LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

TPT domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
TPT domain-containing protein
Gene product:
Triose-phosphate Transporter family, putative
Species:
Leishmania braziliensis
UniProt:
A4HAA0_LEIBR
TriTrypDb:
LbrM.19.1770 , LBRM2903_190024600 *
Length:
321

Annotations

LeishMANIAdb annotations

Related to plant and animal nucleoside-sugar transporters, often localized to the Golgi apparatus.. An expanded family in kinetoplastids, possibly to cover the need for expanded proteoglycan biosynthesis. Localization: Golgi (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 12
GO:0110165 cellular anatomical entity 1 12
GO:0005794 Golgi apparatus 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1

Expansion

Sequence features

A4HAA0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAA0

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 1
GO:0005338 nucleotide-sugar transmembrane transporter activity 4 1
GO:0015291 secondary active transmembrane transporter activity 4 1
GO:0015297 antiporter activity 5 1
GO:0015932 nucleobase-containing compound transmembrane transporter activity 3 1
GO:0022804 active transmembrane transporter activity 3 1
GO:0022857 transmembrane transporter activity 2 1
GO:1901505 carbohydrate derivative transmembrane transporter activity 3 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 140 144 PF00656 0.176
CLV_PCSK_KEX2_1 65 67 PF00082 0.241
CLV_PCSK_PC1ET2_1 65 67 PF00082 0.248
CLV_PCSK_SKI1_1 102 106 PF00082 0.282
CLV_PCSK_SKI1_1 27 31 PF00082 0.323
CLV_PCSK_SKI1_1 271 275 PF00082 0.341
CLV_PCSK_SKI1_1 7 11 PF00082 0.330
DEG_APCC_DBOX_1 270 278 PF00400 0.415
DEG_MDM2_SWIB_1 281 289 PF02201 0.382
DOC_CKS1_1 104 109 PF01111 0.282
DOC_CYCLIN_yCln2_LP_2 104 110 PF00134 0.282
DOC_MAPK_gen_1 296 302 PF00069 0.572
DOC_MAPK_HePTP_8 268 280 PF00069 0.209
DOC_MAPK_MEF2A_6 102 111 PF00069 0.282
DOC_MAPK_MEF2A_6 119 127 PF00069 0.436
DOC_MAPK_MEF2A_6 252 261 PF00069 0.282
DOC_MAPK_MEF2A_6 271 280 PF00069 0.305
DOC_MAPK_MEF2A_6 71 79 PF00069 0.259
DOC_PP1_RVXF_1 25 31 PF00149 0.247
DOC_PP1_RVXF_1 5 11 PF00149 0.367
DOC_PP4_FxxP_1 264 267 PF00568 0.209
DOC_USP7_MATH_1 139 143 PF00917 0.302
DOC_USP7_MATH_1 16 20 PF00917 0.294
DOC_USP7_UBL2_3 305 309 PF12436 0.633
DOC_WW_Pin1_4 103 108 PF00397 0.282
DOC_WW_Pin1_4 238 243 PF00397 0.436
LIG_14-3-3_CanoR_1 32 38 PF00244 0.312
LIG_BIR_II_1 1 5 PF00653 0.590
LIG_BRCT_BRCA1_1 155 159 PF00533 0.259
LIG_BRCT_BRCA1_1 257 261 PF00533 0.365
LIG_BRCT_BRCA1_1 93 97 PF00533 0.262
