Cysteine peptidase A (CPA)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cysteine peptidase A (CPA)

Species:

Leishmania braziliensis

UniProt:

A4HA92_LEIBR

TriTrypDb:

LbrM.19.1690 , LBRM2903_190023100

Length:

479

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 125

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 21

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 33, no: 5
NetGPI	no	yes: 0, no: 38

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	9
GO:0000323	lytic vacuole	6	8
GO:0005615	extracellular space	2	8
GO:0005764	lysosome	7	8
GO:0005773	vacuole	5	8
GO:0043226	organelle	2	8
GO:0043227	membrane-bounded organelle	3	8
GO:0043229	intracellular organelle	3	8
GO:0043231	intracellular membrane-bounded organelle	4	8

Expansion

Sequence features

A4HA92

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HA92

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	39
GO:0006807	nitrogen compound metabolic process	2	39
GO:0008152	metabolic process	1	39
GO:0019538	protein metabolic process	3	39
GO:0043170	macromolecule metabolic process	3	39
GO:0044238	primary metabolic process	2	39
GO:0071704	organic substance metabolic process	2	39
GO:1901564	organonitrogen compound metabolic process	3	39
GO:0051603	proteolysis involved in protein catabolic process	5	8

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	39
GO:0004175	endopeptidase activity	4	29
GO:0004197	cysteine-type endopeptidase activity	5	29
GO:0008233	peptidase activity	3	39
GO:0008234	cysteine-type peptidase activity	4	39
GO:0016787	hydrolase activity	2	39
GO:0140096	catalytic activity, acting on a protein	2	39

