LeishMANIAdb
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Phosphatidic acid phosphatase protein-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Phosphatidic acid phosphatase protein-like protein
Gene product:
phosphatidic acid phosphatase protein-like protein
Species:
Leishmania braziliensis
UniProt:
A4HA84_LEIBR
TriTrypDb:
LbrM.19.1610 , LBRM2903_190022300 * , LBRM2903_190022400 *
Length:
400

Annotations

LeishMANIAdb annotations

Distinctively related to eukaryotic PLPP enzymes.. This family of protens expanded considerably in Kinetoplastids (might be due to metabolic dependence on host lipids)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 22
NetGPI no yes: 0, no: 22
Cellular components
Term Name Level Count
GO:0016020 membrane 2 23
GO:0110165 cellular anatomical entity 1 23

Expansion

Sequence features

A4HA84
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HA84

Function

Biological processes
Term Name Level Count
GO:0006629 lipid metabolic process 3 23
GO:0006644 phospholipid metabolic process 4 23
GO:0006793 phosphorus metabolic process 3 23
GO:0006796 phosphate-containing compound metabolic process 4 23
GO:0008152 metabolic process 1 23
GO:0009987 cellular process 1 23
GO:0019637 organophosphate metabolic process 3 23
GO:0044237 cellular metabolic process 2 23
GO:0044238 primary metabolic process 2 23
GO:0044255 cellular lipid metabolic process 3 23
GO:0071704 organic substance metabolic process 2 23
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 3
GO:0008195 phosphatidate phosphatase activity 6 3
GO:0016787 hydrolase activity 2 3
GO:0016788 hydrolase activity, acting on ester bonds 3 3
GO:0016791 phosphatase activity 5 3
GO:0042578 phosphoric ester hydrolase activity 4 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 116 120 PF00656 0.630
CLV_C14_Caspase3-7 326 330 PF00656 0.313
CLV_C14_Caspase3-7 46 50 PF00656 0.360
CLV_NRD_NRD_1 358 360 PF00675 0.735
CLV_NRD_NRD_1 6 8 PF00675 0.249
CLV_PCSK_KEX2_1 352 354 PF00082 0.772
CLV_PCSK_KEX2_1 358 360 PF00082 0.788
CLV_PCSK_KEX2_1 5 7 PF00082 0.451
CLV_PCSK_PC1ET2_1 352 354 PF00082 0.685
CLV_PCSK_SKI1_1 248 252 PF00082 0.222
DEG_APCC_DBOX_1 143 151 PF00400 0.540
DEG_APCC_DBOX_1 247 255 PF00400 0.341
DOC_MAPK_DCC_7 248 258 PF00069 0.308
DOC_MAPK_gen_1 206 214 PF00069 0.464
DOC_PP1_RVXF_1 209 215 PF00149 0.452
DOC_PP4_FxxP_1 375 378 PF00568 0.339
DOC_PP4_FxxP_1 92 95 PF00568 0.670
DOC_USP7_MATH_1 343 347 PF00917 0.483
DOC_USP7_MATH_1 366 370 PF00917 0.347
DOC_USP7_MATH_1 53 57 PF00917 0.400
DOC_WW_Pin1_4 120 125 PF00397 0.610
LIG_14-3-3_CanoR_1 211 215 PF00244 0.438
LIG_14-3-3_CanoR_1 242 247 PF00244 0.256
LIG_14-3-3_CanoR_1 248 254 PF00244 0.269
LIG_14-3-3_CanoR_1 309 316 PF00244 0.402
LIG_14-3-3_CanoR_1 358 363 PF00244 0.575
LIG_14-3-3_CanoR_1 367 375 PF00244 0.436
LIG_14-3-3_CanoR_1 43 48 PF00244 0.265
LIG_BRCT_BRCA1_1 219 223 PF00533 0.317
LIG_BRCT_BRCA1_1 229 233 PF00533 0.317
LIG_deltaCOP1_diTrp_1 20 28 PF00928 0.152
LIG_DLG_GKlike_1 242 249 PF00625 0.301
LIG_FHA_1 155 161 PF00498 0.509
LIG_FHA_1 245 251 PF00498 0.407
LIG_FHA_1 259 265 PF00498 0.390
LIG_FHA_1 277 283 PF00498 0.279
LIG_FHA_1 335 341 PF00498 0.546
LIG_FHA_2 114 120 PF00498 0.657
LIG_FHA_2 190 196 PF00498 0.524
LIG_IRF3_LxIS_1 250 257 PF10401 0.327
LIG_LIR_Apic_2 374 378 PF02991 0.339
LIG_LIR_Gen_1 195 205 PF02991 0.471
LIG_LIR_Gen_1 20 29 PF02991 0.371
LIG_LIR_Gen_1 220 231 PF02991 0.176
LIG_LIR_Gen_1 245 254 PF02991 0.374
LIG_LIR_Gen_1 286 296 PF02991 0.410
LIG_LIR_Gen_1 313 321 PF02991 0.457
LIG_LIR_Nem_3 195 200 PF02991 0.471
LIG_LIR_Nem_3 20 24 PF02991 0.359
LIG_LIR_Nem_3 220 226 PF02991 0.283
LIG_LIR_Nem_3 245 249 PF02991 0.325
LIG_LIR_Nem_3 286 292 PF02991 0.376
LIG_LIR_Nem_3 295 299 PF02991 0.377
LIG_LIR_Nem_3 313 319 PF02991 0.395
LIG_LIR_Nem_3 58 64 PF02991 0.317
LIG_LIR_Nem_3 8 12 PF02991 0.509
LIG_LYPXL_S_1 139 143 PF13949 0.383
LIG_LYPXL_yS_3 140 143 PF13949 0.581
LIG_MLH1_MIPbox_1 229 233 PF16413 0.198
LIG_PCNA_yPIPBox_3 153 166 PF02747 0.385
LIG_PDZ_Wminus1_1 398 400 PF00595 0.550
LIG_Pex14_2 292 296 PF04695 0.341
LIG_Pex14_2 76 80 PF04695 0.384
LIG_Pex14_2 9 13 PF04695 0.606
LIG_PTB_Apo_2 190 197 PF02174 0.561
LIG_PTB_Phospho_1 190 196 PF10480 0.561
LIG_SH2_CRK 197 201 PF00017 0.486
LIG_SH2_CRK 316 320 PF00017 0.430
LIG_SH2_STAP1 180 184 PF00017 0.540
LIG_SH2_STAP1 64 68 PF00017 0.393
LIG_SH2_STAT5 11 14 PF00017 0.497
LIG_SH2_STAT5 115 118 PF00017 0.654
LIG_SH2_STAT5 171 174 PF00017 0.480
LIG_SH2_STAT5 180 183 PF00017 0.470
LIG_SH2_STAT5 197 200 PF00017 0.477
LIG_SH2_STAT5 293 296 PF00017 0.364
LIG_SH2_STAT5 306 309 PF00017 0.416
LIG_SH2_STAT5 77 80 PF00017 0.311
LIG_SH2_STAT5 83 86 PF00017 0.535
LIG_SH3_3 118 124 PF00018 0.526
LIG_SUMO_SIM_anti_2 65 70 PF11976 0.333
LIG_TYR_ITIM 138 143 PF00017 0.612
LIG_TYR_ITIM 314 319 PF00017 0.456
LIG_WRC_WIRS_1 289 294 PF05994 0.394
LIG_WRC_WIRS_1 372 377 PF05994 0.430
MOD_CDK_SPK_2 120 125 PF00069 0.691
MOD_CK1_1 120 126 PF00069 0.604
MOD_CK1_1 213 219 PF00069 0.442
MOD_CK2_1 189 195 PF00069 0.480
MOD_CK2_1 309 315 PF00069 0.348
MOD_CK2_1 348 354 PF00069 0.371
MOD_GlcNHglycan 135 138 PF01048 0.251
MOD_GlcNHglycan 215 218 PF01048 0.242
MOD_GlcNHglycan 286 289 PF01048 0.348
MOD_GlcNHglycan 29 32 PF01048 0.152
MOD_GlcNHglycan 343 346 PF01048 0.725
MOD_GlcNHglycan 360 363 PF01048 0.761
MOD_GlcNHglycan 375 378 PF01048 0.749
MOD_GSK3_1 113 120 PF00069 0.689
MOD_GSK3_1 213 220 PF00069 0.456
MOD_GSK3_1 254 261 PF00069 0.345
MOD_GSK3_1 27 34 PF00069 0.380
MOD_GSK3_1 272 279 PF00069 0.480
MOD_GSK3_1 284 291 PF00069 0.376
MOD_GSK3_1 324 331 PF00069 0.475
MOD_GSK3_1 343 350 PF00069 0.524
MOD_GSK3_1 354 361 PF00069 0.508
MOD_GSK3_1 53 60 PF00069 0.378
MOD_LATS_1 41 47 PF00433 0.325
MOD_NEK2_1 154 159 PF00069 0.403
MOD_NEK2_1 200 205 PF00069 0.424
MOD_NEK2_1 249 254 PF00069 0.247
MOD_NEK2_1 27 32 PF00069 0.292
MOD_NEK2_1 292 297 PF00069 0.354
MOD_NEK2_1 335 340 PF00069 0.434
MOD_NEK2_2 288 293 PF00069 0.385
MOD_PKA_1 358 364 PF00069 0.571
MOD_PKA_2 210 216 PF00069 0.439
MOD_PKA_2 358 364 PF00069 0.489
MOD_PKA_2 366 372 PF00069 0.561
MOD_PKA_2 380 386 PF00069 0.557
MOD_Plk_1 335 341 PF00069 0.387
MOD_Plk_1 48 54 PF00069 0.302
MOD_Plk_1 57 63 PF00069 0.374
MOD_Plk_4 227 233 PF00069 0.268
MOD_Plk_4 249 255 PF00069 0.315
MOD_Plk_4 278 284 PF00069 0.304
MOD_Plk_4 288 294 PF00069 0.318
MOD_ProDKin_1 120 126 PF00069 0.611
MOD_SUMO_rev_2 315 325 PF00179 0.422
TRG_DiLeu_BaLyEn_6 245 250 PF01217 0.345
TRG_ENDOCYTIC_2 115 118 PF00928 0.714
TRG_ENDOCYTIC_2 140 143 PF00928 0.533
TRG_ENDOCYTIC_2 16 19 PF00928 0.328
TRG_ENDOCYTIC_2 197 200 PF00928 0.490
TRG_ENDOCYTIC_2 293 296 PF00928 0.334
TRG_ENDOCYTIC_2 316 319 PF00928 0.457
TRG_ENDOCYTIC_2 77 80 PF00928 0.275
TRG_ER_diArg_1 127 130 PF00400 0.671
TRG_ER_diArg_1 166 169 PF00400 0.447
TRG_ER_diArg_1 4 7 PF00400 0.453
TRG_Pf-PMV_PEXEL_1 388 392 PF00026 0.741

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P344 Leptomonas seymouri 60% 100%
A0A0N1I1J3 Leptomonas seymouri 29% 100%
A0A0S4JH63 Bodo saltans 31% 100%
A0A1X0P677 Trypanosomatidae 37% 100%
A0A1X0P6S8 Trypanosomatidae 33% 100%
A0A1X0P729 Trypanosomatidae 33% 100%
A0A3Q8ID01 Leishmania donovani 29% 100%
A0A3Q8IK66 Leishmania donovani 71% 100%
A0A3S5IRX0 Trypanosoma rangeli 40% 100%
A0A422MQK2 Trypanosoma rangeli 37% 100%
A4H9I2 Leishmania braziliensis 31% 99%
A4HXR8 Leishmania infantum 29% 100%
A4HYG7 Leishmania infantum 71% 100%
C9ZUG5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 35% 100%
C9ZZW0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 100%
D0A051 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 100%
E9AS87 Leishmania mexicana (strain MHOM/GT/2001/U1103) 71% 100%
E9AS88 Leishmania mexicana (strain MHOM/GT/2001/U1103) 72% 100%
O08564 Rattus norvegicus 26% 100%
O14494 Homo sapiens 27% 100%
O88956 Cavia porcellus 29% 100%
P60588 Sus scrofa 26% 100%
Q4QD76 Leishmania major 70% 100%
Q61469 Mus musculus 29% 100%
Q86AF0 Dictyostelium discoideum 24% 100%
Q9UUA6 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 25% 100%
Q9ZU49 Arabidopsis thaliana 26% 100%
V5B5J9 Trypanosoma cruzi 40% 100%
V5BM01 Trypanosoma cruzi 33% 100%
V5BWA7 Trypanosoma cruzi 31% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS