Eukaryotic translation initiation factor-like

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

eukaryotic translation initiation factor-like

Species:

Leishmania braziliensis

UniProt:

A4HA98_LEIBR

TriTrypDb:

LbrM.19.1750 , LBRM2903_190024400

Length:

278

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016281	eukaryotic translation initiation factor 4F complex	2	1
GO:0032991	protein-containing complex	1	1
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HA98

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HA98

Function

Biological processes
Term	Name	Level	Count
GO:0006413	translational initiation	3	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0044237	cellular metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003743	translation initiation factor activity	4	12
GO:0005488	binding	1	12
GO:0008135	translation factor activity, RNA binding	3	12
GO:0045182	translation regulator activity	1	12
GO:0090079	translation regulator activity, nucleic acid binding	2	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0000339	RNA cap binding	5	1
GO:0000340	RNA 7-methylguanosine cap binding	6	1
GO:0000342	RNA cap 4 binding	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	203	207	PF00656	0.649
CLV_NRD_NRD_1	175	177	PF00675	0.309
CLV_NRD_NRD_1	190	192	PF00675	0.293
CLV_NRD_NRD_1	33	35	PF00675	0.170
CLV_NRD_NRD_1	83	85	PF00675	0.264
CLV_NRD_NRD_1	97	99	PF00675	0.205
CLV_PCSK_KEX2_1	175	177	PF00082	0.283
CLV_PCSK_KEX2_1	33	35	PF00082	0.170
CLV_PCSK_KEX2_1	97	99	PF00082	0.296
DEG_Nend_UBRbox_2	1	3	PF02207	0.702
DOC_CKS1_1	212	217	PF01111	0.496
DOC_CYCLIN_RxL_1	189	200	PF00134	0.498
DOC_MAPK_gen_1	191	198	PF00069	0.476
DOC_MAPK_gen_1	267	276	PF00069	0.542
DOC_MAPK_gen_1	97	106	PF00069	0.463
DOC_MAPK_MEF2A_6	191	198	PF00069	0.370
DOC_MAPK_MEF2A_6	267	276	PF00069	0.571
DOC_MAPK_NFAT4_5	191	199	PF00069	0.370
DOC_PP1_RVXF_1	250	256	PF00149	0.348
DOC_USP7_MATH_1	105	109	PF00917	0.436
DOC_USP7_MATH_1	155	159	PF00917	0.437
DOC_USP7_MATH_1	76	80	PF00917	0.521
DOC_WW_Pin1_4	211	216	PF00397	0.646
DOC_WW_Pin1_4	218	223	PF00397	0.699
DOC_WW_Pin1_4	4	9	PF00397	0.547
LIG_14-3-3_CanoR_1	180	186	PF00244	0.439
LIG_14-3-3_CanoR_1	267	273	PF00244	0.548
LIG_CSL_BTD_1	219	222	PF09270	0.499
LIG_deltaCOP1_diTrp_1	167	173	PF00928	0.463
LIG_deltaCOP1_diTrp_1	59	65	PF00928	0.538
LIG_FHA_1	124	130	PF00498	0.495
LIG_FHA_1	228	234	PF00498	0.459
LIG_FHA_1	269	275	PF00498	0.559
LIG_FHA_2	201	207	PF00498	0.586
LIG_FHA_2	212	218	PF00498	0.618
LIG_GBD_Chelix_1	186	194	PF00786	0.338
LIG_LIR_Gen_1	121	132	PF02991	0.463
LIG_LIR_Gen_1	26	32	PF02991	0.442
LIG_LIR_Nem_3	121	127	PF02991	0.456
LIG_LIR_Nem_3	26	31	PF02991	0.362
LIG_LIR_Nem_3	59	65	PF02991	0.452
LIG_LIR_Nem_3	78	83	PF02991	0.463
LIG_PCNA_yPIPBox_3	176	190	PF02747	0.485
LIG_Pex14_1	102	106	PF04695	0.452
LIG_Pex14_2	61	65	PF04695	0.538
LIG_SH2_STAP1	270	274	PF00017	0.511
LIG_SH2_STAT5	189	192	PF00017	0.558
LIG_SH2_STAT5	270	273	PF00017	0.514
LIG_SH2_STAT5	81	84	PF00017	0.493
LIG_SH3_2	219	224	PF14604	0.726
LIG_SH3_3	216	222	PF00018	0.755
LIG_SUMO_SIM_par_1	270	275	PF11976	0.553
MOD_CDC14_SPxK_1	221	224	PF00782	0.722
MOD_CDK_SPxK_1	218	224	PF00069	0.725
MOD_CDK_SPxxK_3	222	229	PF00069	0.724
MOD_CK1_1	108	114	PF00069	0.498
MOD_CK1_1	200	206	PF00069	0.627
MOD_CK1_1	238	244	PF00069	0.471
MOD_CK1_1	7	13	PF00069	0.654
MOD_CK2_1	179	185	PF00069	0.466
MOD_CK2_1	211	217	PF00069	0.715
MOD_CMANNOS	22	25	PF00535	0.252
MOD_GlcNHglycan	129	132	PF01048	0.338
MOD_GlcNHglycan	157	160	PF01048	0.303
MOD_GlcNHglycan	232	236	PF01048	0.642
MOD_GlcNHglycan	237	240	PF01048	0.531
MOD_GlcNHglycan	56	59	PF01048	0.312
MOD_GlcNHglycan	9	12	PF01048	0.597
MOD_GSK3_1	104	111	PF00069	0.547
MOD_GSK3_1	123	130	PF00069	0.527
MOD_GSK3_1	197	204	PF00069	0.632
MOD_GSK3_1	218	225	PF00069	0.772
MOD_GSK3_1	227	234	PF00069	0.724
MOD_GSK3_1	65	72	PF00069	0.449
MOD_N-GLC_1	65	70	PF02516	0.332
MOD_N-GLC_1	76	81	PF02516	0.239
MOD_N-GLC_2	4	6	PF02516	0.721
MOD_NEK2_1	127	132	PF00069	0.538
MOD_NEK2_1	65	70	PF00069	0.525
MOD_PIKK_1	179	185	PF00454	0.476
MOD_PIKK_1	69	75	PF00454	0.463
MOD_PKA_2	179	185	PF00069	0.476
MOD_Plk_1	65	71	PF00069	0.512
MOD_Plk_1	76	82	PF00069	0.512
MOD_Plk_4	16	22	PF00069	0.527
MOD_Plk_4	65	71	PF00069	0.538
MOD_Plk_4	76	82	PF00069	0.538
MOD_ProDKin_1	211	217	PF00069	0.645
MOD_ProDKin_1	218	224	PF00069	0.701
MOD_ProDKin_1	4	10	PF00069	0.543
MOD_SUMO_rev_2	166	170	PF00179	0.502
TRG_DiLeu_BaLyEn_6	160	165	PF01217	0.370
TRG_ENDOCYTIC_2	80	83	PF00928	0.463
TRG_ER_diArg_1	32	34	PF00400	0.370
TRG_Pf-PMV_PEXEL_1	246	250	PF00026	0.441

