Peptidylprolyl isomerase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

peptidyl-prolyl cis-trans isomerase, macrophage infectivity potentiator precursor, putative

Species:

Leishmania braziliensis

UniProt:

A4HA48_LEIBR

TriTrypDb:

LbrM.19.1230 , LBRM2903_190018500

Length:

204

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 8, no: 6
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HA48

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HA48

Function

Biological processes
Term	Name	Level	Count
GO:0000413	protein peptidyl-prolyl isomerization	7	2
GO:0006457	protein folding	2	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018208	peptidyl-proline modification	6	2
GO:0019538	protein metabolic process	3	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044238	primary metabolic process	2	2
GO:0061077	chaperone-mediated protein folding	3	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3	15
GO:0003824	catalytic activity	1	15
GO:0016853	isomerase activity	2	15
GO:0016859	cis-trans isomerase activity	3	15
GO:0140096	catalytic activity, acting on a protein	2	15

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	178	182	PF00656	0.350
CLV_NRD_NRD_1	72	74	PF00675	0.451
CLV_PCSK_KEX2_1	72	74	PF00082	0.451
CLV_PCSK_SKI1_1	52	56	PF00082	0.485
CLV_PCSK_SKI1_1	8	12	PF00082	0.325
DEG_Nend_UBRbox_3	1	3	PF02207	0.479
DOC_CYCLIN_yCln2_LP_2	136	142	PF00134	0.290
DOC_PP2B_LxvP_1	136	139	PF13499	0.312
DOC_USP7_MATH_1	156	160	PF00917	0.386
DOC_USP7_MATH_1	57	61	PF00917	0.429
DOC_WW_Pin1_4	110	115	PF00397	0.367
DOC_WW_Pin1_4	168	173	PF00397	0.380
DOC_WW_Pin1_4	187	192	PF00397	0.387
LIG_14-3-3_CanoR_1	3	8	PF00244	0.550
LIG_14-3-3_CanoR_1	40	45	PF00244	0.453
LIG_Clathr_ClatBox_1	67	71	PF01394	0.339
LIG_FHA_1	14	20	PF00498	0.446
LIG_FHA_1	194	200	PF00498	0.350
LIG_FHA_1	21	27	PF00498	0.571
LIG_FHA_2	174	180	PF00498	0.351
LIG_GBD_Chelix_1	14	22	PF00786	0.297
LIG_IBAR_NPY_1	106	108	PF08397	0.199
LIG_LIR_Gen_1	200	204	PF02991	0.510
LIG_LIR_Gen_1	43	51	PF02991	0.361
LIG_LIR_Nem_3	132	137	PF02991	0.317
LIG_LIR_Nem_3	200	204	PF02991	0.510
LIG_LIR_Nem_3	43	47	PF02991	0.370
LIG_NRBOX	16	22	PF00104	0.420
LIG_SH2_STAT3	183	186	PF00017	0.295
LIG_SH2_STAT5	137	140	PF00017	0.373
LIG_SH2_STAT5	183	186	PF00017	0.469
LIG_SH2_STAT5	44	47	PF00017	0.340
LIG_SH2_STAT5	90	93	PF00017	0.259
LIG_SH3_3	185	191	PF00018	0.376
LIG_SUMO_SIM_anti_2	16	23	PF11976	0.402
LIG_SUMO_SIM_par_1	16	23	PF11976	0.397
LIG_SUMO_SIM_par_1	25	30	PF11976	0.377
LIG_TYR_ITIM	199	204	PF00017	0.482
LIG_Vh1_VBS_1	11	29	PF01044	0.320
MOD_CDK_SPxxK_3	168	175	PF00069	0.368
MOD_CK1_1	173	179	PF00069	0.384
MOD_CK1_1	32	38	PF00069	0.485
MOD_CK2_1	173	179	PF00069	0.362
MOD_GlcNHglycan	172	175	PF01048	0.606
MOD_GlcNHglycan	59	62	PF01048	0.404
MOD_GlcNHglycan	63	66	PF01048	0.432
MOD_GSK3_1	170	177	PF00069	0.463
MOD_GSK3_1	25	32	PF00069	0.397
MOD_GSK3_1	57	64	PF00069	0.477
MOD_N-GLC_1	57	62	PF02516	0.433
MOD_NEK2_1	20	25	PF00069	0.376
MOD_NEK2_1	88	93	PF00069	0.295
MOD_NEK2_2	156	161	PF00069	0.199
MOD_PIKK_1	112	118	PF00454	0.413
MOD_PKA_2	2	8	PF00069	0.564
MOD_PKB_1	40	48	PF00069	0.338
MOD_Plk_1	29	35	PF00069	0.620
MOD_Plk_1	57	63	PF00069	0.440
MOD_Plk_4	13	19	PF00069	0.401
MOD_Plk_4	29	35	PF00069	0.301
MOD_ProDKin_1	110	116	PF00069	0.367
MOD_ProDKin_1	168	174	PF00069	0.370
MOD_ProDKin_1	187	193	PF00069	0.385
MOD_SUMO_for_1	194	197	PF00179	0.321
MOD_SUMO_rev_2	147	155	PF00179	0.276
TRG_DiLeu_BaEn_1	123	128	PF01217	0.259
TRG_ENDOCYTIC_2	201	204	PF00928	0.526
TRG_ENDOCYTIC_2	44	47	PF00928	0.373
TRG_NES_CRM1_1	116	130	PF08389	0.373

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II12	Leptomonas seymouri	68%	100%
A0A1X0P7N1	Trypanosomatidae	38%	96%
A0A3Q8IB31	Leishmania donovani	32%	100%
A0A3S5H764	Leishmania donovani	77%	100%
A0A3S5IR72	Trypanosoma rangeli	38%	100%
A4H677	Leishmania braziliensis	32%	100%
A4HUK1	Leishmania infantum	32%	100%
A4HYB4	Leishmania infantum	76%	100%
D0A0P0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AN99	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AS47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q09734	Trypanosoma cruzi	40%	100%
Q4QDB9	Leishmania major	77%	99%
Q4QHC5	Leishmania major	32%	100%