PINc domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Fcf1, putative

Species:

Leishmania braziliensis

UniProt:

A4HA60_LEIBR

TriTrypDb:

LbrM.19.1360 , LBRM2903_190020100

Length:

209

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	11
GO:0030684	preribosome	3	11
GO:0032040	small-subunit processome	4	11
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:1990904	ribonucleoprotein complex	2	11

Expansion

Sequence features

A4HA60

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HA60

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006364	rRNA processing	8	11
GO:0006396	RNA processing	6	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0016072	rRNA metabolic process	7	11
GO:0034470	ncRNA processing	7	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034660	ncRNA metabolic process	6	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	178	180	PF00675	0.306
CLV_NRD_NRD_1	54	56	PF00675	0.642
CLV_PCSK_FUR_1	139	143	PF00082	0.306
CLV_PCSK_KEX2_1	141	143	PF00082	0.306
CLV_PCSK_KEX2_1	177	179	PF00082	0.306
CLV_PCSK_KEX2_1	27	29	PF00082	0.589
CLV_PCSK_KEX2_1	5	7	PF00082	0.647
CLV_PCSK_PC1ET2_1	141	143	PF00082	0.306
CLV_PCSK_PC1ET2_1	177	179	PF00082	0.306
CLV_PCSK_PC1ET2_1	27	29	PF00082	0.607
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.650
CLV_PCSK_SKI1_1	13	17	PF00082	0.576
CLV_PCSK_SKI1_1	132	136	PF00082	0.293
CLV_PCSK_SKI1_1	159	163	PF00082	0.325
CLV_PCSK_SKI1_1	43	47	PF00082	0.663
DOC_CYCLIN_yCln2_LP_2	77	83	PF00134	0.444
DOC_MAPK_DCC_7	178	188	PF00069	0.306
DOC_MAPK_gen_1	126	135	PF00069	0.306
DOC_MAPK_gen_1	177	188	PF00069	0.306
DOC_MAPK_HePTP_8	176	188	PF00069	0.306
DOC_MAPK_MEF2A_6	129	137	PF00069	0.306
DOC_MAPK_MEF2A_6	179	188	PF00069	0.306
DOC_MAPK_NFAT4_5	130	138	PF00069	0.306
DOC_PP2B_LxvP_1	77	80	PF13499	0.478
DOC_USP7_UBL2_3	126	130	PF12436	0.306
DOC_USP7_UBL2_3	14	18	PF12436	0.666
DOC_USP7_UBL2_3	43	47	PF12436	0.655
DOC_WW_Pin1_4	33	38	PF00397	0.681
LIG_14-3-3_CanoR_1	145	152	PF00244	0.307
LIG_14-3-3_CanoR_1	159	168	PF00244	0.330
LIG_Actin_WH2_2	120	138	PF00022	0.306
LIG_EH1_1	9	17	PF00400	0.603
LIG_FHA_1	85	91	PF00498	0.391
LIG_GBD_Chelix_1	100	108	PF00786	0.409
LIG_LIR_Apic_2	203	208	PF02991	0.554
LIG_LIR_Gen_1	118	127	PF02991	0.417
LIG_LIR_Gen_1	140	149	PF02991	0.417
LIG_LIR_Gen_1	46	57	PF02991	0.652
LIG_LIR_Gen_1	86	94	PF02991	0.445
LIG_LIR_Nem_3	118	124	PF02991	0.417
LIG_LIR_Nem_3	140	146	PF02991	0.306
LIG_LIR_Nem_3	46	52	PF02991	0.659
LIG_LIR_Nem_3	67	73	PF02991	0.536
LIG_LIR_Nem_3	86	92	PF02991	0.403
LIG_PCNA_yPIPBox_3	97	109	PF02747	0.530
LIG_SH2_CRK	205	209	PF00017	0.451
LIG_SH2_CRK	49	53	PF00017	0.655
LIG_SH2_STAP1	49	53	PF00017	0.687
LIG_SH2_STAT5	167	170	PF00017	0.306
LIG_SH2_STAT5	190	193	PF00017	0.306
LIG_SH2_STAT5	196	199	PF00017	0.306
LIG_SH3_1	181	187	PF00018	0.306
LIG_SH3_3	181	187	PF00018	0.306
LIG_UBA3_1	104	111	PF00899	0.306
LIG_UBA3_1	188	193	PF00899	0.306
MOD_CK1_1	72	78	PF00069	0.631
MOD_CK2_1	29	35	PF00069	0.664
MOD_Cter_Amidation	127	130	PF01082	0.306
MOD_GSK3_1	29	36	PF00069	0.662
MOD_GSK3_1	39	46	PF00069	0.591
MOD_N-GLC_1	39	44	PF02516	0.676
MOD_N-GLC_1	90	95	PF02516	0.477
MOD_NEK2_1	189	194	PF00069	0.227
MOD_PIKK_1	159	165	PF00454	0.378
MOD_PIKK_1	57	63	PF00454	0.592
MOD_PKA_2	144	150	PF00069	0.306
MOD_PKA_2	194	200	PF00069	0.297
MOD_Plk_1	18	24	PF00069	0.615
MOD_Plk_1	90	96	PF00069	0.479
MOD_Plk_2-3	29	35	PF00069	0.647
MOD_ProDKin_1	33	39	PF00069	0.680
MOD_SUMO_rev_2	144	153	PF00179	0.383
TRG_ENDOCYTIC_2	49	52	PF00928	0.645
TRG_ER_diArg_1	178	181	PF00400	0.306
TRG_NES_CRM1_1	125	140	PF08389	0.306
TRG_NLS_MonoExtC_3	176	181	PF00514	0.306
TRG_NLS_MonoExtN_4	126	133	PF00514	0.306

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7T8	Leptomonas seymouri	92%	100%
A0A0S4JGW7	Bodo saltans	75%	100%
A0A1X0P7I3	Trypanosomatidae	78%	100%
A0A3Q8IAB0	Leishmania donovani	96%	100%
A0A3R7LSN9	Trypanosoma rangeli	77%	100%
A4HYD9	Leishmania infantum	96%	100%
D0A0S4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	78%	100%
E9AS72	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
O13610	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	54%	100%
O74862	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	80%
Q05498	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	48%	100%
Q32PD0	Bos taurus	52%	100%
Q4QD94	Leishmania major	95%	100%
Q55GM5	Dictyostelium discoideum	59%	100%
Q5RFQ0	Pongo abelii	52%	100%
Q9CTH6	Mus musculus	52%	100%
Q9Y324	Homo sapiens	52%	100%