Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HA46_LEIBR

TriTrypDb:

LbrM.19.1210 , LBRM2903_190018300

Length:

810

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HA46

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HA46

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	181	185	PF00656	0.532
CLV_C14_Caspase3-7	489	493	PF00656	0.523
CLV_C14_Caspase3-7	716	720	PF00656	0.638
CLV_C14_Caspase3-7	762	766	PF00656	0.558
CLV_NRD_NRD_1	121	123	PF00675	0.671
CLV_NRD_NRD_1	134	136	PF00675	0.574
CLV_NRD_NRD_1	41	43	PF00675	0.434
CLV_NRD_NRD_1	418	420	PF00675	0.565
CLV_NRD_NRD_1	614	616	PF00675	0.731
CLV_PCSK_KEX2_1	121	123	PF00082	0.671
CLV_PCSK_KEX2_1	330	332	PF00082	0.713
CLV_PCSK_KEX2_1	341	343	PF00082	0.596
CLV_PCSK_KEX2_1	41	43	PF00082	0.434
CLV_PCSK_KEX2_1	587	589	PF00082	0.736
CLV_PCSK_KEX2_1	614	616	PF00082	0.731
CLV_PCSK_PC1ET2_1	330	332	PF00082	0.713
CLV_PCSK_PC1ET2_1	341	343	PF00082	0.596
CLV_PCSK_PC1ET2_1	587	589	PF00082	0.703
CLV_PCSK_PC7_1	610	616	PF00082	0.554
CLV_PCSK_SKI1_1	229	233	PF00082	0.657
CLV_PCSK_SKI1_1	344	348	PF00082	0.688
CLV_PCSK_SKI1_1	358	362	PF00082	0.548
CLV_PCSK_SKI1_1	534	538	PF00082	0.549
CLV_PCSK_SKI1_1	539	543	PF00082	0.485
DEG_APCC_DBOX_1	722	730	PF00400	0.673
DEG_SPOP_SBC_1	322	326	PF00917	0.552
DOC_CKS1_1	475	480	PF01111	0.451
DOC_CYCLIN_yCln2_LP_2	69	75	PF00134	0.525
DOC_MAPK_DCC_7	167	176	PF00069	0.566
DOC_MAPK_gen_1	652	662	PF00069	0.643
DOC_MAPK_MEF2A_6	167	176	PF00069	0.708
DOC_PP2B_LxvP_1	312	315	PF13499	0.676
DOC_PP2B_LxvP_1	69	72	PF13499	0.597
DOC_USP7_MATH_1	203	207	PF00917	0.679
DOC_USP7_MATH_1	231	235	PF00917	0.706
DOC_USP7_MATH_1	315	319	PF00917	0.556
DOC_USP7_MATH_1	334	338	PF00917	0.718
DOC_USP7_MATH_1	556	560	PF00917	0.704
DOC_USP7_MATH_1	580	584	PF00917	0.649
DOC_USP7_MATH_1	656	660	PF00917	0.652
DOC_USP7_MATH_1	661	665	PF00917	0.621
DOC_WW_Pin1_4	160	165	PF00397	0.706
DOC_WW_Pin1_4	199	204	PF00397	0.674
DOC_WW_Pin1_4	212	217	PF00397	0.606
DOC_WW_Pin1_4	276	281	PF00397	0.691
DOC_WW_Pin1_4	301	306	PF00397	0.701
DOC_WW_Pin1_4	385	390	PF00397	0.704
DOC_WW_Pin1_4	439	444	PF00397	0.594
DOC_WW_Pin1_4	474	479	PF00397	0.440
DOC_WW_Pin1_4	504	509	PF00397	0.497
DOC_WW_Pin1_4	567	572	PF00397	0.709
DOC_WW_Pin1_4	578	583	PF00397	0.592
LIG_14-3-3_CanoR_1	105	111	PF00244	0.590
LIG_14-3-3_CanoR_1	225	233	PF00244	0.579
LIG_14-3-3_CanoR_1	287	292	PF00244	0.704
LIG_14-3-3_CanoR_1	342	347	PF00244	0.711
LIG_14-3-3_CanoR_1	426	431	PF00244	0.597
LIG_14-3-3_CanoR_1	588	597	PF00244	0.604
LIG_14-3-3_CanoR_1	600	607	PF00244	0.583
LIG_14-3-3_CanoR_1	727	737	PF00244	0.691
