Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania braziliensis

UniProt:

A4HAB0_LEIBR

TriTrypDb:

LbrM.19.1870 , LBRM2903_190025700

Length:

278

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HAB0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAB0

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	8
GO:0006793	phosphorus metabolic process	3	8
GO:0006796	phosphate-containing compound metabolic process	4	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008152	metabolic process	1	8
GO:0009987	cellular process	1	8
GO:0016310	phosphorylation	5	8
GO:0019538	protein metabolic process	3	8
GO:0036211	protein modification process	4	8
GO:0043170	macromolecule metabolic process	3	8
GO:0043412	macromolecule modification	4	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0071704	organic substance metabolic process	2	8
GO:1901564	organonitrogen compound metabolic process	3	8

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	8
GO:0003824	catalytic activity	1	8
GO:0004672	protein kinase activity	3	8
GO:0005488	binding	1	8
GO:0005524	ATP binding	5	8
GO:0016301	kinase activity	4	8
GO:0016740	transferase activity	2	8
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	8
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	8
GO:0017076	purine nucleotide binding	4	8
GO:0030554	adenyl nucleotide binding	5	8
GO:0032553	ribonucleotide binding	3	8
GO:0032555	purine ribonucleotide binding	4	8
GO:0032559	adenyl ribonucleotide binding	5	8
GO:0035639	purine ribonucleoside triphosphate binding	4	8
GO:0036094	small molecule binding	2	8
GO:0043167	ion binding	2	8
GO:0043168	anion binding	3	8
GO:0097159	organic cyclic compound binding	2	8
GO:0097367	carbohydrate derivative binding	2	8
GO:0140096	catalytic activity, acting on a protein	2	8
GO:1901265	nucleoside phosphate binding	3	8
GO:1901363	heterocyclic compound binding	2	8
GO:0004674	protein serine/threonine kinase activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	107	109	PF00675	0.310
CLV_NRD_NRD_1	4	6	PF00675	0.443
CLV_NRD_NRD_1	52	54	PF00675	0.288
CLV_NRD_NRD_1	9	11	PF00675	0.394
CLV_PCSK_FUR_1	7	11	PF00082	0.437
CLV_PCSK_KEX2_1	107	109	PF00082	0.392
CLV_PCSK_KEX2_1	4	6	PF00082	0.443
CLV_PCSK_KEX2_1	52	54	PF00082	0.288
CLV_PCSK_KEX2_1	9	11	PF00082	0.394
CLV_PCSK_PC7_1	48	54	PF00082	0.262
CLV_PCSK_PC7_1	5	11	PF00082	0.442
CLV_PCSK_SKI1_1	103	107	PF00082	0.327
CLV_PCSK_SKI1_1	108	112	PF00082	0.310
CLV_PCSK_SKI1_1	246	250	PF00082	0.332
CLV_PCSK_SKI1_1	86	90	PF00082	0.369
DEG_APCC_DBOX_1	106	114	PF00400	0.327
DEG_APCC_DBOX_1	4	12	PF00400	0.453
DEG_SCF_FBW7_1	150	155	PF00400	0.190
DEG_SCF_FBW7_1	88	95	PF00400	0.212
DEG_SCF_FBW7_2	92	99	PF00400	0.249
DEG_SPOP_SBC_1	132	136	PF00917	0.190
DOC_CKS1_1	89	94	PF01111	0.266
DOC_CYCLIN_RxL_1	103	114	PF00134	0.310
DOC_MAPK_gen_1	107	113	PF00069	0.462
DOC_MAPK_gen_1	243	251	PF00069	0.332
DOC_PP1_RVXF_1	7	14	PF00149	0.431
DOC_PP4_FxxP_1	166	169	PF00568	0.327
DOC_USP7_MATH_1	125	129	PF00917	0.446
DOC_WW_Pin1_4	148	153	PF00397	0.361
DOC_WW_Pin1_4	236	241	PF00397	0.332
DOC_WW_Pin1_4	67	72	PF00397	0.401
DOC_WW_Pin1_4	88	93	PF00397	0.319
LIG_14-3-3_CanoR_1	118	123	PF00244	0.457
LIG_14-3-3_CanoR_1	52	60	PF00244	0.262
LIG_APCC_ABBA_1	179	184	PF00400	0.332
LIG_APCC_ABBA_1	64	69	PF00400	0.394
LIG_BIR_II_1	1	5	PF00653	0.526
