Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania braziliensis

UniProt:

A4HA97_LEIBR

TriTrypDb:

LbrM.19.1740 , LBRM2903_190024200

Length:

568

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HA97

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HA97

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	16
GO:0006793	phosphorus metabolic process	3	16
GO:0006796	phosphate-containing compound metabolic process	4	16
GO:0006807	nitrogen compound metabolic process	2	16
GO:0008152	metabolic process	1	16
GO:0009987	cellular process	1	16
GO:0016310	phosphorylation	5	16
GO:0019538	protein metabolic process	3	16
GO:0036211	protein modification process	4	16
GO:0043170	macromolecule metabolic process	3	16
GO:0043412	macromolecule modification	4	16
GO:0044237	cellular metabolic process	2	16
GO:0044238	primary metabolic process	2	16
GO:0071704	organic substance metabolic process	2	16
GO:1901564	organonitrogen compound metabolic process	3	16
GO:0007165	signal transduction	2	1
GO:0018105	peptidyl-serine phosphorylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018209	peptidyl-serine modification	6	1
GO:0035556	intracellular signal transduction	3	1
GO:0046777	protein autophosphorylation	6	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	16
GO:0003824	catalytic activity	1	16
GO:0004672	protein kinase activity	3	16
GO:0005488	binding	1	16
GO:0005524	ATP binding	5	16
GO:0016301	kinase activity	4	16
GO:0016740	transferase activity	2	16
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	16
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	16
GO:0017076	purine nucleotide binding	4	16
GO:0030554	adenyl nucleotide binding	5	16
GO:0032553	ribonucleotide binding	3	16
GO:0032555	purine ribonucleotide binding	4	16
GO:0032559	adenyl ribonucleotide binding	5	16
GO:0035639	purine ribonucleoside triphosphate binding	4	16
GO:0036094	small molecule binding	2	16
GO:0043167	ion binding	2	16
GO:0043168	anion binding	3	16
GO:0097159	organic cyclic compound binding	2	16
GO:0097367	carbohydrate derivative binding	2	16
GO:0140096	catalytic activity, acting on a protein	2	16
GO:1901265	nucleoside phosphate binding	3	16
GO:1901363	heterocyclic compound binding	2	16
GO:0004674	protein serine/threonine kinase activity	4	7
GO:0004683	calmodulin-dependent protein kinase activity	5	1
GO:0005515	protein binding	2	1
GO:0005516	calmodulin binding	3	1
GO:0009931	calcium-dependent protein serine/threonine kinase activity	5	1
GO:0010857	calcium-dependent protein kinase activity	4	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	108	110	PF00675	0.482
CLV_NRD_NRD_1	141	143	PF00675	0.349
CLV_NRD_NRD_1	150	152	PF00675	0.299
CLV_NRD_NRD_1	163	165	PF00675	0.310
CLV_NRD_NRD_1	30	32	PF00675	0.502
CLV_NRD_NRD_1	336	338	PF00675	0.186
CLV_NRD_NRD_1	450	452	PF00675	0.323
CLV_NRD_NRD_1	518	520	PF00675	0.504
CLV_NRD_NRD_1	6	8	PF00675	0.663
CLV_PCSK_KEX2_1	108	110	PF00082	0.489
CLV_PCSK_KEX2_1	150	152	PF00082	0.471
CLV_PCSK_KEX2_1	163	165	PF00082	0.351
CLV_PCSK_KEX2_1	30	32	PF00082	0.502
CLV_PCSK_KEX2_1	336	338	PF00082	0.289
CLV_PCSK_KEX2_1	394	396	PF00082	0.387
CLV_PCSK_KEX2_1	450	452	PF00082	0.316
CLV_PCSK_KEX2_1	495	497	PF00082	0.452
CLV_PCSK_KEX2_1	6	8	PF00082	0.663
CLV_PCSK_PC1ET2_1	394	396	PF00082	0.387
CLV_PCSK_PC1ET2_1	495	497	PF00082	0.447
CLV_PCSK_PC7_1	104	110	PF00082	0.429
CLV_PCSK_SKI1_1	109	113	PF00082	0.442
CLV_PCSK_SKI1_1	215	219	PF00082	0.405
CLV_PCSK_SKI1_1	233	237	PF00082	0.238
CLV_PCSK_SKI1_1	337	341	PF00082	0.405
CLV_PCSK_SKI1_1	446	450	PF00082	0.367
CLV_PCSK_SKI1_1	48	52	PF00082	0.345
DEG_APCC_DBOX_1	214	222	PF00400	0.433
DEG_Nend_UBRbox_4	1	3	PF02207	0.382
DEG_SCF_FBW7_1	341	348	PF00400	0.342
DOC_AGCK_PIF_2	12	17	PF00069	0.420
DOC_CKS1_1	386	391	PF01111	0.553
DOC_CYCLIN_RxL_1	212	220	PF00134	0.430
DOC_CYCLIN_RxL_1	58	69	PF00134	0.347
DOC_MAPK_gen_1	113	122	PF00069	0.394
DOC_MAPK_gen_1	233	242	PF00069	0.342
DOC_MAPK_gen_1	519	527	PF00069	0.539
DOC_MAPK_MEF2A_6	168	175	PF00069	0.370
DOC_PP1_RVXF_1	46	52	PF00149	0.352
DOC_PP4_FxxP_1	297	300	PF00568	0.186
DOC_PP4_FxxP_1	351	354	PF00568	0.329
DOC_PP4_FxxP_1	433	436	PF00568	0.387
DOC_USP7_MATH_1	269	273	PF00917	0.186
DOC_USP7_MATH_1	301	305	PF00917	0.251
DOC_USP7_MATH_1	444	448	PF00917	0.237
DOC_USP7_MATH_1	554	558	PF00917	0.655
DOC_USP7_UBL2_3	139	143	PF12436	0.329
DOC_USP7_UBL2_3	286	290	PF12436	0.186
DOC_WW_Pin1_4	296	301	PF00397	0.387
DOC_WW_Pin1_4	303	308	PF00397	0.387
DOC_WW_Pin1_4	341	346	PF00397	0.337
DOC_WW_Pin1_4	385	390	PF00397	0.626
DOC_WW_Pin1_4	466	471	PF00397	0.266
LIG_14-3-3_CanoR_1	142	147	PF00244	0.402
LIG_14-3-3_CanoR_1	302	310	PF00244	0.357
LIG_14-3-3_CanoR_1	374	380	PF00244	0.612
LIG_14-3-3_CanoR_1	496	506	PF00244	0.677
LIG_14-3-3_CanoR_1	519	527	PF00244	0.631
LIG_BIR_III_4	529	533	PF00653	0.620
LIG_BRCT_BRCA1_1	143	147	PF00533	0.387
LIG_BRCT_BRCA1_1	507	511	PF00533	0.452
LIG_BRCT_BRCA1_1	84	88	PF00533	0.534
LIG_CtBP_PxDLS_1	389	393	PF00389	0.426
LIG_deltaCOP1_diTrp_1	522	526	PF00928	0.599
LIG_EVH1_1	308	312	PF00568	0.296
LIG_FHA_1	110	116	PF00498	0.462
LIG_FHA_1	133	139	PF00498	0.403
LIG_FHA_1	402	408	PF00498	0.352
