Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HA99_LEIBR

TriTrypDb:

LbrM.19.1760 , LBRM2903_190024500

Length:

114

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HA99

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HA99

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	4	6	PF00675	0.521
CLV_PCSK_KEX2_1	4	6	PF00082	0.521
DEG_Nend_Nbox_1	1	3	PF02207	0.559
DEG_SPOP_SBC_1	37	41	PF00917	0.554
DOC_MAPK_DCC_7	30	38	PF00069	0.528
DOC_MAPK_MEF2A_6	30	38	PF00069	0.484
DOC_PP4_MxPP_1	31	34	PF00568	0.586
DOC_WW_Pin1_4	21	26	PF00397	0.490
DOC_WW_Pin1_4	66	71	PF00397	0.578
DOC_WW_Pin1_4	77	82	PF00397	0.565
LIG_14-3-3_CanoR_1	19	25	PF00244	0.450
LIG_14-3-3_CanoR_1	4	13	PF00244	0.479
LIG_14-3-3_CanoR_1	96	105	PF00244	0.485
LIG_Actin_WH2_2	80	98	PF00022	0.535
LIG_deltaCOP1_diTrp_1	100	107	PF00928	0.360
LIG_FHA_1	37	43	PF00498	0.643
LIG_FHA_1	48	54	PF00498	0.602
LIG_FHA_1	90	96	PF00498	0.468
LIG_FHA_2	56	62	PF00498	0.440
LIG_FHA_2	66	72	PF00498	0.384
LIG_LIR_Gen_1	104	112	PF02991	0.493
LIG_LIR_Gen_1	15	25	PF02991	0.334
LIG_LIR_Nem_3	104	110	PF02991	0.491
LIG_LIR_Nem_3	15	20	PF02991	0.393
LIG_LIR_Nem_3	40	46	PF02991	0.622
LIG_MYND_1	33	37	PF01753	0.622
LIG_NRBOX	72	78	PF00104	0.608
LIG_Pex14_1	103	107	PF04695	0.371
LIG_SH2_CRK	17	21	PF00017	0.488
LIG_SH2_CRK	43	47	PF00017	0.415
LIG_SH2_STAP1	105	109	PF00017	0.508
LIG_SH3_3	31	37	PF00018	0.537
MOD_CK1_1	47	53	PF00069	0.591
MOD_CK2_1	55	61	PF00069	0.676
MOD_CK2_1	65	71	PF00069	0.593
MOD_Cter_Amidation	2	5	PF01082	0.597
MOD_GlcNHglycan	46	49	PF01048	0.567
MOD_GSK3_1	101	108	PF00069	0.518
MOD_GSK3_1	38	45	PF00069	0.588
MOD_N-GLC_1	65	70	PF02516	0.560
MOD_NEK2_1	20	25	PF00069	0.447
MOD_NEK2_1	55	60	PF00069	0.451
MOD_Plk_4	12	18	PF00069	0.327
MOD_Plk_4	38	44	PF00069	0.569
MOD_Plk_4	72	78	PF00069	0.574
MOD_Plk_4	89	95	PF00069	0.425
MOD_Plk_4	98	104	PF00069	0.453
MOD_ProDKin_1	21	27	PF00069	0.488
MOD_ProDKin_1	66	72	PF00069	0.573
MOD_ProDKin_1	77	83	PF00069	0.563
TRG_ENDOCYTIC_2	17	20	PF00928	0.458
TRG_ENDOCYTIC_2	43	46	PF00928	0.418
TRG_ER_diArg_1	4	6	PF00400	0.521

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I123	Leptomonas seymouri	67%	100%
A0A0S4IR74	Bodo saltans	30%	70%
A0A0S4KIC6	Bodo saltans	40%	100%
A0A1X0P673	Trypanosomatidae	46%	100%
A0A1X0P697	Trypanosomatidae	42%	91%
A0A3Q8IBJ2	Leishmania donovani	81%	100%
A0A422NUP2	Trypanosoma rangeli	45%	100%
A4HA86	Leishmania braziliensis	38%	100%
A4HYH9	Leishmania infantum	81%	100%
D0A0V3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	91%
E9ASA3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4QD59	Leishmania major	83%	100%
Q4QD74	Leishmania major	41%	100%