Peptidylprolyl isomerase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative

Species:

Leishmania braziliensis

UniProt:

A4HAA2_LEIBR

TriTrypDb:

LbrM.19.1790 , LBRM2903_190024900

Length:

432

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 5

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HAA2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAA2

Function

Biological processes
Term	Name	Level	Count
GO:0000413	protein peptidyl-prolyl isomerization	7	1
GO:0006457	protein folding	2	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018208	peptidyl-proline modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0061077	chaperone-mediated protein folding	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3	12
GO:0003824	catalytic activity	1	12
GO:0016853	isomerase activity	2	12
GO:0016859	cis-trans isomerase activity	3	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	292	296	PF00656	0.564
CLV_C14_Caspase3-7	66	70	PF00656	0.433
CLV_NRD_NRD_1	225	227	PF00675	0.383
CLV_NRD_NRD_1	288	290	PF00675	0.387
CLV_NRD_NRD_1	310	312	PF00675	0.362
CLV_NRD_NRD_1	358	360	PF00675	0.417
CLV_PCSK_KEX2_1	288	290	PF00082	0.401
CLV_PCSK_KEX2_1	310	312	PF00082	0.347
CLV_PCSK_PC1ET2_1	288	290	PF00082	0.528
CLV_PCSK_SKI1_1	108	112	PF00082	0.331
CLV_PCSK_SKI1_1	359	363	PF00082	0.394
CLV_PCSK_SKI1_1	370	374	PF00082	0.308
CLV_PCSK_SKI1_1	42	46	PF00082	0.382
CLV_PCSK_SKI1_1	424	428	PF00082	0.454
CLV_PCSK_SKI1_1	55	59	PF00082	0.312
DOC_MAPK_gen_1	153	161	PF00069	0.512
DOC_MAPK_gen_1	193	201	PF00069	0.594
DOC_MAPK_gen_1	307	315	PF00069	0.335
DOC_PP4_FxxP_1	247	250	PF00568	0.459
DOC_USP7_MATH_1	248	252	PF00917	0.440
DOC_USP7_UBL2_3	108	112	PF12436	0.320
DOC_USP7_UBL2_3	409	413	PF12436	0.362
DOC_USP7_UBL2_3	424	428	PF12436	0.481
DOC_USP7_UBL2_3	94	98	PF12436	0.320
DOC_WW_Pin1_4	111	116	PF00397	0.314
DOC_WW_Pin1_4	121	126	PF00397	0.271
DOC_WW_Pin1_4	194	199	PF00397	0.565
LIG_14-3-3_CanoR_1	271	276	PF00244	0.505
LIG_14-3-3_CanoR_1	332	338	PF00244	0.381
LIG_14-3-3_CanoR_1	348	357	PF00244	0.384
LIG_Actin_WH2_2	96	114	PF00022	0.354
LIG_BIR_II_1	1	5	PF00653	0.671
LIG_BIR_III_2	242	246	PF00653	0.532
LIG_BRCT_BRCA1_1	353	357	PF00533	0.441
LIG_Clathr_ClatBox_1	135	139	PF01394	0.331
LIG_EH1_1	61	69	PF00400	0.369
LIG_FHA_1	100	106	PF00498	0.270
LIG_FHA_1	142	148	PF00498	0.449
LIG_FHA_1	176	182	PF00498	0.401
LIG_FHA_1	259	265	PF00498	0.400
LIG_FHA_1	367	373	PF00498	0.441
LIG_FHA_1	41	47	PF00498	0.403
LIG_FHA_2	10	16	PF00498	0.641
LIG_FHA_2	64	70	PF00498	0.388
LIG_Integrin_RGD_1	79	81	PF01839	0.441
LIG_LIR_Apic_2	167	171	PF02991	0.432
LIG_LIR_Apic_2	246	250	PF02991	0.472
LIG_LIR_Gen_1	180	190	PF02991	0.289
LIG_LIR_Gen_1	203	211	PF02991	0.399
LIG_LIR_Nem_3	180	185	PF02991	0.306
LIG_LIR_Nem_3	203	208	PF02991	0.491
LIG_LIR_Nem_3	81	85	PF02991	0.292
LIG_Pex14_2	427	431	PF04695	0.581
LIG_PTB_Apo_2	167	174	PF02174	0.524
LIG_SH2_CRK	41	45	PF00017	0.423
LIG_SH2_GRB2like	168	171	PF00017	0.462
LIG_SH2_NCK_1	168	172	PF00017	0.419
LIG_SH2_PTP2	182	185	PF00017	0.266
LIG_SH2_SRC	117	120	PF00017	0.441
LIG_SH2_SRC	168	171	PF00017	0.462
LIG_SH2_SRC	182	185	PF00017	0.278
LIG_SH2_STAT5	182	185	PF00017	0.421
LIG_SH2_STAT5	262	265	PF00017	0.418
LIG_SH2_STAT5	63	66	PF00017	0.312
LIG_SH2_STAT5	82	85	PF00017	0.171
LIG_SH3_3	123	129	PF00018	0.297
LIG_SH3_3	20	26	PF00018	0.513
LIG_SH3_3	28	34	PF00018	0.447
LIG_SUMO_SIM_par_1	261	268	PF11976	0.414
LIG_SUMO_SIM_par_1	393	399	PF11976	0.358
LIG_SUMO_SIM_par_1	42	47	PF11976	0.480
LIG_UBA3_1	158	163	PF00899	0.517
LIG_UBA3_1	372	377	PF00899	0.441
MOD_CDK_SPxK_1	194	200	PF00069	0.572
MOD_CK1_1	124	130	PF00069	0.391
MOD_CK1_1	175	181	PF00069	0.473
MOD_CK1_1	267	273	PF00069	0.580
MOD_CK1_1	394	400	PF00069	0.222
MOD_CK1_1	8	14	PF00069	0.638
MOD_GlcNHglycan	148	152	PF01048	0.450
MOD_GlcNHglycan	251	254	PF01048	0.463
MOD_GlcNHglycan	291	294	PF01048	0.562
MOD_GlcNHglycan	353	356	PF01048	0.511
MOD_GlcNHglycan	7	10	PF01048	0.707
MOD_GSK3_1	149	156	PF00069	0.475
MOD_GSK3_1	267	274	PF00069	0.459
MOD_GSK3_1	351	358	PF00069	0.395
MOD_GSK3_1	5	12	PF00069	0.649
MOD_GSK3_1	68	75	PF00069	0.306
MOD_N-GLC_1	130	135	PF02516	0.297
MOD_N-GLC_1	366	371	PF02516	0.445
MOD_NEK2_1	157	162	PF00069	0.568
MOD_NEK2_1	173	178	PF00069	0.328
MOD_NEK2_1	40	45	PF00069	0.370
MOD_NEK2_1	5	10	PF00069	0.794
MOD_NEK2_1	68	73	PF00069	0.391
MOD_NEK2_1	83	88	PF00069	0.211
MOD_NEK2_2	57	62	PF00069	0.381
MOD_NEK2_2	99	104	PF00069	0.331
MOD_PIKK_1	14	20	PF00454	0.598
MOD_PIKK_1	48	54	PF00454	0.483
MOD_PKA_1	289	295	PF00069	0.457
MOD_PKA_2	333	339	PF00069	0.351
MOD_Plk_1	130	136	PF00069	0.297
MOD_Plk_1	153	159	PF00069	0.374
MOD_Plk_1	173	179	PF00069	0.372
MOD_Plk_1	258	264	PF00069	0.457
MOD_Plk_1	267	273	PF00069	0.434
MOD_Plk_1	83	89	PF00069	0.321
MOD_Plk_4	130	136	PF00069	0.312
MOD_Plk_4	153	159	PF00069	0.385
MOD_Plk_4	258	264	PF00069	0.369
MOD_Plk_4	391	397	PF00069	0.272
MOD_Plk_4	40	46	PF00069	0.376
MOD_Plk_4	422	428	PF00069	0.569
MOD_Plk_4	63	69	PF00069	0.433
MOD_ProDKin_1	111	117	PF00069	0.314
MOD_ProDKin_1	121	127	PF00069	0.271
MOD_ProDKin_1	194	200	PF00069	0.560
MOD_SUMO_for_1	326	329	PF00179	0.550
MOD_SUMO_for_1	412	415	PF00179	0.317
MOD_SUMO_rev_2	276	284	PF00179	0.391
TRG_ENDOCYTIC_2	182	185	PF00928	0.336
TRG_ENDOCYTIC_2	41	44	PF00928	0.417
TRG_ENDOCYTIC_2	82	85	PF00928	0.285
TRG_ER_diArg_1	309	311	PF00400	0.347
TRG_ER_diArg_1	332	335	PF00400	0.500
TRG_ER_diLys_1	428	432	PF00400	0.547
TRG_NES_CRM1_1	22	37	PF08389	0.353
TRG_NES_CRM1_1	387	399	PF08389	0.311

