Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HA59_LEIBR

TriTrypDb:

LbrM.19.1350 , LBRM2903_190020200

Length:

293

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HA59

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HA59

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	65	69	PF00656	0.478
CLV_NRD_NRD_1	179	181	PF00675	0.585
CLV_NRD_NRD_1	260	262	PF00675	0.534
CLV_NRD_NRD_1	54	56	PF00675	0.416
CLV_NRD_NRD_1	72	74	PF00675	0.416
CLV_NRD_NRD_1	85	87	PF00675	0.439
CLV_PCSK_FUR_1	260	264	PF00082	0.524
CLV_PCSK_KEX2_1	179	181	PF00082	0.518
CLV_PCSK_KEX2_1	260	262	PF00082	0.534
CLV_PCSK_KEX2_1	54	56	PF00082	0.416
CLV_PCSK_KEX2_1	71	73	PF00082	0.424
CLV_PCSK_PC1ET2_1	262	264	PF00082	0.516
CLV_PCSK_PC7_1	256	262	PF00082	0.610
CLV_PCSK_SKI1_1	180	184	PF00082	0.468
DEG_Nend_Nbox_1	1	3	PF02207	0.630
DEG_SCF_FBW7_1	168	173	PF00400	0.502
DOC_USP7_MATH_1	170	174	PF00917	0.489
DOC_USP7_MATH_1	236	240	PF00917	0.670
DOC_WW_Pin1_4	166	171	PF00397	0.510
DOC_WW_Pin1_4	3	8	PF00397	0.552
LIG_14-3-3_CanoR_1	54	59	PF00244	0.388
LIG_14-3-3_CanoR_1	86	96	PF00244	0.384
LIG_BRCT_BRCA1_1	172	176	PF00533	0.429
LIG_BRCT_BRCA1_1	56	60	PF00533	0.396
LIG_FHA_1	88	94	PF00498	0.497
LIG_LIR_Apic_2	286	292	PF02991	0.703
LIG_LIR_Gen_1	57	64	PF02991	0.486
LIG_LIR_Nem_3	190	195	PF02991	0.520
LIG_LIR_Nem_3	57	61	PF02991	0.373
LIG_NRBOX	92	98	PF00104	0.323
LIG_SH2_CRK	192	196	PF00017	0.393
LIG_SH2_SRC	92	95	PF00017	0.462
LIG_SH2_STAP1	151	155	PF00017	0.418
LIG_SH2_STAT3	118	121	PF00017	0.540
LIG_SH2_STAT3	273	276	PF00017	0.533
LIG_SH2_STAT5	118	121	PF00017	0.398
LIG_SH2_STAT5	134	137	PF00017	0.356
LIG_SH2_STAT5	92	95	PF00017	0.427
MOD_CDC14_SPxK_1	6	9	PF00782	0.460
MOD_CDK_SPK_2	166	171	PF00069	0.445
MOD_CDK_SPxK_1	3	9	PF00069	0.459
MOD_CK1_1	162	168	PF00069	0.551
MOD_CK1_1	240	246	PF00069	0.630
MOD_CK1_1	279	285	PF00069	0.619
MOD_CK1_1	30	36	PF00069	0.585
MOD_CK1_1	44	50	PF00069	0.641
MOD_CK2_1	240	246	PF00069	0.627
MOD_CK2_1	280	286	PF00069	0.665
MOD_GlcNHglycan	110	113	PF01048	0.446
MOD_GlcNHglycan	164	167	PF01048	0.577
MOD_GlcNHglycan	176	179	PF01048	0.424
MOD_GlcNHglycan	221	224	PF01048	0.587
MOD_GlcNHglycan	33	36	PF01048	0.626
MOD_GlcNHglycan	43	46	PF01048	0.638
MOD_GSK3_1	162	169	PF00069	0.480
MOD_GSK3_1	170	177	PF00069	0.439
MOD_GSK3_1	219	226	PF00069	0.656
MOD_GSK3_1	236	243	PF00069	0.556
MOD_GSK3_1	27	34	PF00069	0.607
MOD_GSK3_1	276	283	PF00069	0.648
MOD_GSK3_1	36	43	PF00069	0.594
MOD_N-GLC_1	116	121	PF02516	0.316
MOD_N-GLC_1	237	242	PF02516	0.601
MOD_NEK2_1	128	133	PF00069	0.354
MOD_NEK2_1	252	257	PF00069	0.454
MOD_NEK2_1	99	104	PF00069	0.339
MOD_NEK2_2	178	183	PF00069	0.309
MOD_PKA_1	54	60	PF00069	0.388
MOD_PKA_1	86	92	PF00069	0.522
MOD_PKA_2	178	184	PF00069	0.450
MOD_PKA_2	219	225	PF00069	0.715
MOD_PKA_2	228	234	PF00069	0.773
MOD_PKA_2	54	60	PF00069	0.441
MOD_Plk_1	159	165	PF00069	0.501
MOD_Plk_1	240	246	PF00069	0.541
MOD_Plk_4	128	134	PF00069	0.354
MOD_Plk_4	170	176	PF00069	0.431
MOD_Plk_4	92	98	PF00069	0.365
MOD_ProDKin_1	166	172	PF00069	0.511
MOD_ProDKin_1	3	9	PF00069	0.555
TRG_ENDOCYTIC_2	192	195	PF00928	0.379
TRG_ENDOCYTIC_2	58	61	PF00928	0.363
TRG_ER_diArg_1	260	263	PF00400	0.527
TRG_ER_diArg_1	71	73	PF00400	0.424
TRG_NLS_MonoExtC_3	182	188	PF00514	0.446
TRG_NLS_MonoExtN_4	180	187	PF00514	0.457
TRG_Pf-PMV_PEXEL_1	193	197	PF00026	0.307
TRG_Pf-PMV_PEXEL_1	72	76	PF00026	0.584

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDU4	Leptomonas seymouri	59%	100%
A0A1X0P732	Trypanosomatidae	47%	99%
A0A3R7K6K4	Trypanosoma rangeli	45%	100%
A0A3S7WVI0	Leishmania donovani	83%	100%
A4HYE0	Leishmania infantum	83%	100%
D0A0S5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AS73	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4QD93	Leishmania major	81%	100%
V5BNH1	Trypanosoma cruzi	43%	100%