Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat, putative

Species:

Leishmania braziliensis

UniProt:

A4HA53_LEIBR

TriTrypDb:

LbrM.19.1290 , LBRM2903_190014300

Length:

803

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	6
GO:0031931	TORC1 complex	4	8
GO:0031932	TORC2 complex	4	8
GO:0032991	protein-containing complex	1	8
GO:0038201	TOR complex	3	8
GO:0043226	organelle	2	6
GO:0043228	non-membrane-bounded organelle	3	6
GO:0043229	intracellular organelle	3	6
GO:0043232	intracellular non-membrane-bounded organelle	4	6
GO:0110165	cellular anatomical entity	1	6
GO:0140535	intracellular protein-containing complex	2	8
GO:1990904	ribonucleoprotein complex	2	6
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4HA53

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HA53

Function

Biological processes
Term	Name	Level	Count
GO:0007165	signal transduction	2	8
GO:0009987	cellular process	1	8
GO:0031929	TOR signaling	4	8
GO:0035556	intracellular signal transduction	3	8
GO:0050789	regulation of biological process	2	8
GO:0050794	regulation of cellular process	3	8
GO:0065007	biological regulation	1	8
GO:0032956	regulation of actin cytoskeleton organization	5	1
GO:0032970	regulation of actin filament-based process	4	1
GO:0033043	regulation of organelle organization	5	1
GO:0051128	regulation of cellular component organization	4	1
GO:0051493	regulation of cytoskeleton organization	6	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	665	669	PF00656	0.705
CLV_NRD_NRD_1	205	207	PF00675	0.539
CLV_NRD_NRD_1	345	347	PF00675	0.575
CLV_NRD_NRD_1	798	800	PF00675	0.614
CLV_PCSK_KEX2_1	205	207	PF00082	0.608
CLV_PCSK_KEX2_1	345	347	PF00082	0.575
CLV_PCSK_KEX2_1	797	799	PF00082	0.530
CLV_PCSK_PC1ET2_1	797	799	PF00082	0.568
CLV_PCSK_SKI1_1	185	189	PF00082	0.526
CLV_PCSK_SKI1_1	206	210	PF00082	0.505
CLV_PCSK_SKI1_1	24	28	PF00082	0.525
CLV_PCSK_SKI1_1	259	263	PF00082	0.632
CLV_PCSK_SKI1_1	270	274	PF00082	0.581
CLV_PCSK_SKI1_1	338	342	PF00082	0.714
CLV_PCSK_SKI1_1	345	349	PF00082	0.682
CLV_PCSK_SKI1_1	433	437	PF00082	0.600
CLV_PCSK_SKI1_1	542	546	PF00082	0.427
DEG_APCC_DBOX_1	286	294	PF00400	0.560
DEG_SCF_FBW7_2	252	258	PF00400	0.566
DOC_ANK_TNKS_1	602	609	PF00023	0.580
DOC_CKS1_1	252	257	PF01111	0.565
DOC_MAPK_gen_1	155	165	PF00069	0.384
DOC_MAPK_MEF2A_6	542	549	PF00069	0.427
DOC_MAPK_MEF2A_6	786	793	PF00069	0.479