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDU7	Leptomonas seymouri	76%	100%
A0A0S4IT01	Bodo saltans	46%	100%
A0A1X0P656	Trypanosomatidae	53%	100%
A0A3R7L7K6	Trypanosoma rangeli	55%	100%
A0A3S7WVP4	Leishmania donovani	87%	100%
A4HYI1	Leishmania infantum	87%	100%
D0A0V5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9ASA6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
P27124	Oryctolagus cuniculus	33%	94%
P30416	Mus musculus	33%	94%
Q02790	Homo sapiens	33%	94%
Q13451	Homo sapiens	30%	95%
Q38931	Arabidopsis thaliana	29%	78%
Q43207	Triticum aestivum	29%	77%
Q4QD56	Leishmania major	87%	100%
Q5RF88	Pongo abelii	30%	95%
Q64378	Mus musculus	30%	95%
Q7DMA9	Arabidopsis thaliana	25%	68%
Q8I4V8	Plasmodium falciparum (isolate 3D7)	24%	100%
Q95L05	Chlorocebus aethiops	30%	95%
Q9FJL3	Arabidopsis thaliana	29%	75%
Q9QVC8	Rattus norvegicus	33%	94%
Q9TRY0	Bos taurus	33%	94%
Q9VL78	Drosophila melanogaster	32%	98%
Q9XSH5	Saimiri boliviensis boliviensis	31%	95%
Q9XSI2	Saguinus oedipus	30%	95%
Q9XT11	Aotus nancymaae	30%	95%
V5AP12	Trypanosoma cruzi	50%	90%