Putative potassium voltage-gated channel

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

potassium voltage-gated channel, putative

Species:

Leishmania braziliensis

UniProt:

A4HAB1_LEIBR

TriTrypDb:

LbrM.19.1880 , LBRM2903_190025800

Length:

343

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0008076	voltage-gated potassium channel complex	4	1
GO:0016020	membrane	2	1
GO:0032991	protein-containing complex	1	1
GO:0034702	monoatomic ion channel complex	4	1
GO:0034703	cation channel complex	5	1
GO:0034705	potassium channel complex	6	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098796	membrane protein complex	2	1
GO:0098797	plasma membrane protein complex	3	1
GO:0110165	cellular anatomical entity	1	1
GO:1902495	transmembrane transporter complex	3	1
GO:1990351	transporter complex	2	1

Expansion

Sequence features

A4HAB1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAB1

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0022607	cellular component assembly	4	12
GO:0043933	protein-containing complex organization	4	12
GO:0051259	protein complex oligomerization	6	12
GO:0051260	protein homooligomerization	7	12
GO:0065003	protein-containing complex assembly	5	12
GO:0071840	cellular component organization or biogenesis	2	12
GO:0006810	transport	3	1
GO:0006811	monoatomic ion transport	4	1
GO:0006812	monoatomic cation transport	5	1
GO:0006813	potassium ion transport	7	1
GO:0030001	metal ion transport	6	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0005216	monoatomic ion channel activity	4	1
GO:0005242	inward rectifier potassium channel activity	7	1
GO:0005244	voltage-gated monoatomic ion channel activity	4	1
GO:0005249	voltage-gated potassium channel activity	6	1
GO:0005261	monoatomic cation channel activity	5	1
GO:0005267	potassium channel activity	6	1
GO:0008324	monoatomic cation transmembrane transporter activity	4	1
GO:0015075	monoatomic ion transmembrane transporter activity	3	1
GO:0015079	potassium ion transmembrane transporter activity	6	1
GO:0015267	channel activity	4	1
GO:0015272	ATP-activated inward rectifier potassium channel activity	8	1
GO:0015276	ligand-gated monoatomic ion channel activity	5	1
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	1
GO:0022803	passive transmembrane transporter activity	3	1
GO:0022832	voltage-gated channel activity	6	1
GO:0022834	ligand-gated channel activity	6	1
GO:0022836	gated channel activity	5	1
GO:0022843	voltage-gated monoatomic cation channel activity	5	1
GO:0022857	transmembrane transporter activity	2	1
GO:0022890	inorganic cation transmembrane transporter activity	4	1
GO:0046873	metal ion transmembrane transporter activity	5	1
GO:0099094	ligand-gated monoatomic cation channel activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	144	148	PF00656	0.613
CLV_NRD_NRD_1	194	196	PF00675	0.408
CLV_NRD_NRD_1	202	204	PF00675	0.369
CLV_NRD_NRD_1	284	286	PF00675	0.363
CLV_NRD_NRD_1	5	7	PF00675	0.447
CLV_PCSK_KEX2_1	179	181	PF00082	0.370
CLV_PCSK_KEX2_1	202	204	PF00082	0.398
CLV_PCSK_KEX2_1	284	286	PF00082	0.358
CLV_PCSK_KEX2_1	5	7	PF00082	0.447
CLV_PCSK_PC1ET2_1	179	181	PF00082	0.358
CLV_PCSK_SKI1_1	222	226	PF00082	0.322
CLV_PCSK_SKI1_1	38	42	PF00082	0.362
DEG_APCC_DBOX_1	284	292	PF00400	0.554
DEG_SCF_FBW7_1	78	84	PF00400	0.189
DOC_CKS1_1	78	83	PF01111	0.454
DOC_CYCLIN_RxL_1	101	111	PF00134	0.331
DOC_MAPK_DCC_7	156	165	PF00069	0.347
DOC_MAPK_gen_1	179	185	PF00069	0.342
DOC_MAPK_MEF2A_6	110	118	PF00069	0.411
DOC_MAPK_MEF2A_6	156	165	PF00069	0.347