DOC_PP1_RVXF_1	320	326	PF00149	0.410
DOC_PP4_FxxP_1	40	43	PF00568	0.484
DOC_PP4_FxxP_1	568	571	PF00568	0.434
DOC_SPAK_OSR1_1	567	571	PF12202	0.430
DOC_USP7_MATH_1	301	305	PF00917	0.425
DOC_USP7_MATH_1	355	359	PF00917	0.766
DOC_USP7_MATH_1	376	380	PF00917	0.684
DOC_USP7_MATH_1	445	449	PF00917	0.627
DOC_USP7_MATH_1	517	521	PF00917	0.718
DOC_USP7_MATH_1	683	687	PF00917	0.685
DOC_USP7_MATH_1	698	702	PF00917	0.696
DOC_USP7_MATH_1	81	85	PF00917	0.693
DOC_WW_Pin1_4	199	204	PF00397	0.443
DOC_WW_Pin1_4	248	253	PF00397	0.785
DOC_WW_Pin1_4	285	290	PF00397	0.404
DOC_WW_Pin1_4	372	377	PF00397	0.775
DOC_WW_Pin1_4	380	385	PF00397	0.825
DOC_WW_Pin1_4	398	403	PF00397	0.501
DOC_WW_Pin1_4	502	507	PF00397	0.573
DOC_WW_Pin1_4	547	552	PF00397	0.420
DOC_WW_Pin1_4	672	677	PF00397	0.818
DOC_WW_Pin1_4	708	713	PF00397	0.697
DOC_WW_Pin1_4	77	82	PF00397	0.568
LIG_14-3-3_CanoR_1	145	151	PF00244	0.649
LIG_14-3-3_CanoR_1	174	184	PF00244	0.480
LIG_14-3-3_CanoR_1	24	30	PF00244	0.433
LIG_14-3-3_CanoR_1	575	582	PF00244	0.570
LIG_14-3-3_CanoR_1	775	780	PF00244	0.508
LIG_14-3-3_CterR_2	798	803	PF00244	0.471
LIG_Actin_WH2_2	143	160	PF00022	0.453
LIG_Actin_WH2_2	562	577	PF00022	0.498
LIG_APCC_ABBA_1	725	730	PF00400	0.478
LIG_APCC_ABBAyCdc20_2	27	33	PF00400	0.582
LIG_BIR_III_4	450	454	PF00653	0.582
LIG_BRCT_BRCA1_1	101	105	PF00533	0.481
LIG_BRCT_BRCA1_1	27	31	PF00533	0.491
LIG_BRCT_BRCA1_1	777	781	PF00533	0.546
LIG_eIF4E_1	543	549	PF01652	0.475
LIG_FHA_1	181	187	PF00498	0.381
LIG_FHA_1	346	352	PF00498	0.699
LIG_FHA_1	395	401	PF00498	0.775
LIG_FHA_1	406	412	PF00498	0.653
LIG_FHA_1	43	49	PF00498	0.504
LIG_FHA_1	635	641	PF00498	0.749
LIG_FHA_1	703	709	PF00498	0.559
LIG_FHA_2	151	157	PF00498	0.511
LIG_FHA_2	165	171	PF00498	0.429
LIG_FHA_2	273	279	PF00498	0.535
LIG_FHA_2	351	357	PF00498	0.783
LIG_FHA_2	362	368	PF00498	0.713
LIG_FHA_2	390	396	PF00498	0.564
LIG_GBD_Chelix_1	225	233	PF00786	0.347
LIG_LIR_Apic_2	218	223	PF02991	0.437
LIG_LIR_Apic_2	38	43	PF02991	0.477
LIG_LIR_Apic_2	421	427	PF02991	0.719
LIG_LIR_Gen_1	102	113	PF02991	0.513
LIG_LIR_Gen_1	159	166	PF02991	0.546
LIG_LIR_Gen_1	298	307	PF02991	0.430
LIG_LIR_Gen_1	44	55	PF02991	0.439
LIG_LIR_Gen_1	532	541	PF02991	0.497
LIG_LIR_LC3C_4	434	438	PF02991	0.620
LIG_LIR_Nem_3	102	108	PF02991	0.492
LIG_LIR_Nem_3	159	165	PF02991	0.556
LIG_LIR_Nem_3	298	302	PF02991	0.507
LIG_LIR_Nem_3	387	391	PF02991	0.574
LIG_LIR_Nem_3	44	50	PF02991	0.432
LIG_LIR_Nem_3	532	537	PF02991	0.502
LIG_LIR_Nem_3	730	734	PF02991	0.430
LIG_Pex14_1	745	749	PF04695	0.517
LIG_SH2_CRK	299	303	PF00017	0.426
LIG_SH2_CRK	388	392	PF00017	0.787
LIG_SH2_CRK	424	428	PF00017	0.713
LIG_SH2_CRK	541	545	PF00017	0.495
LIG_SH2_STAP1	11	15	PF00017	0.436
LIG_SH2_STAT3	11	14	PF00017	0.442
LIG_SH2_STAT5	207	210	PF00017	0.497
LIG_SH2_STAT5	47	50	PF00017	0.412
LIG_SH2_STAT5	543	546	PF00017	0.402
LIG_SH3_3	249	255	PF00018	0.675
LIG_SH3_3	370	376	PF00018	0.690
LIG_SH3_3	730	736	PF00018	0.385
LIG_SUMO_SIM_anti_2	2	8	PF11976	0.552
LIG_SUMO_SIM_par_1	2	8	PF11976	0.494
LIG_TRAF2_1	276	279	PF00917	0.685
LIG_TRAF2_1	364	367	PF00917	0.660
LIG_TYR_ITSM	43	50	PF00017	0.503
LIG_WRC_WIRS_1	26	31	PF05994	0.500
LIG_WRC_WIRS_1	61	66	PF05994	0.606
LIG_WRC_WIRS_1	94	99	PF05994	0.537
LIG_WW_1	91	94	PF00397	0.575
MOD_CDC14_SPxK_1	202	205	PF00782	0.469
MOD_CDC14_SPxK_1	383	386	PF00782	0.740
MOD_CDK_SPxK_1	199	205	PF00069	0.448
MOD_CDK_SPxK_1	380	386	PF00069	0.746
MOD_CDK_SPxK_1	708	714	PF00069	0.553
MOD_CDK_SPxxK_3	199	206	PF00069	0.527
MOD_CK1_1	124	130	PF00069	0.699
MOD_CK1_1	136	142	PF00069	0.572
MOD_CK1_1	180	186	PF00069	0.553
MOD_CK1_1	199	205	PF00069	0.291
MOD_CK1_1	22	28	PF00069	0.469
MOD_CK1_1	248	254	PF00069	0.786
MOD_CK1_1	379	385	PF00069	0.675
MOD_CK1_1	398	404	PF00069	0.729
MOD_CK1_1	467	473	PF00069	0.658
MOD_CK1_1	493	499	PF00069	0.727
MOD_CK1_1	633	639	PF00069	0.584
MOD_CK1_1	669	675	PF00069	0.694
MOD_CK1_1	701	707	PF00069	0.629
MOD_CK1_1	738	744	PF00069	0.522
MOD_CK1_1	750	756	PF00069	0.548
MOD_CK1_1	761	767	PF00069	0.556
MOD_CK1_1	77	83	PF00069	0.753
MOD_CK1_1	84	90	PF00069	0.640
MOD_CK1_1	96	102	PF00069	0.369
MOD_CK2_1	150	156	PF00069	0.469
MOD_CK2_1	272	278	PF00069	0.654
MOD_CK2_1	361	367	PF00069	0.618
MOD_CK2_1	389	395	PF00069	0.821
MOD_CK2_1	410	416	PF00069	0.802
MOD_CK2_1	517	523	PF00069	0.710
MOD_CK2_1	672	678	PF00069	0.817
MOD_CK2_1	92	98	PF00069	0.503
MOD_Cter_Amidation	343	346	PF01082	0.569
MOD_DYRK1A_RPxSP_1	372	376	PF00069	0.570
MOD_GlcNHglycan	126	129	PF01048	0.696
MOD_GlcNHglycan	135	138	PF01048	0.669
MOD_GlcNHglycan	179	182	PF01048	0.576
MOD_GlcNHglycan	198	201	PF01048	0.276
MOD_GlcNHglycan	21	24	PF01048	0.527
MOD_GlcNHglycan	258	262	PF01048	0.815
MOD_GlcNHglycan	265	270	PF01048	0.695
MOD_GlcNHglycan	298	302	PF01048	0.534
