ELMO domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ELMO/CED-12 family, putative

Species:

Leishmania braziliensis

UniProt:

A4HAA6_LEIBR

TriTrypDb:

LbrM.19.1830 , LBRM2903_190025300

Length:

317

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HAA6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAA6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	124	128	PF00656	0.240
CLV_C14_Caspase3-7	24	28	PF00656	0.557
CLV_NRD_NRD_1	3	5	PF00675	0.737
CLV_PCSK_SKI1_1	140	144	PF00082	0.438
CLV_PCSK_SKI1_1	302	306	PF00082	0.416
CLV_PCSK_SKI1_1	79	83	PF00082	0.303
DEG_APCC_DBOX_1	78	86	PF00400	0.310
DEG_COP1_1	92	101	PF00400	0.332
DEG_Nend_UBRbox_1	1	4	PF02207	0.700
DEG_SPOP_SBC_1	11	15	PF00917	0.542
DOC_CKS1_1	52	57	PF01111	0.506
DOC_MAPK_gen_1	281	289	PF00069	0.438
DOC_PP1_RVXF_1	138	144	PF00149	0.438
DOC_PP1_RVXF_1	300	306	PF00149	0.459
DOC_PP2B_LxvP_1	75	78	PF13499	0.563
DOC_USP7_MATH_1	11	15	PF00917	0.581
DOC_USP7_MATH_1	23	27	PF00917	0.604
DOC_WW_Pin1_4	48	53	PF00397	0.803
LIG_14-3-3_CanoR_1	118	126	PF00244	0.492
LIG_14-3-3_CanoR_1	278	287	PF00244	0.378
LIG_14-3-3_CanoR_1	294	304	PF00244	0.471
LIG_14-3-3_CanoR_1	46	52	PF00244	0.553
LIG_BRCT_BRCA1_1	171	175	PF00533	0.438
LIG_BRCT_BRCA1_1	93	97	PF00533	0.422
LIG_CtBP_PxDLS_1	145	149	PF00389	0.240
LIG_deltaCOP1_diTrp_1	159	166	PF00928	0.357
LIG_eIF4E_1	96	102	PF01652	0.337
LIG_FHA_1	213	219	PF00498	0.408
LIG_FHA_1	241	247	PF00498	0.449
LIG_FHA_1	281	287	PF00498	0.457
LIG_FHA_1	52	58	PF00498	0.621
LIG_FHA_2	296	302	PF00498	0.518
LIG_FHA_2	307	313	PF00498	0.363
LIG_FHA_2	36	42	PF00498	0.757
LIG_LIR_Apic_2	114	119	PF02991	0.391
LIG_LIR_Apic_2	94	99	PF02991	0.319
LIG_LIR_Nem_3	191	196	PF02991	0.442
LIG_LYPXL_yS_3	193	196	PF13949	0.240
LIG_MLH1_MIPbox_1	93	97	PF16413	0.422
LIG_MYND_1	99	103	PF01753	0.424
LIG_NRBOX	217	223	PF00104	0.326
LIG_NRBOX	299	305	PF00104	0.459
LIG_PDZ_Class_1	312	317	PF00595	0.478
LIG_SH2_CRK	116	120	PF00017	0.492
LIG_SH2_STAT5	188	191	PF00017	0.391
LIG_SH2_STAT5	217	220	PF00017	0.403
LIG_SH2_STAT5	268	271	PF00017	0.391
LIG_SH2_STAT5	297	300	PF00017	0.466
LIG_SH2_STAT5	96	99	PF00017	0.522
LIG_SH3_3	49	55	PF00018	0.536
LIG_TRAF2_1	121	124	PF00917	0.240
MOD_CAAXbox	314	317	PF01239	0.481
MOD_CK1_1	10	16	PF00069	0.731
MOD_CK1_1	234	240	PF00069	0.486
MOD_CK1_1	25	31	PF00069	0.802
MOD_CK2_1	118	124	PF00069	0.240
MOD_CK2_1	306	312	PF00069	0.486
MOD_CK2_1	35	41	PF00069	0.553
MOD_GlcNHglycan	120	123	PF01048	0.457
MOD_GlcNHglycan	231	234	PF01048	0.240
MOD_GlcNHglycan	254	258	PF01048	0.356
MOD_GlcNHglycan	9	12	PF01048	0.693
MOD_GSK3_1	166	173	PF00069	0.438
MOD_GSK3_1	212	219	PF00069	0.423
MOD_GSK3_1	22	29	PF00069	0.769
MOD_GSK3_1	234	241	PF00069	0.391
MOD_GSK3_1	47	54	PF00069	0.664
MOD_GSK3_1	7	14	PF00069	0.619
MOD_N-GLC_1	212	217	PF02516	0.357
MOD_NEK2_1	148	153	PF00069	0.503
MOD_NEK2_1	196	201	PF00069	0.349
MOD_NEK2_1	212	217	PF00069	0.438
MOD_NEK2_1	231	236	PF00069	0.206
MOD_NEK2_1	280	285	PF00069	0.430
MOD_NEK2_1	304	309	PF00069	0.302
MOD_NEK2_1	70	75	PF00069	0.530
MOD_PIKK_1	26	32	PF00454	0.556
MOD_PKA_2	280	286	PF00069	0.365
MOD_PKA_2	45	51	PF00069	0.556
MOD_Plk_1	212	218	PF00069	0.330
MOD_Plk_1	70	76	PF00069	0.503
MOD_Plk_1	91	97	PF00069	0.567
MOD_Plk_4	196	202	PF00069	0.331
MOD_Plk_4	212	218	PF00069	0.360
MOD_Plk_4	231	237	PF00069	0.388
MOD_Plk_4	70	76	PF00069	0.539
MOD_Plk_4	97	103	PF00069	0.387
MOD_ProDKin_1	48	54	PF00069	0.800
TRG_DiLeu_BaEn_1	299	304	PF01217	0.470
TRG_DiLeu_BaEn_1	312	317	PF01217	0.374
TRG_DiLeu_BaLyEn_6	270	275	PF01217	0.438
TRG_DiLeu_LyEn_5	299	304	PF01217	0.457
TRG_ENDOCYTIC_2	193	196	PF00928	0.240
TRG_ENDOCYTIC_2	277	280	PF00928	0.492
TRG_ENDOCYTIC_2	297	300	PF00928	0.189
TRG_ER_diArg_1	1	4	PF00400	0.609
TRG_ER_diArg_1	245	248	PF00400	0.423
TRG_Pf-PMV_PEXEL_1	284	288	PF00026	0.438
TRG_Pf-PMV_PEXEL_1	308	312	PF00026	0.307

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9A9	Leptomonas seymouri	49%	85%
A0A0S4IWN1	Bodo saltans	32%	93%
A0A1X0P699	Trypanosomatidae	40%	100%
A0A3S7WVN6	Leishmania donovani	76%	100%
A4HYI6	Leishmania infantum	76%	100%
E9ASB0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%
Q4QD52	Leishmania major	74%	100%