Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat, putative

Species:

Leishmania braziliensis

UniProt:

A4HAA4_LEIBR

TriTrypDb:

LbrM.19.1810 , LBRM2903_190025100

Length:

391

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	10
GO:0032991	protein-containing complex	1	10
GO:0043226	organelle	2	10
GO:0043228	non-membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043232	intracellular non-membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	10
GO:1990904	ribonucleoprotein complex	2	10

Expansion

Sequence features

A4HAA4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAA4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0032182	ubiquitin-like protein binding	3	1
GO:0043130	ubiquitin binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	329	333	PF00656	0.553
CLV_MEL_PAP_1	287	293	PF00089	0.364
CLV_NRD_NRD_1	14	16	PF00675	0.486
CLV_PCSK_KEX2_1	14	16	PF00082	0.563
CLV_PCSK_SKI1_1	27	31	PF00082	0.430
CLV_PCSK_SKI1_1	306	310	PF00082	0.341
CLV_PCSK_SKI1_1	328	332	PF00082	0.506
CLV_PCSK_SKI1_1	380	384	PF00082	0.342
DOC_CYCLIN_RxL_1	24	32	PF00134	0.392
DOC_MAPK_gen_1	197	206	PF00069	0.431
DOC_MAPK_gen_1	232	242	PF00069	0.534
DOC_MAPK_gen_1	364	371	PF00069	0.423
DOC_MAPK_MEF2A_6	181	190	PF00069	0.427
DOC_PP4_FxxP_1	142	145	PF00568	0.414
DOC_PP4_FxxP_1	251	254	PF00568	0.376
DOC_USP7_MATH_1	100	104	PF00917	0.556
DOC_USP7_MATH_1	147	151	PF00917	0.499
DOC_USP7_MATH_1	167	171	PF00917	0.541
DOC_USP7_MATH_1	186	190	PF00917	0.337
DOC_WW_Pin1_4	122	127	PF00397	0.539
LIG_14-3-3_CanoR_1	121	126	PF00244	0.396
LIG_14-3-3_CanoR_1	205	211	PF00244	0.443
LIG_14-3-3_CanoR_1	290	297	PF00244	0.430
LIG_Actin_WH2_2	333	350	PF00022	0.487
LIG_ActinCP_TwfCPI_2	251	260	PF01115	0.417
LIG_BIR_II_1	1	5	PF00653	0.534
LIG_deltaCOP1_diTrp_1	35	45	PF00928	0.403
LIG_FHA_1	201	207	PF00498	0.475
LIG_FHA_1	316	322	PF00498	0.468
LIG_FHA_1	69	75	PF00498	0.557
LIG_FHA_2	30	36	PF00498	0.335
LIG_FHA_2	327	333	PF00498	0.496
LIG_HP1_1	186	190	PF01393	0.417
LIG_LIR_Apic_2	140	145	PF02991	0.232
LIG_LIR_Apic_2	248	254	PF02991	0.354
LIG_LIR_Gen_1	28	39	PF02991	0.429
LIG_LIR_Gen_1	42	52	PF02991	0.386
LIG_LIR_Nem_3	28	34	PF02991	0.430
LIG_LIR_Nem_3	42	48	PF02991	0.408
LIG_Pex14_2	34	38	PF04695	0.321
LIG_SH2_CRK	160	164	PF00017	0.565
LIG_SH2_CRK	322	326	PF00017	0.378
LIG_SH2_GRB2like	221	224	PF00017	0.351
LIG_SH2_SRC	221	224	PF00017	0.351
LIG_SH2_SRC	284	287	PF00017	0.359
LIG_SH2_STAT5	286	289	PF00017	0.371
LIG_SH2_STAT5	31	34	PF00017	0.366
LIG_SH3_2	192	197	PF14604	0.533
LIG_SH3_3	189	195	PF00018	0.436
LIG_SH3_3	251	257	PF00018	0.475
LIG_SH3_3	71	77	PF00018	0.468
LIG_SUMO_SIM_par_1	115	120	PF11976	0.285
LIG_SUMO_SIM_par_1	380	385	PF11976	0.295
LIG_TRAF2_1	343	346	PF00917	0.414
LIG_TYR_ITIM	282	287	PF00017	0.366
