LeishMANIAdb
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Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein kinase domain-containing protein
Gene product:
protein kinase, putative
Species:
Leishmania braziliensis
UniProt:
A4HA97_LEIBR
TriTrypDb:
LbrM.19.1740 , LBRM2903_190024200 *
Length:
568

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 15
NetGPI no yes: 0, no: 15
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0005737 cytoplasm 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HA97
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HA97

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 16
GO:0006793 phosphorus metabolic process 3 16
GO:0006796 phosphate-containing compound metabolic process 4 16
GO:0006807 nitrogen compound metabolic process 2 16
GO:0008152 metabolic process 1 16
GO:0009987 cellular process 1 16
GO:0016310 phosphorylation 5 16
GO:0019538 protein metabolic process 3 16
GO:0036211 protein modification process 4 16
GO:0043170 macromolecule metabolic process 3 16
GO:0043412 macromolecule modification 4 16
GO:0044237 cellular metabolic process 2 16
GO:0044238 primary metabolic process 2 16
GO:0071704 organic substance metabolic process 2 16
GO:1901564 organonitrogen compound metabolic process 3 16
GO:0007165 signal transduction 2 1
GO:0018105 peptidyl-serine phosphorylation 6 1
GO:0018193 peptidyl-amino acid modification 5 1
GO:0018209 peptidyl-serine modification 6 1
GO:0035556 intracellular signal transduction 3 1
GO:0046777 protein autophosphorylation 6 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0065007 biological regulation 1 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 16
GO:0003824 catalytic activity 1 16
GO:0004672 protein kinase activity 3 16
GO:0005488 binding 1 16
GO:0005524 ATP binding 5 16
GO:0016301 kinase activity 4 16
GO:0016740 transferase activity 2 16
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 16
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 16
GO:0017076 purine nucleotide binding 4 16
GO:0030554 adenyl nucleotide binding 5 16
GO:0032553 ribonucleotide binding 3 16
GO:0032555 purine ribonucleotide binding 4 16
GO:0032559 adenyl ribonucleotide binding 5 16
GO:0035639 purine ribonucleoside triphosphate binding 4 16
GO:0036094 small molecule binding 2 16
GO:0043167 ion binding 2 16
GO:0043168 anion binding 3 16
GO:0097159 organic cyclic compound binding 2 16
GO:0097367 carbohydrate derivative binding 2 16
GO:0140096 catalytic activity, acting on a protein 2 16
GO:1901265 nucleoside phosphate binding 3 16
GO:1901363 heterocyclic compound binding 2 16
GO:0004674 protein serine/threonine kinase activity 4 7
GO:0004683 calmodulin-dependent protein kinase activity 5 1
GO:0005515 protein binding 2 1
GO:0005516 calmodulin binding 3 1
GO:0009931 calcium-dependent protein serine/threonine kinase activity 5 1
GO:0010857 calcium-dependent protein kinase activity 4 1
GO:0043169 cation binding 3 1
GO:0046872 metal ion binding 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 108 110 PF00675 0.482
CLV_NRD_NRD_1 141 143 PF00675 0.349
CLV_NRD_NRD_1 150 152 PF00675 0.299
CLV_NRD_NRD_1 163 165 PF00675 0.310
CLV_NRD_NRD_1 30 32 PF00675 0.502
CLV_NRD_NRD_1 336 338 PF00675 0.186
CLV_NRD_NRD_1 450 452 PF00675 0.323
CLV_NRD_NRD_1 518 520 PF00675 0.504
CLV_NRD_NRD_1 6 8 PF00675 0.663
CLV_PCSK_KEX2_1 108 110 PF00082 0.489
CLV_PCSK_KEX2_1 150 152 PF00082 0.471
CLV_PCSK_KEX2_1 163 165 PF00082 0.351
CLV_PCSK_KEX2_1 30 32 PF00082 0.502
CLV_PCSK_KEX2_1 336 338 PF00082 0.289
CLV_PCSK_KEX2_1 394 396 PF00082 0.387
CLV_PCSK_KEX2_1 450 452 PF00082 0.316
CLV_PCSK_KEX2_1 495 497 PF00082 0.452
CLV_PCSK_KEX2_1 6 8 PF00082 0.663
CLV_PCSK_PC1ET2_1 394 396 PF00082 0.387
CLV_PCSK_PC1ET2_1 495 497 PF00082 0.447
CLV_PCSK_PC7_1 104 110 PF00082 0.429
CLV_PCSK_SKI1_1 109 113 PF00082 0.442
CLV_PCSK_SKI1_1 215 219 PF00082 0.405
CLV_PCSK_SKI1_1 233 237 PF00082 0.238
CLV_PCSK_SKI1_1 337 341 PF00082 0.405
CLV_PCSK_SKI1_1 446 450 PF00082 0.367
CLV_PCSK_SKI1_1 48 52 PF00082 0.345
DEG_APCC_DBOX_1 214 222 PF00400 0.433
DEG_Nend_UBRbox_4 1 3 PF02207 0.382
DEG_SCF_FBW7_1 341 348 PF00400 0.342
DOC_AGCK_PIF_2 12 17 PF00069 0.420
DOC_CKS1_1 386 391 PF01111 0.553
DOC_CYCLIN_RxL_1 212 220 PF00134 0.430
DOC_CYCLIN_RxL_1 58 69 PF00134 0.347
DOC_MAPK_gen_1 113 122 PF00069 0.394
DOC_MAPK_gen_1 233 242 PF00069 0.342
DOC_MAPK_gen_1 519 527 PF00069 0.539
DOC_MAPK_MEF2A_6 168 175 PF00069 0.370
DOC_PP1_RVXF_1 46 52 PF00149 0.352
DOC_PP4_FxxP_1 297 300 PF00568 0.186
DOC_PP4_FxxP_1 351 354 PF00568 0.329
DOC_PP4_FxxP_1 433 436 PF00568 0.387
DOC_USP7_MATH_1 269 273 PF00917 0.186
DOC_USP7_MATH_1 301 305 PF00917 0.251
DOC_USP7_MATH_1 444 448 PF00917 0.237
DOC_USP7_MATH_1 554 558 PF00917 0.655
DOC_USP7_UBL2_3 139 143 PF12436 0.329
DOC_USP7_UBL2_3 286 290 PF12436 0.186
DOC_WW_Pin1_4 296 301 PF00397 0.387
DOC_WW_Pin1_4 303 308 PF00397 0.387
DOC_WW_Pin1_4 341 346 PF00397 0.337
DOC_WW_Pin1_4 385 390 PF00397 0.626
DOC_WW_Pin1_4 466 471 PF00397 0.266
LIG_14-3-3_CanoR_1 142 147 PF00244 0.402
LIG_14-3-3_CanoR_1 302 310 PF00244 0.357
LIG_14-3-3_CanoR_1 374 380 PF00244 0.612
LIG_14-3-3_CanoR_1 496 506 PF00244 0.677