LIG_FHA_2	386	392	PF00498	0.489
LIG_FHA_2	408	414	PF00498	0.321
LIG_FHA_2	84	90	PF00498	0.498
LIG_GBD_Chelix_1	115	123	PF00786	0.405
LIG_GBD_Chelix_1	213	221	PF00786	0.329
LIG_LIR_Apic_2	294	300	PF02991	0.186
LIG_LIR_Apic_2	348	354	PF02991	0.342
LIG_LIR_Apic_2	432	436	PF02991	0.384
LIG_LIR_Gen_1	181	191	PF02991	0.377
LIG_LIR_Gen_1	194	204	PF02991	0.333
LIG_LIR_Gen_1	207	214	PF02991	0.364
LIG_LIR_Gen_1	281	289	PF02991	0.317
LIG_LIR_Gen_1	435	445	PF02991	0.186
LIG_LIR_Gen_1	462	472	PF02991	0.296
LIG_LIR_Gen_1	502	511	PF02991	0.594
LIG_LIR_Gen_1	521	530	PF02991	0.504
LIG_LIR_Nem_3	10	15	PF02991	0.487
LIG_LIR_Nem_3	181	187	PF02991	0.378
LIG_LIR_Nem_3	194	199	PF02991	0.313
LIG_LIR_Nem_3	207	211	PF02991	0.364
LIG_LIR_Nem_3	281	287	PF02991	0.343
LIG_LIR_Nem_3	413	418	PF02991	0.235
LIG_LIR_Nem_3	425	431	PF02991	0.266
LIG_LIR_Nem_3	435	441	PF02991	0.167
LIG_LIR_Nem_3	462	467	PF02991	0.296
LIG_LIR_Nem_3	502	507	PF02991	0.458
LIG_LIR_Nem_3	521	527	PF02991	0.382
LIG_LIR_Nem_3	562	568	PF02991	0.465
LIG_MLH1_MIPbox_1	84	88	PF16413	0.432
LIG_Pex14_1	47	51	PF04695	0.426
LIG_Pex14_1	84	88	PF04695	0.464
LIG_REV1ctd_RIR_1	85	95	PF16727	0.463
LIG_SH2_CRK	208	212	PF00017	0.346
LIG_SH2_CRK	25	29	PF00017	0.421
LIG_SH2_CRK	284	288	PF00017	0.296
LIG_SH2_NCK_1	478	482	PF00017	0.591
LIG_SH2_PTP2	184	187	PF00017	0.431
LIG_SH2_SRC	189	192	PF00017	0.454
LIG_SH2_SRC	25	28	PF00017	0.423
LIG_SH2_STAP1	17	21	PF00017	0.425
LIG_SH2_STAP1	208	212	PF00017	0.387
LIG_SH2_STAP1	284	288	PF00017	0.387
LIG_SH2_STAT3	360	363	PF00017	0.411
LIG_SH2_STAT3	440	443	PF00017	0.387
LIG_SH2_STAT5	184	187	PF00017	0.394
LIG_SH2_STAT5	189	192	PF00017	0.393
LIG_SH2_STAT5	3	6	PF00017	0.652
LIG_SH2_STAT5	440	443	PF00017	0.323
LIG_SH2_STAT5	478	481	PF00017	0.702
LIG_SH2_STAT5	53	56	PF00017	0.556
LIG_SH3_3	30	36	PF00018	0.486
LIG_SH3_3	304	310	PF00018	0.291
LIG_SH3_3	383	389	PF00018	0.635
LIG_SH3_3	438	444	PF00018	0.318
LIG_SH3_3	70	76	PF00018	0.574
LIG_SUMO_SIM_anti_2	209	214	PF11976	0.387
LIG_SUMO_SIM_anti_2	388	394	PF11976	0.510
LIG_SxIP_EBH_1	530	539	PF03271	0.519
LIG_UBA3_1	119	126	PF00899	0.418
LIG_UBA3_1	379	385	PF00899	0.424
MOD_CDC14_SPxK_1	299	302	PF00782	0.203
MOD_CDK_SPxK_1	296	302	PF00069	0.203
MOD_CDK_SPxxK_3	466	473	PF00069	0.186
MOD_CK1_1	10	16	PF00069	0.522
MOD_CK1_1	373	379	PF00069	0.489
MOD_CK1_1	439	445	PF00069	0.266
MOD_CK1_1	514	520	PF00069	0.522
MOD_CK2_1	288	294	PF00069	0.186
MOD_CK2_1	407	413	PF00069	0.310
MOD_CK2_1	416	422	PF00069	0.277
MOD_CK2_1	459	465	PF00069	0.352
MOD_CK2_1	480	486	PF00069	0.745
MOD_CK2_1	556	562	PF00069	0.462
MOD_CK2_1	83	89	PF00069	0.606
MOD_Cter_Amidation	493	496	PF01082	0.468
MOD_GlcNHglycan	258	261	PF01048	0.300
MOD_GlcNHglycan	269	272	PF01048	0.329
MOD_GlcNHglycan	357	360	PF01048	0.424
MOD_GlcNHglycan	375	378	PF01048	0.711
MOD_GlcNHglycan	461	464	PF01048	0.485
MOD_GlcNHglycan	499	502	PF01048	0.587
MOD_GlcNHglycan	558	561	PF01048	0.559
MOD_GSK3_1	141	148	PF00069	0.404
MOD_GSK3_1	263	270	PF00069	0.368
MOD_GSK3_1	296	303	PF00069	0.231
MOD_GSK3_1	322	329	PF00069	0.295
MOD_GSK3_1	341	348	PF00069	0.359
MOD_GSK3_1	369	376	PF00069	0.617
MOD_GSK3_1	476	483	PF00069	0.631
MOD_GSK3_1	507	514	PF00069	0.498
MOD_GSK3_1	7	14	PF00069	0.508
MOD_N-GLC_1	10	15	PF02516	0.412
MOD_N-GLC_1	246	251	PF02516	0.186
MOD_N-GLC_1	497	502	PF02516	0.509
MOD_NEK2_1	115	120	PF00069	0.576
MOD_NEK2_1	217	222	PF00069	0.368
MOD_NEK2_1	339	344	PF00069	0.387
MOD_NEK2_1	370	375	PF00069	0.483
MOD_NEK2_1	497	502	PF00069	0.558
MOD_NEK2_1	506	511	PF00069	0.503
MOD_NEK2_1	533	538	PF00069	0.602
MOD_NEK2_1	555	560	PF00069	0.648
MOD_NEK2_2	83	88	PF00069	0.517
MOD_PIKK_1	439	445	PF00454	0.387
MOD_PIKK_1	66	72	PF00454	0.471
MOD_PK_1	322	328	PF00069	0.362
MOD_PKA_1	142	148	PF00069	0.387
MOD_PKA_2	141	147	PF00069	0.403
MOD_PKA_2	301	307	PF00069	0.403
MOD_PKA_2	370	376	PF00069	0.595
MOD_PKA_2	459	465	PF00069	0.313
MOD_PKA_2	518	524	PF00069	0.657
MOD_Plk_1	10	16	PF00069	0.413
MOD_Plk_1	246	252	PF00069	0.186
MOD_Plk_2-3	480	486	PF00069	0.691
MOD_Plk_4	142	148	PF00069	0.330
MOD_Plk_4	444	450	PF00069	0.419
MOD_Plk_4	499	505	PF00069	0.559
MOD_Plk_4	83	89	PF00069	0.511
MOD_ProDKin_1	296	302	PF00069	0.387
MOD_ProDKin_1	303	309	PF00069	0.387
MOD_ProDKin_1	341	347	PF00069	0.337
MOD_ProDKin_1	385	391	PF00069	0.624
MOD_ProDKin_1	466	472	PF00069	0.266
MOD_SUMO_for_1	235	238	PF00179	0.342
MOD_SUMO_for_1	289	292	PF00179	0.186
MOD_SUMO_rev_2	118	128	PF00179	0.564
TRG_DiLeu_BaEn_2	218	224	PF01217	0.296
TRG_DiLeu_BaEn_2	521	527	PF01217	0.600
TRG_DiLeu_BaEn_2	88	94	PF01217	0.565
TRG_DiLeu_BaLyEn_6	58	63	PF01217	0.359
TRG_ENDOCYTIC_2	103	106	PF00928	0.602
TRG_ENDOCYTIC_2	184	187	PF00928	0.390
TRG_ENDOCYTIC_2	208	211	PF00928	0.346
TRG_ENDOCYTIC_2	25	28	PF00928	0.423
TRG_ENDOCYTIC_2	284	287	PF00928	0.398
TRG_ENDOCYTIC_2	428	431	PF00928	0.442
TRG_ER_diArg_1	107	109	PF00400	0.475
TRG_ER_diArg_1	149	151	PF00400	0.455
TRG_ER_diArg_1	162	164	PF00400	0.351
TRG_ER_diArg_1	336	338	PF00400	0.186
TRG_ER_diArg_1	449	451	PF00400	0.323
TRG_ER_diArg_1	5	7	PF00400	0.500
TRG_Pf-PMV_PEXEL_1	215	219	PF00026	0.339
TRG_Pf-PMV_PEXEL_1	539	544	PF00026	0.468

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0B4J2F2	Homo sapiens	23%	73%
A0A0N1I6Q7	Leptomonas seymouri	25%	100%
A0A0N1IM89	Leptomonas seymouri	63%	100%
A0A0S4ITS4	Bodo saltans	22%	100%
A0A0S4JCK1	Bodo saltans	22%	100%
A0A0S4JPZ7	Bodo saltans	29%	100%
A0A0S4KKJ1	Bodo saltans	40%	90%
A0A3R7MKJ1	Trypanosoma rangeli	24%	100%
A0A3S5H5G0	Leishmania donovani	27%	100%
A0A3S7WVR6	Leishmania donovani	83%	91%
A0A3S7X8Z8	Leishmania donovani	25%	100%
A4H459	Leishmania braziliensis	27%	100%
A4HD79	Leishmania braziliensis	25%	100%
A4HFF3	Leishmania braziliensis	27%	100%
A4HHE4	Leishmania braziliensis	25%	96%
A4HSE2	Leishmania infantum	27%	100%
A4HYH7	Leishmania infantum	83%	91%
A4IB02	Leishmania infantum	25%	100%
C9ZTU6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
C9ZX15	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	21%	100%
E9AET0	Leishmania major	25%	100%
E9AKB7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9ALU0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	97%
E9ASA1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	91%
E9B5Y5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
O60285	Homo sapiens	22%	86%
O77708	Oryctolagus cuniculus	24%	100%
O94547	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	98%
P00518	Oryctolagus cuniculus	22%	100%
P08414	Mus musculus	23%	100%
P13234	Rattus norvegicus	23%	100%
P15735	Homo sapiens	24%	100%
P15791	Rattus norvegicus	24%	100%
P18654	Mus musculus	24%	77%
P38623	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	93%
P51812	Homo sapiens	24%	77%
P57059	Homo sapiens	23%	73%
Q13557	Homo sapiens	24%	100%
Q16566	Homo sapiens	23%	100%
Q16816	Homo sapiens	22%	100%
Q2HJF7	Bos taurus	24%	100%
Q2KJ16	Bos taurus	24%	100%
Q39030	Arabidopsis thaliana	23%	100%
Q4QD63	Leishmania major	81%	100%
Q4QJJ0	Leishmania major	27%	100%
Q5A649	Candida albicans (strain SC5314 / ATCC MYA-2876)	22%	68%
Q60670	Mus musculus	21%	73%
Q6PHZ2	Mus musculus	24%	100%
Q93VD3	Arabidopsis thaliana	22%	100%
Q94C40	Arabidopsis thaliana	25%	100%
Q95266	Sus scrofa	24%	100%
Q9R1U5	Rattus norvegicus	22%	73%
Q9Y899	Emericella nidulans	21%	100%
V5BI43	Trypanosoma cruzi	28%	100%