Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HA64_LEIBR

TriTrypDb:

LbrM.19.1400 , LBRM2903_190019400 , LBRM2903_190019500

Length:

934

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HA64

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HA64

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	451	455	PF00656	0.410
CLV_C14_Caspase3-7	603	607	PF00656	0.835
CLV_C14_Caspase3-7	617	621	PF00656	0.581
CLV_NRD_NRD_1	166	168	PF00675	0.835
CLV_NRD_NRD_1	459	461	PF00675	0.614
CLV_NRD_NRD_1	492	494	PF00675	0.510
CLV_NRD_NRD_1	50	52	PF00675	0.780
CLV_NRD_NRD_1	95	97	PF00675	0.649
CLV_PCSK_FUR_1	647	651	PF00082	0.558
CLV_PCSK_KEX2_1	166	168	PF00082	0.738
CLV_PCSK_KEX2_1	459	461	PF00082	0.614
CLV_PCSK_KEX2_1	642	644	PF00082	0.731
CLV_PCSK_KEX2_1	646	648	PF00082	0.755
CLV_PCSK_KEX2_1	649	651	PF00082	0.758
CLV_PCSK_KEX2_1	826	828	PF00082	0.598
CLV_PCSK_KEX2_1	95	97	PF00082	0.752
CLV_PCSK_PC1ET2_1	642	644	PF00082	0.731
CLV_PCSK_PC1ET2_1	646	648	PF00082	0.755
CLV_PCSK_PC1ET2_1	649	651	PF00082	0.758
CLV_PCSK_PC1ET2_1	826	828	PF00082	0.523
CLV_PCSK_SKI1_1	138	142	PF00082	0.727
CLV_PCSK_SKI1_1	266	270	PF00082	0.620
CLV_PCSK_SKI1_1	287	291	PF00082	0.812
CLV_PCSK_SKI1_1	299	303	PF00082	0.552
CLV_PCSK_SKI1_1	438	442	PF00082	0.381
CLV_PCSK_SKI1_1	444	448	PF00082	0.533
CLV_PCSK_SKI1_1	466	470	PF00082	0.518
CLV_PCSK_SKI1_1	570	574	PF00082	0.656
CLV_PCSK_SKI1_1	748	752	PF00082	0.579
CLV_PCSK_SKI1_1	888	892	PF00082	0.398
DEG_Nend_UBRbox_3	1	3	PF02207	0.728
DEG_SCF_FBW7_1	116	123	PF00400	0.572
DEG_SPOP_SBC_1	122	126	PF00917	0.578
DEG_SPOP_SBC_1	184	188	PF00917	0.744
DEG_SPOP_SBC_1	191	195	PF00917	0.621
DEG_SPOP_SBC_1	242	246	PF00917	0.651
DEG_SPOP_SBC_1	761	765	PF00917	0.585
DOC_CKS1_1	906	911	PF01111	0.557
DOC_CYCLIN_RxL_1	438	451	PF00134	0.626
DOC_CYCLIN_yCln2_LP_2	226	232	PF00134	0.825
DOC_CYCLIN_yCln2_LP_2	342	348	PF00134	0.705
DOC_MAPK_RevD_3	445	460	PF00069	0.410
DOC_PP1_RVXF_1	102	109	PF00149	0.735
DOC_PP1_RVXF_1	136	142	PF00149	0.725
DOC_PP1_RVXF_1	259	265	PF00149	0.518
DOC_PP4_FxxP_1	171	174	PF00568	0.566
DOC_PP4_FxxP_1	665	668	PF00568	0.669
DOC_PP4_FxxP_1	911	914	PF00568	0.591
DOC_USP7_MATH_1	147	151	PF00917	0.847
DOC_USP7_MATH_1	183	187	PF00917	0.734
DOC_USP7_MATH_1	191	195	PF00917	0.626