MOD_GlcNHglycan	342	345	PF01048	0.741
MOD_GlcNHglycan	376	379	PF01048	0.826
MOD_GlcNHglycan	397	400	PF01048	0.668
MOD_GlcNHglycan	416	419	PF01048	0.763
MOD_GlcNHglycan	433	436	PF01048	0.565
MOD_GlcNHglycan	456	459	PF01048	0.773
MOD_GlcNHglycan	519	522	PF01048	0.592
MOD_GlcNHglycan	559	562	PF01048	0.468
MOD_GlcNHglycan	578	581	PF01048	0.723
MOD_GlcNHglycan	587	590	PF01048	0.748
MOD_GlcNHglycan	604	607	PF01048	0.773
MOD_GlcNHglycan	633	636	PF01048	0.622
MOD_GlcNHglycan	649	652	PF01048	0.682
MOD_GlcNHglycan	66	69	PF01048	0.652
MOD_GlcNHglycan	685	688	PF01048	0.690
MOD_GlcNHglycan	7	10	PF01048	0.411
MOD_GlcNHglycan	70	73	PF01048	0.696
MOD_GlcNHglycan	700	703	PF01048	0.805
MOD_GlcNHglycan	737	740	PF01048	0.320
MOD_GlcNHglycan	76	79	PF01048	0.726
MOD_GSK3_1	120	127	PF00069	0.715
MOD_GSK3_1	146	153	PF00069	0.692
MOD_GSK3_1	18	25	PF00069	0.508
MOD_GSK3_1	221	228	PF00069	0.475
MOD_GSK3_1	297	304	PF00069	0.491
MOD_GSK3_1	31	38	PF00069	0.363
MOD_GSK3_1	330	337	PF00069	0.680
MOD_GSK3_1	345	352	PF00069	0.755
MOD_GSK3_1	372	379	PF00069	0.818
MOD_GSK3_1	380	387	PF00069	0.748
MOD_GSK3_1	394	401	PF00069	0.617
MOD_GSK3_1	410	417	PF00069	0.620
MOD_GSK3_1	427	434	PF00069	0.574
MOD_GSK3_1	467	474	PF00069	0.683
MOD_GSK3_1	557	564	PF00069	0.473
MOD_GSK3_1	576	583	PF00069	0.579
MOD_GSK3_1	598	605	PF00069	0.788
MOD_GSK3_1	60	67	PF00069	0.583
MOD_GSK3_1	626	633	PF00069	0.634
MOD_GSK3_1	643	650	PF00069	0.679
MOD_GSK3_1	658	665	PF00069	0.602
MOD_GSK3_1	668	675	PF00069	0.700
MOD_GSK3_1	696	703	PF00069	0.602
MOD_GSK3_1	704	711	PF00069	0.550
MOD_GSK3_1	757	764	PF00069	0.556
MOD_GSK3_1	77	84	PF00069	0.715
MOD_GSK3_1	92	99	PF00069	0.364
MOD_LATS_1	647	653	PF00433	0.574
MOD_N-GLC_1	103	108	PF02516	0.450
MOD_N-GLC_1	395	400	PF02516	0.672
MOD_N-GLC_1	445	450	PF02516	0.567
MOD_N-GLC_1	672	677	PF02516	0.642
MOD_N-GLC_1	678	683	PF02516	0.621
MOD_N-GLC_1	688	693	PF02516	0.712
MOD_NEK2_1	103	108	PF00069	0.439
MOD_NEK2_1	126	131	PF00069	0.714
MOD_NEK2_1	133	138	PF00069	0.694
MOD_NEK2_1	146	151	PF00069	0.532
MOD_NEK2_1	175	180	PF00069	0.563
MOD_NEK2_1	31	36	PF00069	0.470
MOD_NEK2_1	361	366	PF00069	0.656
MOD_NEK2_1	405	410	PF00069	0.741
MOD_NEK2_1	555	560	PF00069	0.395
MOD_NEK2_1	574	579	PF00069	0.434
MOD_NEK2_1	64	69	PF00069	0.669
MOD_NEK2_1	755	760	PF00069	0.496
MOD_NEK2_2	427	432	PF00069	0.651
MOD_PIKK_1	175	181	PF00454	0.490
MOD_PIKK_1	31	37	PF00454	0.455
MOD_PIKK_1	345	351	PF00454	0.788
MOD_PIKK_1	634	640	PF00454	0.770
MOD_PIKK_1	658	664	PF00454	0.584
MOD_PIKK_1	85	91	PF00454	0.582
MOD_PIKK_1	96	102	PF00454	0.508
MOD_PK_1	330	336	PF00069	0.621
MOD_PK_1	775	781	PF00069	0.542
MOD_PKA_1	345	351	PF00069	0.822
MOD_PKA_2	334	340	PF00069	0.705
MOD_PKA_2	345	351	PF00069	0.733
MOD_PKA_2	427	433	PF00069	0.643
MOD_PKA_2	446	452	PF00069	0.754
MOD_PKA_2	574	580	PF00069	0.628
MOD_PKA_2	602	608	PF00069	0.752
MOD_Plk_1	103	109	PF00069	0.434
MOD_Plk_1	297	303	PF00069	0.535
MOD_Plk_1	330	336	PF00069	0.675
MOD_Plk_1	561	567	PF00069	0.421
MOD_Plk_1	678	684	PF00069	0.630
MOD_Plk_1	696	702	PF00069	0.483
MOD_Plk_1	721	727	PF00069	0.515
MOD_Plk_1	761	767	PF00069	0.520
MOD_Plk_4	136	142	PF00069	0.618
MOD_Plk_4	146	152	PF00069	0.569
MOD_Plk_4	215	221	PF00069	0.431
MOD_Plk_4	25	31	PF00069	0.574
MOD_Plk_4	35	41	PF00069	0.443
MOD_Plk_4	427	433	PF00069	0.580
MOD_Plk_4	60	66	PF00069	0.518
MOD_Plk_4	626	632	PF00069	0.538
MOD_Plk_4	777	783	PF00069	0.578
MOD_ProDKin_1	199	205	PF00069	0.448
MOD_ProDKin_1	248	254	PF00069	0.785
MOD_ProDKin_1	285	291	PF00069	0.397
MOD_ProDKin_1	372	378	PF00069	0.774
MOD_ProDKin_1	380	386	PF00069	0.824
MOD_ProDKin_1	398	404	PF00069	0.500
MOD_ProDKin_1	502	508	PF00069	0.573
MOD_ProDKin_1	547	553	PF00069	0.420
MOD_ProDKin_1	672	678	PF00069	0.822
MOD_ProDKin_1	708	714	PF00069	0.698
MOD_ProDKin_1	77	83	PF00069	0.567
MOD_SUMO_rev_2	228	235	PF00179	0.587
MOD_SUMO_rev_2	457	467	PF00179	0.557
MOD_SUMO_rev_2	665	672	PF00179	0.636
TRG_DiLeu_BaEn_1	159	164	PF01217	0.560
TRG_DiLeu_BaLyEn_6	142	147	PF01217	0.483
TRG_DiLeu_BaLyEn_6	182	187	PF01217	0.340
TRG_ENDOCYTIC_2	299	302	PF00928	0.472
TRG_ENDOCYTIC_2	388	391	PF00928	0.573
TRG_ENDOCYTIC_2	47	50	PF00928	0.412
TRG_ENDOCYTIC_2	541	544	PF00928	0.456
TRG_ENDOCYTIC_2	94	97	PF00928	0.532
TRG_ER_diArg_1	205	207	PF00400	0.608
TRG_ER_diArg_1	345	347	PF00400	0.575
TRG_ER_diArg_1	798	800	PF00400	0.583
TRG_Pf-PMV_PEXEL_1	155	159	PF00026	0.656
TRG_Pf-PMV_PEXEL_1	185	189	PF00026	0.526
TRG_Pf-PMV_PEXEL_1	567	572	PF00026	0.319

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7T2	Leptomonas seymouri	54%	100%
A0A1X0P678	Trypanosomatidae	34%	100%
A0A3S7WVI8	Leishmania donovani	71%	99%
A4HYB8	Leishmania infantum	71%	99%
E9AS52	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	92%
Q4QDB4	Leishmania major	72%	100%