PAP-associated domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Cid1 family poly A polymerase, putative

Species:

Leishmania braziliensis

UniProt:

A4HA91_LEIBR

TriTrypDb:

LbrM.19.1680 , LBRM2903_190023000

Length:

934

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A4HA91

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HA91

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006396	RNA processing	6	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016070	RNA metabolic process	5	7
GO:0031123	RNA 3'-end processing	7	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0043170	macromolecule metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0046483	heterocycle metabolic process	3	7
GO:0071076	RNA 3' uridylation	8	7
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0005488	binding	1	7
GO:0016740	transferase activity	2	7
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	7
GO:0016779	nucleotidyltransferase activity	4	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0050265	RNA uridylyltransferase activity	4	7
GO:0070569	uridylyltransferase activity	5	7
GO:0140098	catalytic activity, acting on RNA	3	7
GO:0140640	catalytic activity, acting on a nucleic acid	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	330	334	PF00656	0.552
CLV_C14_Caspase3-7	353	357	PF00656	0.492
CLV_NRD_NRD_1	266	268	PF00675	0.344
CLV_NRD_NRD_1	299	301	PF00675	0.286
CLV_NRD_NRD_1	350	352	PF00675	0.345
CLV_NRD_NRD_1	384	386	PF00675	0.297
CLV_NRD_NRD_1	432	434	PF00675	0.521
CLV_NRD_NRD_1	502	504	PF00675	0.414
CLV_NRD_NRD_1	595	597	PF00675	0.543
CLV_NRD_NRD_1	681	683	PF00675	0.674
CLV_NRD_NRD_1	727	729	PF00675	0.643
CLV_NRD_NRD_1	756	758	PF00675	0.713
CLV_NRD_NRD_1	766	768	PF00675	0.640
CLV_PCSK_FUR_1	266	270	PF00082	0.408
CLV_PCSK_FUR_1	303	307	PF00082	0.261
CLV_PCSK_KEX2_1	234	236	PF00082	0.350
CLV_PCSK_KEX2_1	266	268	PF00082	0.344
CLV_PCSK_KEX2_1	305	307	PF00082	0.269
CLV_PCSK_KEX2_1	384	386	PF00082	0.340
CLV_PCSK_KEX2_1	432	434	PF00082	0.521
CLV_PCSK_KEX2_1	597	599	PF00082	0.544
CLV_PCSK_KEX2_1	681	683	PF00082	0.674
CLV_PCSK_KEX2_1	756	758	PF00082	0.699
CLV_PCSK_PC1ET2_1	234	236	PF00082	0.350
CLV_PCSK_PC1ET2_1	268	270	PF00082	0.426
CLV_PCSK_PC1ET2_1	305	307	PF00082	0.269
CLV_PCSK_PC1ET2_1	597	599	PF00082	0.602
CLV_PCSK_SKI1_1	552	556	PF00082	0.537
CLV_PCSK_SKI1_1	871	875	PF00082	0.512
