PIH1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pre-RNA processing PIH1/Nop17, putative

Species:

Leishmania braziliensis

UniProt:

A4HA93_LEIBR

TriTrypDb:

LbrM.19.1700 , LBRM2903_190023700

Length:

322

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 8
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HA93

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HA93

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	114	116	PF00675	0.580
CLV_PCSK_KEX2_1	30	32	PF00082	0.490
CLV_PCSK_PC1ET2_1	30	32	PF00082	0.490
CLV_PCSK_SKI1_1	160	164	PF00082	0.474
CLV_PCSK_SKI1_1	305	309	PF00082	0.409
DEG_Nend_UBRbox_3	1	3	PF02207	0.378
DEG_SPOP_SBC_1	233	237	PF00917	0.765
DOC_CDC14_PxL_1	206	214	PF14671	0.459
DOC_CKS1_1	153	158	PF01111	0.585
DOC_CKS1_1	49	54	PF01111	0.292
DOC_CYCLIN_yCln2_LP_2	17	23	PF00134	0.363
DOC_MAPK_DCC_7	204	214	PF00069	0.448
DOC_MAPK_gen_1	305	315	PF00069	0.368
DOC_MAPK_RevD_3	100	116	PF00069	0.392
DOC_PP2B_LxvP_1	17	20	PF13499	0.378
DOC_PP4_FxxP_1	263	266	PF00568	0.495
DOC_SPAK_OSR1_1	249	253	PF12202	0.507
DOC_SPAK_OSR1_1	262	266	PF12202	0.472
DOC_USP7_MATH_1	173	177	PF00917	0.588
DOC_USP7_UBL2_3	218	222	PF12436	0.682
DOC_USP7_UBL2_3	238	242	PF12436	0.496
DOC_WW_Pin1_4	152	157	PF00397	0.556
DOC_WW_Pin1_4	220	225	PF00397	0.738
DOC_WW_Pin1_4	48	53	PF00397	0.374
LIG_Actin_WH2_2	257	275	PF00022	0.411
LIG_deltaCOP1_diTrp_1	243	250	PF00928	0.566
LIG_EH1_1	11	19	PF00400	0.405
LIG_FHA_1	153	159	PF00498	0.609
LIG_FHA_1	221	227	PF00498	0.783
LIG_FHA_1	279	285	PF00498	0.450
LIG_FHA_1	297	303	PF00498	0.426
LIG_FHA_1	308	314	PF00498	0.417
LIG_FHA_1	42	48	PF00498	0.453
LIG_FHA_1	59	65	PF00498	0.423
LIG_FHA_1	82	88	PF00498	0.592
LIG_FHA_1	95	101	PF00498	0.682
LIG_FHA_2	127	133	PF00498	0.662
LIG_FHA_2	27	33	PF00498	0.447
LIG_GBD_Chelix_1	41	49	PF00786	0.276
LIG_LIR_Gen_1	244	255	PF02991	0.584
LIG_LIR_Nem_3	244	250	PF02991	0.630
LIG_MAD2	258	266	PF02301	0.277
LIG_MYND_1	224	228	PF01753	0.613
LIG_PCNA_yPIPBox_3	145	153	PF02747	0.595
LIG_PTB_Apo_2	87	94	PF02174	0.562
LIG_PTB_Phospho_1	87	93	PF10480	0.564
LIG_SH2_STAP1	34	38	PF00017	0.452
LIG_SH2_STAT5	36	39	PF00017	0.427
LIG_SH2_STAT5	8	11	PF00017	0.371
LIG_SH2_STAT5	93	96	PF00017	0.475
LIG_SH3_3	138	144	PF00018	0.482
LIG_SH3_3	20	26	PF00018	0.405
LIG_SH3_3	207	213	PF00018	0.558
LIG_SH3_3	95	101	PF00018	0.460
LIG_SH3_4	218	225	PF00018	0.497
LIG_SH3_4	238	245	PF00018	0.475
LIG_SUMO_SIM_par_1	19	25	PF11976	0.495
LIG_SUMO_SIM_par_1	293	301	PF11976	0.368
LIG_SUMO_SIM_par_1	310	316	PF11976	0.518
LIG_SUMO_SIM_par_1	317	322	PF11976	0.514
LIG_UBA3_1	56	63	PF00899	0.429
MOD_CDK_SPK_2	220	225	PF00069	0.515
MOD_CDK_SPxxK_3	152	159	PF00069	0.559
MOD_CK1_1	117	123	PF00069	0.624
MOD_CK1_1	248	254	PF00069	0.466
MOD_CK1_1	278	284	PF00069	0.431
MOD_CK1_1	296	302	PF00069	0.460
MOD_CK2_1	115	121	PF00069	0.561
MOD_CK2_1	19	25	PF00069	0.530
MOD_CK2_1	26	32	PF00069	0.530
MOD_GlcNHglycan	166	169	PF01048	0.531
MOD_GlcNHglycan	174	178	PF01048	0.606
MOD_GlcNHglycan	179	182	PF01048	0.614
MOD_GlcNHglycan	276	280	PF01048	0.547
MOD_GSK3_1	115	122	PF00069	0.590
MOD_GSK3_1	173	180	PF00069	0.610
MOD_N-GLC_1	164	169	PF02516	0.624
MOD_N-GLC_1	245	250	PF02516	0.492
MOD_N-GLC_2	74	76	PF02516	0.368
MOD_NEK2_1	136	141	PF00069	0.486
MOD_NEK2_1	232	237	PF00069	0.682
MOD_NEK2_1	313	318	PF00069	0.347
MOD_NEK2_1	94	99	PF00069	0.450
MOD_NEK2_2	213	218	PF00069	0.626
MOD_PKA_1	115	121	PF00069	0.478
MOD_PKA_2	114	120	PF00069	0.599
MOD_PKA_2	248	254	PF00069	0.558
MOD_Plk_1	245	251	PF00069	0.574
MOD_Plk_2-3	126	132	PF00069	0.600
MOD_Plk_2-3	202	208	PF00069	0.629
MOD_Plk_4	227	233	PF00069	0.640
MOD_Plk_4	293	299	PF00069	0.343
MOD_Plk_4	41	47	PF00069	0.434
MOD_ProDKin_1	152	158	PF00069	0.552
MOD_ProDKin_1	220	226	PF00069	0.738
MOD_ProDKin_1	48	54	PF00069	0.369
MOD_SUMO_rev_2	139	147	PF00179	0.522
MOD_SUMO_rev_2	22	29	PF00179	0.507
MOD_SUMO_rev_2	251	260	PF00179	0.376
TRG_NES_CRM1_1	253	267	PF08389	0.302
TRG_NES_CRM1_1	58	70	PF08389	0.477
TRG_NLS_MonoExtC_3	26	31	PF00514	0.324
TRG_NLS_MonoExtN_4	26	31	PF00514	0.370
TRG_Pf-PMV_PEXEL_1	262	267	PF00026	0.454

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2M6	Leptomonas seymouri	52%	88%
A0A1X0P5Z2	Trypanosomatidae	38%	89%
A0A3S5H773	Leishmania donovani	70%	88%
A0A422NUP7	Trypanosoma rangeli	35%	90%
A4HYH3	Leishmania infantum	71%	88%
D0A0U7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	91%
E9AS97	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	88%
Q4QD67	Leishmania major	72%	100%
V5D4Q0	Trypanosoma cruzi	37%	92%