Dynein light chain

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Dynein light chain

Gene product:

dynein light chain, putative

Species:

Leishmania braziliensis

UniProt:

A4HA47_LEIBR

TriTrypDb:

LbrM.19.1220 , LBRM2903_190018400

Length:

112

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	11
GO:0005874	microtubule	6	11
GO:0005875	microtubule associated complex	2	11
GO:0030286	dynein complex	3	11
GO:0032991	protein-containing complex	1	11
GO:0099080	supramolecular complex	2	11
GO:0099081	supramolecular polymer	3	11
GO:0099512	supramolecular fiber	4	11
GO:0099513	polymeric cytoskeletal fiber	5	11
GO:0110165	cellular anatomical entity	1	11
GO:1902494	catalytic complex	2	11
GO:0005868	cytoplasmic dynein complex	4	1

Expansion

Sequence features

A4HA47

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HA47

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	11
GO:0009987	cellular process	1	11

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0045505	dynein intermediate chain binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DOC_MAPK_MEF2A_6	9	17	PF00069	0.504
DOC_USP7_UBL2_3	5	9	PF12436	0.352
LIG_14-3-3_CanoR_1	89	95	PF00244	0.478
LIG_APCC_ABBA_1	74	79	PF00400	0.369
LIG_BIR_II_1	1	5	PF00653	0.415
LIG_BRCT_BRCA1_1	81	85	PF00533	0.352
LIG_FHA_1	2	8	PF00498	0.254
LIG_FHA_1	29	35	PF00498	0.522
LIG_GBD_Chelix_1	40	48	PF00786	0.266
LIG_LIR_Gen_1	72	83	PF02991	0.423
LIG_LIR_Nem_3	71	77	PF02991	0.427
LIG_MLH1_MIPbox_1	81	85	PF16413	0.352
LIG_PCNA_yPIPBox_3	33	44	PF02747	0.418
LIG_Pex14_2	74	78	PF04695	0.448
LIG_Pex14_2	84	88	PF04695	0.464
LIG_SH2_STAT3	52	55	PF00017	0.464
LIG_SH2_STAT5	77	80	PF00017	0.437
LIG_UBA3_1	29	33	PF00899	0.504
LIG_UBA3_1	83	92	PF00899	0.369
MOD_CK1_1	63	69	PF00069	0.443
MOD_GlcNHglycan	1	4	PF01048	0.457
MOD_GlcNHglycan	10	13	PF01048	0.205
MOD_GSK3_1	79	86	PF00069	0.378
MOD_N-GLC_1	90	95	PF02516	0.309
MOD_NEK2_1	1	6	PF00069	0.407
MOD_NEK2_2	28	33	PF00069	0.512
MOD_PK_1	97	103	PF00069	0.300
MOD_Plk_1	90	96	PF00069	0.471
MOD_Plk_4	79	85	PF00069	0.433
MOD_SUMO_for_1	44	47	PF00179	0.441
TRG_DiLeu_BaEn_2	38	44	PF01217	0.369
TRG_ENDOCYTIC_2	77	80	PF00928	0.410

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0W1	Leptomonas seymouri	42%	100%
A0A0N1I1Z7	Leptomonas seymouri	34%	100%
A0A0N1PBY8	Leptomonas seymouri	34%	100%
A0A0N1PCF1	Leptomonas seymouri	69%	100%
A0A0S4IS05	Bodo saltans	38%	100%
A0A0S4IUR3	Bodo saltans	40%	100%
A0A0S4J005	Bodo saltans	33%	85%
A0A0S4J1R8	Bodo saltans	40%	100%
A0A0S4JE57	Bodo saltans	35%	100%
A0A0S4JH61	Bodo saltans	40%	89%
A0A0S4JKR9	Bodo saltans	58%	100%
A0A0S4JQ28	Bodo saltans	36%	100%
A0A1X0P6I9	Trypanosomatidae	53%	93%
A0A3Q8IDB7	Leishmania donovani	86%	100%
A0A3Q8IDX2	Leishmania donovani	45%	100%
A0A3R7KXV2	Trypanosoma rangeli	29%	99%
A0A3S5H7E1	Leishmania donovani	34%	100%
A0A3S5H7R1	Leishmania donovani	42%	100%
A0A3S7WNY4	Leishmania donovani	34%	100%
A0A422NC25	Trypanosoma rangeli	32%	100%
A0A422NHE2	Trypanosoma rangeli	59%	100%
A4H453	Leishmania braziliensis	38%	100%
A4HDX3	Leishmania braziliensis	33%	100%
A4HGR7	Leishmania braziliensis	45%	100%
A4HK04	Leishmania braziliensis	42%	100%
A4HSD6	Leishmania infantum	34%	100%
A4HYB3	Leishmania infantum	86%	100%
A4I168	Leishmania infantum	34%	100%
A4I3U2	Leishmania infantum	45%	100%
A4I7I7	Leishmania infantum	42%	100%
C9ZPY0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
D0A0N9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	86%
D0A5F4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
D0A5K4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AKB1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9AS46	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
E9AXA2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9B034	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E9B2E4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
O02414	Heliocidaris crassispina	48%	100%
O96860	Drosophila melanogaster	47%	100%
P61273	Macaca fascicularis	40%	100%
P61285	Bos taurus	40%	100%
P63167	Homo sapiens	40%	100%
P63168	Mus musculus	40%	100%
P63169	Oryctolagus cuniculus	40%	100%
P63170	Rattus norvegicus	40%	100%
Q02647	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	36%	100%
Q22799	Caenorhabditis elegans	43%	100%
Q24117	Drosophila melanogaster	46%	100%
Q39579	Chlamydomonas reinhardtii	32%	93%
Q39580	Chlamydomonas reinhardtii	40%	100%
Q3MHR3	Bos taurus	46%	100%
Q4Q5R2	Leishmania major	39%	100%
Q4Q852	Leishmania major	45%	100%
Q4QA70	Leishmania major	34%	100%
Q4QDC0	Leishmania major	85%	100%
Q4QJJ6	Leishmania major	32%	100%
Q6BZF8	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	39%	100%
Q6CWX4	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	35%	100%
Q6FUJ0	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	43%	100%
Q759T0	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	35%	100%
Q78P75	Rattus norvegicus	46%	100%
Q86A88	Dictyostelium discoideum	47%	100%
Q94748	Schistosoma mansoni	39%	100%
Q94758	Schistosoma mansoni	39%	100%
Q96FJ2	Homo sapiens	46%	100%
Q9D0M5	Mus musculus	46%	100%
Q9UR05	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	38%	100%
V5AV01	Trypanosoma cruzi	32%	100%
V5BXL9	Trypanosoma cruzi	32%	100%