DOC_USP7_MATH_1	203	207	PF00917	0.550
DOC_USP7_MATH_1	241	245	PF00917	0.698
DOC_USP7_MATH_1	295	299	PF00917	0.661
DOC_USP7_MATH_1	306	310	PF00917	0.745
DOC_USP7_MATH_1	331	335	PF00917	0.700
DOC_USP7_MATH_1	338	342	PF00917	0.670
DOC_USP7_MATH_1	409	413	PF00917	0.722
DOC_USP7_MATH_1	513	517	PF00917	0.515
DOC_USP7_MATH_1	595	599	PF00917	0.726
DOC_USP7_MATH_1	600	604	PF00917	0.730
DOC_USP7_MATH_1	632	636	PF00917	0.849
DOC_USP7_MATH_1	674	678	PF00917	0.551
DOC_USP7_MATH_1	705	709	PF00917	0.713
DOC_USP7_MATH_1	711	715	PF00917	0.606
DOC_USP7_MATH_1	760	764	PF00917	0.586
DOC_USP7_MATH_1	779	783	PF00917	0.774
DOC_USP7_MATH_1	8	12	PF00917	0.639
DOC_USP7_MATH_1	904	908	PF00917	0.662
DOC_USP7_MATH_1	99	103	PF00917	0.622
DOC_USP7_UBL2_3	642	646	PF12436	0.734
DOC_USP7_UBL2_3	744	748	PF12436	0.584
DOC_WW_Pin1_4	114	119	PF00397	0.533
DOC_WW_Pin1_4	187	192	PF00397	0.829
DOC_WW_Pin1_4	198	203	PF00397	0.571
DOC_WW_Pin1_4	225	230	PF00397	0.720
DOC_WW_Pin1_4	237	242	PF00397	0.690
DOC_WW_Pin1_4	290	295	PF00397	0.766
DOC_WW_Pin1_4	323	328	PF00397	0.642
DOC_WW_Pin1_4	348	353	PF00397	0.746
DOC_WW_Pin1_4	354	359	PF00397	0.742
DOC_WW_Pin1_4	368	373	PF00397	0.549
DOC_WW_Pin1_4	42	47	PF00397	0.771
DOC_WW_Pin1_4	467	472	PF00397	0.689
DOC_WW_Pin1_4	541	546	PF00397	0.777
DOC_WW_Pin1_4	668	673	PF00397	0.576
DOC_WW_Pin1_4	685	690	PF00397	0.766
DOC_WW_Pin1_4	698	703	PF00397	0.556
DOC_WW_Pin1_4	748	753	PF00397	0.744
DOC_WW_Pin1_4	762	767	PF00397	0.748
DOC_WW_Pin1_4	799	804	PF00397	0.693
DOC_WW_Pin1_4	898	903	PF00397	0.597
DOC_WW_Pin1_4	905	910	PF00397	0.665
DOC_WW_Pin1_4	915	920	PF00397	0.790
DOC_WW_Pin1_4	97	102	PF00397	0.759
LIG_14-3-3_CanoR_1	151	157	PF00244	0.710
LIG_14-3-3_CanoR_1	166	172	PF00244	0.704
LIG_14-3-3_CanoR_1	266	275	PF00244	0.532
LIG_14-3-3_CanoR_1	287	294	PF00244	0.707
LIG_14-3-3_CanoR_1	299	306	PF00244	0.546
LIG_14-3-3_CanoR_1	387	391	PF00244	0.767
LIG_14-3-3_CanoR_1	51	56	PF00244	0.656
LIG_14-3-3_CanoR_1	514	521	PF00244	0.401
LIG_14-3-3_CanoR_1	85	93	PF00244	0.702
LIG_14-3-3_CanoR_1	895	899	PF00244	0.605
LIG_14-3-3_CanoR_1	95	101	PF00244	0.737
LIG_Actin_WH2_2	59	76	PF00022	0.577
LIG_AP2alpha_2	161	163	PF02296	0.564
LIG_APCC_ABBA_1	844	849	PF00400	0.737
LIG_BIR_III_2	736	740	PF00653	0.561
LIG_BRCT_BRCA1_1	167	171	PF00533	0.571
LIG_BRCT_BRCA1_2	167	173	PF00533	0.572
LIG_FHA_1	193	199	PF00498	0.739
LIG_FHA_1	210	216	PF00498	0.695
LIG_FHA_1	380	386	PF00498	0.619
LIG_FHA_1	467	473	PF00498	0.514
LIG_FHA_1	54	60	PF00498	0.677
LIG_FHA_1	829	835	PF00498	0.530
LIG_FHA_2	30	36	PF00498	0.549
LIG_LIR_Apic_2	168	174	PF02991	0.569
LIG_LIR_Apic_2	802	808	PF02991	0.692
LIG_LIR_Apic_2	908	914	PF02991	0.585
LIG_LIR_LC3C_4	516	521	PF02991	0.626
LIG_LIR_Nem_3	714	720	PF02991	0.663
LIG_MYND_1	10	14	PF01753	0.602
LIG_MYND_1	668	672	PF01753	0.805
LIG_MYND_1	910	914	PF01753	0.667
LIG_NRBOX	441	447	PF00104	0.360
LIG_PAM2_1	246	258	PF00658	0.542
LIG_Pex14_1	575	579	PF04695	0.576
LIG_SH2_CRK	652	656	PF00017	0.534
LIG_SH2_CRK	683	687	PF00017	0.739
LIG_SH2_CRK	717	721	PF00017	0.619
LIG_SH2_STAP1	55	59	PF00017	0.607
LIG_SH2_STAP1	579	583	PF00017	0.603
LIG_SH2_STAT3	609	612	PF00017	0.543
LIG_SH2_STAT3	859	862	PF00017	0.578
LIG_SH2_STAT3	864	867	PF00017	0.558
LIG_SH2_STAT5	376	379	PF00017	0.558
LIG_SH2_STAT5	55	58	PF00017	0.727
LIG_SH2_STAT5	706	709	PF00017	0.702
LIG_SH2_STAT5	847	850	PF00017	0.622
LIG_SH2_STAT5	864	867	PF00017	0.558
LIG_SH3_3	11	17	PF00018	0.608
LIG_SH3_3	110	116	PF00018	0.678
LIG_SH3_3	342	348	PF00018	0.711
LIG_SH3_3	378	384	PF00018	0.580
LIG_SH3_3	387	393	PF00018	0.509
LIG_SH3_3	4	10	PF00018	0.691
LIG_SH3_3	625	631	PF00018	0.715
LIG_SH3_3	686	692	PF00018	0.773
LIG_SH3_3	697	703	PF00018	0.798
LIG_SH3_3	749	755	PF00018	0.799
LIG_SH3_3	763	769	PF00018	0.647
LIG_SH3_3	903	909	PF00018	0.767
LIG_SUMO_SIM_par_1	445	451	PF11976	0.532
LIG_SxIP_EBH_1	82	95	PF03271	0.524
LIG_TRAF2_1	483	486	PF00917	0.439
LIG_TRAF2_1	560	563	PF00917	0.535
LIG_TYR_ITIM	715	720	PF00017	0.500
LIG_WW_1	680	683	PF00397	0.589
MOD_CDK_SPxK_1	541	547	PF00069	0.566
MOD_CDK_SPxxK_3	467	474	PF00069	0.509
MOD_CDK_SPxxK_3	97	104	PF00069	0.670
MOD_CK1_1	124	130	PF00069	0.761
MOD_CK1_1	150	156	PF00069	0.643
MOD_CK1_1	186	192	PF00069	0.701
MOD_CK1_1	194	200	PF00069	0.697
MOD_CK1_1	246	252	PF00069	0.704
MOD_CK1_1	279	285	PF00069	0.659
MOD_CK1_1	310	316	PF00069	0.655
MOD_CK1_1	386	392	PF00069	0.570
MOD_CK1_1	412	418	PF00069	0.625
MOD_CK1_1	42	48	PF00069	0.810
MOD_CK1_1	554	560	PF00069	0.695
MOD_CK1_1	685	691	PF00069	0.763
MOD_CK1_1	810	816	PF00069	0.793
MOD_CK1_1	840	846	PF00069	0.585
MOD_CK1_1	97	103	PF00069	0.769
MOD_CK2_1	274	280	PF00069	0.528
MOD_CK2_1	323	329	PF00069	0.573
MOD_CK2_1	557	563	PF00069	0.529
MOD_CMANNOS	575	578	PF00535	0.571
MOD_GlcNHglycan	126	129	PF01048	0.809
MOD_GlcNHglycan	152	155	PF01048	0.752
MOD_GlcNHglycan	245	248	PF01048	0.779
MOD_GlcNHglycan	256	259	PF01048	0.544
MOD_GlcNHglycan	276	279	PF01048	0.636
MOD_GlcNHglycan	3	6	PF01048	0.566
MOD_GlcNHglycan	309	312	PF01048	0.683
MOD_GlcNHglycan	403	407	PF01048	0.637
MOD_GlcNHglycan	41	44	PF01048	0.722
MOD_GlcNHglycan	410	414	PF01048	0.616
MOD_GlcNHglycan	415	418	PF01048	0.545
MOD_GlcNHglycan	581	584	PF01048	0.677
MOD_GlcNHglycan	602	605	PF01048	0.830
MOD_GlcNHglycan	656	659	PF01048	0.551
MOD_GlcNHglycan	707	710	PF01048	0.626
MOD_GlcNHglycan	726	729	PF01048	0.758
MOD_GlcNHglycan	745	748	PF01048	0.569
MOD_GlcNHglycan	809	812	PF01048	0.699
MOD_GlcNHglycan	902	905	PF01048	0.751
MOD_GlcNHglycan	915	918	PF01048	0.540
MOD_GlcNHglycan	923	926	PF01048	0.755
MOD_GlcNHglycan	97	100	PF01048	0.738
MOD_GSK3_1	116	123	PF00069	0.699
MOD_GSK3_1	124	131	PF00069	0.625
MOD_GSK3_1	172	179	PF00069	0.737
MOD_GSK3_1	183	190	PF00069	0.662
MOD_GSK3_1	194	201	PF00069	0.736
MOD_GSK3_1	237	244	PF00069	0.735
MOD_GSK3_1	246	253	PF00069	0.770
MOD_GSK3_1	285	292	PF00069	0.633
MOD_GSK3_1	29	36	PF00069	0.587
MOD_GSK3_1	295	302	PF00069	0.650
MOD_GSK3_1	306	313	PF00069	0.751
MOD_GSK3_1	379	386	PF00069	0.638
MOD_GSK3_1	398	405	PF00069	0.655
MOD_GSK3_1	409	416	PF00069	0.727
MOD_GSK3_1	508	515	PF00069	0.399
MOD_GSK3_1	551	558	PF00069	0.693
MOD_GSK3_1	591	598	PF00069	0.695
MOD_GSK3_1	619	626	PF00069	0.693
MOD_GSK3_1	769	776	PF00069	0.610
MOD_GSK3_1	786	793	PF00069	0.582
MOD_GSK3_1	894	901	PF00069	0.651
MOD_GSK3_1	95	102	PF00069	0.629
MOD_NEK2_1	1	6	PF00069	0.611
MOD_NEK2_1	289	294	PF00069	0.688
MOD_NEK2_1	317	322	PF00069	0.577
MOD_NEK2_1	431	436	PF00069	0.362
MOD_NEK2_2	203	208	PF00069	0.757
MOD_NEK2_2	842	847	PF00069	0.479
MOD_PIKK_1	231	237	PF00454	0.703
MOD_PIKK_1	279	285	PF00454	0.523
MOD_PIKK_1	340	346	PF00454	0.605
MOD_PIKK_1	505	511	PF00454	0.519
MOD_PIKK_1	551	557	PF00454	0.774
MOD_PIKK_1	858	864	PF00454	0.540
MOD_PKA_1	51	57	PF00069	0.651
MOD_PKA_1	641	647	PF00069	0.682
MOD_PKA_1	95	101	PF00069	0.568
MOD_PKA_2	150	156	PF00069	0.674
MOD_PKA_2	165	171	PF00069	0.559
MOD_PKA_2	386	392	PF00069	0.767
MOD_PKA_2	431	437	PF00069	0.363
MOD_PKA_2	513	519	PF00069	0.627
MOD_PKA_2	718	724	PF00069	0.566
MOD_PKA_2	779	785	PF00069	0.671
MOD_PKA_2	84	90	PF00069	0.579
MOD_PKA_2	894	900	PF00069	0.602
MOD_PKA_2	94	100	PF00069	0.679
MOD_Plk_1	279	285	PF00069	0.791
MOD_Plk_1	402	408	PF00069	0.550
MOD_Plk_1	605	611	PF00069	0.557
MOD_Plk_4	109	115	PF00069	0.739
MOD_Plk_4	222	228	PF00069	0.724
MOD_Plk_4	250	256	PF00069	0.708
MOD_Plk_4	271	277	PF00069	0.622
MOD_Plk_4	33	39	PF00069	0.555
MOD_Plk_4	391	397	PF00069	0.640
MOD_Plk_4	711	717	PF00069	0.630
MOD_Plk_4	842	848	PF00069	0.506
MOD_ProDKin_1	114	120	PF00069	0.533
MOD_ProDKin_1	187	193	PF00069	0.830
MOD_ProDKin_1	198	204	PF00069	0.572
MOD_ProDKin_1	225	231	PF00069	0.721
MOD_ProDKin_1	237	243	PF00069	0.689
MOD_ProDKin_1	290	296	PF00069	0.767
MOD_ProDKin_1	323	329	PF00069	0.644
MOD_ProDKin_1	348	354	PF00069	0.748
MOD_ProDKin_1	368	374	PF00069	0.551
MOD_ProDKin_1	42	48	PF00069	0.769
MOD_ProDKin_1	467	473	PF00069	0.688
MOD_ProDKin_1	541	547	PF00069	0.783
MOD_ProDKin_1	668	674	PF00069	0.576
MOD_ProDKin_1	685	691	PF00069	0.767
MOD_ProDKin_1	698	704	PF00069	0.552
MOD_ProDKin_1	748	754	PF00069	0.742
MOD_ProDKin_1	762	768	PF00069	0.749
MOD_ProDKin_1	799	805	PF00069	0.693
MOD_ProDKin_1	898	904	PF00069	0.600
MOD_ProDKin_1	905	911	PF00069	0.668
MOD_ProDKin_1	915	921	PF00069	0.790
MOD_ProDKin_1	97	103	PF00069	0.758
MOD_SUMO_rev_2	635	644	PF00179	0.574
TRG_DiLeu_BaLyEn_6	258	263	PF01217	0.522
TRG_DiLeu_BaLyEn_6	441	446	PF01217	0.356
TRG_DiLeu_BaLyEn_6	468	473	PF01217	0.517
TRG_ENDOCYTIC_2	683	686	PF00928	0.740
TRG_ENDOCYTIC_2	717	720	PF00928	0.620
TRG_ER_diArg_1	136	139	PF00400	0.826
TRG_ER_diArg_1	166	169	PF00400	0.745
TRG_ER_diArg_1	459	462	PF00400	0.514
TRG_Pf-PMV_PEXEL_1	315	319	PF00026	0.539
TRG_Pf-PMV_PEXEL_1	497	501	PF00026	0.473
TRG_Pf-PMV_PEXEL_1	64	69	PF00026	0.571
TRG_Pf-PMV_PEXEL_1	875	879	PF00026	0.567

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I094	Leptomonas seymouri	34%	86%
A0A3S5H766	Leishmania donovani	62%	99%
A4HYD5	Leishmania infantum	63%	94%
E9AS68	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	94%
Q4QD98	Leishmania major	61%	97%