FYVE-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

FYVE zinc finger, putative

Species:

Leishmania braziliensis

UniProt:

A4HA51_LEIBR

TriTrypDb:

LbrM.19.1260 , LBRM2903_190021200

Length:

962

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HA51

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HA51

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	310	314	PF00656	0.640
CLV_C14_Caspase3-7	902	906	PF00656	0.544
CLV_C14_Caspase3-7	943	947	PF00656	0.543
CLV_NRD_NRD_1	220	222	PF00675	0.430
CLV_NRD_NRD_1	415	417	PF00675	0.612
CLV_NRD_NRD_1	5	7	PF00675	0.608
CLV_NRD_NRD_1	558	560	PF00675	0.491
CLV_NRD_NRD_1	570	572	PF00675	0.365
CLV_NRD_NRD_1	598	600	PF00675	0.339
CLV_NRD_NRD_1	605	607	PF00675	0.332
CLV_NRD_NRD_1	613	615	PF00675	0.358
CLV_NRD_NRD_1	618	620	PF00675	0.189
CLV_NRD_NRD_1	688	690	PF00675	0.350
CLV_NRD_NRD_1	761	763	PF00675	0.443
CLV_PCSK_FUR_1	603	607	PF00082	0.312
CLV_PCSK_FUR_1	759	763	PF00082	0.430
CLV_PCSK_KEX2_1	219	221	PF00082	0.444
CLV_PCSK_KEX2_1	415	417	PF00082	0.612
CLV_PCSK_KEX2_1	5	7	PF00082	0.608
CLV_PCSK_KEX2_1	558	560	PF00082	0.513
CLV_PCSK_KEX2_1	570	572	PF00082	0.363
CLV_PCSK_KEX2_1	598	600	PF00082	0.337
CLV_PCSK_KEX2_1	605	607	PF00082	0.329
CLV_PCSK_KEX2_1	613	615	PF00082	0.353
CLV_PCSK_KEX2_1	618	620	PF00082	0.184
CLV_PCSK_KEX2_1	688	690	PF00082	0.350
CLV_PCSK_KEX2_1	71	73	PF00082	0.611
CLV_PCSK_KEX2_1	761	763	PF00082	0.443
CLV_PCSK_PC1ET2_1	71	73	PF00082	0.611
CLV_PCSK_PC7_1	216	222	PF00082	0.485
CLV_PCSK_PC7_1	614	620	PF00082	0.312
CLV_PCSK_SKI1_1	563	567	PF00082	0.425
CLV_PCSK_SKI1_1	571	575	PF00082	0.417
CLV_PCSK_SKI1_1	605	609	PF00082	0.343
CLV_PCSK_SKI1_1	68	72	PF00082	0.585
CLV_PCSK_SKI1_1	876	880	PF00082	0.610
DEG_APCC_DBOX_1	147	155	PF00400	0.585
DEG_SCF_FBW7_2	527	534	PF00400	0.539
DEG_SPOP_SBC_1	439	443	PF00917	0.557
DEG_SPOP_SBC_1	457	461	PF00917	0.619
DOC_CKS1_1	376	381	PF01111	0.640
DOC_CKS1_1	432	437	PF01111	0.662
DOC_CKS1_1	504	509	PF01111	0.642
DOC_CKS1_1	840	845	PF01111	0.539
DOC_CYCLIN_RxL_1	599	612	PF00134	0.312
DOC_MAPK_gen_1	219	227	PF00069	0.465
DOC_MAPK_gen_1	740	749	PF00069	0.312
DOC_MAPK_RevD_3	207	221	PF00069	0.498
DOC_MAPK_RevD_3	747	762	PF00069	0.312
DOC_PP1_RVXF_1	556	563	PF00149	0.337
DOC_PP2B_LxvP_1	385	388	PF13499	0.608
DOC_PP2B_LxvP_1	454	457	PF13499	0.634
DOC_PP2B_LxvP_1	47	50	PF13499	0.537
DOC_USP7_MATH_1	102	106	PF00917	0.713
DOC_USP7_MATH_1	112	116	PF00917	0.643
DOC_USP7_MATH_1	142	146	PF00917	0.633
DOC_USP7_MATH_1	274	278	PF00917	0.576
DOC_USP7_MATH_1	291	295	PF00917	0.696
DOC_USP7_MATH_1	334	338	PF00917	0.535
DOC_USP7_MATH_1	414	418	PF00917	0.802
DOC_USP7_MATH_1	458	462	PF00917	0.620
DOC_USP7_MATH_1	490	494	PF00917	0.718
DOC_USP7_MATH_1	626	630	PF00917	0.342
DOC_USP7_MATH_1	644	648	PF00917	0.215
DOC_USP7_MATH_1	856	860	PF00917	0.511
DOC_WW_Pin1_4	108	113	PF00397	0.599
DOC_WW_Pin1_4	115	120	PF00397	0.576
DOC_WW_Pin1_4	243	248	PF00397	0.617
DOC_WW_Pin1_4	314	319	PF00397	0.630
DOC_WW_Pin1_4	330	335	PF00397	0.769
DOC_WW_Pin1_4	375	380	PF00397	0.637
DOC_WW_Pin1_4	431	436	PF00397	0.654
DOC_WW_Pin1_4	440	445	PF00397	0.696
DOC_WW_Pin1_4	476	481	PF00397	0.658
DOC_WW_Pin1_4	484	489	PF00397	0.623
DOC_WW_Pin1_4	492	497	PF00397	0.672
DOC_WW_Pin1_4	498	503	PF00397	0.738
DOC_WW_Pin1_4	505	510	PF00397	0.610
DOC_WW_Pin1_4	519	524	PF00397	0.606
DOC_WW_Pin1_4	527	532	PF00397	0.623
DOC_WW_Pin1_4	534	539	PF00397	0.573
DOC_WW_Pin1_4	63	68	PF00397	0.681
DOC_WW_Pin1_4	694	699	PF00397	0.328
DOC_WW_Pin1_4	839	844	PF00397	0.584
DOC_WW_Pin1_4	98	103	PF00397	0.583
LIG_14-3-3_CanoR_1	210	218	PF00244	0.535
LIG_14-3-3_CanoR_1	309	313	PF00244	0.626
LIG_14-3-3_CanoR_1	342	349	PF00244	0.696
LIG_14-3-3_CanoR_1	371	379	PF00244	0.754
LIG_14-3-3_CanoR_1	403	407	PF00244	0.712
LIG_14-3-3_CanoR_1	415	419	PF00244	0.600
LIG_14-3-3_CanoR_1	465	469	PF00244	0.721
LIG_14-3-3_CanoR_1	558	563	PF00244	0.336
LIG_14-3-3_CanoR_1	59	64	PF00244	0.615
LIG_14-3-3_CanoR_1	605	611	PF00244	0.472
LIG_14-3-3_CanoR_1	72	78	PF00244	0.615
LIG_14-3-3_CanoR_1	794	802	PF00244	0.578
LIG_14-3-3_CanoR_1	861	868	PF00244	0.517
LIG_BRCT_BRCA1_1	388	392	PF00533	0.704
LIG_Clathr_ClatBox_1	185	189	PF01394	0.642
LIG_Clathr_ClatBox_1	917	921	PF01394	0.689
LIG_CSL_BTD_1	535	538	PF09270	0.539
LIG_eIF4E_1	568	574	PF01652	0.430
LIG_eIF4E_1	602	608	PF01652	0.312
LIG_FHA_1	171	177	PF00498	0.525
LIG_FHA_1	196	202	PF00498	0.516
LIG_FHA_1	210	216	PF00498	0.456
LIG_FHA_1	25	31	PF00498	0.545
LIG_FHA_1	376	382	PF00498	0.664
LIG_FHA_1	402	408	PF00498	0.545
LIG_FHA_1	458	464	PF00498	0.624
LIG_FHA_1	479	485	PF00498	0.594
LIG_FHA_1	493	499	PF00498	0.679
LIG_FHA_1	520	526	PF00498	0.599
LIG_FHA_1	636	642	PF00498	0.312
LIG_FHA_1	663	669	PF00498	0.509
LIG_FHA_1	709	715	PF00498	0.330
LIG_FHA_1	787	793	PF00498	0.506
LIG_FHA_1	840	846	PF00498	0.540
LIG_FHA_1	902	908	PF00498	0.550
LIG_FHA_2	132	138	PF00498	0.646
LIG_FHA_2	299	305	PF00498	0.625
LIG_FHA_2	308	314	PF00498	0.551
LIG_FHA_2	548	554	PF00498	0.552
LIG_FHA_2	786	792	PF00498	0.412
LIG_FHA_2	861	867	PF00498	0.531
LIG_FHA_2	941	947	PF00498	0.623
LIG_FHA_2	950	956	PF00498	0.614
LIG_HCF-1_HBM_1	683	686	PF13415	0.312
LIG_KLC1_Yacidic_2	184	189	PF13176	0.642
LIG_LIR_Gen_1	184	192	PF02991	0.576
LIG_LIR_Nem_3	184	190	PF02991	0.581
LIG_LIR_Nem_3	534	539	PF02991	0.540
LIG_LIR_Nem_3	778	784	PF02991	0.410
LIG_MYND_1	379	383	PF01753	0.627
LIG_MYND_1	698	702	PF01753	0.327
LIG_SH2_GRB2like	754	757	PF00017	0.312
LIG_SH2_NCK_1	289	293	PF00017	0.546
LIG_SH2_PTP2	187	190	PF00017	0.575
LIG_SH2_STAP1	418	422	PF00017	0.711
LIG_SH2_STAP1	664	668	PF00017	0.312
LIG_SH2_STAT3	349	352	PF00017	0.688
LIG_SH2_STAT5	187	190	PF00017	0.575
LIG_SH2_STAT5	349	352	PF00017	0.664
LIG_SH2_STAT5	610	613	PF00017	0.388
LIG_SH2_STAT5	631	634	PF00017	0.312
LIG_SH2_STAT5	640	643	PF00017	0.312
LIG_SH2_STAT5	664	667	PF00017	0.321
LIG_SH2_STAT5	823	826	PF00017	0.630
LIG_SH2_STAT5	867	870	PF00017	0.510
LIG_SH2_STAT5	871	874	PF00017	0.551
LIG_SH3_3	241	247	PF00018	0.681
LIG_SH3_3	315	321	PF00018	0.557
LIG_SH3_3	380	386	PF00018	0.705
LIG_SH3_3	477	483	PF00018	0.569
LIG_SH3_3	499	505	PF00018	0.791
LIG_SH3_3	506	512	PF00018	0.668
LIG_SH3_3	518	524	PF00018	0.710
LIG_SH3_3	541	547	PF00018	0.506
LIG_SH3_3	61	67	PF00018	0.534
LIG_SH3_3	638	644	PF00018	0.442
LIG_SH3_3	746	752	PF00018	0.388
LIG_SH3_3	951	957	PF00018	0.530
LIG_SUMO_SIM_par_1	122	127	PF11976	0.616
LIG_SUMO_SIM_par_1	481	487	PF11976	0.548
LIG_SUMO_SIM_par_1	522	530	PF11976	0.600
LIG_SUMO_SIM_par_1	916	922	PF11976	0.533
LIG_SUMO_SIM_par_1	955	962	PF11976	0.677
LIG_TRAF2_1	531	534	PF00917	0.540
LIG_TRAF2_1	702	705	PF00917	0.231
LIG_TRAF2_1	788	791	PF00917	0.503
LIG_TYR_ITIM	185	190	PF00017	0.581
MOD_CDC14_SPxK_1	479	482	PF00782	0.555
MOD_CDK_SPK_2	314	319	PF00069	0.641
MOD_CDK_SPK_2	330	335	PF00069	0.583
MOD_CDK_SPK_2	63	68	PF00069	0.573
MOD_CDK_SPxK_1	476	482	PF00069	0.558
MOD_CDK_SPxxK_3	440	447	PF00069	0.647
MOD_CK1_1	105	111	PF00069	0.687
MOD_CK1_1	115	121	PF00069	0.731
MOD_CK1_1	254	260	PF00069	0.672
MOD_CK1_1	261	267	PF00069	0.749
MOD_CK1_1	283	289	PF00069	0.662
MOD_CK1_1	294	300	PF00069	0.625
MOD_CK1_1	311	317	PF00069	0.580
MOD_CK1_1	33	39	PF00069	0.600
MOD_CK1_1	369	375	PF00069	0.654
MOD_CK1_1	377	383	PF00069	0.672
MOD_CK1_1	405	411	PF00069	0.643
MOD_CK1_1	41	47	PF00069	0.541
MOD_CK1_1	430	436	PF00069	0.676
MOD_CK1_1	459	465	PF00069	0.546
MOD_CK1_1	514	520	PF00069	0.830
MOD_CK1_1	609	615	PF00069	0.312
MOD_CK1_1	62	68	PF00069	0.571
MOD_CK1_1	662	668	PF00069	0.312
MOD_CK1_1	831	837	PF00069	0.541
MOD_CK1_1	913	919	PF00069	0.664
MOD_CK2_1	108	114	PF00069	0.632
MOD_CK2_1	131	137	PF00069	0.646
MOD_CK2_1	547	553	PF00069	0.489
MOD_CK2_1	785	791	PF00069	0.406
MOD_Cter_Amidation	632	635	PF01082	0.312
MOD_GlcNHglycan	253	256	PF01048	0.560
MOD_GlcNHglycan	276	279	PF01048	0.628
MOD_GlcNHglycan	296	299	PF01048	0.570
MOD_GlcNHglycan	344	347	PF01048	0.755
MOD_GlcNHglycan	35	38	PF01048	0.601
MOD_GlcNHglycan	46	50	PF01048	0.578
MOD_GlcNHglycan	513	516	PF01048	0.622
MOD_GlcNHglycan	646	649	PF01048	0.265
MOD_GlcNHglycan	770	773	PF01048	0.544
MOD_GlcNHglycan	818	822	PF01048	0.646
MOD_GlcNHglycan	830	833	PF01048	0.653
MOD_GlcNHglycan	858	861	PF01048	0.612
MOD_GlcNHglycan	98	101	PF01048	0.722
MOD_GSK3_1	108	115	PF00069	0.680
MOD_GSK3_1	124	131	PF00069	0.516
MOD_GSK3_1	191	198	PF00069	0.580
MOD_GSK3_1	250	257	PF00069	0.656
MOD_GSK3_1	269	276	PF00069	0.507
MOD_GSK3_1	279	286	PF00069	0.744
MOD_GSK3_1	294	301	PF00069	0.587
MOD_GSK3_1	307	314	PF00069	0.618
MOD_GSK3_1	330	337	PF00069	0.669
MOD_GSK3_1	338	345	PF00069	0.636
MOD_GSK3_1	363	370	PF00069	0.644
MOD_GSK3_1	371	378	PF00069	0.658
MOD_GSK3_1	401	408	PF00069	0.538
MOD_GSK3_1	41	48	PF00069	0.621
MOD_GSK3_1	423	430	PF00069	0.639
MOD_GSK3_1	452	459	PF00069	0.686
MOD_GSK3_1	478	485	PF00069	0.694
MOD_GSK3_1	486	493	PF00069	0.661
MOD_GSK3_1	511	518	PF00069	0.674
MOD_GSK3_1	59	66	PF00069	0.549
MOD_GSK3_1	723	730	PF00069	0.460
MOD_GSK3_1	856	863	PF00069	0.517
MOD_GSK3_1	870	877	PF00069	0.496
MOD_GSK3_1	932	939	PF00069	0.671
MOD_GSK3_1	940	947	PF00069	0.528
MOD_GSK3_1	98	105	PF00069	0.621
MOD_N-GLC_1	127	132	PF02516	0.535
MOD_N-GLC_1	280	285	PF02516	0.738
MOD_N-GLC_1	33	38	PF02516	0.559
MOD_N-GLC_1	356	361	PF02516	0.688
MOD_N-GLC_2	52	54	PF02516	0.537
MOD_N-GLC_2	773	775	PF02516	0.419
MOD_NEK2_1	124	129	PF00069	0.716
MOD_NEK2_1	273	278	PF00069	0.535
MOD_NEK2_1	279	284	PF00069	0.559
MOD_NEK2_1	30	35	PF00069	0.550
MOD_NEK2_1	367	372	PF00069	0.652
MOD_NEK2_1	407	412	PF00069	0.722
MOD_NEK2_1	491	496	PF00069	0.718
MOD_NEK2_1	516	521	PF00069	0.573
MOD_NEK2_1	70	75	PF00069	0.611
MOD_NEK2_1	872	877	PF00069	0.569
MOD_PIKK_1	209	215	PF00454	0.442
MOD_PIKK_1	283	289	PF00454	0.528
MOD_PIKK_1	347	353	PF00454	0.667
MOD_PK_1	482	488	PF00069	0.539
MOD_PKA_1	558	564	PF00069	0.489
MOD_PKA_2	209	215	PF00069	0.494
MOD_PKA_2	269	275	PF00069	0.624
MOD_PKA_2	308	314	PF00069	0.723
MOD_PKA_2	334	340	PF00069	0.767
MOD_PKA_2	367	373	PF00069	0.696
MOD_PKA_2	402	408	PF00069	0.627
MOD_PKA_2	414	420	PF00069	0.614
MOD_PKA_2	464	470	PF00069	0.758
MOD_PKA_2	558	564	PF00069	0.482
MOD_PKA_2	793	799	PF00069	0.566
MOD_PKA_2	860	866	PF00069	0.516
MOD_PKB_1	421	429	PF00069	0.641
MOD_Plk_1	626	632	PF00069	0.312
MOD_Plk_1	636	642	PF00069	0.312
MOD_Plk_1	682	688	PF00069	0.356
MOD_Plk_1	913	919	PF00069	0.642
MOD_Plk_2-3	940	946	PF00069	0.689
MOD_Plk_4	334	340	PF00069	0.745
MOD_Plk_4	402	408	PF00069	0.703
MOD_Plk_4	59	65	PF00069	0.563
MOD_Plk_4	636	642	PF00069	0.312
MOD_Plk_4	913	919	PF00069	0.693
MOD_ProDKin_1	108	114	PF00069	0.600
MOD_ProDKin_1	115	121	PF00069	0.571
MOD_ProDKin_1	243	249	PF00069	0.621
MOD_ProDKin_1	314	320	PF00069	0.632
MOD_ProDKin_1	330	336	PF00069	0.768
MOD_ProDKin_1	375	381	PF00069	0.639
MOD_ProDKin_1	431	437	PF00069	0.654
MOD_ProDKin_1	440	446	PF00069	0.694
MOD_ProDKin_1	476	482	PF00069	0.660
MOD_ProDKin_1	484	490	PF00069	0.620
MOD_ProDKin_1	492	498	PF00069	0.672
MOD_ProDKin_1	503	509	PF00069	0.807
MOD_ProDKin_1	519	525	PF00069	0.612
MOD_ProDKin_1	527	533	PF00069	0.639
MOD_ProDKin_1	534	540	PF00069	0.571
MOD_ProDKin_1	63	69	PF00069	0.681
MOD_ProDKin_1	694	700	PF00069	0.328
MOD_ProDKin_1	839	845	PF00069	0.580
MOD_ProDKin_1	98	104	PF00069	0.579
MOD_SUMO_for_1	660	663	PF00179	0.312
MOD_SUMO_rev_2	551	557	PF00179	0.528
MOD_SUMO_rev_2	936	943	PF00179	0.546
TRG_DiLeu_BaEn_4	790	796	PF01217	0.538
TRG_DiLeu_BaLyEn_6	13	18	PF01217	0.546
TRG_DiLeu_BaLyEn_6	149	154	PF01217	0.521
TRG_DiLeu_BaLyEn_6	244	249	PF01217	0.665
TRG_DiLeu_BaLyEn_6	577	582	PF01217	0.501
TRG_DiLeu_LyEn_5	499	504	PF01217	0.557
TRG_ENDOCYTIC_2	187	190	PF00928	0.619
TRG_ENDOCYTIC_2	783	786	PF00928	0.401
TRG_ER_diArg_1	148	151	PF00400	0.517
TRG_ER_diArg_1	218	221	PF00400	0.428
TRG_ER_diArg_1	231	234	PF00400	0.517
TRG_ER_diArg_1	267	270	PF00400	0.574
TRG_ER_diArg_1	557	559	PF00400	0.504
TRG_ER_diArg_1	602	605	PF00400	0.328
TRG_ER_diArg_1	687	689	PF00400	0.349
TRG_ER_diArg_1	758	761	PF00400	0.399
TRG_NLS_MonoExtN_4	5	10	PF00514	0.602
TRG_Pf-PMV_PEXEL_1	571	576	PF00026	0.428

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0R7	Leptomonas seymouri	50%	100%
A0A3S7WVE0	Leishmania donovani	80%	100%
A4HYB5	Leishmania infantum	81%	100%
E9AS48	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4QDB8	Leishmania major	79%	100%