Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HAA1_LEIBR

TriTrypDb:

LbrM.19.1780 , LBRM2903_190024800

Length:

872

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HAA1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAA1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	106	110	PF00656	0.646
CLV_C14_Caspase3-7	134	138	PF00656	0.490
CLV_NRD_NRD_1	223	225	PF00675	0.599
CLV_NRD_NRD_1	277	279	PF00675	0.657
CLV_NRD_NRD_1	36	38	PF00675	0.474
CLV_NRD_NRD_1	410	412	PF00675	0.541
CLV_NRD_NRD_1	445	447	PF00675	0.485
CLV_NRD_NRD_1	518	520	PF00675	0.330
CLV_NRD_NRD_1	541	543	PF00675	0.438
CLV_NRD_NRD_1	704	706	PF00675	0.574
CLV_NRD_NRD_1	845	847	PF00675	0.596
CLV_PCSK_FUR_1	221	225	PF00082	0.693
CLV_PCSK_FUR_1	37	41	PF00082	0.578
CLV_PCSK_FUR_1	843	847	PF00082	0.667
CLV_PCSK_KEX2_1	223	225	PF00082	0.622
CLV_PCSK_KEX2_1	277	279	PF00082	0.660
CLV_PCSK_KEX2_1	31	33	PF00082	0.488
CLV_PCSK_KEX2_1	36	38	PF00082	0.456
CLV_PCSK_KEX2_1	39	41	PF00082	0.476
CLV_PCSK_KEX2_1	409	411	PF00082	0.545
CLV_PCSK_KEX2_1	518	520	PF00082	0.330
CLV_PCSK_KEX2_1	541	543	PF00082	0.438
CLV_PCSK_KEX2_1	633	635	PF00082	0.474
CLV_PCSK_KEX2_1	794	796	PF00082	0.500
CLV_PCSK_KEX2_1	845	847	PF00082	0.570
CLV_PCSK_PC1ET2_1	31	33	PF00082	0.538
CLV_PCSK_PC1ET2_1	39	41	PF00082	0.508
CLV_PCSK_PC1ET2_1	633	635	PF00082	0.474
CLV_PCSK_PC1ET2_1	794	796	PF00082	0.500
CLV_PCSK_PC7_1	32	38	PF00082	0.562
CLV_PCSK_SKI1_1	327	331	PF00082	0.669
CLV_PCSK_SKI1_1	36	40	PF00082	0.553
CLV_PCSK_SKI1_1	425	429	PF00082	0.528
CLV_PCSK_SKI1_1	600	604	PF00082	0.373
CLV_PCSK_SKI1_1	734	738	PF00082	0.464
CLV_PCSK_SKI1_1	834	838	PF00082	0.505
DEG_SCF_FBW7_1	674	679	PF00400	0.366
DEG_SCF_FBW7_2	366	373	PF00400	0.488
DEG_SPOP_SBC_1	155	159	PF00917	0.560
DOC_CKS1_1	367	372	PF01111	0.488
DOC_CKS1_1	615	620	PF01111	0.411
DOC_CYCLIN_RxL_1	324	333	PF00134	0.504
DOC_CYCLIN_yCln2_LP_2	79	85	PF00134	0.527
DOC_MAPK_gen_1	36	47	PF00069	0.510
DOC_MAPK_gen_1	444	453	PF00069	0.452
DOC_MAPK_gen_1	518	526	PF00069	0.387
DOC_MAPK_gen_1	538	546	PF00069	0.351
DOC_MAPK_gen_1	561	569	PF00069	0.478
DOC_MAPK_gen_1	59	67	PF00069	0.634
DOC_MAPK_gen_1	633	639	PF00069	0.434
DOC_MAPK_gen_1	705	715	PF00069	0.545
DOC_MAPK_gen_1	732	740	PF00069	0.470
DOC_MAPK_gen_1	794	800	PF00069	0.501
DOC_MAPK_MEF2A_6	519	528	PF00069	0.460
DOC_MAPK_MEF2A_6	541	548	PF00069	0.441
DOC_MAPK_MEF2A_6	575	582	PF00069	0.467
DOC_MAPK_MEF2A_6	605	612	PF00069	0.474
DOC_MAPK_MEF2A_6	732	740	PF00069	0.470
DOC_MAPK_NFAT4_5	541	549	PF00069	0.446
DOC_PP1_RVXF_1	478	484	PF00149	0.497
DOC_PP1_RVXF_1	690	697	PF00149	0.394
DOC_PP2B_LxvP_1	45	48	PF13499	0.524
DOC_PP2B_LxvP_1	489	492	PF13499	0.483
DOC_PP4_FxxP_1	123	126	PF00568	0.503
DOC_PP4_FxxP_1	472	475	PF00568	0.505
DOC_PP4_FxxP_1	615	618	PF00568	0.407
DOC_USP7_MATH_1	140	144	PF00917	0.721
DOC_USP7_MATH_1	145	149	PF00917	0.668
DOC_USP7_MATH_1	155	159	PF00917	0.541
DOC_USP7_MATH_1	163	167	PF00917	0.467
DOC_USP7_MATH_1	229	233	PF00917	0.639
DOC_USP7_MATH_1	244	248	PF00917	0.513
DOC_USP7_MATH_1	479	483	PF00917	0.568
DOC_USP7_MATH_1	777	781	PF00917	0.602
DOC_USP7_MATH_1	91	95	PF00917	0.661
DOC_USP7_UBL2_3	702	706	PF12436	0.508
DOC_WW_Pin1_4	122	127	PF00397	0.561
DOC_WW_Pin1_4	146	151	PF00397	0.561
DOC_WW_Pin1_4	156	161	PF00397	0.579
DOC_WW_Pin1_4	366	371	PF00397	0.690
DOC_WW_Pin1_4	49	54	PF00397	0.514
DOC_WW_Pin1_4	614	619	PF00397	0.418
DOC_WW_Pin1_4	663	668	PF00397	0.534
DOC_WW_Pin1_4	672	677	PF00397	0.501
DOC_WW_Pin1_4	806	811	PF00397	0.572
DOC_WW_Pin1_4	92	97	PF00397	0.684
LIG_14-3-3_CanoR_1	297	302	PF00244	0.491
LIG_14-3-3_CanoR_1	327	337	PF00244	0.638
LIG_14-3-3_CanoR_1	480	484	PF00244	0.498
LIG_14-3-3_CanoR_1	764	768	PF00244	0.517
LIG_14-3-3_CanoR_1	818	828	PF00244	0.641
LIG_BIR_III_2	8	12	PF00653	0.578
LIG_BRCT_BRCA1_1	180	184	PF00533	0.647
LIG_BRCT_BRCA1_1	229	233	PF00533	0.668
LIG_EH1_1	455	463	PF00400	0.395
LIG_EVH1_1	489	493	PF00568	0.474
LIG_EVH1_2	2	6	PF00568	0.634
LIG_FHA_1	178	184	PF00498	0.653
LIG_FHA_1	23	29	PF00498	0.546
LIG_FHA_1	375	381	PF00498	0.566
LIG_FHA_1	440	446	PF00498	0.521
LIG_FHA_1	853	859	PF00498	0.690
LIG_FHA_2	391	397	PF00498	0.515
LIG_FHA_2	615	621	PF00498	0.383
LIG_FHA_2	673	679	PF00498	0.399
LIG_FHA_2	812	818	PF00498	0.569
LIG_Integrin_RGD_1	754	756	PF01839	0.568
LIG_LIR_Apic_2	122	126	PF02991	0.506
LIG_LIR_Apic_2	613	618	PF02991	0.416
LIG_LIR_Gen_1	230	241	PF02991	0.672
LIG_LIR_Gen_1	464	474	PF02991	0.397
LIG_LIR_Gen_1	650	660	PF02991	0.378
LIG_LIR_Gen_1	693	703	PF02991	0.531
LIG_LIR_Nem_3	210	216	PF02991	0.545
LIG_LIR_Nem_3	230	236	PF02991	0.416
LIG_LIR_Nem_3	464	469	PF02991	0.389
LIG_LIR_Nem_3	620	625	PF02991	0.398
LIG_LIR_Nem_3	650	655	PF02991	0.433
LIG_LIR_Nem_3	693	699	PF02991	0.406
LIG_NRBOX	325	331	PF00104	0.507
LIG_PTB_Apo_2	309	316	PF02174	0.598
LIG_SH2_NCK_1	265	269	PF00017	0.621
LIG_SH2_NCK_1	652	656	PF00017	0.368
LIG_SH2_SRC	265	268	PF00017	0.621
LIG_SH2_SRC	652	655	PF00017	0.560
LIG_SH2_SRC	658	661	PF00017	0.246
LIG_SH2_STAP1	265	269	PF00017	0.621
LIG_SH2_STAP1	652	656	PF00017	0.435
LIG_SH2_STAT3	269	272	PF00017	0.619