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A075QQ08	Nicotiana tabacum	27%	100%
A0A0N0P8A8	Leptomonas seymouri	63%	100%
A0A0S4KG92	Bodo saltans	47%	95%
A0A1X0P6Z9	Trypanosomatidae	42%	100%
A0A2J6L8Y7	Lactuca sativa	29%	100%
A0A3Q7FGP1	Solanum lycopersicum	27%	100%
A0A3Q8IE78	Leishmania donovani	27%	100%
A0A3S5H774	Leishmania donovani	81%	99%
A0A3S5IRX1	Trypanosoma rangeli	41%	96%
A4HYH8	Leishmania infantum	82%	99%
A4I2V4	Leishmania infantum	27%	100%
A6NMX2	Homo sapiens	26%	100%
A7KWF8	Cucumis zeyherii	29%	100%
C6ZJZ3	Glycine max	27%	100%
C7SG33	Citrullus lanatus	29%	100%
D0A0V2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9ADE1	Leishmania major	26%	100%
E9ASA2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	99%
E9AZ65	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
K0P2S0	Arachis hypogaea	28%	100%
O23252	Arabidopsis thaliana	27%	100%
O60573	Homo sapiens	30%	100%
O74743	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	100%
O81481	Zea mays	30%	100%
O81482	Zea mays	29%	100%
P07260	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	100%
P29557	Triticum aestivum	28%	100%
P48597	Xenopus laevis	27%	100%
P48599	Oryza sativa subsp. japonica	27%	100%
Q00LS8	Cucumis melo	28%	100%
Q0GRC4	Pisum sativum	27%	100%
Q3UTA9	Mus musculus	27%	100%
Q4QD60	Leishmania major	82%	100%
Q4QXS7	Hordeum vulgare subsp. vulgare	27%	100%
Q66UV4	Nicotiana tabacum	27%	100%
Q9C7P2	Arabidopsis thaliana	25%	100%
Q9C7P6	Arabidopsis thaliana	25%	100%
Q9PW28	Danio rerio	29%	100%
V5AP07	Trypanosoma cruzi	41%	100%
V7BSD0	Phaseolus vulgaris	28%	100%