PHB domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SPFH domain / Band 7 family, putative

Species:

Leishmania braziliensis

UniProt:

A4HA74_LEIBR

TriTrypDb:

LbrM.19.1500 , LBRM2903_190020900

Length:

277

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	1
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HA74

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HA74

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	125	129	PF00656	0.429
CLV_NRD_NRD_1	191	193	PF00675	0.486
CLV_NRD_NRD_1	201	203	PF00675	0.420
CLV_NRD_NRD_1	40	42	PF00675	0.389
CLV_PCSK_KEX2_1	179	181	PF00082	0.448
CLV_PCSK_KEX2_1	191	193	PF00082	0.414
CLV_PCSK_KEX2_1	40	42	PF00082	0.389
CLV_PCSK_PC1ET2_1	179	181	PF00082	0.524
CLV_PCSK_PC7_1	187	193	PF00082	0.549
CLV_PCSK_SKI1_1	221	225	PF00082	0.574
CLV_PCSK_SKI1_1	263	267	PF00082	0.425
CLV_PCSK_SKI1_1	40	44	PF00082	0.389
DEG_SPOP_SBC_1	246	250	PF00917	0.574
DOC_ANK_TNKS_1	191	198	PF00023	0.492
DOC_MAPK_gen_1	40	46	PF00069	0.436
DOC_MAPK_gen_1	56	65	PF00069	0.221
DOC_MAPK_HePTP_8	53	65	PF00069	0.313
DOC_MAPK_MEF2A_6	56	65	PF00069	0.334
DOC_USP7_MATH_1	245	249	PF00917	0.518
DOC_USP7_MATH_1	84	88	PF00917	0.389
DOC_USP7_UBL2_3	52	56	PF12436	0.429
LIG_14-3-3_CanoR_1	166	171	PF00244	0.442
LIG_14-3-3_CanoR_1	20	27	PF00244	0.389
LIG_14-3-3_CanoR_1	40	45	PF00244	0.389
LIG_Actin_WH2_2	152	168	PF00022	0.313
LIG_BRCT_BRCA1_1	74	78	PF00533	0.232
LIG_FHA_1	131	137	PF00498	0.357
LIG_FHA_1	173	179	PF00498	0.429
LIG_FHA_1	227	233	PF00498	0.582
LIG_FHA_1	41	47	PF00498	0.381
LIG_FHA_1	62	68	PF00498	0.377
LIG_FHA_2	222	228	PF00498	0.569
LIG_GBD_Chelix_1	38	46	PF00786	0.304
LIG_KLC1_Yacidic_2	110	115	PF13176	0.429
LIG_LIR_Gen_1	59	69	PF02991	0.313
LIG_LIR_Gen_1	75	84	PF02991	0.313
LIG_LIR_Nem_3	59	65	PF02991	0.313
LIG_LIR_Nem_3	75	81	PF02991	0.313
LIG_PCNA_PIPBox_1	231	240	PF02747	0.569
LIG_PTB_Apo_2	232	239	PF02174	0.450
LIG_PTB_Phospho_1	232	238	PF10480	0.474
LIG_SH2_CRK	238	242	PF00017	0.505
LIG_SH2_STAP1	49	53	PF00017	0.343
LIG_SH2_STAT5	113	116	PF00017	0.429
LIG_SH2_STAT5	95	98	PF00017	0.383
LIG_SUMO_SIM_anti_2	64	69	PF11976	0.389
LIG_SUMO_SIM_par_1	248	257	PF11976	0.601
MOD_CK1_1	248	254	PF00069	0.544
MOD_CK2_1	5	11	PF00069	0.386
MOD_CK2_1	84	90	PF00069	0.380
MOD_GlcNHglycan	139	142	PF01048	0.367
MOD_GlcNHglycan	193	196	PF01048	0.520
MOD_GSK3_1	137	144	PF00069	0.355
MOD_GSK3_1	222	229	PF00069	0.618
MOD_GSK3_1	3	10	PF00069	0.476
MOD_N-GLC_1	246	251	PF02516	0.635
MOD_NEK2_1	209	214	PF00069	0.445
MOD_NEK2_1	254	259	PF00069	0.588
MOD_NMyristoyl	1	7	PF02799	0.479
MOD_PIKK_1	117	123	PF00454	0.337
MOD_PIKK_1	263	269	PF00454	0.530
MOD_PIKK_1	5	11	PF00454	0.429
MOD_PK_1	166	172	PF00069	0.429
MOD_PKA_1	191	197	PF00069	0.493
MOD_PKA_1	40	46	PF00069	0.389
MOD_PKA_2	115	121	PF00069	0.313
MOD_PKA_2	19	25	PF00069	0.389
MOD_PKA_2	191	197	PF00069	0.493
MOD_PKA_2	40	46	PF00069	0.467
MOD_PKB_1	164	172	PF00069	0.429
MOD_Plk_1	85	91	PF00069	0.370
MOD_Plk_2-3	222	228	PF00069	0.498
MOD_Plk_4	248	254	PF00069	0.544
MOD_Plk_4	34	40	PF00069	0.432
MOD_Plk_4	63	69	PF00069	0.429
MOD_SUMO_for_1	123	126	PF00179	0.313
MOD_SUMO_for_1	51	54	PF00179	0.429
MOD_SUMO_rev_2	48	57	PF00179	0.372
TRG_ENDOCYTIC_2	238	241	PF00928	0.491
TRG_ER_diArg_1	164	167	PF00400	0.337
TRG_ER_diArg_1	191	193	PF00400	0.512
TRG_ER_diArg_1	39	41	PF00400	0.425
TRG_NLS_MonoExtN_4	177	183	PF00514	0.550
TRG_Pf-PMV_PEXEL_1	191	196	PF00026	0.468
TRG_Pf-PMV_PEXEL_1	221	226	PF00026	0.518

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7U5	Leptomonas seymouri	86%	100%
A0A0N0P871	Leptomonas seymouri	33%	97%
A0A0S4INL5	Bodo saltans	37%	99%
A0A0S4IW13	Bodo saltans	49%	98%
A0A0S4JWM2	Bodo saltans	28%	89%
A0A1X0NF09	Trypanosomatidae	52%	99%
A0A1X0NZM1	Trypanosomatidae	35%	99%
A0A3Q8IK54	Leishmania donovani	31%	98%
A0A3R7NUY2	Trypanosoma rangeli	33%	99%
A0A3S7WVJ3	Leishmania donovani	96%	100%
A4HYE6	Leishmania infantum	96%	100%
A4HYE7	Leishmania infantum	31%	98%
E9AS79	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
E9AS80	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	98%
O26788	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	25%	87%
O60121	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	78%
P0AA53	Escherichia coli (strain K12)	26%	91%
P0AA54	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	26%	91%
P0AA55	Escherichia coli O157:H7	26%	91%
P0AA56	Shigella flexneri	26%	91%
P0DKS0	Wigglesworthia glossinidia brevipalpis	25%	88%
P63694	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	21%	73%
P72655	Synechocystis sp. (strain PCC 6803 / Kazusa)	25%	86%
P9WPR8	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	21%	73%
P9WPR9	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	21%	73%
Q4QD86	Leishmania major	31%	100%
Q4QD87	Leishmania major	94%	100%
Q5GI04	Capsicum annuum	38%	97%
Q6K550	Oryza sativa subsp. japonica	38%	97%
Q6L4S3	Oryza sativa subsp. japonica	39%	96%
Q6ZIV7	Oryza sativa subsp. japonica	37%	98%
Q9CAR7	Arabidopsis thaliana	38%	97%
Q9FHM7	Arabidopsis thaliana	35%	95%
Q9FM19	Arabidopsis thaliana	38%	97%
Q9SRH6	Arabidopsis thaliana	37%	97%
V5BQ22	Trypanosoma cruzi	35%	99%
V5D2B9	Trypanosoma cruzi	48%	99%