DEG_SPOP_SBC_1	87	91	PF00917	0.486
DOC_CKS1_1	592	597	PF01111	0.428
DOC_CYCLIN_RxL_1	319	333	PF00134	0.570
DOC_CYCLIN_yClb5_NLxxxL_5	848	855	PF00134	0.310
DOC_MAPK_DCC_7	924	934	PF00069	0.442
DOC_MAPK_gen_1	300	310	PF00069	0.472
DOC_MAPK_gen_1	321	329	PF00069	0.563
DOC_MAPK_gen_1	924	934	PF00069	0.442
DOC_MAPK_MEF2A_6	250	258	PF00069	0.569
DOC_MAPK_MEF2A_6	323	331	PF00069	0.543
DOC_MAPK_MEF2A_6	394	402	PF00069	0.430
DOC_MAPK_MEF2A_6	522	530	PF00069	0.316
DOC_MAPK_MEF2A_6	848	855	PF00069	0.310
DOC_MAPK_MEF2A_6	927	934	PF00069	0.446
DOC_MAPK_NFAT4_5	848	856	PF00069	0.312
DOC_MAPK_RevD_3	254	269	PF00069	0.573
DOC_MIT_MIM_1	654	662	PF04212	0.383
DOC_PP1_RVXF_1	23	30	PF00149	0.550
DOC_PP1_RVXF_1	411	417	PF00149	0.469
DOC_PP1_RVXF_1	561	567	PF00149	0.311
DOC_PP2B_LxvP_1	329	332	PF13499	0.559
DOC_PP2B_LxvP_1	723	726	PF13499	0.476
DOC_PP4_FxxP_1	146	149	PF00568	0.524
DOC_PP4_FxxP_1	438	441	PF00568	0.311
DOC_PP4_FxxP_1	592	595	PF00568	0.401
DOC_USP7_MATH_1	126	130	PF00917	0.452
DOC_USP7_MATH_1	211	215	PF00917	0.692
DOC_USP7_MATH_1	281	285	PF00917	0.602
DOC_USP7_MATH_1	505	509	PF00917	0.269
DOC_USP7_MATH_1	71	75	PF00917	0.668
DOC_USP7_MATH_1	88	92	PF00917	0.484
DOC_USP7_MATH_1	923	927	PF00917	0.439
DOC_USP7_UBL2_3	301	305	PF12436	0.476
DOC_USP7_UBL2_3	401	405	PF12436	0.509
DOC_USP7_UBL2_3	871	875	PF12436	0.337
DOC_WW_Pin1_4	357	362	PF00397	0.577
DOC_WW_Pin1_4	552	557	PF00397	0.336
DOC_WW_Pin1_4	583	588	PF00397	0.434
DOC_WW_Pin1_4	591	596	PF00397	0.361
DOC_WW_Pin1_4	684	689	PF00397	0.467
DOC_WW_Pin1_4	831	836	PF00397	0.397
DOC_WW_Pin1_4	900	905	PF00397	0.400
LIG_14-3-3_CanoR_1	323	328	PF00244	0.553
LIG_14-3-3_CanoR_1	378	382	PF00244	0.488
LIG_14-3-3_CanoR_1	571	581	PF00244	0.312
LIG_14-3-3_CanoR_1	681	689	PF00244	0.511
LIG_14-3-3_CanoR_1	812	816	PF00244	0.401
LIG_14-3-3_CanoR_1	912	919	PF00244	0.407
LIG_Actin_WH2_2	41	58	PF00022	0.534
LIG_Actin_WH2_2	418	434	PF00022	0.304
LIG_Actin_WH2_2	600	615	PF00022	0.435
LIG_BRCT_BRCA1_1	364	368	PF00533	0.497
LIG_BRCT_BRCA1_1	913	917	PF00533	0.404
LIG_DLG_GKlike_1	323	331	PF00625	0.501
LIG_eIF4E_1	759	765	PF01652	0.380
LIG_FHA_1	14	20	PF00498	0.557
LIG_FHA_1	196	202	PF00498	0.639
LIG_FHA_1	312	318	PF00498	0.486
LIG_FHA_1	333	339	PF00498	0.498
LIG_FHA_1	473	479	PF00498	0.304
LIG_FHA_1	495	501	PF00498	0.212
LIG_FHA_1	523	529	PF00498	0.279
LIG_FHA_1	701	707	PF00498	0.504
LIG_FHA_1	747	753	PF00498	0.382
LIG_FHA_1	901	907	PF00498	0.355
LIG_FHA_2	174	180	PF00498	0.670
LIG_FHA_2	512	518	PF00498	0.269
LIG_FHA_2	685	691	PF00498	0.454
LIG_FHA_2	832	838	PF00498	0.399
LIG_LIR_Apic_2	143	149	PF02991	0.512
LIG_LIR_Apic_2	150	156	PF02991	0.615
LIG_LIR_Apic_2	435	441	PF02991	0.309
LIG_LIR_Apic_2	684	689	PF02991	0.508
LIG_LIR_Gen_1	141	151	PF02991	0.526
LIG_LIR_Gen_1	284	293	PF02991	0.513
LIG_LIR_Gen_1	423	431	PF02991	0.304
LIG_LIR_Gen_1	532	543	PF02991	0.263
LIG_LIR_Gen_1	586	595	PF02991	0.414
LIG_LIR_Gen_1	672	680	PF02991	0.477
LIG_LIR_Gen_1	697	706	PF02991	0.505
LIG_LIR_Nem_3	135	139	PF02991	0.540
LIG_LIR_Nem_3	141	147	PF02991	0.484
LIG_LIR_Nem_3	284	288	PF02991	0.502
LIG_LIR_Nem_3	423	429	PF02991	0.304
LIG_LIR_Nem_3	455	461	PF02991	0.328
LIG_LIR_Nem_3	532	538	PF02991	0.263
LIG_LIR_Nem_3	586	592	PF02991	0.412
LIG_LIR_Nem_3	697	701	PF02991	0.597
LIG_LIR_Nem_3	867	873	PF02991	0.393
LIG_LIR_Nem_3	97	103	PF02991	0.599
LIG_MYND_1	275	279	PF01753	0.577
LIG_MYND_1	898	902	PF01753	0.447
LIG_NRBOX	109	115	PF00104	0.515
LIG_NRBOX	477	483	PF00104	0.316
LIG_PCNA_yPIPBox_3	101	114	PF02747	0.459
LIG_PDZ_Class_2	929	934	PF00595	0.451
LIG_Pex14_2	364	368	PF04695	0.497
LIG_Pex14_2	399	403	PF04695	0.493
LIG_Rb_pABgroove_1	586	594	PF01858	0.398
LIG_RPA_C_Fungi	601	613	PF08784	0.480
LIG_SH2_CRK	153	157	PF00017	0.608
LIG_SH2_CRK	608	612	PF00017	0.560
LIG_SH2_CRK	870	874	PF00017	0.338
LIG_SH2_NCK_1	153	157	PF00017	0.608
LIG_SH2_NCK_1	506	510	PF00017	0.227
LIG_SH2_NCK_1	686	690	PF00017	0.599
LIG_SH2_PTP2	458	461	PF00017	0.362
LIG_SH2_SRC	153	156	PF00017	0.465
LIG_SH2_STAP1	420	424	PF00017	0.304
LIG_SH2_STAP1	544	548	PF00017	0.304
LIG_SH2_STAP1	608	612	PF00017	0.560
LIG_SH2_STAP1	759	763	PF00017	0.576
LIG_SH2_STAP1	809	813	PF00017	0.499
LIG_SH2_STAT3	184	187	PF00017	0.556
LIG_SH2_STAT3	386	389	PF00017	0.343
LIG_SH2_STAT3	798	801	PF00017	0.593
LIG_SH2_STAT5	309	312	PF00017	0.312
LIG_SH2_STAT5	386	389	PF00017	0.408
LIG_SH2_STAT5	428	431	PF00017	0.304
LIG_SH2_STAT5	458	461	PF00017	0.362
LIG_SH2_STAT5	487	490	PF00017	0.294
LIG_SH2_STAT5	610	613	PF00017	0.565
LIG_SH2_STAT5	648	651	PF00017	0.476
LIG_SH2_STAT5	679	682	PF00017	0.718
LIG_SH2_STAT5	686	689	PF00017	0.726
LIG_SH2_STAT5	884	887	PF00017	0.536
LIG_SH3_1	686	692	PF00018	0.585
LIG_SH3_1	767	773	PF00018	0.506
LIG_SH3_2	445	450	PF14604	0.337