DOC_PP1_RVXF_1	102	109	PF00149	0.411
DOC_PP1_RVXF_1	320	326	PF00149	0.639
DOC_USP7_MATH_1	14	18	PF00917	0.445
DOC_USP7_MATH_1	60	64	PF00917	0.473
DOC_WW_Pin1_4	263	268	PF00397	0.403
DOC_WW_Pin1_4	325	330	PF00397	0.603
DOC_WW_Pin1_4	77	82	PF00397	0.406
LIG_14-3-3_CanoR_1	13	19	PF00244	0.448
LIG_14-3-3_CanoR_1	52	57	PF00244	0.373
LIG_BIR_II_1	1	5	PF00653	0.432
LIG_BIR_III_2	96	100	PF00653	0.360
LIG_deltaCOP1_diTrp_1	4	9	PF00928	0.440
LIG_FHA_1	109	115	PF00498	0.314
LIG_FHA_1	226	232	PF00498	0.341
LIG_FHA_1	238	244	PF00498	0.350
LIG_FHA_1	249	255	PF00498	0.393
LIG_FHA_1	258	264	PF00498	0.434
LIG_FHA_2	86	92	PF00498	0.331
LIG_GBD_Chelix_1	197	205	PF00786	0.353
LIG_LIR_Gen_1	100	109	PF02991	0.331
LIG_LIR_Gen_1	260	270	PF02991	0.399
LIG_LIR_Gen_1	308	318	PF02991	0.609
LIG_LIR_Gen_1	61	71	PF02991	0.331
LIG_LIR_Nem_3	100	105	PF02991	0.331
LIG_LIR_Nem_3	211	217	PF02991	0.345
LIG_LIR_Nem_3	260	265	PF02991	0.387
LIG_LIR_Nem_3	308	313	PF02991	0.610
LIG_MYND_3	288	292	PF01753	0.563
LIG_NRBOX	52	58	PF00104	0.411
LIG_PCNA_yPIPBox_3	47	57	PF02747	0.411
LIG_Pex14_2	3	7	PF04695	0.440
LIG_Pex14_2	64	68	PF04695	0.360
LIG_PTB_Apo_2	277	284	PF02174	0.306
LIG_SH2_GRB2like	310	313	PF00017	0.595
LIG_SH2_PTP2	262	265	PF00017	0.364
LIG_SH2_STAT5	262	265	PF00017	0.368
LIG_SH2_STAT5	48	51	PF00017	0.411
LIG_SH3_2	317	322	PF14604	0.601
LIG_SH3_2	329	334	PF14604	0.612
LIG_SH3_3	24	30	PF00018	0.458
LIG_SH3_3	283	289	PF00018	0.429
LIG_SH3_3	314	320	PF00018	0.544
LIG_SH3_3	326	332	PF00018	0.598
LIG_SH3_3	75	81	PF00018	0.416
LIG_SUMO_SIM_par_1	156	162	PF11976	0.519
LIG_TRAF2_1	333	336	PF00917	0.380
LIG_TYR_ITIM	131	136	PF00017	0.189
LIG_WW_3	331	335	PF00397	0.487
MOD_CDC14_SPxK_1	328	331	PF00782	0.636
MOD_CDK_SPxK_1	325	331	PF00069	0.634
MOD_CK1_1	261	267	PF00069	0.389
MOD_CK1_1	79	85	PF00069	0.330
MOD_CK2_1	14	20	PF00069	0.448
MOD_CK2_1	85	91	PF00069	0.421
MOD_GlcNHglycan	143	146	PF01048	0.501
MOD_GSK3_1	237	244	PF00069	0.365
MOD_GSK3_1	257	264	PF00069	0.477
MOD_GSK3_1	48	55	PF00069	0.266
MOD_GSK3_1	72	79	PF00069	0.251
MOD_GSK3_1	81	88	PF00069	0.261
MOD_LATS_1	11	17	PF00433	0.446
MOD_NEK2_1	108	113	PF00069	0.266
MOD_NEK2_1	183	188	PF00069	0.344
MOD_NEK2_1	209	214	PF00069	0.370
MOD_NEK2_1	225	230	PF00069	0.483
MOD_NEK2_1	239	244	PF00069	0.350
MOD_NEK2_1	258	263	PF00069	0.581
MOD_NEK2_1	71	76	PF00069	0.393
MOD_PIKK_1	241	247	PF00454	0.360
MOD_PKA_2	51	57	PF00069	0.411
MOD_Plk_1	31	37	PF00069	0.387
MOD_Plk_1	60	66	PF00069	0.309
MOD_Plk_4	209	215	PF00069	0.355
MOD_Plk_4	258	264	PF00069	0.370
MOD_Plk_4	52	58	PF00069	0.272
MOD_ProDKin_1	263	269	PF00069	0.406
MOD_ProDKin_1	325	331	PF00069	0.598
MOD_ProDKin_1	77	83	PF00069	0.406
TRG_DiLeu_BaEn_1	153	158	PF01217	0.466
TRG_DiLeu_LyEn_5	153	158	PF01217	0.378
TRG_ENDOCYTIC_2	133	136	PF00928	0.189
TRG_ENDOCYTIC_2	262	265	PF00928	0.393
TRG_ENDOCYTIC_2	310	313	PF00928	0.607
TRG_ER_diArg_1	201	203	PF00400	0.410
TRG_ER_diArg_1	283	285	PF00400	0.352
TRG_ER_diArg_1	5	7	PF00400	0.447
TRG_NES_CRM1_1	159	170	PF08389	0.351
TRG_Pf-PMV_PEXEL_1	195	199	PF00026	0.384
TRG_Pf-PMV_PEXEL_1	203	207	PF00026	0.410

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8A6	Leptomonas seymouri	80%	100%
A0A0S4JGQ4	Bodo saltans	53%	99%
A0A1X0P666	Trypanosomatidae	58%	100%
A0A3R7KT76	Trypanosoma rangeli	59%	100%
A0A3S7WVV0	Leishmania donovani	92%	100%
A4HYJ1	Leishmania infantum	92%	100%
D0A0W5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9ASB5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QD47	Leishmania major	92%	100%
V5AP17	Trypanosoma cruzi	57%	100%