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	220	224	PF00656	0.215
CLV_NRD_NRD_1	3	5	PF00675	0.571
CLV_NRD_NRD_1	390	392	PF00675	0.222
CLV_PCSK_KEX2_1	3	5	PF00082	0.525
CLV_PCSK_KEX2_1	389	391	PF00082	0.237
CLV_PCSK_SKI1_1	111	115	PF00082	0.348
CLV_PCSK_SKI1_1	322	326	PF00082	0.326
CLV_PCSK_SKI1_1	367	371	PF00082	0.426
CLV_PCSK_SKI1_1	459	463	PF00082	0.451
DEG_APCC_DBOX_1	126	134	PF00400	0.512
DEG_APCC_KENBOX_2	66	70	PF00400	0.271
DEG_SPOP_SBC_1	349	353	PF00917	0.362
DEG_SPOP_SBC_1	447	451	PF00917	0.539
DOC_CYCLIN_RxL_1	364	374	PF00134	0.262
DOC_CYCLIN_yCln2_LP_2	457	463	PF00134	0.422
DOC_MAPK_gen_1	3	9	PF00069	0.470
DOC_MAPK_gen_1	389	398	PF00069	0.215
DOC_MAPK_MEF2A_6	258	266	PF00069	0.394
DOC_USP7_MATH_1	218	222	PF00917	0.376
DOC_USP7_MATH_1	324	328	PF00917	0.293
DOC_USP7_MATH_1	356	360	PF00917	0.245
DOC_USP7_UBL2_3	47	51	PF12436	0.270
DOC_WW_Pin1_4	92	97	PF00397	0.284
LIG_14-3-3_CanoR_1	127	135	PF00244	0.401
LIG_14-3-3_CanoR_1	348	358	PF00244	0.239
LIG_14-3-3_CanoR_1	375	383	PF00244	0.245
LIG_BIR_II_1	1	5	PF00653	0.590
LIG_BRCT_BRCA1_1	279	283	PF00533	0.215
LIG_BRCT_BRCA1_1	38	42	PF00533	0.339
LIG_BRCT_BRCA1_1	87	91	PF00533	0.398
LIG_deltaCOP1_diTrp_1	197	202	PF00928	0.230
LIG_FHA_1	108	114	PF00498	0.402
LIG_FHA_1	230	236	PF00498	0.237
LIG_FHA_1	268	274	PF00498	0.381
LIG_FHA_1	359	365	PF00498	0.271
LIG_FHA_2	218	224	PF00498	0.215
LIG_FHA_2	349	355	PF00498	0.242
LIG_FHA_2	397	403	PF00498	0.333
LIG_FHA_2	93	99	PF00498	0.274
LIG_HCF-1_HBM_1	317	320	PF13415	0.215
LIG_LIR_Gen_1	197	204	PF02991	0.218
LIG_LIR_Gen_1	317	324	PF02991	0.446
LIG_LIR_Gen_1	88	99	PF02991	0.263
LIG_LIR_Nem_3	197	203	PF02991	0.216
LIG_LIR_Nem_3	269	274	PF02991	0.365
LIG_LIR_Nem_3	317	323	PF02991	0.365
LIG_LIR_Nem_3	39	45	PF02991	0.321
LIG_LIR_Nem_3	432	436	PF02991	0.393
LIG_LIR_Nem_3	88	94	PF02991	0.462
LIG_PCNA_yPIPBox_3	3	12	PF02747	0.356
LIG_Pex14_1	271	275	PF04695	0.259
LIG_PTB_Apo_2	102	109	PF02174	0.459
LIG_PTB_Apo_2	298	305	PF02174	0.224
LIG_PTB_Phospho_1	102	108	PF10480	0.462
LIG_PTB_Phospho_1	298	304	PF10480	0.224
LIG_SH2_GRB2like	103	106	PF00017	0.490
LIG_SH2_GRB2like	75	78	PF00017	0.215
LIG_SH2_NCK_1	212	216	PF00017	0.359
LIG_SH2_PTP2	320	323	PF00017	0.365
LIG_SH2_SRC	103	106	PF00017	0.556
LIG_SH2_SRC	75	78	PF00017	0.215
LIG_SH2_STAP1	109	113	PF00017	0.311
LIG_SH2_STAP1	335	339	PF00017	0.347
LIG_SH2_STAT3	109	112	PF00017	0.358
LIG_SH2_STAT5	103	106	PF00017	0.488
LIG_SH2_STAT5	109	112	PF00017	0.455
LIG_SH2_STAT5	21	24	PF00017	0.381
LIG_SH2_STAT5	212	215	PF00017	0.369
LIG_SH2_STAT5	219	222	PF00017	0.356
