Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HA78_LEIBR

TriTrypDb:

LbrM.19.1540 , LBRM2903_190021100

Length:

952

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HA78

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HA78

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	220	224	PF00656	0.667
CLV_C14_Caspase3-7	230	234	PF00656	0.621
CLV_C14_Caspase3-7	360	364	PF00656	0.558
CLV_C14_Caspase3-7	568	572	PF00656	0.622
CLV_NRD_NRD_1	127	129	PF00675	0.658
CLV_NRD_NRD_1	146	148	PF00675	0.661
CLV_NRD_NRD_1	273	275	PF00675	0.672
CLV_NRD_NRD_1	349	351	PF00675	0.817
CLV_NRD_NRD_1	374	376	PF00675	0.573
CLV_NRD_NRD_1	403	405	PF00675	0.830
CLV_NRD_NRD_1	560	562	PF00675	0.791
CLV_NRD_NRD_1	585	587	PF00675	0.564
CLV_NRD_NRD_1	758	760	PF00675	0.465
CLV_NRD_NRD_1	798	800	PF00675	0.503
CLV_NRD_NRD_1	844	846	PF00675	0.754
CLV_PCSK_FUR_1	374	378	PF00082	0.575
CLV_PCSK_FUR_1	796	800	PF00082	0.486
CLV_PCSK_KEX2_1	127	129	PF00082	0.591
CLV_PCSK_KEX2_1	273	275	PF00082	0.672
CLV_PCSK_KEX2_1	349	351	PF00082	0.817
CLV_PCSK_KEX2_1	374	376	PF00082	0.573
CLV_PCSK_KEX2_1	403	405	PF00082	0.830
CLV_PCSK_KEX2_1	560	562	PF00082	0.791
CLV_PCSK_KEX2_1	584	586	PF00082	0.565
CLV_PCSK_KEX2_1	798	800	PF00082	0.503
CLV_PCSK_KEX2_1	844	846	PF00082	0.754
CLV_PCSK_PC1ET2_1	376	378	PF00082	0.572
CLV_PCSK_SKI1_1	350	354	PF00082	0.820
CLV_PCSK_SKI1_1	560	564	PF00082	0.788
CLV_PCSK_SKI1_1	731	735	PF00082	0.611
CLV_PCSK_SKI1_1	748	752	PF00082	0.679
DEG_Nend_UBRbox_2	1	3	PF02207	0.817
DEG_SCF_FBW7_1	55	62	PF00400	0.603
DEG_SPOP_SBC_1	911	915	PF00917	0.686
DOC_CKS1_1	342	347	PF01111	0.582
DOC_CKS1_1	497	502	PF01111	0.564
DOC_CKS1_1	889	894	PF01111	0.594
DOC_CYCLIN_RxL_1	557	567	PF00134	0.783
DOC_CYCLIN_RxL_1	745	754	PF00134	0.749
DOC_CYCLIN_yCln2_LP_2	894	900	PF00134	0.811
DOC_MAPK_MEF2A_6	847	856	PF00069	0.541
DOC_PP1_RVXF_1	575	581	PF00149	0.574
DOC_PP1_RVXF_1	930	937	PF00149	0.718
DOC_PP2B_LxvP_1	212	215	PF13499	0.559
DOC_PP2B_LxvP_1	484	487	PF13499	0.567
DOC_PP2B_LxvP_1	707	710	PF13499	0.723
DOC_USP7_MATH_1	146	150	PF00917	0.680
DOC_USP7_MATH_1	161	165	PF00917	0.576
DOC_USP7_MATH_1	213	217	PF00917	0.639
DOC_USP7_MATH_1	283	287	PF00917	0.535
DOC_USP7_MATH_1	322	326	PF00917	0.590
DOC_USP7_MATH_1	366	370	PF00917	0.652
DOC_USP7_MATH_1	419	423	PF00917	0.680
DOC_USP7_MATH_1	42	46	PF00917	0.832
DOC_USP7_MATH_1	517	521	PF00917	0.672
DOC_USP7_MATH_1	538	542	PF00917	0.798
DOC_USP7_MATH_1	591	595	PF00917	0.588
DOC_USP7_MATH_1	600	604	PF00917	0.553
DOC_USP7_MATH_1	612	616	PF00917	0.539
DOC_USP7_MATH_1	698	702	PF00917	0.625
DOC_USP7_MATH_1	71	75	PF00917	0.570
DOC_USP7_MATH_1	710	714	PF00917	0.664
DOC_USP7_MATH_1	723	727	PF00917	0.596
DOC_USP7_MATH_1	763	767	PF00917	0.686
DOC_USP7_MATH_1	911	915	PF00917	0.763
DOC_USP7_MATH_1	928	932	PF00917	0.743
DOC_USP7_MATH_1	943	947	PF00917	0.500
DOC_USP7_MATH_2	875	881	PF00917	0.565
DOC_USP7_UBL2_3	138	142	PF12436	0.583
DOC_WW_Pin1_4	147	152	PF00397	0.768
DOC_WW_Pin1_4	159	164	PF00397	0.573
DOC_WW_Pin1_4	221	226	PF00397	0.800
DOC_WW_Pin1_4	254	259	PF00397	0.670
DOC_WW_Pin1_4	341	346	PF00397	0.714
DOC_WW_Pin1_4	362	367	PF00397	0.731
DOC_WW_Pin1_4	375	380	PF00397	0.655
DOC_WW_Pin1_4	412	417	PF00397	0.637
DOC_WW_Pin1_4	427	432	PF00397	0.727
DOC_WW_Pin1_4	496	501	PF00397	0.603
DOC_WW_Pin1_4	51	56	PF00397	0.832
DOC_WW_Pin1_4	65	70	PF00397	0.692
DOC_WW_Pin1_4	708	713	PF00397	0.587
DOC_WW_Pin1_4	739	744	PF00397	0.565
DOC_WW_Pin1_4	80	85	PF00397	0.745
DOC_WW_Pin1_4	822	827	PF00397	0.581
DOC_WW_Pin1_4	882	887	PF00397	0.792
DOC_WW_Pin1_4	888	893	PF00397	0.695
DOC_WW_Pin1_4	89	94	PF00397	0.692
DOC_WW_Pin1_4	900	905	PF00397	0.504
DOC_WW_Pin1_4	912	917	PF00397	0.765
DOC_WW_Pin1_4	922	927	PF00397	0.519
DOC_WW_Pin1_4	947	952	PF00397	0.757
LIG_14-3-3_CanoR_1	13	22	PF00244	0.539
LIG_14-3-3_CanoR_1	147	151	PF00244	0.718
LIG_14-3-3_CanoR_1	190	196	PF00244	0.763
LIG_14-3-3_CanoR_1	334	342	PF00244	0.640
LIG_14-3-3_CanoR_1	349	353	PF00244	0.599
LIG_14-3-3_CanoR_1	628	634	PF00244	0.793
LIG_14-3-3_CanoR_1	691	695	PF00244	0.598
LIG_14-3-3_CanoR_1	912	916	PF00244	0.610
LIG_BIR_III_2	551	555	PF00653	0.540
LIG_CSL_BTD_1	158	161	PF09270	0.535
LIG_deltaCOP1_diTrp_1	287	295	PF00928	0.572
LIG_eIF4E_1	256	262	PF01652	0.713
LIG_eIF4E_1	900	906	PF01652	0.562
LIG_FHA_1	177	183	PF00498	0.683
LIG_FHA_1	394	400	PF00498	0.816
LIG_FHA_1	739	745	PF00498	0.562
LIG_FHA_1	869	875	PF00498	0.557
LIG_FHA_1	889	895	PF00498	0.594
LIG_FHA_2	255	261	PF00498	0.715
LIG_FHA_2	342	348	PF00498	0.580
LIG_FHA_2	358	364	PF00498	0.506
LIG_FHA_2	628	634	PF00498	0.706
LIG_FHA_2	648	654	PF00498	0.565
LIG_FHA_2	813	819	PF00498	0.616
LIG_FHA_2	937	943	PF00498	0.702
LIG_LIR_Gen_1	24	33	PF02991	0.651
LIG_LIR_Gen_1	446	453	PF02991	0.542
LIG_LIR_Gen_1	942	952	PF02991	0.735
LIG_LIR_LC3C_4	259	263	PF02991	0.687
LIG_LIR_Nem_3	24	29	PF02991	0.688
LIG_LIR_Nem_3	446	451	PF02991	0.765
LIG_LIR_Nem_3	556	562	PF02991	0.777
LIG_LIR_Nem_3	942	947	PF02991	0.718
LIG_LYPXL_yS_3	435	438	PF13949	0.560
LIG_MYND_1	715	719	PF01753	0.593
LIG_PDZ_Class_1	947	952	PF00595	0.751
LIG_Pex14_1	291	295	PF04695	0.539
LIG_RPA_C_Fungi	580	592	PF08784	0.573
LIG_SH2_CRK	559	563	PF00017	0.788
LIG_SH2_SRC	492	495	PF00017	0.578
LIG_SH2_STAP1	22	26	PF00017	0.731
LIG_SH2_STAP1	769	773	PF00017	0.742
LIG_SH2_STAP1	944	948	PF00017	0.730
LIG_SH2_STAT3	96	99	PF00017	0.605
LIG_SH2_STAT5	256	259	PF00017	0.707
LIG_SH2_STAT5	372	375	PF00017	0.573
LIG_SH2_STAT5	893	896	PF00017	0.593
LIG_SH2_STAT5	900	903	PF00017	0.539
LIG_SH3_3	129	135	PF00018	0.616
LIG_SH3_3	155	161	PF00018	0.641
LIG_SH3_3	219	225	PF00018	0.797
LIG_SH3_3	339	345	PF00018	0.587
LIG_SH3_3	439	445	PF00018	0.569
LIG_SH3_3	480	486	PF00018	0.638
LIG_SH3_3	54	60	PF00018	0.831
LIG_SH3_3	596	602	PF00018	0.572
LIG_SH3_3	63	69	PF00018	0.688
LIG_SH3_3	709	715	PF00018	0.651
LIG_SH3_3	898	904	PF00018	0.672
LIG_SUMO_SIM_par_1	649	656	PF11976	0.757
LIG_TRAF2_1	453	456	PF00917	0.549
LIG_TRAF2_1	907	910	PF00917	0.571
LIG_TRAF2_1	916	919	PF00917	0.548
LIG_TRFH_1	893	897	PF08558	0.591
LIG_WW_1	93	96	PF00397	0.590
MOD_CDC14_SPxK_1	224	227	PF00782	0.573
MOD_CDK_SPxK_1	221	227	PF00069	0.575
MOD_CDK_SPxxK_3	377	384	PF00069	0.586
MOD_CDK_SPxxK_3	427	434	PF00069	0.764
MOD_CK1_1	232	238	PF00069	0.601
MOD_CK1_1	249	255	PF00069	0.526
MOD_CK1_1	286	292	PF00069	0.695
MOD_CK1_1	351	357	PF00069	0.682
MOD_CK1_1	370	376	PF00069	0.658
MOD_CK1_1	412	418	PF00069	0.806
MOD_CK1_1	422	428	PF00069	0.636
MOD_CK1_1	463	469	PF00069	0.580
MOD_CK1_1	496	502	PF00069	0.564
MOD_CK1_1	520	526	PF00069	0.556
MOD_CK1_1	541	547	PF00069	0.798
MOD_CK1_1	619	625	PF00069	0.718
MOD_CK1_1	656	662	PF00069	0.740
MOD_CK1_1	713	719	PF00069	0.702
MOD_CK1_1	812	818	PF00069	0.793
MOD_CK1_1	859	865	PF00069	0.761
MOD_CK1_1	885	891	PF00069	0.559
MOD_CK2_1	170	176	PF00069	0.641
MOD_CK2_1	286	292	PF00069	0.762
MOD_CK2_1	543	549	PF00069	0.710
MOD_CK2_1	601	607	PF00069	0.804
MOD_CK2_1	619	625	PF00069	0.515
MOD_CK2_1	647	653	PF00069	0.630
MOD_CK2_1	656	662	PF00069	0.549
MOD_CK2_1	677	683	PF00069	0.809
MOD_CK2_1	812	818	PF00069	0.618
MOD_CK2_1	904	910	PF00069	0.677
MOD_CK2_1	912	918	PF00069	0.748
MOD_Cter_Amidation	401	404	PF01082	0.831
MOD_DYRK1A_RPxSP_1	912	916	PF00069	0.688
MOD_GlcNHglycan	131	135	PF01048	0.745
MOD_GlcNHglycan	144	147	PF01048	0.596
MOD_GlcNHglycan	16	19	PF01048	0.715
MOD_GlcNHglycan	215	218	PF01048	0.772
MOD_GlcNHglycan	229	232	PF01048	0.560
MOD_GlcNHglycan	235	238	PF01048	0.577
MOD_GlcNHglycan	251	254	PF01048	0.517
MOD_GlcNHglycan	287	291	PF01048	0.675
MOD_GlcNHglycan	338	341	PF01048	0.828
MOD_GlcNHglycan	369	372	PF01048	0.578
MOD_GlcNHglycan	390	393	PF01048	0.793
MOD_GlcNHglycan	400	403	PF01048	0.699
MOD_GlcNHglycan	462	465	PF01048	0.618
MOD_GlcNHglycan	480	483	PF01048	0.524
MOD_GlcNHglycan	587	591	PF01048	0.623
MOD_GlcNHglycan	61	64	PF01048	0.657
MOD_GlcNHglycan	619	622	PF01048	0.607
MOD_GlcNHglycan	700	703	PF01048	0.625
MOD_GlcNHglycan	73	76	PF01048	0.579
MOD_GlcNHglycan	736	739	PF01048	0.582
MOD_GlcNHglycan	832	835	PF01048	0.521
MOD_GlcNHglycan	858	861	PF01048	0.771
MOD_GlcNHglycan	879	882	PF01048	0.712
MOD_GlcNHglycan	926	929	PF01048	0.778
MOD_GSK3_1	137	144	PF00069	0.752
MOD_GSK3_1	176	183	PF00069	0.628
MOD_GSK3_1	229	236	PF00069	0.561
MOD_GSK3_1	293	300	PF00069	0.779
MOD_GSK3_1	348	355	PF00069	0.713
MOD_GSK3_1	357	364	PF00069	0.558
MOD_GSK3_1	366	373	PF00069	0.595
MOD_GSK3_1	375	382	PF00069	0.582
MOD_GSK3_1	384	391	PF00069	0.632
MOD_GSK3_1	393	400	PF00069	0.648
MOD_GSK3_1	474	481	PF00069	0.597
MOD_GSK3_1	51	58	PF00069	0.734
MOD_GSK3_1	513	520	PF00069	0.647
MOD_GSK3_1	538	545	PF00069	0.707
MOD_GSK3_1	612	619	PF00069	0.670
MOD_GSK3_1	652	659	PF00069	0.804
MOD_GSK3_1	677	684	PF00069	0.612
MOD_GSK3_1	690	697	PF00069	0.617
MOD_GSK3_1	713	720	PF00069	0.705
MOD_GSK3_1	734	741	PF00069	0.583
MOD_GSK3_1	806	813	PF00069	0.788
MOD_GSK3_1	822	829	PF00069	0.535
MOD_GSK3_1	877	884	PF00069	0.709
MOD_GSK3_1	900	907	PF00069	0.612
MOD_GSK3_1	920	927	PF00069	0.797
MOD_GSK3_1	943	950	PF00069	0.733
MOD_LATS_1	386	392	PF00433	0.590
MOD_LATS_1	524	530	PF00433	0.549
MOD_N-GLC_1	233	238	PF02516	0.585
MOD_N-GLC_1	298	303	PF02516	0.611
MOD_N-GLC_1	334	339	PF02516	0.789
MOD_N-GLC_1	636	641	PF02516	0.707
MOD_NEK2_1	104	109	PF00069	0.824
MOD_NEK2_1	367	372	PF00069	0.577
MOD_NEK2_1	424	429	PF00069	0.558
MOD_NEK2_1	542	547	PF00069	0.657
MOD_NEK2_1	616	621	PF00069	0.583
MOD_NEK2_1	647	652	PF00069	0.593
MOD_NEK2_1	694	699	PF00069	0.695
MOD_NEK2_1	734	739	PF00069	0.586
MOD_NEK2_1	768	773	PF00069	0.762
MOD_NEK2_2	36	41	PF00069	0.594
MOD_PIKK_1	619	625	PF00454	0.574
MOD_PIKK_1	677	683	PF00454	0.615
MOD_PIKK_1	700	706	PF00454	0.564
MOD_PIKK_1	725	731	PF00454	0.604
MOD_PIKK_1	885	891	PF00454	0.559
MOD_PKA_1	585	591	PF00069	0.576
MOD_PKA_2	146	152	PF00069	0.553
MOD_PKA_2	170	176	PF00069	0.678
MOD_PKA_2	191	197	PF00069	0.682
MOD_PKA_2	315	321	PF00069	0.592
MOD_PKA_2	322	328	PF00069	0.559
MOD_PKA_2	348	354	PF00069	0.588
MOD_PKA_2	460	466	PF00069	0.716
MOD_PKA_2	585	591	PF00069	0.576
MOD_PKA_2	627	633	PF00069	0.687
MOD_PKA_2	690	696	PF00069	0.587
MOD_PKA_2	717	723	PF00069	0.796
MOD_PKA_2	911	917	PF00069	0.685
MOD_PKB_1	584	592	PF00069	0.576
MOD_Plk_1	122	128	PF00069	0.599
MOD_Plk_1	286	292	PF00069	0.666
MOD_Plk_1	298	304	PF00069	0.650
MOD_Plk_1	410	416	PF00069	0.708
MOD_Plk_1	520	526	PF00069	0.556
MOD_Plk_1	636	642	PF00069	0.676
MOD_Plk_1	682	688	PF00069	0.586
MOD_Plk_1	689	695	PF00069	0.564
MOD_Plk_4	104	110	PF00069	0.625
MOD_Plk_4	161	167	PF00069	0.544
MOD_Plk_4	419	425	PF00069	0.785
MOD_Plk_4	443	449	PF00069	0.762
MOD_Plk_4	553	559	PF00069	0.767
MOD_Plk_4	647	653	PF00069	0.744
MOD_Plk_4	763	769	PF00069	0.706
MOD_Plk_4	812	818	PF00069	0.793
MOD_Plk_4	943	949	PF00069	0.762
MOD_ProDKin_1	147	153	PF00069	0.770
MOD_ProDKin_1	159	165	PF00069	0.577
MOD_ProDKin_1	221	227	PF00069	0.802
MOD_ProDKin_1	254	260	PF00069	0.669
MOD_ProDKin_1	341	347	PF00069	0.717
MOD_ProDKin_1	362	368	PF00069	0.735
MOD_ProDKin_1	375	381	PF00069	0.654
MOD_ProDKin_1	412	418	PF00069	0.635
MOD_ProDKin_1	427	433	PF00069	0.727
MOD_ProDKin_1	496	502	PF00069	0.603
MOD_ProDKin_1	51	57	PF00069	0.827
MOD_ProDKin_1	65	71	PF00069	0.690
MOD_ProDKin_1	708	714	PF00069	0.589
MOD_ProDKin_1	739	745	PF00069	0.562
MOD_ProDKin_1	80	86	PF00069	0.741
MOD_ProDKin_1	822	828	PF00069	0.582
MOD_ProDKin_1	882	888	PF00069	0.789
MOD_ProDKin_1	89	95	PF00069	0.691
MOD_ProDKin_1	900	906	PF00069	0.504
MOD_ProDKin_1	912	918	PF00069	0.765
MOD_ProDKin_1	922	928	PF00069	0.516
MOD_SUMO_for_1	724	727	PF00179	0.597
TRG_DiLeu_BaEn_2	781	787	PF01217	0.650
TRG_DiLeu_BaLyEn_6	746	751	PF01217	0.781
TRG_DiLeu_BaLyEn_6	769	774	PF01217	0.730
TRG_DiLeu_BaLyEn_6	901	906	PF01217	0.543
TRG_ENDOCYTIC_2	435	438	PF00928	0.560
TRG_ENDOCYTIC_2	559	562	PF00928	0.791
TRG_ENDOCYTIC_2	944	947	PF00928	0.726
TRG_ER_diArg_1	126	128	PF00400	0.577
TRG_ER_diArg_1	190	193	PF00400	0.595
TRG_ER_diArg_1	272	274	PF00400	0.653
TRG_ER_diArg_1	374	377	PF00400	0.577
TRG_ER_diArg_1	559	561	PF00400	0.793
TRG_ER_diArg_1	584	586	PF00400	0.565
TRG_ER_diArg_1	796	799	PF00400	0.503
TRG_NLS_MonoExtC_3	374	379	PF00514	0.575
TRG_NLS_MonoExtN_4	374	379	PF00514	0.575
TRG_Pf-PMV_PEXEL_1	560	565	PF00026	0.789
TRG_Pf-PMV_PEXEL_1	772	777	PF00026	0.722

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H768	Leishmania donovani	57%	98%
A4HYE9	Leishmania infantum	57%	98%
E9AS82	Leishmania mexicana (strain MHOM/GT/2001/U1103)	58%	97%
Q4QD84	Leishmania major	58%	100%