Putative RNA binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA binding protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HA73_LEIBR

TriTrypDb:

LbrM.19.1490 , LBRM2903_190020800

Length:

250

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	6
GO:0032991	protein-containing complex	1	6
GO:0140513	nuclear protein-containing complex	2	6
GO:1990904	ribonucleoprotein complex	2	6
GO:0005654	nucleoplasm	2	1
GO:0005684	U2-type spliceosomal complex	4	1
GO:0005686	U2 snRNP	5	1
GO:0030532	small nuclear ribonucleoprotein complex	3	1
GO:0071004	U2-type prespliceosome	5	1
GO:0071010	prespliceosome	4	1
GO:0071013	catalytic step 2 spliceosome	3	1
GO:0097525	spliceosomal snRNP complex	4	1
GO:0110165	cellular anatomical entity	1	1
GO:0120114	Sm-like protein family complex	2	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

A4HA73

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HA73

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	6
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	6
GO:0000398	mRNA splicing, via spliceosome	8	6
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006396	RNA processing	6	7
GO:0006397	mRNA processing	7	6
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0008380	RNA splicing	7	6
GO:0009987	cellular process	1	7
GO:0016070	RNA metabolic process	5	7
GO:0016071	mRNA metabolic process	6	6
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0043170	macromolecule metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0045292	mRNA cis splicing, via spliceosome	9	6
GO:0046483	heterocycle metabolic process	3	7
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	246	248	PF00675	0.613
CLV_PCSK_KEX2_1	248	250	PF00082	0.635
CLV_PCSK_PC1ET2_1	248	250	PF00082	0.635
DOC_USP7_MATH_1	171	175	PF00917	0.728
DOC_USP7_MATH_1	188	192	PF00917	0.552
DOC_USP7_MATH_1	26	30	PF00917	0.536
LIG_14-3-3_CanoR_1	8	18	PF00244	0.511
LIG_FHA_1	157	163	PF00498	0.706
LIG_FHA_1	26	32	PF00498	0.753
LIG_FHA_2	39	45	PF00498	0.663
LIG_IBAR_NPY_1	74	76	PF08397	0.619
LIG_LIR_Gen_1	12	21	PF02991	0.510
LIG_LIR_Gen_1	232	239	PF02991	0.659
LIG_LIR_Nem_3	12	17	PF02991	0.511
LIG_LIR_Nem_3	135	141	PF02991	0.699
LIG_LIR_Nem_3	173	179	PF02991	0.518
LIG_LIR_Nem_3	232	238	PF02991	0.659
LIG_PCNA_yPIPBox_3	42	50	PF02747	0.411
LIG_PTB_Apo_2	71	78	PF02174	0.619
LIG_SH2_CRK	90	94	PF00017	0.546
LIG_SH2_NCK_1	21	25	PF00017	0.776
LIG_SH2_SRC	203	206	PF00017	0.782
LIG_SH2_STAP1	176	180	PF00017	0.556
LIG_SH2_STAP1	235	239	PF00017	0.644
LIG_SH2_STAT3	145	148	PF00017	0.670
LIG_SH2_STAT5	179	182	PF00017	0.633
LIG_SH2_STAT5	49	52	PF00017	0.546
LIG_SH2_STAT5	53	56	PF00017	0.546
LIG_SH2_STAT5	76	79	PF00017	0.546
LIG_SH2_STAT5	92	95	PF00017	0.546
MOD_CK2_1	147	153	PF00069	0.764
MOD_GlcNHglycan	149	152	PF01048	0.781
MOD_GlcNHglycan	164	168	PF01048	0.554
MOD_GlcNHglycan	173	176	PF01048	0.782
MOD_GlcNHglycan	196	199	PF01048	0.618
MOD_GlcNHglycan	204	208	PF01048	0.781
MOD_GSK3_1	184	191	PF00069	0.690
MOD_GSK3_1	2	9	PF00069	0.524
MOD_N-GLC_1	156	161	PF02516	0.537
MOD_NEK2_1	93	98	PF00069	0.546
MOD_PKA_2	101	107	PF00069	0.743
MOD_Plk_1	26	32	PF00069	0.539
MOD_Plk_4	26	32	PF00069	0.569
TRG_ENDOCYTIC_2	14	17	PF00928	0.514
TRG_ENDOCYTIC_2	235	238	PF00928	0.640
TRG_ENDOCYTIC_2	76	79	PF00928	0.546
TRG_ENDOCYTIC_2	90	93	PF00928	0.504
TRG_ER_diArg_1	247	250	PF00400	0.731
TRG_ER_diArg_1	67	70	PF00400	0.546

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PET4	Leptomonas seymouri	53%	100%
A0A3S7WVH7	Leishmania donovani	79%	100%
A4HYE5	Leishmania infantum	80%	100%
E9AS78	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4QD88	Leishmania major	80%	97%