SRP19

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

SRP19

Gene product:

SRP19 protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HAA9_LEIBR

TriTrypDb:

LbrM.19.1860 , LBRM2903_190025600

Length:

156

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005786	signal recognition particle, endoplasmic reticulum targeting	4	10
GO:0032991	protein-containing complex	1	10
GO:0048500	signal recognition particle	3	10
GO:1990904	ribonucleoprotein complex	2	10

Expansion

Sequence features

A4HAA9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAA9

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	9
GO:0006612	protein targeting to membrane	5	9
GO:0006613	cotranslational protein targeting to membrane	6	9
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	7	9
GO:0006810	transport	3	9
GO:0006886	intracellular protein transport	4	9
GO:0008104	protein localization	4	9
GO:0009987	cellular process	1	10
GO:0015031	protein transport	4	9
GO:0033036	macromolecule localization	2	9
GO:0033365	protein localization to organelle	5	9
GO:0045047	protein targeting to ER	6	9
GO:0045184	establishment of protein localization	3	9
GO:0046907	intracellular transport	3	9
GO:0051179	localization	1	9
GO:0051234	establishment of localization	2	9
GO:0051641	cellular localization	2	9
GO:0051649	establishment of localization in cell	3	9
GO:0051668	localization within membrane	3	9
GO:0070727	cellular macromolecule localization	3	9
GO:0070972	protein localization to endoplasmic reticulum	6	9
GO:0071702	organic substance transport	4	9
GO:0071705	nitrogen compound transport	4	9
GO:0072594	establishment of protein localization to organelle	4	9
GO:0072599	establishment of protein localization to endoplasmic reticulum	5	9
GO:0072657	protein localization to membrane	4	9
GO:0090150	establishment of protein localization to membrane	4	9
GO:0006617	SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition	6	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003723	RNA binding	4	10
GO:0005488	binding	1	10
GO:0008312	7S RNA binding	5	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	120	122	PF00675	0.214
CLV_NRD_NRD_1	29	31	PF00675	0.214
CLV_PCSK_KEX2_1	120	122	PF00082	0.214
CLV_PCSK_KEX2_1	132	134	PF00082	0.370
CLV_PCSK_KEX2_1	29	31	PF00082	0.214
CLV_PCSK_PC1ET2_1	132	134	PF00082	0.370
CLV_PCSK_SKI1_1	121	125	PF00082	0.238
CLV_PCSK_SKI1_1	29	33	PF00082	0.214
CLV_Separin_Metazoa	117	121	PF03568	0.414
DEG_APCC_DBOX_1	132	140	PF00400	0.511
DEG_SCF_FBW7_2	86	92	PF00400	0.463
DOC_CKS1_1	86	91	PF01111	0.463
DOC_MAPK_MEF2A_6	79	86	PF00069	0.444
DOC_USP7_MATH_1	61	65	PF00917	0.456
DOC_WW_Pin1_4	21	26	PF00397	0.428
DOC_WW_Pin1_4	85	90	PF00397	0.463
LIG_14-3-3_CanoR_1	120	126	PF00244	0.459
LIG_14-3-3_CanoR_1	133	143	PF00244	0.476
LIG_14-3-3_CanoR_1	30	40	PF00244	0.431
LIG_14-3-3_CanoR_1	67	77	PF00244	0.428
LIG_Actin_WH2_1	105	122	PF00022	0.463
LIG_FHA_2	112	118	PF00498	0.527
LIG_FHA_2	136	142	PF00498	0.522
LIG_FHA_2	22	28	PF00498	0.430
LIG_FHA_2	39	45	PF00498	0.422
LIG_FHA_2	86	92	PF00498	0.463
LIG_LIR_Nem_3	13	18	PF02991	0.422
LIG_LIR_Nem_3	71	77	PF02991	0.456
LIG_SH2_CRK	11	15	PF00017	0.250
LIG_SH2_CRK	146	150	PF00017	0.375
LIG_SH2_NCK_1	146	150	PF00017	0.375
LIG_SH2_SRC	18	21	PF00017	0.414
LIG_SH2_STAP1	6	10	PF00017	0.476
LIG_SH2_STAT5	18	21	PF00017	0.414
LIG_SH2_STAT5	94	97	PF00017	0.434
LIG_SH3_3	128	134	PF00018	0.499
LIG_SH3_3	146	152	PF00018	0.492
LIG_SH3_3	34	40	PF00018	0.414
LIG_SH3_3	72	78	PF00018	0.456
LIG_TRAF2_1	114	117	PF00917	0.431
LIG_TRAF2_1	138	141	PF00917	0.422
LIG_TYR_ITIM	52	57	PF00017	0.497
LIG_WW_3	1	5	PF00397	0.432
MOD_CK1_1	111	117	PF00069	0.358
MOD_CK1_1	21	27	PF00069	0.487
MOD_CK1_1	68	74	PF00069	0.456
MOD_CK1_1	85	91	PF00069	0.456
MOD_CK2_1	111	117	PF00069	0.448
MOD_CK2_1	134	140	PF00069	0.543
MOD_CK2_1	21	27	PF00069	0.467
MOD_CK2_1	38	44	PF00069	0.415
MOD_Cter_Amidation	27	30	PF01082	0.214
MOD_GlcNHglycan	105	108	PF01048	0.246
MOD_GSK3_1	61	68	PF00069	0.431
MOD_GSK3_1	95	102	PF00069	0.418
MOD_N-GLC_1	21	26	PF02516	0.183
MOD_NEK2_1	31	36	PF00069	0.431
MOD_NEK2_2	10	15	PF00069	0.399
MOD_PIKK_1	31	37	PF00454	0.431
MOD_PIKK_1	65	71	PF00454	0.415
MOD_PIKK_1	99	105	PF00454	0.431
MOD_PKA_1	29	35	PF00069	0.414
MOD_PKA_2	29	35	PF00069	0.414
MOD_PKA_2	82	88	PF00069	0.432
MOD_Plk_2-3	38	44	PF00069	0.497
MOD_Plk_4	10	16	PF00069	0.250
MOD_Plk_4	121	127	PF00069	0.371
MOD_ProDKin_1	21	27	PF00069	0.428
MOD_ProDKin_1	85	91	PF00069	0.463
MOD_SUMO_rev_2	5	10	PF00179	0.595
TRG_ENDOCYTIC_2	11	14	PF00928	0.341
TRG_ENDOCYTIC_2	146	149	PF00928	0.504
TRG_ENDOCYTIC_2	54	57	PF00928	0.431
TRG_ER_diArg_1	119	121	PF00400	0.414
TRG_ER_diArg_1	29	31	PF00400	0.414

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMF8	Leptomonas seymouri	64%	95%
A0A0S4J7U0	Bodo saltans	53%	89%
A0A1X0P851	Trypanosomatidae	55%	100%
A0A3R7MSQ5	Trypanosoma rangeli	53%	100%
A0A3S7WVQ7	Leishmania donovani	86%	94%
A4HYI9	Leishmania infantum	86%	94%
E9ASB3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	94%
Q4QD49	Leishmania major	86%	100%
Q554G7	Dictyostelium discoideum	29%	88%