LIG_14-3-3_CanoR_1 519 527 PF00244 0.631
LIG_BIR_III_4 529 533 PF00653 0.620
LIG_BRCT_BRCA1_1 143 147 PF00533 0.387
LIG_BRCT_BRCA1_1 507 511 PF00533 0.452
LIG_BRCT_BRCA1_1 84 88 PF00533 0.534
LIG_CtBP_PxDLS_1 389 393 PF00389 0.426
LIG_deltaCOP1_diTrp_1 522 526 PF00928 0.599
LIG_EVH1_1 308 312 PF00568 0.296
LIG_FHA_1 110 116 PF00498 0.462
LIG_FHA_1 133 139 PF00498 0.403
LIG_FHA_1 402 408 PF00498 0.352
LIG_FHA_2 386 392 PF00498 0.489
LIG_FHA_2 408 414 PF00498 0.321
LIG_FHA_2 84 90 PF00498 0.498
LIG_GBD_Chelix_1 115 123 PF00786 0.405
LIG_GBD_Chelix_1 213 221 PF00786 0.329
LIG_LIR_Apic_2 294 300 PF02991 0.186
LIG_LIR_Apic_2 348 354 PF02991 0.342
LIG_LIR_Apic_2 432 436 PF02991 0.384
LIG_LIR_Gen_1 181 191 PF02991 0.377
LIG_LIR_Gen_1 194 204 PF02991 0.333
LIG_LIR_Gen_1 207 214 PF02991 0.364
LIG_LIR_Gen_1 281 289 PF02991 0.317
LIG_LIR_Gen_1 435 445 PF02991 0.186
LIG_LIR_Gen_1 462 472 PF02991 0.296
LIG_LIR_Gen_1 502 511 PF02991 0.594
LIG_LIR_Gen_1 521 530 PF02991 0.504
LIG_LIR_Nem_3 10 15 PF02991 0.487
LIG_LIR_Nem_3 181 187 PF02991 0.378
LIG_LIR_Nem_3 194 199 PF02991 0.313
LIG_LIR_Nem_3 207 211 PF02991 0.364
LIG_LIR_Nem_3 281 287 PF02991 0.343
LIG_LIR_Nem_3 413 418 PF02991 0.235
LIG_LIR_Nem_3 425 431 PF02991 0.266
LIG_LIR_Nem_3 435 441 PF02991 0.167
LIG_LIR_Nem_3 462 467 PF02991 0.296
LIG_LIR_Nem_3 502 507 PF02991 0.458
LIG_LIR_Nem_3 521 527 PF02991 0.382
LIG_LIR_Nem_3 562 568 PF02991 0.465
LIG_MLH1_MIPbox_1 84 88 PF16413 0.432
LIG_Pex14_1 47 51 PF04695 0.426
LIG_Pex14_1 84 88 PF04695 0.464
LIG_REV1ctd_RIR_1 85 95 PF16727 0.463
LIG_SH2_CRK 208 212 PF00017 0.346
LIG_SH2_CRK 25 29 PF00017 0.421
LIG_SH2_CRK 284 288 PF00017 0.296
LIG_SH2_NCK_1 478 482 PF00017 0.591
LIG_SH2_PTP2 184 187 PF00017 0.431
LIG_SH2_SRC 189 192 PF00017 0.454
LIG_SH2_SRC 25 28 PF00017 0.423
LIG_SH2_STAP1 17 21 PF00017 0.425
LIG_SH2_STAP1 208 212 PF00017 0.387
LIG_SH2_STAP1 284 288 PF00017 0.387
LIG_SH2_STAT3 360 363 PF00017 0.411
LIG_SH2_STAT3 440 443 PF00017 0.387
LIG_SH2_STAT5 184 187 PF00017 0.394
LIG_SH2_STAT5 189 192 PF00017 0.393
LIG_SH2_STAT5 3 6 PF00017 0.652
LIG_SH2_STAT5 440 443 PF00017 0.323
LIG_SH2_STAT5 478 481 PF00017 0.702
LIG_SH2_STAT5 53 56 PF00017 0.556
LIG_SH3_3 30 36 PF00018 0.486
LIG_SH3_3 304 310 PF00018 0.291
LIG_SH3_3 383 389 PF00018 0.635
LIG_SH3_3 438 444 PF00018 0.318
LIG_SH3_3 70 76 PF00018 0.574
LIG_SUMO_SIM_anti_2 209 214 PF11976 0.387
LIG_SUMO_SIM_anti_2 388 394 PF11976 0.510
LIG_SxIP_EBH_1 530 539 PF03271 0.519
LIG_UBA3_1 119 126 PF00899 0.418
LIG_UBA3_1 379 385 PF00899 0.424
MOD_CDC14_SPxK_1 299 302 PF00782 0.203
MOD_CDK_SPxK_1 296 302 PF00069 0.203
MOD_CDK_SPxxK_3 466 473 PF00069 0.186
MOD_CK1_1 10 16 PF00069 0.522
MOD_CK1_1 373 379 PF00069 0.489
MOD_CK1_1 439 445 PF00069 0.266
MOD_CK1_1 514 520 PF00069 0.522
MOD_CK2_1 288 294 PF00069 0.186
MOD_CK2_1 407 413 PF00069 0.310
MOD_CK2_1 416 422 PF00069 0.277
MOD_CK2_1 459 465 PF00069 0.352
MOD_CK2_1 480 486 PF00069 0.745
MOD_CK2_1 556 562 PF00069 0.462
MOD_CK2_1 83 89 PF00069 0.606
MOD_Cter_Amidation 493 496 PF01082 0.468
MOD_GlcNHglycan 258 261 PF01048 0.300
MOD_GlcNHglycan 269 272 PF01048 0.329
MOD_GlcNHglycan 357 360 PF01048 0.424
MOD_GlcNHglycan 375 378 PF01048 0.711
MOD_GlcNHglycan 461 464 PF01048 0.485
MOD_GlcNHglycan 499 502 PF01048 0.587
MOD_GlcNHglycan 558 561 PF01048 0.559
MOD_GSK3_1 141 148 PF00069 0.404
MOD_GSK3_1 263 270 PF00069 0.368
MOD_GSK3_1 296 303 PF00069 0.231
MOD_GSK3_1 322 329 PF00069 0.295
MOD_GSK3_1 341 348 PF00069 0.359
MOD_GSK3_1 369 376 PF00069 0.617
MOD_GSK3_1 476 483 PF00069 0.631
MOD_GSK3_1 507 514 PF00069 0.498
MOD_GSK3_1 7 14 PF00069 0.508
MOD_N-GLC_1 10 15 PF02516 0.412
MOD_N-GLC_1 246 251 PF02516 0.186
MOD_N-GLC_1 497 502 PF02516 0.509
MOD_NEK2_1 115 120 PF00069 0.576
MOD_NEK2_1 217 222 PF00069 0.368
MOD_NEK2_1 339 344 PF00069 0.387
MOD_NEK2_1 370 375 PF00069 0.483
MOD_NEK2_1 497 502 PF00069 0.558
MOD_NEK2_1 506 511 PF00069 0.503
MOD_NEK2_1 533 538 PF00069 0.602
MOD_NEK2_1 555 560 PF00069 0.648
MOD_NEK2_2 83 88 PF00069 0.517
MOD_PIKK_1 439 445 PF00454 0.387
MOD_PIKK_1 66 72 PF00454 0.471
MOD_PK_1 322 328 PF00069 0.362
MOD_PKA_1 142 148 PF00069 0.387
MOD_PKA_2 141 147 PF00069 0.403
MOD_PKA_2 301 307 PF00069 0.403
MOD_PKA_2 370 376 PF00069 0.595
MOD_PKA_2 459 465 PF00069 0.313
MOD_PKA_2 518 524 PF00069 0.657
MOD_Plk_1 10 16 PF00069 0.413
MOD_Plk_1 246 252 PF00069 0.186
MOD_Plk_2-3 480 486 PF00069 0.691
MOD_Plk_4 142 148 PF00069 0.330
MOD_Plk_4 444 450 PF00069 0.419
MOD_Plk_4 499 505 PF00069 0.559
MOD_Plk_4 83 89 PF00069 0.511
MOD_ProDKin_1 296 302 PF00069 0.387
MOD_ProDKin_1 303 309 PF00069 0.387
MOD_ProDKin_1 341 347 PF00069 0.337
MOD_ProDKin_1 385 391 PF00069 0.624
MOD_ProDKin_1 466 472 PF00069 0.266
MOD_SUMO_for_1 235 238 PF00179 0.342
MOD_SUMO_for_1 289 292 PF00179 0.186
MOD_SUMO_rev_2 118 128 PF00179 0.564
TRG_DiLeu_BaEn_2 218 224 PF01217 0.296
TRG_DiLeu_BaEn_2 521 527 PF01217 0.600
TRG_DiLeu_BaEn_2 88 94 PF01217 0.565
TRG_DiLeu_BaLyEn_6 58 63 PF01217 0.359
TRG_ENDOCYTIC_2 103 106 PF00928 0.602
TRG_ENDOCYTIC_2 184 187 PF00928 0.390
TRG_ENDOCYTIC_2 208 211 PF00928 0.346
TRG_ENDOCYTIC_2 25 28 PF00928 0.423
TRG_ENDOCYTIC_2 284 287 PF00928 0.398