LIG_UBA3_1	228	235	PF00899	0.393
MOD_CK1_1	120	126	PF00069	0.601
MOD_CK1_1	134	140	PF00069	0.575
MOD_CK1_1	292	298	PF00069	0.361
MOD_CK1_1	4	10	PF00069	0.662
MOD_CK1_1	90	96	PF00069	0.553
MOD_CK2_1	261	267	PF00069	0.348
MOD_GlcNHglycan	127	130	PF01048	0.591
MOD_GlcNHglycan	160	163	PF01048	0.304
MOD_GlcNHglycan	3	6	PF01048	0.736
MOD_GlcNHglycan	310	313	PF01048	0.352
MOD_GlcNHglycan	8	11	PF01048	0.638
MOD_GlcNHglycan	93	96	PF01048	0.595
MOD_GSK3_1	1	8	PF00069	0.659
MOD_GSK3_1	117	124	PF00069	0.475
MOD_GSK3_1	127	134	PF00069	0.483
MOD_GSK3_1	167	174	PF00069	0.621
MOD_GSK3_1	25	32	PF00069	0.464
MOD_GSK3_1	292	299	PF00069	0.392
MOD_GSK3_1	371	378	PF00069	0.326
MOD_GSK3_1	87	94	PF00069	0.476
MOD_N-GLC_1	362	367	PF02516	0.442
MOD_N-GLC_1	87	92	PF02516	0.499
MOD_NEK2_1	1	6	PF00069	0.663
MOD_NEK2_1	110	115	PF00069	0.464
MOD_NEK2_1	117	122	PF00069	0.469
MOD_NEK2_1	240	245	PF00069	0.477
MOD_NEK2_1	261	266	PF00069	0.366
MOD_NEK2_1	29	34	PF00069	0.401
MOD_NEK2_1	375	380	PF00069	0.331
MOD_NEK2_1	91	96	PF00069	0.681
MOD_NEK2_2	326	331	PF00069	0.460
MOD_NEK2_2	56	61	PF00069	0.393
MOD_PIKK_1	100	106	PF00454	0.339
MOD_PIKK_1	230	236	PF00454	0.451
MOD_PK_1	171	177	PF00069	0.508
MOD_PKA_1	14	20	PF00069	0.487
MOD_PKA_2	120	126	PF00069	0.497
MOD_PKA_2	14	20	PF00069	0.499
MOD_PKA_2	158	164	PF00069	0.508
MOD_PKA_2	180	186	PF00069	0.479
MOD_PKA_2	289	295	PF00069	0.391
MOD_Plk_1	117	123	PF00069	0.548
MOD_Plk_1	315	321	PF00069	0.326
MOD_Plk_1	326	332	PF00069	0.399
MOD_Plk_1	375	381	PF00069	0.324
MOD_Plk_1	87	93	PF00069	0.550
MOD_Plk_4	137	143	PF00069	0.498
MOD_Plk_4	147	153	PF00069	0.472
MOD_Plk_4	25	31	PF00069	0.482
MOD_Plk_4	292	298	PF00069	0.361
MOD_Plk_4	56	62	PF00069	0.415
MOD_ProDKin_1	122	128	PF00069	0.548
MOD_SUMO_rev_2	222	229	PF00179	0.390
TRG_ENDOCYTIC_2	284	287	PF00928	0.359
TRG_ENDOCYTIC_2	31	34	PF00928	0.346
TRG_ER_diArg_1	13	15	PF00400	0.500
TRG_Pf-PMV_PEXEL_1	235	239	PF00026	0.435
TRG_Pf-PMV_PEXEL_1	300	304	PF00026	0.349
TRG_Pf-PMV_PEXEL_1	328	332	PF00026	0.389

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF14	Leptomonas seymouri	84%	99%
A0A0S4IXZ3	Bodo saltans	67%	100%
A0A1X0P6T7	Trypanosomatidae	70%	100%
A0A3R7NXE0	Trypanosoma rangeli	70%	100%
A0A3S7WVM1	Leishmania donovani	89%	98%
A4HYI4	Leishmania infantum	91%	98%
A4QNE6	Xenopus tropicalis	44%	100%
A8J3F6	Chlamydomonas reinhardtii	46%	100%
D0A0V7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	71%	100%
E9ASA8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	98%
Q29RZ9	Bos taurus	46%	100%
Q4QD54	Leishmania major	91%	100%
Q54E33	Dictyostelium discoideum	20%	100%
Q561Y0	Danio rerio	44%	100%
Q5M7F6	Xenopus laevis	45%	100%
Q8BGF3	Mus musculus	46%	100%
Q96MX6	Homo sapiens	46%	100%
V5B8V8	Trypanosoma cruzi	70%	100%