LIG_SH2_STAT5	274	277	PF00017	0.328
LIG_SH2_STAT5	320	323	PF00017	0.365
LIG_SH2_STAT5	436	439	PF00017	0.378
LIG_SH2_STAT5	75	78	PF00017	0.257
LIG_SH3_3	212	218	PF00018	0.229
LIG_SH3_3	240	246	PF00018	0.349
LIG_SH3_3	463	469	PF00018	0.544
LIG_SUMO_SIM_anti_2	402	410	PF11976	0.215
LIG_SUMO_SIM_par_1	172	178	PF11976	0.378
LIG_TRAF2_1	399	402	PF00917	0.215
LIG_TRAF2_1	95	98	PF00917	0.302
MOD_CK1_1	169	175	PF00069	0.387
MOD_CK1_1	183	189	PF00069	0.245
MOD_CK1_1	225	231	PF00069	0.430
MOD_CK1_1	310	316	PF00069	0.398
MOD_CK1_1	413	419	PF00069	0.264
MOD_CK1_1	455	461	PF00069	0.524
MOD_CK2_1	172	178	PF00069	0.350
MOD_CK2_1	311	317	PF00069	0.382
MOD_CK2_1	348	354	PF00069	0.242
MOD_CK2_1	396	402	PF00069	0.288
MOD_CK2_1	49	55	PF00069	0.441
MOD_CK2_1	92	98	PF00069	0.365
MOD_GlcNHglycan	130	133	PF01048	0.618
MOD_GlcNHglycan	156	159	PF01048	0.504
MOD_GlcNHglycan	168	171	PF01048	0.504
MOD_GlcNHglycan	207	210	PF01048	0.252
MOD_GlcNHglycan	220	223	PF01048	0.362
MOD_GlcNHglycan	239	242	PF01048	0.289
MOD_GlcNHglycan	298	301	PF01048	0.291
MOD_GlcNHglycan	337	340	PF01048	0.357
MOD_GlcNHglycan	38	41	PF01048	0.548
MOD_GlcNHglycan	415	418	PF01048	0.257
MOD_GlcNHglycan	86	90	PF01048	0.332
MOD_GSK3_1	213	220	PF00069	0.403
MOD_GSK3_1	225	232	PF00069	0.360
MOD_GSK3_1	237	244	PF00069	0.408
MOD_GSK3_1	307	314	PF00069	0.288
MOD_GSK3_1	337	344	PF00069	0.413
MOD_GSK3_1	371	378	PF00069	0.252
MOD_GSK3_1	392	399	PF00069	0.243
MOD_GSK3_1	409	416	PF00069	0.338
MOD_GSK3_1	448	455	PF00069	0.517
MOD_N-GLC_1	205	210	PF02516	0.470
MOD_N-GLC_1	296	301	PF02516	0.447
MOD_N-GLC_2	328	330	PF02516	0.395
MOD_N-GLC_2	371	373	PF02516	0.215
MOD_N-GLC_2	427	429	PF02516	0.415
MOD_N-GLC_2	439	441	PF02516	0.396
MOD_NEK2_1	11	16	PF00069	0.662
MOD_NEK2_1	149	154	PF00069	0.376
MOD_NEK2_1	337	342	PF00069	0.384
MOD_NEK2_1	376	381	PF00069	0.332
MOD_NEK2_1	410	415	PF00069	0.363
MOD_PIKK_1	416	422	PF00454	0.467
MOD_PKA_2	237	243	PF00069	0.232
MOD_PKA_2	410	416	PF00069	0.227
MOD_Plk_1	213	219	PF00069	0.357
MOD_Plk_1	266	272	PF00069	0.365
MOD_Plk_4	11	17	PF00069	0.569
MOD_Plk_4	169	175	PF00069	0.373
MOD_Plk_4	21	27	PF00069	0.519
MOD_Plk_4	358	364	PF00069	0.236
MOD_Plk_4	392	398	PF00069	0.275
MOD_Plk_4	429	435	PF00069	0.460
MOD_ProDKin_1	92	98	PF00069	0.284
TRG_DiLeu_BaEn_1	404	409	PF01217	0.215
TRG_DiLeu_BaLyEn_6	3	8	PF01217	0.404
TRG_DiLeu_BaLyEn_6	457	462	PF01217	0.431
TRG_ENDOCYTIC_2	123	126	PF00928	0.431
TRG_ENDOCYTIC_2	212	215	PF00928	0.377
TRG_ENDOCYTIC_2	304	307	PF00928	0.374
TRG_ENDOCYTIC_2	320	323	PF00928	0.365
TRG_ER_diArg_1	388	391	PF00400	0.224

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A072UTP9	Medicago truncatula	32%	100%
A0A0N1PA65	Leptomonas seymouri	60%	100%
A0A0S4ISD8	Bodo saltans	43%	90%
A0A0S4IY45	Bodo saltans	34%	100%
A0A0S4J3Q7	Bodo saltans	29%	100%
A0A0S4J628	Bodo saltans	43%	87%
A0A0S4JV57	Bodo saltans	31%	100%
A0A0S4JXJ3	Bodo saltans	28%	100%
A0A0S4KJA5	Bodo saltans	41%	100%
A0A1X0NIG8	Trypanosomatidae	32%	100%
A0A1X0NXC8	Trypanosomatidae	32%	100%
A0A3R7L7E7	Trypanosoma rangeli	50%	91%
A0A3S5H682	Leishmania donovani	47%	100%
A0A3S5H683	Leishmania donovani	45%	100%
A0A3S5H684	Leishmania donovani	45%	100%
A0A3S5H685	Leishmania donovani	45%	100%
A0A3S7WQD0	Leishmania donovani	45%	100%
A0A6L0WJ22	Leishmania infantum	45%	100%
A1KXI0	Blomia tropicalis	30%	100%
A2XQE8	Oryza sativa subsp. indica	39%	100%
A4H5E4	Leishmania braziliensis	45%	100%
A4H5E5	Leishmania braziliensis	45%	100%
A4H5E6	Leishmania braziliensis	45%	100%
A4HH90	Leishmania braziliensis	29%	100%
A4HTP0	Leishmania infantum	45%	100%
A4HYH2	Leishmania infantum	66%	100%
A4I4D6	Leishmania infantum	29%	100%
A5HII1	Actinidia deliciosa	34%	100%
C9ZQB3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
C9ZQB5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
C9ZQB6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
D3ZZ07	Rattus norvegicus	30%	100%
E8NHD8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	100%
E8NHH6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	100%
E8NHJ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	95%
E8NHL3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	90%
E8NHS3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E9ADT5	Leishmania major	29%	100%
E9ALZ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AMH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	100%
E9AMH6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9AMH7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	100%
E9AS96	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%
F4JNL3	Arabidopsis thaliana	34%	100%
O10364	Orgyia pseudotsugata multicapsid polyhedrosis virus	34%	100%
O35186	Rattus norvegicus	32%	100%
O60911	Homo sapiens	35%	100%
O65493	Arabidopsis thaliana	35%	100%
O91466	Cydia pomonella granulosis virus (isolate Mexico/1963)	32%	100%
P00785	Actinidia chinensis var. chinensis	34%	100%
P04988	Dictyostelium discoideum	39%	100%
P05994	Carica papaya	32%	100%
P07711	Homo sapiens	36%	100%
P14658	Trypanosoma brucei brucei	46%	100%
P15242	Rattus norvegicus	34%	100%
P16311	Dermatophagoides farinae	29%	100%
P22497	Theileria parva	28%	100%
P25326	Bos taurus	36%	100%
P25773	Felis catus	36%	100%
P25774	Homo sapiens	36%	100%
P25775	Leishmania mexicana	70%	100%
P25779	Trypanosoma cruzi	49%	100%
P25781	Theileria annulata	33%	100%
P25792	Schistosoma mansoni	23%	100%
P25804	Pisum sativum	40%	100%
P25805	Plasmodium falciparum	30%	84%
P25975	Bos taurus	38%	100%
P35591	Leishmania pifanoi	70%	100%
P36400	Leishmania mexicana	44%	100%
P41715	Choristoneura fumiferana nuclear polyhedrosis virus	33%	100%
P42666	Plasmodium vivax (strain Salvador I)	27%	82%
P43156	Hemerocallis sp.	39%	100%
P43236	Oryctolagus cuniculus	33%	100%
P43295	Arabidopsis thaliana	36%	100%
P43296	Arabidopsis thaliana	39%	100%
P46102	Plasmodium vinckei	29%	95%
P54640	Dictyostelium discoideum	35%	100%
P56202	Homo sapiens	29%	100%
P56203	Mus musculus	31%	100%
Q05094	Leishmania pifanoi	44%	100%
Q10716	Zea mays	38%	100%
Q1EIQ3	Psoroptes ovis	27%	100%
Q23894	Dictyostelium discoideum	34%	100%
Q28944	Sus scrofa	39%	100%
Q4QD68	Leishmania major	69%	100%
Q4QI61	Leishmania major	44%	100%
Q4QI62	Leishmania major	48%	100%
Q4QI64	Leishmania major	48%	100%
Q4QI65	Leishmania major	48%	100%
Q4QI66	Leishmania major	44%	100%
Q4QI67	Leishmania major	48%	100%
Q4QI68	Leishmania major	48%	100%
Q5E998	Bos taurus	38%	100%
Q63088	Rattus norvegicus	34%	100%
Q6VTL7	Choristoneura fumiferana defective polyhedrosis virus	33%	100%
Q7XWK5	Oryza sativa subsp. japonica	39%	100%
Q80LP4	Adoxophyes honmai nucleopolyhedrovirus	33%	100%
Q80UB0	Mus musculus	35%	100%
Q86GF7	Pandalus borealis	36%	100%
Q8HY81	Canis lupus familiaris	36%	100%
Q8HY82	Saimiri boliviensis boliviensis	35%	100%
Q8QLK1	Mamestra configurata nucleopolyhedrovirus	37%	100%
Q8RWQ9	Arabidopsis thaliana	33%	100%
Q8V5U0	Heliothis zea nuclear polyhedrosis virus	37%	100%
Q91BH1	Spodoptera litura multicapsid nucleopolyhedrovirus	38%	100%
Q91CL9	Antheraea pernyi nuclear polyhedrosis virus	33%	100%
Q9BIE1	Leishmania donovani	66%	100%
Q9FGR9	Arabidopsis thaliana	35%	100%
Q9FJ47	Arabidopsis thaliana	36%	100%
Q9GKL8	Chlorocebus aethiops	37%	100%
Q9GL24	Canis lupus familiaris	38%	100%
Q9GQM5	Leishmania donovani	29%	100%
Q9JI81	Mus musculus	30%	100%
Q9JIA9	Mus musculus	33%	100%
Q9JL96	Mus musculus	32%	100%
Q9LT78	Arabidopsis thaliana	37%	100%
Q9PYY5	Xestia c-nigrum granulosis virus	34%	100%
Q9R014	Mus musculus	33%	100%
Q9STL4	Arabidopsis thaliana	36%	100%
Q9SUL1	Arabidopsis thaliana	37%	100%
Q9SUT0	Arabidopsis thaliana	33%	100%
Q9TST1	Felis catus	30%	100%
Q9WGE0	Hyphantria cunea nuclear polyhedrosis virus	33%	100%
V5B261	Trypanosoma cruzi	32%	100%