TATA box-binding protein-like 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TATA-box-binding protein

Species:

Leishmania braziliensis

UniProt:

A4HA89_LEIBR

TriTrypDb:

LbrM.19.1660 , LBRM2903_190022800

Length:

292

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HA89

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HA89

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006352	DNA-templated transcription initiation	6	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009059	macromolecule biosynthetic process	4	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0018130	heterocycle biosynthetic process	4	11
GO:0019438	aromatic compound biosynthetic process	4	11
GO:0032774	RNA biosynthetic process	5	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034654	nucleobase-containing compound biosynthetic process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044271	cellular nitrogen compound biosynthetic process	4	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:1901362	organic cyclic compound biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003677	DNA binding	4	11
GO:0003743	translation initiation factor activity	4	7
GO:0005488	binding	1	11
GO:0008135	translation factor activity, RNA binding	3	7
GO:0045182	translation regulator activity	1	7
GO:0090079	translation regulator activity, nucleic acid binding	2	7
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11
GO:0016251	RNA polymerase II general transcription initiation factor activity	2	1
GO:0140223	general transcription initiation factor activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	242	246	PF00656	0.561
CLV_NRD_NRD_1	172	174	PF00675	0.258
CLV_NRD_NRD_1	288	290	PF00675	0.676
CLV_PCSK_SKI1_1	173	177	PF00082	0.344
CLV_PCSK_SKI1_1	272	276	PF00082	0.325
DEG_Nend_UBRbox_2	1	3	PF02207	0.578
DOC_CYCLIN_RxL_1	170	182	PF00134	0.529
DOC_MAPK_gen_1	170	180	PF00069	0.526
DOC_MAPK_MEF2A_6	173	180	PF00069	0.547
DOC_MAPK_MEF2A_6	209	218	PF00069	0.408
DOC_MAPK_NFAT4_5	173	181	PF00069	0.550
DOC_MAPK_RevD_3	277	290	PF00069	0.561
DOC_PP2B_LxvP_1	73	76	PF13499	0.650
DOC_PP4_FxxP_1	24	27	PF00568	0.707
DOC_SPAK_OSR1_1	193	197	PF12202	0.479
DOC_USP7_MATH_1	100	104	PF00917	0.538
DOC_USP7_MATH_1	156	160	PF00917	0.488
DOC_USP7_MATH_1	64	68	PF00917	0.596
DOC_WW_Pin1_4	195	200	PF00397	0.538
LIG_14-3-3_CterR_2	289	292	PF00244	0.711
LIG_Actin_WH2_2	256	274	PF00022	0.538
LIG_BIR_III_2	90	94	PF00653	0.527
LIG_BRCT_BRCA1_1	181	185	PF00533	0.436
LIG_deltaCOP1_diTrp_1	245	255	PF00928	0.488
LIG_FHA_1	115	121	PF00498	0.456
LIG_FHA_1	130	136	PF00498	0.424
LIG_FHA_1	137	143	PF00498	0.446
LIG_FHA_1	255	261	PF00498	0.492
LIG_FHA_1	37	43	PF00498	0.736
LIG_FHA_2	39	45	PF00498	0.488
LIG_FHA_2	46	52	PF00498	0.457
LIG_FXI_DFP_1	21	25	PF00024	0.688
LIG_Integrin_RGD_1	243	245	PF01839	0.338
LIG_LIR_Apic_2	23	27	PF02991	0.681
LIG_LIR_Gen_1	179	187	PF02991	0.345
LIG_LIR_Gen_1	2	13	PF02991	0.601
LIG_LIR_Nem_3	179	183	PF02991	0.341
LIG_LIR_Nem_3	2	8	PF02991	0.605
LIG_LIR_Nem_3	90	95	PF02991	0.484
LIG_PCNA_yPIPBox_3	229	238	PF02747	0.538
LIG_RPA_C_Fungi	157	169	PF08784	0.423
LIG_SH3_3	193	199	PF00018	0.354
LIG_TRFH_1	208	212	PF08558	0.456
MOD_CDC14_SPxK_1	198	201	PF00782	0.423
MOD_CDK_SPxK_1	195	201	PF00069	0.423
MOD_CK1_1	114	120	PF00069	0.305
MOD_CK2_1	154	160	PF00069	0.330
MOD_CK2_1	264	270	PF00069	0.297
MOD_GlcNHglycan	129	132	PF01048	0.357
MOD_GlcNHglycan	146	149	PF01048	0.205
MOD_GSK3_1	144	151	PF00069	0.382
MOD_GSK3_1	246	253	PF00069	0.344
MOD_N-GLC_2	195	197	PF02516	0.423
MOD_N-GLC_2	231	233	PF02516	0.423
MOD_NEK2_1	144	149	PF00069	0.372
MOD_NEK2_2	129	134	PF00069	0.330
MOD_PK_1	186	192	PF00069	0.330
MOD_Plk_4	148	154	PF00069	0.384
MOD_Plk_4	250	256	PF00069	0.311
MOD_ProDKin_1	195	201	PF00069	0.423
MOD_SUMO_rev_2	287	292	PF00179	0.679
TRG_DiLeu_BaEn_1	9	14	PF01217	0.703
TRG_ENDOCYTIC_2	5	8	PF00928	0.726
TRG_ER_diArg_1	185	188	PF00400	0.311
TRG_Pf-PMV_PEXEL_1	284	288	PF00026	0.575

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSM2	Leptomonas seymouri	83%	100%
A0A0S4IM21	Bodo saltans	46%	100%
A0A1X0P6C1	Trypanosomatidae	50%	100%
A0A3Q8IBD3	Leishmania donovani	91%	100%
A0A3R7KKB8	Trypanosoma rangeli	49%	100%
A4HYG9	Leishmania infantum	91%	100%
A7UFC2	Entamoeba histolytica	24%	100%
C4M7H7	Entamoeba histolytica	28%	100%
D0A0T9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	100%
E9AS93	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
P20227	Drosophila melanogaster	30%	83%
P26354	Acanthamoeba castellanii	31%	100%
P26355	Dictyostelium discoideum	27%	100%
P26356	Triticum aestivum	30%	100%
P26357	Solanum tuberosum	29%	100%
P28147	Arabidopsis thaliana	28%	100%
P28148	Arabidopsis thaliana	28%	100%
P48511	Mesembryanthemum crystallinum	29%	100%
P50158	Zea mays	30%	100%
P50159	Zea mays	29%	100%
P52653	Entamoeba histolytica	28%	100%
P58177	Pyrodictium occultum	25%	100%
P93348	Nicotiana tabacum	30%	100%
Q02879	Triticum aestivum	30%	100%
Q27850	Tetrahymena thermophila	24%	100%
Q42808	Glycine max	29%	100%
Q4QD71	Leishmania major	91%	100%
Q8W0W4	Oryza sativa subsp. japonica	30%	100%
Q9NHP5	Drosophila virilis	27%	84%