Cir_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HA55_LEIBR

TriTrypDb:

LbrM.19.1310 , LBRM2903_190014100

Length:

285

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HA55

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HA55

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	148	152	PF00656	0.543
CLV_NRD_NRD_1	166	168	PF00675	0.650
CLV_NRD_NRD_1	194	196	PF00675	0.597
CLV_NRD_NRD_1	217	219	PF00675	0.519
CLV_NRD_NRD_1	227	229	PF00675	0.459
CLV_NRD_NRD_1	24	26	PF00675	0.499
CLV_NRD_NRD_1	281	283	PF00675	0.446
CLV_NRD_NRD_1	54	56	PF00675	0.460
CLV_PCSK_KEX2_1	168	170	PF00082	0.649
CLV_PCSK_KEX2_1	226	228	PF00082	0.410
CLV_PCSK_KEX2_1	24	26	PF00082	0.499
CLV_PCSK_KEX2_1	281	283	PF00082	0.404
CLV_PCSK_KEX2_1	54	56	PF00082	0.460
CLV_PCSK_PC1ET2_1	168	170	PF00082	0.649
CLV_PCSK_PC1ET2_1	226	228	PF00082	0.383
CLV_PCSK_PC1ET2_1	281	283	PF00082	0.404
CLV_PCSK_SKI1_1	274	278	PF00082	0.530
CLV_PCSK_SKI1_1	79	83	PF00082	0.508
CLV_PCSK_SKI1_1	91	95	PF00082	0.482
DEG_APCC_KENBOX_2	195	199	PF00400	0.500
DEG_Nend_Nbox_1	1	3	PF02207	0.530
DOC_MAPK_gen_1	226	235	PF00069	0.604
DOC_MAPK_gen_1	272	279	PF00069	0.531
DOC_MAPK_gen_1	54	61	PF00069	0.422
DOC_USP7_MATH_1	104	108	PF00917	0.688
DOC_USP7_MATH_1	152	156	PF00917	0.775
DOC_USP7_MATH_1	64	68	PF00917	0.378
DOC_WW_Pin1_4	161	166	PF00397	0.649
DOC_WW_Pin1_4	97	102	PF00397	0.702
LIG_14-3-3_CanoR_1	11	16	PF00244	0.395
LIG_BRCT_BRCA1_1	117	121	PF00533	0.547
LIG_FHA_1	204	210	PF00498	0.526
LIG_FHA_1	76	82	PF00498	0.578
LIG_FHA_2	208	214	PF00498	0.501
LIG_FHA_2	254	260	PF00498	0.553
LIG_LIR_Gen_1	53	64	PF02991	0.543
LIG_LIR_Nem_3	14	18	PF02991	0.454
LIG_LIR_Nem_3	19	23	PF02991	0.437
LIG_LIR_Nem_3	53	59	PF02991	0.582
LIG_PCNA_yPIPBox_3	266	277	PF02747	0.553
LIG_Pex14_2	126	130	PF04695	0.610
LIG_SH2_CRK	20	24	PF00017	0.459
LIG_SH2_GRB2like	238	241	PF00017	0.537
LIG_SH2_SRC	238	241	PF00017	0.537
LIG_SH2_STAP1	56	60	PF00017	0.419
LIG_SH2_STAP1	86	90	PF00017	0.574
LIG_SH3_3	95	101	PF00018	0.753
LIG_TYR_ITIM	18	23	PF00017	0.455
LIG_UBA3_1	276	283	PF00899	0.427
MOD_CDK_SPxK_1	161	167	PF00069	0.558
MOD_CDK_SPxxK_3	161	168	PF00069	0.560
MOD_CK1_1	100	106	PF00069	0.667
MOD_CK2_1	207	213	PF00069	0.567
MOD_CK2_1	253	259	PF00069	0.403
MOD_GlcNHglycan	117	120	PF01048	0.550
MOD_GlcNHglycan	154	157	PF01048	0.743
MOD_GlcNHglycan	184	188	PF01048	0.697
MOD_GlcNHglycan	199	202	PF01048	0.519
MOD_GlcNHglycan	210	213	PF01048	0.460
MOD_GlcNHglycan	68	71	PF01048	0.439
MOD_GSK3_1	100	107	PF00069	0.657
MOD_GSK3_1	113	120	PF00069	0.565
MOD_GSK3_1	203	210	PF00069	0.492
MOD_N-GLC_1	11	16	PF02516	0.430
MOD_N-GLC_1	197	202	PF02516	0.574
MOD_N-GLC_2	240	242	PF02516	0.530
MOD_NEK2_1	113	118	PF00069	0.630
MOD_PIKK_1	190	196	PF00454	0.511
MOD_PKA_2	75	81	PF00069	0.547
MOD_Plk_1	11	17	PF00069	0.472
MOD_ProDKin_1	161	167	PF00069	0.650
MOD_ProDKin_1	97	103	PF00069	0.701
MOD_SUMO_for_1	130	133	PF00179	0.566
MOD_SUMO_for_1	142	145	PF00179	0.621
MOD_SUMO_rev_2	85	93	PF00179	0.513
TRG_ENDOCYTIC_2	20	23	PF00928	0.458
TRG_ENDOCYTIC_2	56	59	PF00928	0.473
TRG_ER_diArg_1	166	169	PF00400	0.708
TRG_ER_diArg_1	23	25	PF00400	0.497
TRG_ER_diArg_1	54	56	PF00400	0.454
TRG_ER_diLys_1	281	285	PF00400	0.556
TRG_NLS_MonoCore_2	279	284	PF00514	0.481
TRG_NLS_MonoExtC_3	166	171	PF00514	0.651
TRG_NLS_MonoExtC_3	279	285	PF00514	0.494
TRG_NLS_MonoExtN_4	165	171	PF00514	0.656

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD46	Leptomonas seymouri	49%	100%
A0A3S7WVP3	Leishmania donovani	77%	97%
A0A422NC58	Trypanosoma rangeli	43%	100%
A4HYC0	Leishmania infantum	76%	97%
D0A642	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AS54	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	99%
Q4QDB2	Leishmania major	77%	100%
V5BKZ5	Trypanosoma cruzi	42%	100%