LIG_FHA_1 143 149 PF00498 0.268
LIG_FHA_1 213 219 PF00498 0.263
LIG_FHA_1 23 29 PF00498 0.358
LIG_FHA_1 238 244 PF00498 0.446
LIG_FHA_1 4 10 PF00498 0.530
LIG_FHA_1 48 54 PF00498 0.356
LIG_FHA_1 99 105 PF00498 0.283
LIG_FHA_2 138 144 PF00498 0.282
LIG_LIR_Gen_1 178 187 PF02991 0.450
LIG_LIR_Gen_1 222 231 PF02991 0.288
LIG_LIR_Gen_1 232 242 PF02991 0.289
LIG_LIR_Gen_1 244 253 PF02991 0.282
LIG_LIR_Gen_1 89 100 PF02991 0.297
LIG_LIR_LC3C_4 106 111 PF02991 0.373
LIG_LIR_Nem_3 178 183 PF02991 0.451
LIG_LIR_Nem_3 222 227 PF02991 0.270
LIG_LIR_Nem_3 232 237 PF02991 0.289
LIG_LIR_Nem_3 244 248 PF02991 0.282
LIG_LIR_Nem_3 258 264 PF02991 0.282
LIG_LIR_Nem_3 279 284 PF02991 0.383
LIG_LIR_Nem_3 36 40 PF02991 0.281
LIG_LIR_Nem_3 89 95 PF02991 0.359
LIG_Pex14_2 281 285 PF04695 0.382
LIG_SH2_CRK 245 249 PF00017 0.282
LIG_SH2_CRK 37 41 PF00017 0.301
LIG_SH2_CRK 92 96 PF00017 0.240
LIG_SH2_GRB2like 24 27 PF00017 0.415
LIG_SH2_NCK_1 184 188 PF00017 0.412
LIG_SH2_NCK_1 92 96 PF00017 0.248
LIG_SH2_STAP1 24 28 PF00017 0.398
LIG_SH2_STAT5 11 14 PF00017 0.317
LIG_SH2_STAT5 199 202 PF00017 0.312
LIG_SH2_STAT5 24 27 PF00017 0.290
LIG_SH2_STAT5 286 289 PF00017 0.282
LIG_SH3_1 208 214 PF00018 0.330
LIG_SH3_3 208 214 PF00018 0.331
LIG_SH3_3 58 64 PF00018 0.501
LIG_SUMO_SIM_anti_2 215 222 PF11976 0.347
LIG_SUMO_SIM_anti_2 86 92 PF11976 0.211
LIG_SUMO_SIM_par_1 108 114 PF11976 0.306
LIG_SUMO_SIM_par_1 215 222 PF11976 0.380
LIG_TYR_ITIM 243 248 PF00017 0.282
LIG_TYR_ITIM 284 289 PF00017 0.302
LIG_TYR_ITIM 9 14 PF00017 0.412
LIG_TYR_ITIM 90 95 PF00017 0.297
LIG_UBA3_1 233 239 PF00899 0.297
MOD_CK1_1 137 143 PF00069 0.389
MOD_CK1_1 241 247 PF00069 0.436
MOD_Cter_Amidation 294 297 PF01082 0.253
MOD_GlcNHglycan 155 158 PF01048 0.250
MOD_GlcNHglycan 221 224 PF01048 0.341
MOD_GSK3_1 237 244 PF00069 0.437
MOD_GSK3_1 98 105 PF00069 0.443
MOD_N-GLC_1 229 234 PF02516 0.311
MOD_N-GLC_1 86 91 PF02516 0.282
MOD_NEK2_1 127 132 PF00069 0.366
MOD_NEK2_1 158 163 PF00069 0.285
MOD_NEK2_1 46 51 PF00069 0.310
MOD_Plk_1 229 235 PF00069 0.311
MOD_Plk_1 3 9 PF00069 0.432
MOD_Plk_1 86 92 PF00069 0.282
MOD_Plk_4 111 117 PF00069 0.282
MOD_Plk_4 148 154 PF00069 0.297
MOD_Plk_4 212 218 PF00069 0.260
MOD_Plk_4 36 42 PF00069 0.241
MOD_Plk_4 86 92 PF00069 0.317
MOD_ProDKin_1 103 109 PF00069 0.282
MOD_ProDKin_1 238 244 PF00069 0.436
MOD_SUMO_rev_2 304 311 PF00179 0.613
MOD_SUMO_rev_2 314 321 PF00179 0.685
TRG_ENDOCYTIC_2 11 14 PF00928 0.317
TRG_ENDOCYTIC_2 245 248 PF00928 0.282
TRG_ENDOCYTIC_2 286 289 PF00928 0.317
TRG_ENDOCYTIC_2 37 40 PF00928 0.283
TRG_ENDOCYTIC_2 92 95 PF00928 0.240

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P8N6 Leptomonas seymouri 68% 99%
A0A0N1PAW1 Leptomonas seymouri 36% 99%
A0A0S4IKX4 Bodo saltans 62% 100%
A0A0S4JRZ1 Bodo saltans 58% 100%
A0A1X0P276 Trypanosomatidae 36% 100%
A0A1X0P5Z4 Trypanosomatidae 59% 100%
A0A3R7NGZ9 Trypanosoma rangeli 37% 100%
A0A3S7WVL9 Leishmania donovani 79% 100%
A0A3S7X3R1 Leishmania donovani 34% 99%
A0A422NUS0 Trypanosoma rangeli 58% 100%
A2AKQ0 Mus musculus 24% 90%
A2VE55 Bos taurus 24% 90%
A4HYI0 Leishmania infantum 79% 100%
A4I5U5 Leishmania infantum 34% 99%
A4IFK2 Bos taurus 47% 100%
A9UUB8 Monosiga brevicollis 23% 96%
C9ZR66 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 35% 100%
E9ASA4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 79% 100%
E9B140 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 99%
F4IHS9 Arabidopsis thaliana 36% 94%
P0C6B1 Rattus norvegicus 25% 78%
Q15B89 Sus scrofa 24% 94%
Q1JQ66 Danio rerio 48% 100%
Q3E6T0 Arabidopsis thaliana 23% 92%
Q4Q726 Leishmania major 37% 100%
Q4QD58 Leishmania major 79% 100%
Q550W6 Dictyostelium discoideum 24% 87%
Q5RDC9 Pongo abelii 24% 90%
Q5RKL7 Rattus norvegicus 27% 92%
Q5XF09 Arabidopsis thaliana 27% 100%
Q6DBP3 Arabidopsis thaliana 27% 100%
Q6PGC7 Mus musculus 45% 100%
Q76EJ3 Homo sapiens 25% 95%
Q7Z769 Homo sapiens 46% 100%
Q84QU8 Oryza sativa subsp. japonica 24% 79%
Q8BLX4 Mus musculus 25% 88%
Q8C811 Mus musculus 22% 79%
Q8CD26 Mus musculus 25% 78%
Q8GUJ1 Arabidopsis thaliana 37% 91%
Q8H184 Arabidopsis thaliana 24% 78%
Q8RWW7 Arabidopsis thaliana 31% 95%
Q8RXL8 Arabidopsis thaliana 38% 90%
Q94B65 Arabidopsis thaliana 25% 99%
Q96K37 Homo sapiens 24% 78%
Q9C521 Arabidopsis thaliana 29% 96%
Q9FDZ5 Arabidopsis thaliana 31% 96%
Q9FG70 Arabidopsis thaliana 28% 81%
Q9FIH5 Arabidopsis thaliana 31% 92%
Q9FYE5 Arabidopsis thaliana 26% 100%
Q9LDH3 Arabidopsis thaliana 29% 89%
Q9LFN3 Arabidopsis thaliana 26% 91%
Q9LPU2 Arabidopsis thaliana 33% 92%
Q9LU76 Arabidopsis thaliana 29% 82%
Q9NTN3 Homo sapiens 24% 90%
Q9SFE9 Arabidopsis thaliana 27% 94%
Q9SKJ7 Arabidopsis thaliana 23% 93%
Q9SRE4 Arabidopsis thaliana 32% 93%
Q9SS40 Arabidopsis thaliana 24% 90%
Q9SUV2 Arabidopsis thaliana 23% 92%
Q9SZ96 Arabidopsis thaliana 32% 96%
Q9VHT4 Drosophila melanogaster 24% 95%
Q9VR50 Drosophila melanogaster 25% 86%
V5BMW3 Trypanosoma cruzi 40% 100%
V5D4Q6 Trypanosoma cruzi 57% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS