LeishMANIAdb
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Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Transmembrane protein
Gene product:
hypothetical protein, unknown function
Species:
Leishmania braziliensis
UniProt:
A4HA85_LEIBR
TriTrypDb:
LbrM.19.1620 , LBRM2903_190022500
Length:
88

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 4
NetGPI no yes: 0, no: 5
Cellular components
Term Name Level Count
GO:0016020 membrane 2 5
GO:0110165 cellular anatomical entity 1 5

Expansion

Sequence features

A4HA85
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HA85

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_SKI1_1 54 58 PF00082 0.417
DEG_APCC_DBOX_1 3 11 PF00400 0.509
DOC_MAPK_DCC_7 54 64 PF00069 0.217
DOC_MAPK_MEF2A_6 48 57 PF00069 0.417
LIG_14-3-3_CterR_2 85 88 PF00244 0.558
LIG_LIR_Nem_3 16 22 PF02991 0.283
LIG_Pex14_2 60 64 PF04695 0.335
LIG_SH2_PTP2 76 79 PF00017 0.299
LIG_SH2_STAT5 76 79 PF00017 0.299
LIG_TRAF2_1 39 42 PF00917 0.457
MOD_NEK2_1 13 18 PF00069 0.377
TRG_ENDOCYTIC_2 76 79 PF00928 0.299
TRG_ER_diArg_1 4 7 PF00400 0.513

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PBK3 Leptomonas seymouri 39% 90%
A0A3S5H771 Leishmania donovani 65% 100%
A4HYG6 Leishmania infantum 65% 100%
Q4QD75 Leishmania major 62% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS