG_ENDOCYTIC_2	165	168	PF00928	0.539
TRG_ENDOCYTIC_2	57	60	PF00928	0.513
TRG_ER_diArg_1	189	192	PF00400	0.584

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZS0	Leptomonas seymouri	25%	70%
A0A0N1I824	Leptomonas seymouri	30%	100%
C9ZLX5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	82%