Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HA72_LEIBR

TriTrypDb:

LbrM.19.1480 , LBRM2903_190020700

Length:

168

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HA72

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HA72

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	14	16	PF00675	0.494
CLV_NRD_NRD_1	33	35	PF00675	0.446
CLV_NRD_NRD_1	48	50	PF00675	0.459
CLV_PCSK_KEX2_1	110	112	PF00082	0.468
CLV_PCSK_KEX2_1	122	124	PF00082	0.579
CLV_PCSK_KEX2_1	14	16	PF00082	0.494
CLV_PCSK_KEX2_1	33	35	PF00082	0.446
CLV_PCSK_KEX2_1	48	50	PF00082	0.459
CLV_PCSK_PC1ET2_1	110	112	PF00082	0.468
CLV_PCSK_PC1ET2_1	122	124	PF00082	0.590
CLV_PCSK_PC1ET2_1	33	35	PF00082	0.470
CLV_PCSK_SKI1_1	136	140	PF00082	0.479
CLV_PCSK_SKI1_1	24	28	PF00082	0.534
DEG_APCC_DBOX_1	135	143	PF00400	0.371
DOC_MAPK_FxFP_2	37	40	PF00069	0.511
DOC_MAPK_gen_1	110	116	PF00069	0.439
DOC_PP4_FxxP_1	26	29	PF00568	0.556
DOC_PP4_FxxP_1	37	40	PF00568	0.446
DOC_USP7_MATH_1	134	138	PF00917	0.376
DOC_USP7_MATH_1	17	21	PF00917	0.487
DOC_USP7_MATH_1	91	95	PF00917	0.755
DOC_WW_Pin1_4	55	60	PF00397	0.494
DOC_WW_Pin1_4	87	92	PF00397	0.726
LIG_14-3-3_CanoR_1	14	21	PF00244	0.585
LIG_14-3-3_CanoR_1	150	160	PF00244	0.340
LIG_14-3-3_CanoR_1	34	38	PF00244	0.548
LIG_14-3-3_CanoR_1	87	91	PF00244	0.692
LIG_14-3-3_CterR_2	166	168	PF00244	0.644
LIG_Actin_WH2_2	1	16	PF00022	0.531
LIG_BRCT_BRCA1_1	79	83	PF00533	0.606
LIG_FHA_1	155	161	PF00498	0.424
LIG_FHA_1	58	64	PF00498	0.610
LIG_FHA_2	160	166	PF00498	0.531
LIG_LIR_Apic_2	36	40	PF02991	0.597
LIG_LIR_Nem_3	124	129	PF02991	0.398
LIG_LIR_Nem_3	64	68	PF02991	0.327
LIG_RPA_C_Fungi	10	22	PF08784	0.572
LIG_SH2_STAP1	156	160	PF00017	0.417
LIG_SH2_STAT5	156	159	PF00017	0.414
LIG_SUMO_SIM_par_1	137	145	PF11976	0.525
LIG_WRC_WIRS_1	8	13	PF05994	0.495
MOD_CDC14_SPxK_1	90	93	PF00782	0.494
MOD_CDK_SPxK_1	87	93	PF00069	0.495
MOD_CK1_1	154	160	PF00069	0.283
MOD_CK1_1	86	92	PF00069	0.743
MOD_CK1_1	94	100	PF00069	0.667
MOD_CK2_1	159	165	PF00069	0.532
MOD_Cter_Amidation	120	123	PF01082	0.575
MOD_DYRK1A_RPxSP_1	87	91	PF00069	0.747
MOD_GlcNHglycan	136	139	PF01048	0.510
MOD_GlcNHglycan	93	96	PF01048	0.754
MOD_GSK3_1	13	20	PF00069	0.612
MOD_GSK3_1	53	60	PF00069	0.600
MOD_GSK3_1	77	84	PF00069	0.537
MOD_GSK3_1	87	94	PF00069	0.650
MOD_NEK2_1	13	18	PF00069	0.575
MOD_NEK2_1	151	156	PF00069	0.264
MOD_NEK2_1	83	88	PF00069	0.573
MOD_NEK2_2	17	22	PF00069	0.517
MOD_NMyristoyl	1	7	PF02799	0.412
MOD_PKA_1	110	116	PF00069	0.551
MOD_PKA_1	122	128	PF00069	0.548
MOD_PKA_1	33	39	PF00069	0.591
MOD_PKA_2	110	116	PF00069	0.446
MOD_PKA_2	122	128	PF00069	0.548
MOD_PKA_2	13	19	PF00069	0.555
MOD_PKA_2	33	39	PF00069	0.542
MOD_PKA_2	77	83	PF00069	0.548
MOD_PKA_2	86	92	PF00069	0.697
MOD_Plk_1	81	87	PF00069	0.543
MOD_Plk_4	122	128	PF00069	0.387
MOD_Plk_4	7	13	PF00069	0.493
MOD_ProDKin_1	55	61	PF00069	0.497
MOD_ProDKin_1	87	93	PF00069	0.726
TRG_ENDOCYTIC_2	68	71	PF00928	0.521
TRG_ER_diArg_1	13	15	PF00400	0.475
TRG_ER_diArg_1	48	50	PF00400	0.459
TRG_ER_diArg_1	76	79	PF00400	0.491

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JUD0	Bodo saltans	52%	100%
A0A1X0P6W6	Trypanosomatidae	67%	100%
A0A3S7WVI2	Leishmania donovani	95%	98%
A0A422NUM9	Trypanosoma rangeli	67%	100%
A4HYE4	Leishmania infantum	95%	98%
D0A0S9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	67%	100%
E9AS77	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	98%
Q4QD89	Leishmania major	95%	100%