LIG_SH3_3	273	279	PF00018	0.408
LIG_SH3_3	442	448	PF00018	0.409
LIG_SH3_3	457	463	PF00018	0.370
LIG_SH3_3	59	65	PF00018	0.481
LIG_SH3_3	686	692	PF00018	0.602
LIG_SH3_3	767	773	PF00018	0.530
LIG_SH3_3	877	883	PF00018	0.520
LIG_SUMO_SIM_anti_2	252	258	PF11976	0.435
LIG_SUMO_SIM_anti_2	421	426	PF11976	0.227
LIG_SUMO_SIM_anti_2	523	530	PF11976	0.369
LIG_SUMO_SIM_par_1	326	336	PF11976	0.303
LIG_SUMO_SIM_par_1	903	908	PF11976	0.418
LIG_SxIP_EBH_1	259	268	PF03271	0.337
LIG_TRAF2_1	270	273	PF00917	0.580
LIG_TRAF2_1	641	644	PF00917	0.483
LIG_TYR_ITIM	456	461	PF00017	0.367
LIG_UBA3_1	307	312	PF00899	0.300
LIG_UBA3_1	851	857	PF00899	0.433
LIG_WRC_WIRS_1	82	87	PF05994	0.425
MOD_CDK_SPK_2	591	596	PF00069	0.509
MOD_CDK_SPK_2	831	836	PF00069	0.483
MOD_CDK_SPxK_1	552	558	PF00069	0.396
MOD_CDK_SPxK_1	591	597	PF00069	0.519
MOD_CDK_SPxxK_3	591	598	PF00069	0.526
MOD_CK1_1	12	18	PF00069	0.539
MOD_CK1_1	129	135	PF00069	0.354
MOD_CK1_1	189	195	PF00069	0.545
MOD_CK1_1	632	638	PF00069	0.498
MOD_CK1_1	731	737	PF00069	0.505
MOD_CK1_1	915	921	PF00069	0.521
MOD_CK2_1	169	175	PF00069	0.777
MOD_CK2_1	638	644	PF00069	0.494
MOD_CK2_1	684	690	PF00069	0.563
MOD_CK2_1	741	747	PF00069	0.502
MOD_CK2_1	831	837	PF00069	0.486
MOD_Cter_Amidation	179	182	PF01082	0.679
MOD_GlcNHglycan	11	14	PF01048	0.596
MOD_GlcNHglycan	114	117	PF01048	0.323
MOD_GlcNHglycan	188	192	PF01048	0.614
MOD_GlcNHglycan	293	296	PF01048	0.324
MOD_GlcNHglycan	507	510	PF01048	0.308
MOD_GlcNHglycan	640	643	PF01048	0.510
MOD_GlcNHglycan	665	668	PF01048	0.434
MOD_GlcNHglycan	69	72	PF01048	0.433
MOD_GlcNHglycan	914	917	PF01048	0.609
MOD_GSK3_1	169	176	PF00069	0.662
MOD_GSK3_1	311	318	PF00069	0.397
MOD_GSK3_1	323	330	PF00069	0.329
MOD_GSK3_1	416	423	PF00069	0.304
MOD_GSK3_1	494	501	PF00069	0.303
MOD_GSK3_1	507	514	PF00069	0.294
MOD_GSK3_1	520	527	PF00069	0.295
MOD_GSK3_1	67	74	PF00069	0.418
MOD_GSK3_1	742	749	PF00069	0.461
MOD_GSK3_1	859	866	PF00069	0.403
MOD_GSK3_1	896	903	PF00069	0.578
MOD_GSK3_1	9	16	PF00069	0.592
MOD_GSK3_1	911	918	PF00069	0.495
MOD_N-GLC_1	409	414	PF02516	0.408
MOD_N-GLC_1	632	637	PF02516	0.498
MOD_N-GLC_1	638	643	PF02516	0.486
MOD_N-GLC_1	831	836	PF02516	0.515
MOD_N-GLC_1	912	917	PF02516	0.485
MOD_NEK2_1	327	332	PF00069	0.307
MOD_NEK2_1	368	373	PF00069	0.340
MOD_NEK2_1	416	421	PF00069	0.237
MOD_NEK2_1	454	459	PF00069	0.300
MOD_NEK2_1	741	746	PF00069	0.517
