TPT domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Triose-phosphate Transporter family, putative

Species:

Leishmania braziliensis

UniProt:

A4HAA0_LEIBR

TriTrypDb:

LbrM.19.1770 , LBRM2903_190024600

Length:

321

Annotations

LeishMANIAdb annotations

Related to plant and animal nucleoside-sugar transporters, often localized to the Golgi apparatus.. An expanded family in kinetoplastids, possibly to cover the need for expanded proteoglycan biosynthesis. Localization: Golgi (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005794	Golgi apparatus	5	1
GO:0016020	membrane	2	12
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	12

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Expansion

Sequence features

A4HAA0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAA0

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0005338	nucleotide-sugar transmembrane transporter activity	4	1
GO:0015291	secondary active transmembrane transporter activity	4	1
GO:0015297	antiporter activity	5	1
GO:0015932	nucleobase-containing compound transmembrane transporter activity	3	1
GO:0022804	active transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1
GO:1901505	carbohydrate derivative transmembrane transporter activity	3	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	140	144	PF00656	0.176
CLV_PCSK_KEX2_1	65	67	PF00082	0.241
CLV_PCSK_PC1ET2_1	65	67	PF00082	0.248
CLV_PCSK_SKI1_1	102	106	PF00082	0.282
CLV_PCSK_SKI1_1	27	31	PF00082	0.323
CLV_PCSK_SKI1_1	271	275	PF00082	0.341
CLV_PCSK_SKI1_1	7	11	PF00082	0.330
DEG_APCC_DBOX_1	270	278	PF00400	0.415
DEG_MDM2_SWIB_1	281	289	PF02201	0.382
DOC_CKS1_1	104	109	PF01111	0.282

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8N6	Leptomonas seymouri	68%	99%
A0A0N1PAW1	Leptomonas seymouri	36%	99%
A0A0S4IKX4	Bodo saltans	62%	100%
A0A0S4JRZ1	Bodo saltans	58%	100%
A0A1X0P276	Trypanosomatidae	36%	100%
A0A1X0P5Z4	Trypanosomatidae	59%	100%
A0A3R7NGZ9	Trypanosoma rangeli	37%	100%
A0A3S7WVL9	Leishmania donovani	79%	100%
A0A3S7X3R1	Leishmania donovani	34%	99%
A0A422NUS0	Trypanosoma rangeli	58%	100%

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