TRG_ENDOCYTIC_2 428 431 PF00928 0.442
TRG_ER_diArg_1 107 109 PF00400 0.475
TRG_ER_diArg_1 149 151 PF00400 0.455
TRG_ER_diArg_1 162 164 PF00400 0.351
TRG_ER_diArg_1 336 338 PF00400 0.186
TRG_ER_diArg_1 449 451 PF00400 0.323
TRG_ER_diArg_1 5 7 PF00400 0.500
TRG_Pf-PMV_PEXEL_1 215 219 PF00026 0.339
TRG_Pf-PMV_PEXEL_1 539 544 PF00026 0.468

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0B4J2F2 Homo sapiens 23% 73%
A0A0N1I6Q7 Leptomonas seymouri 25% 100%
A0A0N1IM89 Leptomonas seymouri 63% 100%
A0A0S4ITS4 Bodo saltans 22% 100%
A0A0S4JCK1 Bodo saltans 22% 100%
A0A0S4JPZ7 Bodo saltans 29% 100%
A0A0S4KKJ1 Bodo saltans 40% 90%
A0A3R7MKJ1 Trypanosoma rangeli 24% 100%
A0A3S5H5G0 Leishmania donovani 27% 100%
A0A3S7WVR6 Leishmania donovani 83% 91%
A0A3S7X8Z8 Leishmania donovani 25% 100%
A4H459 Leishmania braziliensis 27% 100%
A4HD79 Leishmania braziliensis 25% 100%
A4HFF3 Leishmania braziliensis 27% 100%
A4HHE4 Leishmania braziliensis 25% 96%
A4HSE2 Leishmania infantum 27% 100%
A4HYH7 Leishmania infantum 83% 91%
A4IB02 Leishmania infantum 25% 100%
C9ZTU6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 24% 100%
C9ZX15 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 21% 100%
E9AET0 Leishmania major 25% 100%
E9AKB7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
E9ALU0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 97%
E9ASA1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 82% 91%
E9B5Y5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
O60285 Homo sapiens 22% 86%
O77708 Oryctolagus cuniculus 24% 100%
O94547 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 26% 98%
P00518 Oryctolagus cuniculus 22% 100%
P08414 Mus musculus 23% 100%
P13234 Rattus norvegicus 23% 100%
P15735 Homo sapiens 24% 100%
P15791 Rattus norvegicus 24% 100%
P18654 Mus musculus 24% 77%
P38623 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 22% 93%
P51812 Homo sapiens 24% 77%
P57059 Homo sapiens 23% 73%
Q13557 Homo sapiens 24% 100%
Q16566 Homo sapiens 23% 100%
Q16816 Homo sapiens 22% 100%
Q2HJF7 Bos taurus 24% 100%
Q2KJ16 Bos taurus 24% 100%
Q39030 Arabidopsis thaliana 23% 100%
Q4QD63 Leishmania major 81% 100%
Q4QJJ0 Leishmania major 27% 100%
Q5A649 Candida albicans (strain SC5314 / ATCC MYA-2876) 22% 68%
Q60670 Mus musculus 21% 73%
Q6PHZ2 Mus musculus 24% 100%
Q93VD3 Arabidopsis thaliana 22% 100%
Q94C40 Arabidopsis thaliana 25% 100%
Q95266 Sus scrofa 24% 100%
Q9R1U5 Rattus norvegicus 22% 73%
Q9Y899 Emericella nidulans 21% 100%
V5BI43 Trypanosoma cruzi 28% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS