LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HA86_LEIBR
TriTrypDb:
LbrM.19.1630
Length:
120

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 15
NetGPI no yes: 0, no: 15
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HA86
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HA86

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 4 6 PF00675 0.513
CLV_PCSK_KEX2_1 4 6 PF00082 0.513
CLV_PCSK_SKI1_1 4 8 PF00082 0.512
DEG_Nend_Nbox_1 1 3 PF02207 0.535
DOC_MAPK_MEF2A_6 95 102 PF00069 0.429
DOC_SPAK_OSR1_1 95 99 PF12202 0.394
DOC_USP7_MATH_1 103 107 PF00917 0.677
DOC_USP7_MATH_1 37 41 PF00917 0.529
DOC_USP7_MATH_1 62 66 PF00917 0.632
LIG_14-3-3_CanoR_1 5 11 PF00244 0.485
LIG_FHA_1 44 50 PF00498 0.591
LIG_FHA_1 68 74 PF00498 0.578
LIG_LIR_Gen_1 106 114 PF02991 0.559
LIG_LIR_Nem_3 106 110 PF02991 0.511
LIG_LIR_Nem_3 34 38 PF02991 0.394
LIG_PCNA_yPIPBox_3 95 108 PF02747 0.387
LIG_SH3_3 97 103 PF00018 0.482
LIG_WRC_WIRS_1 104 109 PF05994 0.458
LIG_WRC_WIRS_1 32 37 PF05994 0.368
MOD_CK1_1 40 46 PF00069 0.566
MOD_CK1_1 82 88 PF00069 0.481
MOD_CK2_1 103 109 PF00069 0.458
MOD_Cter_Amidation 2 5 PF01082 0.521
MOD_GlcNHglycan 64 67 PF01048 0.584
MOD_GlcNHglycan 79 82 PF01048 0.569
MOD_GlcNHglycan 8 11 PF01048 0.409
MOD_GSK3_1 38 45 PF00069 0.602
MOD_GSK3_1 48 55 PF00069 0.538
MOD_GSK3_1 62 69 PF00069 0.613
MOD_NEK2_1 38 43 PF00069 0.594
MOD_NEK2_1 79 84 PF00069 0.627
MOD_PIKK_1 48 54 PF00454 0.581
MOD_PKA_2 43 49 PF00069 0.476
MOD_PKA_2 94 100 PF00069 0.416
MOD_Plk_4 103 109 PF00069 0.693
MOD_Plk_4 79 85 PF00069 0.500
MOD_SUMO_rev_2 109 119 PF00179 0.396
TRG_ER_diArg_1 4 6 PF00400 0.513

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P3I1 Leptomonas seymouri 58% 100%
A0A1X0P697 Trypanosomatidae 41% 96%
A0A3Q8IE17 Leishmania donovani 35% 100%
A0A3S7WVJ6 Leishmania donovani 74% 73%
A4HA99 Leishmania braziliensis 38% 100%
A4HF75 Leishmania braziliensis 36% 100%
A4HYG5 Leishmania infantum 74% 73%
A4I2F8 Leishmania infantum 35% 100%
D0A0T3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 38% 100%
E9AS90 Leishmania mexicana (strain MHOM/GT/2001/U1103) 71% 97%
E9AYL1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 100%
Q4Q8W1 Leishmania major 34% 100%
Q4QD74 Leishmania major 74% 100%
V5D1C6 Trypanosoma cruzi 41% 88%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS