CHCH domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CHCH domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HA62_LEIBR

TriTrypDb:

LbrM.19.1380 , LBRM2903_190019900

Length:

130

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005758	mitochondrial intermembrane space	6	1
GO:0031970	organelle envelope lumen	5	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HA62

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HA62

Function

Biological processes
Term	Name	Level	Count
GO:0008535	respiratory chain complex IV assembly	7	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0017004	cytochrome complex assembly	6	1
GO:0022607	cellular component assembly	4	1
GO:0033108	mitochondrial respiratory chain complex assembly	6	1
GO:0033617	mitochondrial cytochrome c oxidase assembly	7	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DEG_APCC_KENBOX_2	41	45	PF00400	0.543
DOC_CKS1_1	118	123	PF01111	0.629
DOC_CKS1_1	46	51	PF01111	0.467
DOC_MAPK_gen_1	99	107	PF00069	0.622
DOC_PP4_FxxP_1	76	79	PF00568	0.455
DOC_USP7_UBL2_3	70	74	PF12436	0.612
DOC_WW_Pin1_4	117	122	PF00397	0.633
DOC_WW_Pin1_4	45	50	PF00397	0.480
LIG_14-3-3_CanoR_1	11	19	PF00244	0.591
LIG_BIR_II_1	1	5	PF00653	0.593
LIG_CtBP_PxDLS_1	16	20	PF00389	0.634
LIG_FHA_1	79	85	PF00498	0.448
LIG_LIR_Apic_2	43	49	PF02991	0.441
LIG_LIR_Apic_2	75	79	PF02991	0.484
LIG_LIR_Gen_1	35	46	PF02991	0.427
LIG_LIR_Nem_3	35	41	PF02991	0.413
LIG_SH2_CRK	38	42	PF00017	0.441
LIG_SH2_CRK	46	50	PF00017	0.446
LIG_SH2_STAT5	113	116	PF00017	0.685
LIG_SH2_STAT5	58	61	PF00017	0.552
LIG_WRC_WIRS_1	73	78	PF05994	0.574
MOD_CDK_SPxxK_3	45	52	PF00069	0.467
MOD_GSK3_1	68	75	PF00069	0.559
MOD_NEK2_1	10	15	PF00069	0.583
MOD_PKA_2	10	16	PF00069	0.605
MOD_ProDKin_1	117	123	PF00069	0.623
MOD_ProDKin_1	45	51	PF00069	0.472
TRG_ENDOCYTIC_2	38	41	PF00928	0.409
TRG_ER_diLys_1	126	130	PF00400	0.647
TRG_NES_CRM1_1	96	111	PF08389	0.608

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P869	Leptomonas seymouri	83%	100%
A0A0S4JMW5	Bodo saltans	64%	100%
A0A1X0P636	Trypanosomatidae	76%	90%
A0A3R7MHI5	Trypanosoma rangeli	75%	86%
A0A3S7WVM9	Leishmania donovani	94%	100%
A4HYD7	Leishmania infantum	94%	100%
D0A0R8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	70%	90%
E9AS70	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QD96	Leishmania major	93%	100%