LIG_Actin_WH2_2	467	484	PF00022	0.553
LIG_Actin_WH2_2	714	729	PF00022	0.499
LIG_BIR_II_1	1	5	PF00653	0.574
LIG_BRCT_BRCA1_1	658	662	PF00533	0.658
LIG_CSL_BTD_1	413	416	PF09270	0.525
LIG_CtBP_PxDLS_1	478	482	PF00389	0.488
LIG_FHA_1	152	158	PF00498	0.712
LIG_FHA_1	213	219	PF00498	0.574
LIG_FHA_1	24	30	PF00498	0.573
LIG_FHA_1	470	476	PF00498	0.574
LIG_FHA_1	501	507	PF00498	0.543
LIG_FHA_1	645	651	PF00498	0.483
LIG_FHA_1	683	689	PF00498	0.630
LIG_FHA_1	93	99	PF00498	0.615
LIG_FHA_2	113	119	PF00498	0.618
LIG_FHA_2	153	159	PF00498	0.631
LIG_FHA_2	219	225	PF00498	0.569
LIG_FHA_2	471	477	PF00498	0.520
LIG_FHA_2	555	561	PF00498	0.666
LIG_FHA_2	601	607	PF00498	0.707
LIG_FHA_2	74	80	PF00498	0.515
LIG_LIR_Apic_2	683	689	PF02991	0.538
LIG_LIR_Apic_2	711	715	PF02991	0.778
LIG_LIR_Gen_1	22	32	PF02991	0.592
LIG_LIR_Gen_1	251	260	PF02991	0.706
LIG_LIR_Gen_1	317	323	PF02991	0.551
LIG_LIR_Nem_3	186	191	PF02991	0.587
LIG_LIR_Nem_3	20	24	PF02991	0.631
LIG_LIR_Nem_3	251	255	PF02991	0.816
LIG_LIR_Nem_3	317	322	PF02991	0.549
LIG_LIR_Nem_3	790	796	PF02991	0.638
LIG_LYPXL_SIV_4	46	54	PF13949	0.569
LIG_MYND_1	216	220	PF01753	0.562
LIG_MYND_3	697	701	PF01753	0.673
LIG_Pex14_2	410	414	PF04695	0.491
LIG_PTAP_UEV_1	304	309	PF05743	0.659
LIG_PTB_Apo_2	182	189	PF02174	0.531
LIG_PTB_Apo_2	263	270	PF02174	0.535
LIG_PTB_Phospho_1	182	188	PF10480	0.530
LIG_PTB_Phospho_1	263	269	PF10480	0.534
LIG_Rb_LxCxE_1	154	175	PF01857	0.564
LIG_SH2_CRK	104	108	PF00017	0.587
LIG_SH2_CRK	24	28	PF00017	0.597
LIG_SH2_NCK_1	88	92	PF00017	0.580
LIG_SH2_PTP2	288	291	PF00017	0.548
LIG_SH2_SRC	47	50	PF00017	0.572
LIG_SH2_SRC	795	798	PF00017	0.625
LIG_SH2_STAP1	108	112	PF00017	0.448
LIG_SH2_STAP1	47	51	PF00017	0.569
LIG_SH2_STAP1	531	535	PF00017	0.563
LIG_SH2_STAP1	597	601	PF00017	0.552
LIG_SH2_STAT5	108	111	PF00017	0.446
LIG_SH2_STAT5	273	276	PF00017	0.813
LIG_SH2_STAT5	288	291	PF00017	0.588
LIG_SH2_STAT5	470	473	PF00017	0.583
LIG_SH2_STAT5	712	715	PF00017	0.664
LIG_SH2_STAT5	795	798	PF00017	0.625
LIG_SH3_2	386	391	PF14604	0.740
LIG_SH3_3	163	169	PF00018	0.685
LIG_SH3_3	272	278	PF00018	0.652
LIG_SH3_3	302	308	PF00018	0.756
LIG_SH3_3	380	386	PF00018	0.707
LIG_SH3_3	429	435	PF00018	0.571
LIG_SH3_3	770	776	PF00018	0.652
LIG_SUMO_SIM_anti_2	533	540	PF11976	0.529
LIG_SUMO_SIM_par_1	25	31	PF11976	0.587
LIG_TRAF2_1	221	224	PF00917	0.573
LIG_TRAF2_1	681	684	PF00917	0.714
LIG_TRAF2_1	76	79	PF00917	0.592
LIG_UBA3_1	106	111	PF00899	0.589
LIG_UBA3_1	537	542	PF00899	0.381
MOD_CDC14_SPxK_1	388	391	PF00782	0.737
MOD_CDK_SPK_2	162	167	PF00069	0.565
MOD_CDK_SPxK_1	385	391	PF00069	0.738
MOD_CDK_SPxxK_3	160	167	PF00069	0.707
MOD_CDK_SPxxK_3	567	574	PF00069	0.574
MOD_CK1_1	148	154	PF00069	0.696
MOD_CK1_1	199	205	PF00069	0.659
MOD_CK1_1	2	8	PF00069	0.709
MOD_CK1_1	210	216	PF00069	0.623
MOD_CK1_1	251	257	PF00069	0.558
MOD_CK1_1	265	271	PF00069	0.551
MOD_CK1_1	292	298	PF00069	0.635
MOD_CK1_1	301	307	PF00069	0.608
MOD_CK1_1	317	323	PF00069	0.518
MOD_CK1_1	345	351	PF00069	0.550
MOD_CK1_1	387	393	PF00069	0.660
MOD_CK1_1	504	510	PF00069	0.587
MOD_CK1_1	57	63	PF00069	0.590
MOD_CK1_1	570	576	PF00069	0.692
MOD_CK1_1	589	595	PF00069	0.690
MOD_CK1_1	622	628	PF00069	0.630
MOD_CK1_1	670	676	PF00069	0.672
MOD_CK1_1	682	688	PF00069	0.581
MOD_CK1_1	731	737	PF00069	0.684
MOD_CK2_1	112	118	PF00069	0.615
MOD_CK2_1	152	158	PF00069	0.568
MOD_CK2_1	218	224	PF00069	0.572
MOD_CK2_1	554	560	PF00069	0.663
MOD_CK2_1	73	79	PF00069	0.594
MOD_CMANNOS	404	407	PF00535	0.576
MOD_Cter_Amidation	133	136	PF01082	0.552
MOD_Cter_Amidation	327	330	PF01082	0.559
MOD_DYRK1A_RPxSP_1	578	582	PF00069	0.700
MOD_GlcNHglycan	21	24	PF01048	0.459
MOD_GlcNHglycan	291	294	PF01048	0.701
MOD_GlcNHglycan	305	308	PF01048	0.732
MOD_GlcNHglycan	33	36	PF01048	0.480
MOD_GlcNHglycan	483	486	PF01048	0.607
MOD_GlcNHglycan	5	8	PF01048	0.709
MOD_GlcNHglycan	521	524	PF01048	0.486
MOD_GlcNHglycan	528	531	PF01048	0.653
MOD_GlcNHglycan	582	585	PF01048	0.652
MOD_GlcNHglycan	627	630	PF01048	0.661
MOD_GlcNHglycan	640	643	PF01048	0.496
MOD_GlcNHglycan	669	672	PF01048	0.777
MOD_GlcNHglycan	730	733	PF01048	0.627
MOD_GlcNHglycan	746	749	PF01048	0.539
MOD_GlcNHglycan	765	768	PF01048	0.571
MOD_GlcNHglycan	790	793	PF01048	0.504
MOD_GSK3_1	147	154	PF00069	0.692
MOD_GSK3_1	19	26	PF00069	0.623
MOD_GSK3_1	199	206	PF00069	0.669
MOD_GSK3_1	225	232	PF00069	0.587
MOD_GSK3_1	27	34	PF00069	0.495
MOD_GSK3_1	294	301	PF00069	0.632
MOD_GSK3_1	317	324	PF00069	0.733
MOD_GSK3_1	342	349	PF00069	0.693
MOD_GSK3_1	426	433	PF00069	0.619
MOD_GSK3_1	470	477	PF00069	0.481
MOD_GSK3_1	497	504	PF00069	0.542
MOD_GSK3_1	57	64	PF00069	0.578
MOD_GSK3_1	586	593	PF00069	0.714
MOD_GSK3_1	596	603	PF00069	0.594
MOD_GSK3_1	619	626	PF00069	0.645
MOD_GSK3_1	662	669	PF00069	0.723
MOD_GSK3_1	675	682	PF00069	0.702
MOD_GSK3_1	759	766	PF00069	0.656
MOD_LATS_1	797	803	PF00433	0.652
MOD_N-GLC_1	112	117	PF02516	0.456
MOD_N-GLC_1	129	134	PF02516	0.506
MOD_N-GLC_1	265	270	PF02516	0.538
MOD_N-GLC_1	298	303	PF02516	0.567
MOD_N-GLC_1	54	59	PF02516	0.424
MOD_NEK2_1	1	6	PF00069	0.599
MOD_NEK2_1	106	111	PF00069	0.589
MOD_NEK2_1	207	212	PF00069	0.546
MOD_NEK2_1	323	328	PF00069	0.621
MOD_NEK2_1	360	365	PF00069	0.530
MOD_NEK2_1	481	486	PF00069	0.662
MOD_NEK2_1	501	506	PF00069	0.492
MOD_NEK2_1	586	591	PF00069	0.661
MOD_NEK2_1	638	643	PF00069	0.648
MOD_NEK2_1	788	793	PF00069	0.525
MOD_PIKK_1	299	305	PF00454	0.569
MOD_PIKK_1	334	340	PF00454	0.710
MOD_PIKK_1	346	352	PF00454	0.584
MOD_PIKK_1	360	366	PF00454	0.548
MOD_PIKK_1	586	592	PF00454	0.672
MOD_PIKK_1	675	681	PF00454	0.729
MOD_PIKK_1	765	771	PF00454	0.646
MOD_PK_1	342	348	PF00069	0.712
MOD_PKA_2	224	230	PF00069	0.570
MOD_PKA_2	418	424	PF00069	0.553
MOD_PKA_2	425	431	PF00069	0.557
MOD_PKA_2	481	487	PF00069	0.542
MOD_PKA_2	590	596	PF00069	0.663
MOD_PKA_2	599	605	PF00069	0.612
MOD_PKA_2	656	662	PF00069	0.654
MOD_PKB_1	342	350	PF00069	0.687
MOD_Plk_1	112	118	PF00069	0.458
MOD_Plk_1	148	154	PF00069	0.624
MOD_Plk_1	501	507	PF00069	0.626
MOD_Plk_1	54	60	PF00069	0.428
MOD_Plk_1	546	552	PF00069	0.592
MOD_Plk_1	682	688	PF00069	0.626
MOD_Plk_2-3	554	560	PF00069	0.530
MOD_Plk_4	23	29	PF00069	0.596
MOD_Plk_4	248	254	PF00069	0.697
MOD_Plk_4	308	314	PF00069	0.549
MOD_Plk_4	470	476	PF00069	0.581
MOD_Plk_4	501	507	PF00069	0.530
MOD_Plk_4	546	552	PF00069	0.459
MOD_Plk_4	645	651	PF00069	0.640
MOD_Plk_4	778	784	PF00069	0.627
MOD_ProDKin_1	160	166	PF00069	0.705
MOD_ProDKin_1	199	205	PF00069	0.674
MOD_ProDKin_1	212	218	PF00069	0.611
MOD_ProDKin_1	276	282	PF00069	0.690
MOD_ProDKin_1	301	307	PF00069	0.698
MOD_ProDKin_1	385	391	PF00069	0.706
MOD_ProDKin_1	439	445	PF00069	0.587
MOD_ProDKin_1	474	480	PF00069	0.447
MOD_ProDKin_1	504	510	PF00069	0.491
MOD_ProDKin_1	567	573	PF00069	0.710
MOD_ProDKin_1	578	584	PF00069	0.594
MOD_SUMO_for_1	146	149	PF00179	0.539
MOD_SUMO_for_1	178	181	PF00179	0.696
MOD_SUMO_for_1	255	258	PF00179	0.707
MOD_SUMO_rev_2	489	496	PF00179	0.521
MOD_SUMO_rev_2	559	567	PF00179	0.691
TRG_DiLeu_BaEn_1	533	538	PF01217	0.654
TRG_DiLeu_BaEn_4	683	689	PF01217	0.695
TRG_DiLeu_BaLyEn_6	102	107	PF01217	0.568
TRG_DiLeu_BaLyEn_6	375	380	PF01217	0.548
TRG_ENDOCYTIC_2	104	107	PF00928	0.578
TRG_ENDOCYTIC_2	188	191	PF00928	0.535
TRG_ENDOCYTIC_2	24	27	PF00928	0.604
TRG_ENDOCYTIC_2	288	291	PF00928	0.548
TRG_ER_diArg_1	376	379	PF00400	0.548
TRG_ER_diArg_1	40	42	PF00400	0.429
TRG_NLS_Bipartite_1	121	139	PF00514	0.675
TRG_NLS_Bipartite_1	329	345	PF00514	0.707
TRG_NLS_MonoExtC_3	134	140	PF00514	0.557
TRG_NLS_MonoExtN_4	340	345	PF00514	0.649
TRG_Pf-PMV_PEXEL_1	514	518	PF00026	0.602
TRG_Pf-PMV_PEXEL_1	752	756	PF00026	0.467

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IAA0	Leishmania donovani	70%	100%
A4HYB2	Leishmania infantum	70%	100%
E9AS45	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%
Q4QDC1	Leishmania major	70%	100%