CAP-Gly domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CAP-Gly domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HA45_LEIBR

TriTrypDb:

LbrM.19.1200 , LBRM2903_190018200

Length:

650

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0035371	microtubule plus-end	3	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990752	microtubule end	2	1

Expansion

Sequence features

A4HA45

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HA45

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0007017	microtubule-based process	2	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0031122	cytoplasmic microtubule organization	4	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0097435	supramolecular fiber organization	4	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0008017	microtubule binding	5	1
GO:0008092	cytoskeletal protein binding	3	1
GO:0015631	tubulin binding	4	1
GO:0051010	microtubule plus-end binding	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	124	126	PF00675	0.502
CLV_NRD_NRD_1	234	236	PF00675	0.475
CLV_NRD_NRD_1	33	35	PF00675	0.346
CLV_PCSK_KEX2_1	124	126	PF00082	0.502
CLV_PCSK_KEX2_1	226	228	PF00082	0.554
CLV_PCSK_KEX2_1	32	34	PF00082	0.345
CLV_PCSK_PC1ET2_1	226	228	PF00082	0.551
CLV_PCSK_SKI1_1	198	202	PF00082	0.452
CLV_PCSK_SKI1_1	320	324	PF00082	0.464
CLV_PCSK_SKI1_1	34	38	PF00082	0.388
CLV_PCSK_SKI1_1	640	644	PF00082	0.620
DEG_SPOP_SBC_1	437	441	PF00917	0.686
DOC_CKS1_1	643	648	PF01111	0.640
DOC_CYCLIN_RxL_1	464	474	PF00134	0.553
DOC_CYCLIN_RxL_1	620	633	PF00134	0.553
DOC_CYCLIN_yCln2_LP_2	302	308	PF00134	0.484
DOC_MAPK_gen_1	193	202	PF00069	0.345
DOC_MAPK_gen_1	32	39	PF00069	0.312
DOC_MAPK_gen_1	578	587	PF00069	0.541
DOC_MAPK_gen_1	607	616	PF00069	0.660
DOC_MAPK_RevD_3	21	34	PF00069	0.502
DOC_PP1_RVXF_1	623	630	PF00149	0.543
DOC_PP1_SILK_1	34	39	PF00149	0.388
DOC_PP4_FxxP_1	612	615	PF00568	0.714
DOC_PP4_FxxP_1	643	646	PF00568	0.642
DOC_PP4_FxxP_1	81	84	PF00568	0.319
DOC_USP7_MATH_1	153	157	PF00917	0.439
DOC_USP7_MATH_1	16	20	PF00917	0.501
DOC_USP7_MATH_1	244	248	PF00917	0.414
DOC_USP7_MATH_1	268	272	PF00917	0.642
DOC_USP7_MATH_1	274	278	PF00917	0.646
DOC_USP7_MATH_1	282	286	PF00917	0.551
DOC_USP7_MATH_1	333	337	PF00917	0.583
DOC_USP7_MATH_1	437	441	PF00917	0.671
DOC_USP7_MATH_1	446	450	PF00917	0.476
DOC_USP7_MATH_1	499	503	PF00917	0.583
DOC_USP7_MATH_1	592	596	PF00917	0.459
DOC_USP7_MATH_1	6	10	PF00917	0.724
DOC_USP7_MATH_1	615	619	PF00917	0.489
DOC_WW_Pin1_4	562	567	PF00397	0.698
DOC_WW_Pin1_4	642	647	PF00397	0.671
LIG_14-3-3_CanoR_1	152	162	PF00244	0.398
LIG_14-3-3_CanoR_1	340	348	PF00244	0.401
LIG_14-3-3_CanoR_1	398	408	PF00244	0.448
LIG_14-3-3_CanoR_1	421	427	PF00244	0.524
LIG_14-3-3_CanoR_1	472	478	PF00244	0.384
LIG_14-3-3_CanoR_1	507	511	PF00244	0.599
LIG_14-3-3_CanoR_1	578	583	PF00244	0.635
LIG_14-3-3_CanoR_1	593	601	PF00244	0.445
LIG_14-3-3_CanoR_1	8	16	PF00244	0.604
LIG_Actin_WH2_2	137	154	PF00022	0.512
LIG_BIR_II_1	1	5	PF00653	0.603
LIG_DLG_GKlike_1	578	585	PF00625	0.563
LIG_FHA_1	298	304	PF00498	0.574
LIG_FHA_1	375	381	PF00498	0.570
LIG_FHA_1	423	429	PF00498	0.409
LIG_FHA_1	464	470	PF00498	0.422
LIG_FHA_1	472	478	PF00498	0.381
LIG_FHA_1	637	643	PF00498	0.452
LIG_FHA_2	172	178	PF00498	0.547
LIG_FHA_2	440	446	PF00498	0.577
LIG_FHA_2	563	569	PF00498	0.459
LIG_LIR_Gen_1	18	28	PF02991	0.440
LIG_LIR_Nem_3	18	23	PF02991	0.415
LIG_LIR_Nem_3	47	53	PF02991	0.321
LIG_LIR_Nem_3	606	612	PF02991	0.528
LIG_NRBOX	357	363	PF00104	0.485
LIG_NRBOX	581	587	PF00104	0.565
LIG_Rb_LxCxE_1	480	497	PF01857	0.410
LIG_RPA_C_Fungi	230	242	PF08784	0.573
LIG_SH2_CRK	306	310	PF00017	0.492
LIG_SH2_NCK_1	306	310	PF00017	0.488
LIG_SH2_STAP1	334	338	PF00017	0.404
LIG_SH2_STAP1	575	579	PF00017	0.524
LIG_SH2_STAP1	90	94	PF00017	0.420
LIG_SH2_STAT5	71	74	PF00017	0.352
LIG_SH3_3	10	16	PF00018	0.607
LIG_SH3_3	22	28	PF00018	0.361
LIG_SH3_3	264	270	PF00018	0.506
LIG_SH3_3	431	437	PF00018	0.502
LIG_SH3_3	598	604	PF00018	0.489
LIG_SUMO_SIM_anti_2	18	25	PF11976	0.402
LIG_TRAF2_1	136	139	PF00917	0.358
LIG_TRAF2_1	273	276	PF00917	0.504
LIG_TRAF2_1	401	404	PF00917	0.472
LIG_WRC_WIRS_1	17	22	PF05994	0.410
MOD_CK1_1	140	146	PF00069	0.590
MOD_CK1_1	438	444	PF00069	0.752
MOD_CK1_1	537	543	PF00069	0.504
MOD_CK1_1	553	559	PF00069	0.518
MOD_CK1_1	89	95	PF00069	0.462
MOD_CK2_1	133	139	PF00069	0.390
MOD_CK2_1	16	22	PF00069	0.417
MOD_CK2_1	171	177	PF00069	0.521
MOD_CK2_1	210	216	PF00069	0.522
MOD_CK2_1	270	276	PF00069	0.504
MOD_CK2_1	439	445	PF00069	0.535
MOD_CK2_1	615	621	PF00069	0.550
MOD_CK2_1	627	633	PF00069	0.414
MOD_GlcNHglycan	109	112	PF01048	0.651
MOD_GlcNHglycan	212	215	PF01048	0.605
MOD_GlcNHglycan	264	267	PF01048	0.464
MOD_GlcNHglycan	272	275	PF01048	0.622
MOD_GlcNHglycan	284	287	PF01048	0.513
MOD_GlcNHglycan	399	402	PF01048	0.559
MOD_GlcNHglycan	552	555	PF01048	0.572
MOD_GlcNHglycan	562	565	PF01048	0.572
MOD_GlcNHglycan	595	598	PF01048	0.619
MOD_GlcNHglycan	600	604	PF01048	0.587
MOD_GlcNHglycan	9	12	PF01048	0.700
MOD_GSK3_1	133	140	PF00069	0.559
MOD_GSK3_1	270	277	PF00069	0.675
MOD_GSK3_1	370	377	PF00069	0.590
MOD_GSK3_1	435	442	PF00069	0.756
MOD_GSK3_1	550	557	PF00069	0.635
MOD_GSK3_1	599	606	PF00069	0.598
MOD_N-GLC_1	164	169	PF02516	0.487
MOD_N-GLC_1	62	67	PF02516	0.231
MOD_NEK2_1	137	142	PF00069	0.497
MOD_NEK2_1	207	212	PF00069	0.375
MOD_NEK2_1	254	259	PF00069	0.482
MOD_NEK2_1	471	476	PF00069	0.468
MOD_NEK2_1	627	632	PF00069	0.530
MOD_NEK2_1	86	91	PF00069	0.366
MOD_NEK2_2	615	620	PF00069	0.489
MOD_PIKK_1	153	159	PF00454	0.382
MOD_PIKK_1	268	274	PF00454	0.607
MOD_PIKK_1	399	405	PF00454	0.404
MOD_PIKK_1	471	477	PF00454	0.445
MOD_PIKK_1	537	543	PF00454	0.406
MOD_PKA_1	235	241	PF00069	0.446
MOD_PKA_2	397	403	PF00069	0.406
MOD_PKA_2	471	477	PF00069	0.383
MOD_PKA_2	506	512	PF00069	0.587
MOD_PKA_2	592	598	PF00069	0.605
MOD_PKA_2	7	13	PF00069	0.651
MOD_Plk_1	137	143	PF00069	0.456
MOD_Plk_1	164	170	PF00069	0.478
MOD_Plk_1	254	260	PF00069	0.562
MOD_Plk_4	16	22	PF00069	0.437
MOD_ProDKin_1	562	568	PF00069	0.693
MOD_ProDKin_1	642	648	PF00069	0.673
MOD_SUMO_for_1	111	114	PF00179	0.468
MOD_SUMO_for_1	348	351	PF00179	0.539
MOD_SUMO_for_1	386	389	PF00179	0.406
MOD_SUMO_rev_2	204	210	PF00179	0.503
MOD_SUMO_rev_2	317	324	PF00179	0.520
MOD_SUMO_rev_2	363	371	PF00179	0.490
TRG_DiLeu_BaEn_1	357	362	PF01217	0.484
TRG_DiLeu_BaEn_4	353	359	PF01217	0.555
TRG_DiLeu_BaLyEn_6	622	627	PF01217	0.625
TRG_ER_diArg_1	32	34	PF00400	0.350
TRG_ER_diArg_1	465	468	PF00400	0.562
TRG_Pf-PMV_PEXEL_1	235	239	PF00026	0.422
TRG_Pf-PMV_PEXEL_1	410	414	PF00026	0.525
TRG_Pf-PMV_PEXEL_1	580	584	PF00026	0.498

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSH8	Leptomonas seymouri	37%	91%
A0A3Q8IEJ2	Leishmania donovani	69%	98%
A4HYB1	Leishmania infantum	69%	98%
E9AS44	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%
Q4QDC2	Leishmania major	67%	98%