LIG_BRCT_BRCA1_1	162	166	PF00533	0.332
LIG_Clathr_ClatBox_1	110	114	PF01394	0.327
LIG_deltaCOP1_diTrp_1	183	188	PF00928	0.270
LIG_FHA_1	195	201	PF00498	0.332
LIG_FHA_1	32	38	PF00498	0.435
LIG_FHA_2	207	213	PF00498	0.310
LIG_LIR_Apic_2	163	169	PF02991	0.267
LIG_LIR_Gen_1	136	147	PF02991	0.191
LIG_LIR_Gen_1	215	224	PF02991	0.275
LIG_LIR_Gen_1	62	71	PF02991	0.401
LIG_LIR_Nem_3	136	142	PF02991	0.271
LIG_LIR_Nem_3	214	220	PF02991	0.272
LIG_LIR_Nem_3	62	66	PF02991	0.434
LIG_MLH1_MIPbox_1	162	166	PF16413	0.245
LIG_SH2_CRK	193	197	PF00017	0.327
LIG_SH2_SRC	122	125	PF00017	0.363
LIG_SH2_STAP1	213	217	PF00017	0.190
LIG_SH2_STAT5	122	125	PF00017	0.371
LIG_SH2_STAT5	164	167	PF00017	0.281
LIG_SH2_STAT5	59	62	PF00017	0.405
LIG_SH2_STAT5	63	66	PF00017	0.442
LIG_SH3_3	175	181	PF00018	0.474
LIG_SH3_3	197	203	PF00018	0.346
LIG_SH3_3	65	71	PF00018	0.265
LIG_SUMO_SIM_par_1	109	114	PF11976	0.332
LIG_SUMO_SIM_par_1	18	24	PF11976	0.377
LIG_SUMO_SIM_par_1	219	225	PF11976	0.190
LIG_TYR_ITIM	191	196	PF00017	0.332
LIG_UBA3_1	220	228	PF00899	0.226
LIG_ULM_U2AF65_1	9	14	PF00076	0.369
MOD_CDK_SPK_2	67	72	PF00069	0.268
MOD_CDK_SPxxK_3	236	243	PF00069	0.332
MOD_CK1_1	135	141	PF00069	0.467
MOD_CK1_1	239	245	PF00069	0.332
MOD_CK2_1	262	268	PF00069	0.453
MOD_GlcNHglycan	264	267	PF01048	0.441
MOD_GSK3_1	131	138	PF00069	0.388
MOD_GSK3_1	148	155	PF00069	0.372
MOD_GSK3_1	270	277	PF00069	0.278
MOD_GSK3_1	77	84	PF00069	0.439
MOD_GSK3_1	88	95	PF00069	0.297
MOD_NEK2_1	133	138	PF00069	0.365
MOD_NEK2_1	270	275	PF00069	0.332
MOD_NEK2_1	77	82	PF00069	0.457
MOD_PKA_2	117	123	PF00069	0.453
MOD_PKA_2	242	248	PF00069	0.357
MOD_PKA_2	262	268	PF00069	0.146
MOD_PKA_2	3	9	PF00069	0.470
MOD_PKA_2	51	57	PF00069	0.264
MOD_Plk_1	125	131	PF00069	0.327
MOD_Plk_2-3	26	32	PF00069	0.326
MOD_Plk_4	118	124	PF00069	0.325
MOD_Plk_4	160	166	PF00069	0.284
MOD_Plk_4	270	276	PF00069	0.332
MOD_ProDKin_1	148	154	PF00069	0.361
MOD_ProDKin_1	236	242	PF00069	0.332
MOD_ProDKin_1	67	73	PF00069	0.399
MOD_ProDKin_1	88	94	PF00069	0.319
TRG_DiLeu_BaEn_2	246	252	PF01217	0.332
TRG_ENDOCYTIC_2	164	167	PF00928	0.332
TRG_ENDOCYTIC_2	193	196	PF00928	0.327
TRG_ENDOCYTIC_2	217	220	PF00928	0.332
TRG_ENDOCYTIC_2	63	66	PF00928	0.420
TRG_ENDOCYTIC_2	74	77	PF00928	0.365
TRG_ER_diArg_1	106	108	PF00400	0.310
TRG_ER_diArg_1	4	7	PF00400	0.438
TRG_ER_diArg_1	45	48	PF00400	0.405
TRG_ER_diArg_1	8	10	PF00400	0.407
TRG_NES_CRM1_1	17	31	PF08389	0.408
TRG_Pf-PMV_PEXEL_1	12	17	PF00026	0.376

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8N2	Leptomonas seymouri	44%	89%
A0A0S4IKC2	Bodo saltans	29%	73%
A0A0S4IQX7	Bodo saltans	28%	72%
A0A1X0PAW2	Trypanosomatidae	29%	78%
A0A3Q8IEN2	Leishmania donovani	85%	100%
A0A3R7KMF0	Trypanosoma rangeli	26%	79%
A4HYJ0	Leishmania infantum	85%	100%
A9RWC9	Physcomitrium patens	28%	79%
A9S5R3	Physcomitrium patens	25%	80%
A9SR33	Physcomitrium patens	27%	81%
D0A0W4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	82%
E9ASB4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QD48	Leishmania major	85%	100%
Q54CY9	Dictyostelium discoideum	29%	89%
Q5QN75	Oryza sativa subsp. japonica	25%	78%
Q94A06	Arabidopsis thaliana	26%	79%
Q9FJV0	Arabidopsis thaliana	25%	78%
Q9S7U9	Arabidopsis thaliana	27%	77%
Q9ZVP5	Arabidopsis thaliana	27%	82%
V5BFK9	Trypanosoma cruzi	29%	99%
V5BQF4	Trypanosoma cruzi	24%	75%