MOD_NEK2_1	752	757	PF00069	0.575
MOD_NEK2_1	905	910	PF00069	0.550
MOD_PIKK_1	885	891	PF00454	0.484
MOD_PKA_1	681	687	PF00069	0.500
MOD_PKA_1	728	734	PF00069	0.515
MOD_PKA_2	377	383	PF00069	0.327
MOD_PKA_2	473	479	PF00069	0.275
MOD_PKA_2	612	618	PF00069	0.610
MOD_PKA_2	681	687	PF00069	0.634
MOD_PKA_2	811	817	PF00069	0.518
MOD_PKA_2	911	917	PF00069	0.494
MOD_PKB_1	321	329	PF00069	0.360
MOD_Plk_1	142	148	PF00069	0.413
MOD_Plk_1	158	164	PF00069	0.608
MOD_Plk_1	173	179	PF00069	0.600
MOD_Plk_1	409	415	PF00069	0.406
MOD_Plk_1	454	460	PF00069	0.305
MOD_Plk_1	746	752	PF00069	0.466
MOD_Plk_2-3	169	175	PF00069	0.636
MOD_Plk_2-3	362	368	PF00069	0.343
MOD_Plk_4	126	132	PF00069	0.358
MOD_Plk_4	158	164	PF00069	0.737
MOD_Plk_4	281	287	PF00069	0.446
MOD_Plk_4	377	383	PF00069	0.327
MOD_Plk_4	454	460	PF00069	0.305
MOD_Plk_4	524	530	PF00069	0.369
MOD_Plk_4	788	794	PF00069	0.564
MOD_Plk_4	811	817	PF00069	0.376
MOD_ProDKin_1	357	363	PF00069	0.446
MOD_ProDKin_1	552	558	PF00069	0.396
MOD_ProDKin_1	583	589	PF00069	0.534
MOD_ProDKin_1	591	597	PF00069	0.442
MOD_ProDKin_1	684	690	PF00069	0.584
MOD_ProDKin_1	831	837	PF00069	0.486
MOD_ProDKin_1	900	906	PF00069	0.480
MOD_SUMO_rev_2	226	236	PF00179	0.399
MOD_SUMO_rev_2	632	637	PF00179	0.498
MOD_SUMO_rev_2	705	715	PF00179	0.646
TRG_DiLeu_BaEn_1	252	257	PF01217	0.434
TRG_DiLeu_BaEn_1	760	765	PF01217	0.458
TRG_DiLeu_BaEn_3	760	766	PF01217	0.465
TRG_DiLeu_BaEn_4	545	551	PF01217	0.306
TRG_DiLeu_BaEn_4	824	830	PF01217	0.455
TRG_DiLeu_BaLyEn_6	109	114	PF01217	0.363
TRG_DiLeu_BaLyEn_6	303	308	PF01217	0.294
TRG_DiLeu_BaLyEn_6	901	906	PF01217	0.422
TRG_ENDOCYTIC_2	428	431	PF00928	0.304
TRG_ENDOCYTIC_2	458	461	PF00928	0.362
TRG_ENDOCYTIC_2	535	538	PF00928	0.304
TRG_ENDOCYTIC_2	608	611	PF00928	0.491
TRG_ENDOCYTIC_2	870	873	PF00928	0.458
TRG_ER_diArg_1	258	261	PF00400	0.452
TRG_ER_diArg_1	265	267	PF00400	0.379
TRG_ER_diArg_1	383	385	PF00400	0.405
TRG_ER_diArg_1	431	433	PF00400	0.358
TRG_ER_diArg_1	595	598	PF00400	0.487
TRG_ER_diArg_1	603	606	PF00400	0.491
TRG_ER_diArg_1	680	682	PF00400	0.485
TRG_Pf-PMV_PEXEL_1	836	840	PF00026	0.513

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZT3	Leptomonas seymouri	45%	94%
A0A3Q8IEM2	Leishmania donovani	71%	100%
A4HYH1	Leishmania infantum	71%	100%
E9AS95	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%
Q4QD69	Leishmania major	70%	100%