LIG_SH2_STAT3	821	824	PF00017	0.537
LIG_SH2_STAT5	452	455	PF00017	0.423
LIG_SH2_STAT5	658	661	PF00017	0.415
LIG_SH2_STAT5	695	698	PF00017	0.398
LIG_SH2_STAT5	742	745	PF00017	0.461
LIG_SH2_STAT5	821	824	PF00017	0.653
LIG_SH3_3	310	316	PF00018	0.607
LIG_SH3_3	331	337	PF00018	0.614
LIG_SH3_3	364	370	PF00018	0.635
LIG_SH3_3	482	488	PF00018	0.571
LIG_SH3_3	507	513	PF00018	0.352
LIG_SH3_3	566	572	PF00018	0.527
LIG_SH3_3	668	674	PF00018	0.463
LIG_SH3_3	754	760	PF00018	0.574
LIG_SH3_3	807	813	PF00018	0.593
LIG_SH3_3	841	847	PF00018	0.549
LIG_SH3_3	90	96	PF00018	0.501
LIG_SUMO_SIM_anti_2	362	369	PF11976	0.494
LIG_TRAF2_1	159	162	PF00917	0.720
LIG_TRAF2_1	271	274	PF00917	0.569
LIG_TRAF2_1	675	678	PF00917	0.392
LIG_TRAF2_1	74	77	PF00917	0.547
LIG_UBA3_1	628	633	PF00899	0.454
LIG_UBA3_1	739	745	PF00899	0.463
MOD_CDK_SPK_2	614	619	PF00069	0.418
MOD_CDK_SPK_2	663	668	PF00069	0.490
MOD_CK1_1	119	125	PF00069	0.617
MOD_CK1_1	143	149	PF00069	0.714
MOD_CK1_1	282	288	PF00069	0.569
MOD_CK1_1	362	368	PF00069	0.631
MOD_CK1_1	536	542	PF00069	0.549
MOD_CK1_1	766	772	PF00069	0.519
MOD_CK1_1	775	781	PF00069	0.518
MOD_CK1_1	95	101	PF00069	0.612
MOD_CK2_1	155	161	PF00069	0.654
MOD_CK2_1	390	396	PF00069	0.589
MOD_CK2_1	433	439	PF00069	0.658
MOD_CK2_1	498	504	PF00069	0.502
MOD_CK2_1	614	620	PF00069	0.395
MOD_CK2_1	672	678	PF00069	0.448
MOD_CK2_1	777	783	PF00069	0.557
MOD_CK2_1	86	92	PF00069	0.563
MOD_Cter_Amidation	221	224	PF01082	0.612
MOD_Cter_Amidation	792	795	PF01082	0.513
MOD_GlcNHglycan	137	140	PF01048	0.654
MOD_GlcNHglycan	142	145	PF01048	0.660
MOD_GlcNHglycan	17	20	PF01048	0.539
MOD_GlcNHglycan	330	333	PF01048	0.540
MOD_GlcNHglycan	346	349	PF01048	0.630
MOD_GlcNHglycan	413	418	PF01048	0.556
MOD_GlcNHglycan	514	517	PF01048	0.303
MOD_GlcNHglycan	88	91	PF01048	0.652
MOD_GlcNHglycan	97	100	PF01048	0.736
MOD_GSK3_1	122	129	PF00069	0.665
MOD_GSK3_1	146	153	PF00069	0.667
MOD_GSK3_1	179	186	PF00069	0.547
MOD_GSK3_1	284	291	PF00069	0.622
MOD_GSK3_1	355	362	PF00069	0.560
MOD_GSK3_1	435	442	PF00069	0.460
MOD_GSK3_1	49	56	PF00069	0.548
MOD_GSK3_1	498	505	PF00069	0.595
MOD_GSK3_1	610	617	PF00069	0.393
MOD_GSK3_1	659	666	PF00069	0.456
MOD_GSK3_1	672	679	PF00069	0.510
MOD_GSK3_1	763	770	PF00069	0.511
MOD_GSK3_1	864	871	PF00069	0.754
MOD_GSK3_1	91	98	PF00069	0.629
MOD_N-GLC_1	610	615	PF02516	0.385
MOD_N-GLC_1	716	721	PF02516	0.513
MOD_NEK2_1	154	159	PF00069	0.496
MOD_NEK2_1	216	221	PF00069	0.695
MOD_NEK2_1	279	284	PF00069	0.570
MOD_NEK2_1	763	768	PF00069	0.516
MOD_NEK2_1	819	824	PF00069	0.650
MOD_NEK2_1	97	102	PF00069	0.777
MOD_NEK2_2	126	131	PF00069	0.503
MOD_NEK2_2	179	184	PF00069	0.651
MOD_PIKK_1	216	222	PF00454	0.631
MOD_PIKK_1	533	539	PF00454	0.550
MOD_PIKK_1	811	817	PF00454	0.646
MOD_PK_1	297	303	PF00069	0.492
MOD_PKA_1	446	452	PF00069	0.446
MOD_PKA_2	119	125	PF00069	0.655
MOD_PKA_2	15	21	PF00069	0.540
MOD_PKA_2	282	288	PF00069	0.569
MOD_PKA_2	362	368	PF00069	0.666
MOD_PKA_2	387	393	PF00069	0.651
MOD_PKA_2	479	485	PF00069	0.428
MOD_PKA_2	763	769	PF00069	0.517
MOD_Plk_1	21	27	PF00069	0.492
MOD_Plk_1	390	396	PF00069	0.589
MOD_Plk_1	413	419	PF00069	0.502
MOD_Plk_2-3	498	504	PF00069	0.476
MOD_Plk_4	107	113	PF00069	0.504
MOD_Plk_4	126	132	PF00069	0.458
MOD_Plk_4	179	185	PF00069	0.538
MOD_Plk_4	246	252	PF00069	0.681
MOD_Plk_4	362	368	PF00069	0.639
MOD_Plk_4	390	396	PF00069	0.589
MOD_Plk_4	446	452	PF00069	0.446
MOD_Plk_4	624	630	PF00069	0.401
MOD_Plk_4	767	773	PF00069	0.445
MOD_ProDKin_1	122	128	PF00069	0.560
MOD_ProDKin_1	146	152	PF00069	0.563
MOD_ProDKin_1	156	162	PF00069	0.578
MOD_ProDKin_1	366	372	PF00069	0.689
MOD_ProDKin_1	49	55	PF00069	0.511
MOD_ProDKin_1	614	620	PF00069	0.419
MOD_ProDKin_1	663	669	PF00069	0.536
MOD_ProDKin_1	672	678	PF00069	0.501
MOD_ProDKin_1	806	812	PF00069	0.561
MOD_ProDKin_1	92	98	PF00069	0.684
MOD_SUMO_for_1	60	63	PF00179	0.465
MOD_SUMO_for_1	713	716	PF00179	0.553
MOD_SUMO_rev_2	109	119	PF00179	0.617
MOD_SUMO_rev_2	355	362	PF00179	0.545
MOD_SUMO_rev_2	829	836	PF00179	0.485
TRG_DiLeu_BaEn_1	63	68	PF01217	0.523
TRG_DiLeu_BaEn_4	274	280	PF01217	0.451
TRG_ENDOCYTIC_2	213	216	PF00928	0.545
TRG_ENDOCYTIC_2	652	655	PF00928	0.376
TRG_ER_diArg_1	221	224	PF00400	0.644
TRG_ER_diArg_1	277	279	PF00400	0.540
TRG_ER_diArg_1	36	38	PF00400	0.604
TRG_ER_diArg_1	409	411	PF00400	0.453
TRG_ER_diArg_1	467	470	PF00400	0.414
TRG_ER_diArg_1	518	520	PF00400	0.330
TRG_ER_diArg_1	541	543	PF00400	0.438
TRG_ER_diArg_1	843	846	PF00400	0.667
TRG_NES_CRM1_1	554	565	PF08389	0.449
TRG_NES_CRM1_1	829	841	PF08389	0.565
TRG_NLS_MonoExtN_4	36	43	PF00514	0.486
TRG_NLS_MonoExtN_4	702	709	PF00514	0.490
TRG_Pf-PMV_PEXEL_1	101	106	PF00026	0.691
TRG_Pf-PMV_PEXEL_1	686	691	PF00026	0.410

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8A9	Leptomonas seymouri	68%	95%
A0A1X0P5Z6	Trypanosomatidae	54%	100%
A0A3Q8IBG1	Leishmania donovani	85%	100%
A4HYI2	Leishmania infantum	85%	100%
D0A0V4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9ASA5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QD57	Leishmania major	85%	100%
V5B4C3	Trypanosoma cruzi	47%	97%