Pre-mRNA-splicing factor ISY1

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HA65_LEIBR

TriTrypDb:

LbrM.19.1410 , LBRM2903_190019300

Length:

335

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HA65

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HA65

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	143	147	PF00656	0.798
CLV_C14_Caspase3-7	199	203	PF00656	0.440
CLV_NRD_NRD_1	123	125	PF00675	0.646
CLV_NRD_NRD_1	136	138	PF00675	0.540
CLV_NRD_NRD_1	255	257	PF00675	0.564
CLV_NRD_NRD_1	314	316	PF00675	0.504
CLV_NRD_NRD_1	78	80	PF00675	0.624
CLV_NRD_NRD_1	92	94	PF00675	0.605
CLV_PCSK_FUR_1	56	60	PF00082	0.652
CLV_PCSK_FUR_1	76	80	PF00082	0.323
CLV_PCSK_FUR_1	90	94	PF00082	0.649
CLV_PCSK_KEX2_1	123	125	PF00082	0.646
CLV_PCSK_KEX2_1	136	138	PF00082	0.540
CLV_PCSK_KEX2_1	219	221	PF00082	0.470
CLV_PCSK_KEX2_1	58	60	PF00082	0.514
CLV_PCSK_KEX2_1	78	80	PF00082	0.324
CLV_PCSK_KEX2_1	84	86	PF00082	0.606
CLV_PCSK_KEX2_1	92	94	PF00082	0.529
CLV_PCSK_PC1ET2_1	219	221	PF00082	0.519
CLV_PCSK_PC1ET2_1	58	60	PF00082	0.514
CLV_PCSK_PC1ET2_1	84	86	PF00082	0.660
CLV_PCSK_SKI1_1	177	181	PF00082	0.660
CLV_PCSK_SKI1_1	187	191	PF00082	0.515
CLV_PCSK_SKI1_1	308	312	PF00082	0.604
CLV_PCSK_SKI1_1	78	82	PF00082	0.670
DEG_COP1_1	228	237	PF00400	0.632
DOC_CKS1_1	169	174	PF01111	0.654
DOC_MAPK_gen_1	53	63	PF00069	0.523
DOC_MAPK_MEF2A_6	43	50	PF00069	0.676
DOC_USP7_MATH_1	238	242	PF00917	0.533
DOC_USP7_MATH_1	322	326	PF00917	0.411
DOC_USP7_UBL2_3	180	184	PF12436	0.692
DOC_WW_Pin1_4	168	173	PF00397	0.621
LIG_14-3-3_CanoR_1	273	278	PF00244	0.621
LIG_14-3-3_CanoR_1	304	311	PF00244	0.605
LIG_14-3-3_CanoR_1	78	86	PF00244	0.581
LIG_FHA_1	160	166	PF00498	0.715
LIG_FHA_1	23	29	PF00498	0.602
LIG_FHA_2	16	22	PF00498	0.547
LIG_FHA_2	169	175	PF00498	0.651
LIG_FHA_2	216	222	PF00498	0.549
LIG_FHA_2	297	303	PF00498	0.592
LIG_GBD_Chelix_1	182	190	PF00786	0.662
LIG_GBD_Chelix_1	46	54	PF00786	0.578
LIG_PDZ_Class_2	330	335	PF00595	0.559
LIG_REV1ctd_RIR_1	308	317	PF16727	0.596
LIG_RPA_C_Fungi	247	259	PF08784	0.495
LIG_SH2_SRC	200	203	PF00017	0.447
LIG_SH2_STAP1	270	274	PF00017	0.443
LIG_SH2_STAT3	263	266	PF00017	0.609
LIG_SH2_STAT5	197	200	PF00017	0.428
LIG_SH3_3	166	172	PF00018	0.628
LIG_SH3_3	229	235	PF00018	0.502
LIG_SUMO_SIM_anti_2	60	68	PF11976	0.674
LIG_SUMO_SIM_par_1	46	52	PF11976	0.665
LIG_TRAF2_1	118	121	PF00917	0.662
LIG_TRAF2_1	171	174	PF00917	0.730
LIG_TRAF2_1	291	294	PF00917	0.733
LIG_TRAF2_1	65	68	PF00917	0.602
LIG_TRAF2_1	71	74	PF00917	0.589
MOD_CK1_1	298	304	PF00069	0.627
MOD_CK2_1	15	21	PF00069	0.555
MOD_CK2_1	168	174	PF00069	0.750
MOD_CK2_1	215	221	PF00069	0.545
MOD_CK2_1	238	244	PF00069	0.547
MOD_CK2_1	288	294	PF00069	0.703
MOD_CK2_1	296	302	PF00069	0.501
MOD_GlcNHglycan	244	248	PF01048	0.589
MOD_GlcNHglycan	324	327	PF01048	0.430
MOD_GSK3_1	140	147	PF00069	0.703
MOD_GSK3_1	148	155	PF00069	0.698
MOD_GSK3_1	159	166	PF00069	0.542
MOD_GSK3_1	201	208	PF00069	0.466
MOD_N-GLC_1	15	20	PF02516	0.694
MOD_N-GLC_1	215	220	PF02516	0.608
MOD_N-GLC_2	231	233	PF02516	0.648
MOD_NEK2_1	189	194	PF00069	0.554
MOD_NEK2_1	201	206	PF00069	0.382
MOD_PK_1	273	279	PF00069	0.616
MOD_PKA_1	78	84	PF00069	0.671
MOD_PKA_2	303	309	PF00069	0.613
MOD_PKA_2	78	84	PF00069	0.671
MOD_PKB_1	76	84	PF00069	0.671
MOD_Plk_1	238	244	PF00069	0.540
MOD_Plk_1	295	301	PF00069	0.646
MOD_Plk_2-3	144	150	PF00069	0.805
MOD_Plk_2-3	152	158	PF00069	0.671
MOD_Plk_2-3	296	302	PF00069	0.641
MOD_Plk_4	196	202	PF00069	0.423
MOD_ProDKin_1	168	174	PF00069	0.616
TRG_DiLeu_BaEn_4	133	139	PF01217	0.723
TRG_ENDOCYTIC_2	262	265	PF00928	0.598
TRG_ER_diArg_1	106	109	PF00400	0.578
TRG_ER_diArg_1	123	126	PF00400	0.609
TRG_ER_diArg_1	136	138	PF00400	0.493
TRG_ER_diArg_1	76	79	PF00400	0.634
TRG_ER_diArg_1	90	93	PF00400	0.570
TRG_NES_CRM1_1	52	67	PF08389	0.596
TRG_Pf-PMV_PEXEL_1	78	82	PF00026	0.670
TRG_Pf-PMV_PEXEL_1	84	88	PF00026	0.660

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P630	Trypanosomatidae	33%	100%
V5AZ24	Trypanosoma cruzi	30%	100%