Putative cation transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cation transporter, putative

Species:

Leishmania braziliensis

UniProt:

A4HA88_LEIBR

TriTrypDb:

LbrM.19.1650 , LBRM2903_190022700

Length:

615

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

A4HA88

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HA88

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	12
GO:0008324	monoatomic cation transmembrane transporter activity	4	12
GO:0015075	monoatomic ion transmembrane transporter activity	3	12
GO:0022857	transmembrane transporter activity	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	104	106	PF00675	0.298
CLV_NRD_NRD_1	2	4	PF00675	0.413
CLV_NRD_NRD_1	255	257	PF00675	0.321
CLV_NRD_NRD_1	392	394	PF00675	0.659
CLV_NRD_NRD_1	438	440	PF00675	0.621
CLV_NRD_NRD_1	590	592	PF00675	0.567
CLV_PCSK_KEX2_1	106	108	PF00082	0.211
CLV_PCSK_KEX2_1	2	4	PF00082	0.404
CLV_PCSK_KEX2_1	255	257	PF00082	0.268
CLV_PCSK_KEX2_1	392	394	PF00082	0.610
CLV_PCSK_KEX2_1	438	440	PF00082	0.621
CLV_PCSK_PC1ET2_1	106	108	PF00082	0.199
CLV_PCSK_SKI1_1	2	6	PF00082	0.417
CLV_PCSK_SKI1_1	247	251	PF00082	0.267
CLV_PCSK_SKI1_1	264	268	PF00082	0.314
CLV_PCSK_SKI1_1	364	368	PF00082	0.573
CLV_PCSK_SKI1_1	533	537	PF00082	0.558
CLV_PCSK_SKI1_1	555	559	PF00082	0.619
DEG_Nend_UBRbox_1	1	4	PF02207	0.596
DOC_CYCLIN_RxL_1	244	254	PF00134	0.368
DOC_MAPK_gen_1	105	117	PF00069	0.491
DOC_MAPK_gen_1	392	400	PF00069	0.372
DOC_MAPK_HePTP_8	390	402	PF00069	0.411
DOC_MAPK_MEF2A_6	393	402	PF00069	0.406
DOC_PP1_RVXF_1	245	252	PF00149	0.368
DOC_PP1_RVXF_1	391	398	PF00149	0.384
DOC_PP4_FxxP_1	544	547	PF00568	0.455
DOC_USP7_MATH_1	177	181	PF00917	0.209
DOC_USP7_MATH_1	195	199	PF00917	0.562
DOC_USP7_MATH_1	240	244	PF00917	0.368
DOC_USP7_MATH_1	365	369	PF00917	0.553
DOC_USP7_MATH_1	370	374	PF00917	0.571
DOC_USP7_MATH_1	381	385	PF00917	0.403
DOC_USP7_MATH_1	437	441	PF00917	0.363
DOC_USP7_MATH_1	498	502	PF00917	0.458
DOC_USP7_MATH_1	598	602	PF00917	0.525
DOC_USP7_MATH_1	611	615	PF00917	0.551
DOC_USP7_MATH_1	74	78	PF00917	0.310
DOC_WW_Pin1_4	375	380	PF00397	0.597
DOC_WW_Pin1_4	6	11	PF00397	0.567
LIG_14-3-3_CanoR_1	438	442	PF00244	0.460
LIG_14-3-3_CanoR_1	533	539	PF00244	0.435
LIG_14-3-3_CanoR_1	549	553	PF00244	0.434
LIG_14-3-3_CanoR_1	555	560	PF00244	0.367
LIG_BIR_III_4	470	474	PF00653	0.383
LIG_FHA_1	159	165	PF00498	0.311
LIG_FHA_1	252	258	PF00498	0.398
LIG_FHA_1	412	418	PF00498	0.359
LIG_FHA_1	428	434	PF00498	0.352
LIG_FHA_1	446	452	PF00498	0.397
LIG_FHA_1	513	519	PF00498	0.571
LIG_FHA_1	521	527	PF00498	0.490
LIG_FHA_1	543	549	PF00498	0.497
LIG_FHA_1	87	93	PF00498	0.417
LIG_FHA_2	472	478	PF00498	0.565
LIG_LIR_Apic_2	543	547	PF02991	0.413
LIG_LIR_Gen_1	145	155	PF02991	0.300
LIG_LIR_Gen_1	216	223	PF02991	0.496
LIG_LIR_Gen_1	445	452	PF02991	0.362
LIG_LIR_Gen_1	540	548	PF02991	0.454
LIG_LIR_Gen_1	83	93	PF02991	0.240
LIG_LIR_Gen_1	97	103	PF02991	0.290
LIG_LIR_Nem_3	145	151	PF02991	0.327
LIG_LIR_Nem_3	298	303	PF02991	0.196
LIG_LIR_Nem_3	323	327	PF02991	0.329
LIG_LIR_Nem_3	445	450	PF02991	0.359
LIG_LIR_Nem_3	540	544	PF02991	0.364
LIG_LIR_Nem_3	60	66	PF02991	0.313
LIG_LIR_Nem_3	83	88	PF02991	0.249
LIG_LIR_Nem_3	97	101	PF02991	0.275
LIG_NRBOX	150	156	PF00104	0.337
LIG_Pex14_2	397	401	PF04695	0.405
LIG_RPA_C_Fungi	586	598	PF08784	0.442
LIG_SH2_CRK	98	102	PF00017	0.205
LIG_SH2_GRB2like	327	330	PF00017	0.548
LIG_SH2_NCK_1	201	205	PF00017	0.484
LIG_SH2_NCK_1	98	102	PF00017	0.303
LIG_SH2_SRC	223	226	PF00017	0.451
LIG_SH2_SRC	327	330	PF00017	0.548
LIG_SH2_STAP1	409	413	PF00017	0.410
LIG_SH2_STAT3	357	360	PF00017	0.454
LIG_SH2_STAT5	377	380	PF00017	0.501
LIG_SH2_STAT5	456	459	PF00017	0.682
LIG_SUMO_SIM_anti_2	77	83	PF11976	0.289
LIG_SUMO_SIM_par_1	413	420	PF11976	0.462
LIG_SUMO_SIM_par_1	448	454	PF11976	0.581
LIG_TRAF2_1	474	477	PF00917	0.486
LIG_TRAF2_1	537	540	PF00917	0.555
LIG_TRAF2_1	551	554	PF00917	0.311
LIG_TYR_ITIM	96	101	PF00017	0.274
LIG_UBA3_1	4	8	PF00899	0.454
LIG_WRC_WIRS_1	541	546	PF05994	0.511
MOD_CK1_1	180	186	PF00069	0.509
MOD_CK1_1	34	40	PF00069	0.664
MOD_CK1_1	454	460	PF00069	0.566
MOD_CK1_1	484	490	PF00069	0.662
MOD_CK1_1	561	567	PF00069	0.548
MOD_CK1_1	601	607	PF00069	0.742
MOD_CK2_1	365	371	PF00069	0.627
MOD_CK2_1	380	386	PF00069	0.569
MOD_CK2_1	471	477	PF00069	0.730
MOD_CK2_1	534	540	PF00069	0.553
MOD_CK2_1	548	554	PF00069	0.297
MOD_CK2_1	570	576	PF00069	0.576
MOD_GlcNHglycan	121	125	PF01048	0.458
MOD_GlcNHglycan	178	182	PF01048	0.481
MOD_GlcNHglycan	186	189	PF01048	0.726
MOD_GlcNHglycan	278	281	PF01048	0.275
MOD_GlcNHglycan	373	376	PF01048	0.778
MOD_GlcNHglycan	42	45	PF01048	0.487
MOD_GlcNHglycan	421	424	PF01048	0.556
MOD_GlcNHglycan	483	486	PF01048	0.664
MOD_GlcNHglycan	515	518	PF01048	0.598
MOD_GlcNHglycan	72	75	PF01048	0.368
MOD_GSK3_1	146	153	PF00069	0.371
MOD_GSK3_1	154	161	PF00069	0.358
MOD_GSK3_1	177	184	PF00069	0.745
MOD_GSK3_1	19	26	PF00069	0.704
MOD_GSK3_1	195	202	PF00069	0.713
MOD_GSK3_1	27	34	PF00069	0.603
MOD_GSK3_1	371	378	PF00069	0.717
MOD_GSK3_1	427	434	PF00069	0.439
MOD_GSK3_1	456	463	PF00069	0.698
MOD_GSK3_1	498	505	PF00069	0.613
MOD_GSK3_1	555	562	PF00069	0.505
MOD_GSK3_1	70	77	PF00069	0.377
MOD_N-GLC_1	375	380	PF02516	0.496
MOD_N-GLC_1	40	45	PF02516	0.546
MOD_N-GLC_1	454	459	PF02516	0.600
MOD_N-GLC_1	512	517	PF02516	0.491
MOD_NEK2_1	120	125	PF00069	0.377
MOD_NEK2_1	154	159	PF00069	0.390
MOD_NEK2_1	168	173	PF00069	0.325
MOD_NEK2_1	251	256	PF00069	0.276
MOD_NEK2_1	303	308	PF00069	0.288
MOD_NEK2_1	451	456	PF00069	0.615
MOD_NEK2_1	587	592	PF00069	0.584
MOD_NEK2_1	64	69	PF00069	0.338
MOD_NEK2_2	598	603	PF00069	0.458
MOD_PIKK_1	19	25	PF00454	0.626
MOD_PIKK_1	356	362	PF00454	0.538
MOD_PKA_2	437	443	PF00069	0.482
MOD_PKA_2	548	554	PF00069	0.564
MOD_Plk_1	386	392	PF00069	0.595
MOD_Plk_1	460	466	PF00069	0.600
MOD_Plk_1	553	559	PF00069	0.568
MOD_Plk_1	569	575	PF00069	0.501
MOD_Plk_2-3	570	576	PF00069	0.538
MOD_Plk_4	150	156	PF00069	0.444
MOD_Plk_4	240	246	PF00069	0.344
MOD_Plk_4	411	417	PF00069	0.401
MOD_Plk_4	446	452	PF00069	0.499
MOD_ProDKin_1	375	381	PF00069	0.778
MOD_ProDKin_1	6	12	PF00069	0.456
TRG_DiLeu_BaEn_1	150	155	PF01217	0.303
TRG_DiLeu_BaEn_1	428	433	PF01217	0.568
TRG_ENDOCYTIC_2	314	317	PF00928	0.325
TRG_ENDOCYTIC_2	98	101	PF00928	0.274
TRG_ER_diArg_1	1	3	PF00400	0.521
TRG_ER_diArg_1	105	108	PF00400	0.276
TRG_ER_diArg_1	109	112	PF00400	0.270
TRG_ER_diArg_1	255	257	PF00400	0.431
TRG_NLS_MonoExtC_3	104	109	PF00514	0.350
TRG_Pf-PMV_PEXEL_1	439	444	PF00026	0.505

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHD4	Leptomonas seymouri	62%	98%
A0A0S4IWL9	Bodo saltans	34%	100%
A0A1X0P615	Trypanosomatidae	47%	100%
A0A3Q8IBF0	Leishmania donovani	77%	100%
A0A3R7MPI1	Trypanosoma rangeli	43%	100%
A4HYG8	Leishmania infantum	77%	100%
D0A0T8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9AS92	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4QD72	Leishmania major	78%	100%
V5B132	Trypanosoma cruzi	44%	100%