Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HA69_LEIBR

TriTrypDb:

LbrM.19.1450 , LBRM2903_190020400

Length:

378

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HA69

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HA69

PDB structure(s): 7aih_Aq , 7ane_Aq

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	112	116	PF00656	0.816
CLV_NRD_NRD_1	10	12	PF00675	0.614
CLV_NRD_NRD_1	212	214	PF00675	0.470
CLV_NRD_NRD_1	356	358	PF00675	0.669
CLV_NRD_NRD_1	39	41	PF00675	0.488
CLV_PCSK_KEX2_1	212	214	PF00082	0.470
CLV_PCSK_KEX2_1	356	358	PF00082	0.669
CLV_PCSK_KEX2_1	39	41	PF00082	0.429
CLV_PCSK_PC1ET2_1	356	358	PF00082	0.669
DEG_Nend_Nbox_1	1	3	PF02207	0.598
DOC_CKS1_1	228	233	PF01111	0.522
DOC_CYCLIN_yCln2_LP_2	204	210	PF00134	0.523
DOC_MAPK_gen_1	174	182	PF00069	0.517
DOC_MAPK_MEF2A_6	165	173	PF00069	0.516
DOC_MAPK_MEF2A_6	80	87	PF00069	0.587
DOC_MAPK_NFAT4_5	80	88	PF00069	0.589
DOC_PP2B_LxvP_1	71	74	PF13499	0.684
DOC_PP4_FxxP_1	259	262	PF00568	0.421
DOC_USP7_MATH_1	109	113	PF00917	0.702
DOC_USP7_MATH_1	17	21	PF00917	0.552
DOC_USP7_MATH_1	294	298	PF00917	0.770
DOC_USP7_MATH_1	308	312	PF00917	0.464
DOC_USP7_MATH_1	330	334	PF00917	0.577
DOC_WW_Pin1_4	227	232	PF00397	0.677
LIG_14-3-3_CanoR_1	145	153	PF00244	0.675
LIG_14-3-3_CanoR_1	174	182	PF00244	0.517
LIG_14-3-3_CanoR_1	212	220	PF00244	0.478
LIG_14-3-3_CanoR_1	302	308	PF00244	0.768
LIG_14-3-3_CanoR_1	357	363	PF00244	0.599
LIG_CtBP_PxDLS_1	73	77	PF00389	0.436
LIG_FHA_1	156	162	PF00498	0.577
LIG_FHA_1	175	181	PF00498	0.512
LIG_FHA_1	239	245	PF00498	0.649
LIG_FHA_1	258	264	PF00498	0.343
LIG_FHA_2	152	158	PF00498	0.497
LIG_FHA_2	228	234	PF00498	0.556
LIG_LIR_Apic_2	205	209	PF02991	0.480
LIG_LIR_Apic_2	225	231	PF02991	0.758
LIG_LIR_Apic_2	257	262	PF02991	0.434
LIG_LIR_Gen_1	214	222	PF02991	0.669
LIG_LIR_Nem_3	150	156	PF02991	0.623
LIG_LIR_Nem_3	214	219	PF02991	0.657
LIG_LIR_Nem_3	311	317	PF02991	0.580
LIG_LIR_Nem_3	45	51	PF02991	0.402
LIG_SH2_CRK	216	220	PF00017	0.665
LIG_SH2_CRK	228	232	PF00017	0.732
LIG_SH2_CRK	48	52	PF00017	0.368
LIG_SH2_CRK	96	100	PF00017	0.637
LIG_SH2_NCK_1	216	220	PF00017	0.443
LIG_SH2_NCK_1	228	232	PF00017	0.732
LIG_SH2_STAP1	216	220	PF00017	0.443
LIG_SH2_STAT3	55	58	PF00017	0.622
LIG_SH2_STAT5	153	156	PF00017	0.575
LIG_SH2_STAT5	55	58	PF00017	0.557
LIG_SH3_3	283	289	PF00018	0.659
LIG_SH3_3	333	339	PF00018	0.660
LIG_SH3_3	54	60	PF00018	0.524
LIG_TRAF2_1	231	234	PF00917	0.622
MOD_CK1_1	211	217	PF00069	0.550
MOD_CK1_1	254	260	PF00069	0.508
MOD_CK1_1	270	276	PF00069	0.788
MOD_CK1_1	303	309	PF00069	0.748
MOD_CK2_1	17	23	PF00069	0.552
MOD_CK2_1	227	233	PF00069	0.551
MOD_GlcNHglycan	19	22	PF01048	0.575
MOD_GlcNHglycan	269	272	PF01048	0.777
MOD_GlcNHglycan	296	299	PF01048	0.772
MOD_GlcNHglycan	305	308	PF01048	0.621
MOD_GlcNHglycan	327	330	PF01048	0.574
MOD_GlcNHglycan	333	336	PF01048	0.550
MOD_GlcNHglycan	76	79	PF01048	0.443
MOD_GSK3_1	147	154	PF00069	0.537
MOD_GSK3_1	25	32	PF00069	0.496
MOD_GSK3_1	265	272	PF00069	0.624
MOD_GSK3_1	303	310	PF00069	0.655
MOD_N-GLC_1	147	152	PF02516	0.675
MOD_NEK2_1	2	7	PF00069	0.596
MOD_NEK2_1	323	328	PF00069	0.422
MOD_NEK2_1	331	336	PF00069	0.457
MOD_PIKK_1	211	217	PF00454	0.652
MOD_PIKK_1	265	271	PF00454	0.485
MOD_PIKK_1	308	314	PF00454	0.645
MOD_PKA_1	356	362	PF00069	0.643
MOD_PKA_2	211	217	PF00069	0.459
MOD_PKA_2	220	226	PF00069	0.510
MOD_PKA_2	303	309	PF00069	0.533
MOD_PKA_2	331	337	PF00069	0.564
MOD_PKA_2	356	362	PF00069	0.643
MOD_Plk_1	109	115	PF00069	0.772
MOD_Plk_1	147	153	PF00069	0.671
MOD_Plk_1	254	260	PF00069	0.575
MOD_Plk_1	280	286	PF00069	0.710
MOD_Plk_2-3	110	116	PF00069	0.759
MOD_Plk_4	254	260	PF00069	0.566
MOD_Plk_4	29	35	PF00069	0.439
MOD_ProDKin_1	227	233	PF00069	0.681
MOD_SUMO_rev_2	346	353	PF00179	0.628
TRG_ENDOCYTIC_2	216	219	PF00928	0.661
TRG_ENDOCYTIC_2	48	51	PF00928	0.409
TRG_ENDOCYTIC_2	96	99	PF00928	0.638
TRG_ER_diArg_1	173	176	PF00400	0.521
TRG_ER_diArg_1	180	183	PF00400	0.524
TRG_ER_diArg_1	38	40	PF00400	0.515
TRG_NLS_MonoExtC_3	355	360	PF00514	0.654
TRG_NLS_MonoExtN_4	356	361	PF00514	0.644
TRG_Pf-PMV_PEXEL_1	313	318	PF00026	0.582
TRG_Pf-PMV_PEXEL_1	360	364	PF00026	0.630

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM80	Leptomonas seymouri	68%	100%
A0A3Q8IDC8	Leishmania donovani	84%	100%
A4HYE1	Leishmania infantum	84%	100%
E9AS74	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QD92	Leishmania major	82%	99%