Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HA44_LEIBR

TriTrypDb:

LbrM.19.1190 , LBRM2903_190018100

Length:

881

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HA44

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HA44

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	167	171	PF00656	0.396
CLV_C14_Caspase3-7	298	302	PF00656	0.447
CLV_C14_Caspase3-7	791	795	PF00656	0.482
CLV_C14_Caspase3-7	807	811	PF00656	0.479
CLV_MEL_PAP_1	348	354	PF00089	0.447
CLV_NRD_NRD_1	113	115	PF00675	0.524
CLV_NRD_NRD_1	167	169	PF00675	0.416
CLV_NRD_NRD_1	338	340	PF00675	0.372
CLV_NRD_NRD_1	386	388	PF00675	0.410
CLV_NRD_NRD_1	444	446	PF00675	0.425
CLV_NRD_NRD_1	524	526	PF00675	0.530
CLV_NRD_NRD_1	687	689	PF00675	0.476
CLV_NRD_NRD_1	691	693	PF00675	0.466
CLV_NRD_NRD_1	788	790	PF00675	0.515
CLV_PCSK_FUR_1	111	115	PF00082	0.505
CLV_PCSK_FUR_1	336	340	PF00082	0.357
CLV_PCSK_FUR_1	522	526	PF00082	0.522
CLV_PCSK_FUR_1	688	692	PF00082	0.481
CLV_PCSK_KEX2_1	113	115	PF00082	0.524
CLV_PCSK_KEX2_1	338	340	PF00082	0.372
CLV_PCSK_KEX2_1	386	388	PF00082	0.410
CLV_PCSK_KEX2_1	419	421	PF00082	0.666
CLV_PCSK_KEX2_1	444	446	PF00082	0.425
CLV_PCSK_KEX2_1	524	526	PF00082	0.530
CLV_PCSK_KEX2_1	687	689	PF00082	0.473
CLV_PCSK_KEX2_1	690	692	PF00082	0.466
CLV_PCSK_KEX2_1	788	790	PF00082	0.515
CLV_PCSK_KEX2_1	805	807	PF00082	0.453
CLV_PCSK_PC1ET2_1	419	421	PF00082	0.530
CLV_PCSK_PC1ET2_1	805	807	PF00082	0.458
CLV_PCSK_PC7_1	382	388	PF00082	0.414
CLV_PCSK_PC7_1	687	693	PF00082	0.463
CLV_PCSK_SKI1_1	169	173	PF00082	0.385
CLV_PCSK_SKI1_1	447	451	PF00082	0.421
CLV_PCSK_SKI1_1	826	830	PF00082	0.552
CLV_PCSK_SKI1_1	861	865	PF00082	0.466
DEG_APCC_DBOX_1	128	136	PF00400	0.344
DEG_APCC_DBOX_1	507	515	PF00400	0.481
DEG_APCC_DBOX_1	860	868	PF00400	0.465
DEG_Nend_UBRbox_2	1	3	PF02207	0.508
DEG_SIAH_1	307	315	PF03145	0.494
DEG_SPOP_SBC_1	266	270	PF00917	0.503
DEG_SPOP_SBC_1	569	573	PF00917	0.585
DEG_SPOP_SBC_1	8	12	PF00917	0.470
DEG_SPOP_SBC_1	93	97	PF00917	0.452
DOC_CDC14_PxL_1	832	840	PF14671	0.438
DOC_CKS1_1	458	463	PF01111	0.487
DOC_CYCLIN_yCln2_LP_2	16	22	PF00134	0.501
DOC_MAPK_gen_1	168	174	PF00069	0.390
DOC_MAPK_gen_1	236	244	PF00069	0.413
DOC_MAPK_gen_1	505	513	PF00069	0.481
DOC_MAPK_MEF2A_6	761	770	PF00069	0.662
DOC_MAPK_RevD_3	98	114	PF00069	0.430
DOC_PP1_RVXF_1	236	242	PF00149	0.425
DOC_PP2B_LxvP_1	16	19	PF13499	0.498
DOC_PP2B_LxvP_1	193	196	PF13499	0.464
DOC_PP2B_LxvP_1	517	520	PF13499	0.467
DOC_PP2B_LxvP_1	869	872	PF13499	0.476
DOC_USP7_MATH_1	225	229	PF00917	0.555
DOC_USP7_MATH_1	24	28	PF00917	0.520
DOC_USP7_MATH_1	350	354	PF00917	0.423
DOC_USP7_MATH_1	407	411	PF00917	0.613
DOC_USP7_MATH_1	499	503	PF00917	0.451
DOC_USP7_MATH_1	506	510	PF00917	0.583
DOC_USP7_MATH_1	569	573	PF00917	0.581
DOC_USP7_MATH_1	584	588	PF00917	0.554
DOC_USP7_MATH_1	616	620	PF00917	0.721
DOC_USP7_MATH_1	635	639	PF00917	0.592
DOC_USP7_MATH_1	700	704	PF00917	0.524
DOC_USP7_MATH_1	92	96	PF00917	0.504
DOC_USP7_MATH_2	60	66	PF00917	0.481
DOC_WW_Pin1_4	11	16	PF00397	0.469
DOC_WW_Pin1_4	112	117	PF00397	0.472
DOC_WW_Pin1_4	310	315	PF00397	0.543
DOC_WW_Pin1_4	342	347	PF00397	0.503
DOC_WW_Pin1_4	457	462	PF00397	0.473
DOC_WW_Pin1_4	532	537	PF00397	0.555
DOC_WW_Pin1_4	56	61	PF00397	0.472
DOC_WW_Pin1_4	575	580	PF00397	0.578
DOC_WW_Pin1_4	593	598	PF00397	0.520
DOC_WW_Pin1_4	711	716	PF00397	0.527
DOC_WW_Pin1_4	735	740	PF00397	0.511
DOC_WW_Pin1_4	792	797	PF00397	0.481
DOC_WW_Pin1_4	88	93	PF00397	0.509
LIG_14-3-3_CanoR_1	236	242	PF00244	0.445
LIG_14-3-3_CanoR_1	338	348	PF00244	0.469
LIG_14-3-3_CanoR_1	351	359	PF00244	0.423
LIG_14-3-3_CanoR_1	37	45	PF00244	0.480
LIG_14-3-3_CanoR_1	428	434	PF00244	0.467
LIG_14-3-3_CanoR_1	447	455	PF00244	0.388
LIG_14-3-3_CanoR_1	464	468	PF00244	0.524
LIG_14-3-3_CanoR_1	489	494	PF00244	0.483
LIG_14-3-3_CanoR_1	505	514	PF00244	0.438
LIG_14-3-3_CanoR_1	676	682	PF00244	0.445
LIG_14-3-3_CanoR_1	776	782	PF00244	0.437
LIG_14-3-3_CanoR_1	859	867	PF00244	0.461
LIG_Actin_WH2_2	431	446	PF00022	0.445
LIG_BIR_III_2	148	152	PF00653	0.395
LIG_BRCT_BRCA1_1	727	731	PF00533	0.486
LIG_CaM_NSCaTE_8	296	303	PF13499	0.441
LIG_CaM_NSCaTE_8	493	500	PF13499	0.455
LIG_CSL_BTD_1	240	243	PF09270	0.440
LIG_eIF4E_1	356	362	PF01652	0.369
LIG_eIF4E_1	833	839	PF01652	0.433
LIG_FHA_1	120	126	PF00498	0.445
LIG_FHA_1	243	249	PF00498	0.481
LIG_FHA_1	332	338	PF00498	0.393
LIG_FHA_1	343	349	PF00498	0.469
LIG_FHA_1	356	362	PF00498	0.308
LIG_FHA_1	576	582	PF00498	0.554
LIG_FHA_1	780	786	PF00498	0.470
LIG_FHA_1	817	823	PF00498	0.470
LIG_FHA_1	95	101	PF00498	0.440
LIG_FHA_2	165	171	PF00498	0.398
LIG_FHA_2	627	633	PF00498	0.514
LIG_LIR_Apic_2	831	836	PF02991	0.435
LIG_LIR_Gen_1	209	216	PF02991	0.399
LIG_LIR_Gen_1	395	403	PF02991	0.390
LIG_LIR_Gen_1	490	499	PF02991	0.452
LIG_LIR_Gen_1	728	739	PF02991	0.483
LIG_LIR_Nem_3	209	213	PF02991	0.396
LIG_LIR_Nem_3	240	244	PF02991	0.417
LIG_LIR_Nem_3	353	359	PF02991	0.375
LIG_LIR_Nem_3	395	399	PF02991	0.390
LIG_LIR_Nem_3	490	494	PF02991	0.450
LIG_LIR_Nem_3	619	623	PF02991	0.526
LIG_LIR_Nem_3	728	734	PF02991	0.487
LIG_LYPXL_yS_3	875	878	PF13949	0.494
LIG_MYND_1	196	200	PF01753	0.425
LIG_MYND_1	876	880	PF01753	0.496
LIG_NRBOX	176	182	PF00104	0.367
LIG_PTAP_UEV_1	307	312	PF05743	0.536
LIG_REV1ctd_RIR_1	158	168	PF16727	0.362
LIG_SH2_CRK	678	682	PF00017	0.453
LIG_SH2_NCK_1	696	700	PF00017	0.532
LIG_SH2_PTP2	833	836	PF00017	0.428
LIG_SH2_SRC	210	213	PF00017	0.446
LIG_SH2_STAP1	154	158	PF00017	0.347
LIG_SH2_STAP1	210	214	PF00017	0.403
LIG_SH2_STAP1	678	682	PF00017	0.444
LIG_SH2_STAP1	781	785	PF00017	0.432
LIG_SH2_STAP1	823	827	PF00017	0.412
LIG_SH2_STAT3	812	815	PF00017	0.471
LIG_SH2_STAT5	134	137	PF00017	0.333
LIG_SH2_STAT5	173	176	PF00017	0.383
LIG_SH2_STAT5	250	253	PF00017	0.471
LIG_SH2_STAT5	356	359	PF00017	0.368
LIG_SH2_STAT5	481	484	PF00017	0.433
LIG_SH2_STAT5	594	597	PF00017	0.526
LIG_SH2_STAT5	620	623	PF00017	0.528
LIG_SH2_STAT5	781	784	PF00017	0.430
LIG_SH2_STAT5	812	815	PF00017	0.471
LIG_SH2_STAT5	833	836	PF00017	0.428
LIG_SH3_1	83	89	PF00018	0.476
LIG_SH3_3	193	199	PF00018	0.473
LIG_SH3_3	221	227	PF00018	0.457
LIG_SH3_3	248	254	PF00018	0.485
LIG_SH3_3	305	311	PF00018	0.528
LIG_SH3_3	357	363	PF00018	0.376
LIG_SH3_3	455	461	PF00018	0.455
LIG_SH3_3	576	582	PF00018	0.573
LIG_SH3_3	709	715	PF00018	0.525
LIG_SH3_3	83	89	PF00018	0.514
LIG_SH3_3	868	874	PF00018	0.478
LIG_SH3_CIN85_PxpxPR_1	580	585	PF14604	0.578
LIG_SUMO_SIM_anti_2	124	130	PF11976	0.367
LIG_SUMO_SIM_anti_2	183	190	PF11976	0.407
LIG_SUMO_SIM_anti_2	204	209	PF11976	0.404
LIG_SUMO_SIM_anti_2	358	364	PF11976	0.375
LIG_SUMO_SIM_par_1	17	23	PF11976	0.490
LIG_SUMO_SIM_par_1	183	190	PF11976	0.457
LIG_SUMO_SIM_par_1	199	204	PF11976	0.404
LIG_SUMO_SIM_par_1	358	364	PF11976	0.384
LIG_SUMO_SIM_par_1	817	824	PF11976	0.455
LIG_TRAF2_1	657	660	PF00917	0.528
LIG_TRAF2_1	715	718	PF00917	0.545
LIG_TYR_ITIM	208	213	PF00017	0.391
LIG_ULM_U2AF65_1	444	449	PF00076	0.425
LIG_WRC_WIRS_1	488	493	PF05994	0.471
LIG_WW_2	579	582	PF00397	0.537
MOD_CDC14_SPxK_1	535	538	PF00782	0.550
MOD_CDK_SPK_2	580	585	PF00069	0.569
MOD_CDK_SPxK_1	532	538	PF00069	0.555
MOD_CDK_SPxxK_3	457	464	PF00069	0.486
MOD_CK1_1	101	107	PF00069	0.435
MOD_CK1_1	14	20	PF00069	0.520
MOD_CK1_1	237	243	PF00069	0.437
MOD_CK1_1	256	262	PF00069	0.480
MOD_CK1_1	27	33	PF00069	0.530
MOD_CK1_1	278	284	PF00069	0.488
MOD_CK1_1	302	308	PF00069	0.508
MOD_CK1_1	342	348	PF00069	0.543
MOD_CK1_1	47	53	PF00069	0.435
MOD_CK1_1	571	577	PF00069	0.581
MOD_CK1_1	603	609	PF00069	0.656
MOD_CK1_1	638	644	PF00069	0.673
MOD_CK1_1	647	653	PF00069	0.520
MOD_CK1_1	703	709	PF00069	0.533
MOD_CK1_1	724	730	PF00069	0.659
MOD_CK2_1	267	273	PF00069	0.581
MOD_CK2_1	36	42	PF00069	0.517
MOD_CK2_1	411	417	PF00069	0.480
MOD_CK2_1	527	533	PF00069	0.594
MOD_CK2_1	56	62	PF00069	0.452
MOD_CK2_1	677	683	PF00069	0.448
MOD_Cter_Amidation	111	114	PF01082	0.505
MOD_GlcNHglycan	100	103	PF01048	0.480
MOD_GlcNHglycan	11	14	PF01048	0.503
MOD_GlcNHglycan	16	19	PF01048	0.522
MOD_GlcNHglycan	22	25	PF01048	0.535
MOD_GlcNHglycan	227	230	PF01048	0.515
MOD_GlcNHglycan	255	258	PF01048	0.512
MOD_GlcNHglycan	280	283	PF01048	0.464
MOD_GlcNHglycan	301	304	PF01048	0.523
MOD_GlcNHglycan	308	311	PF01048	0.532
MOD_GlcNHglycan	352	355	PF01048	0.513
MOD_GlcNHglycan	399	402	PF01048	0.565
MOD_GlcNHglycan	49	52	PF01048	0.446
MOD_GlcNHglycan	573	576	PF01048	0.582
MOD_GlcNHglycan	586	589	PF01048	0.545
MOD_GlcNHglycan	602	605	PF01048	0.554
MOD_GlcNHglycan	731	734	PF01048	0.511
MOD_GlcNHglycan	77	80	PF01048	0.512
MOD_GSK3_1	101	108	PF00069	0.423
MOD_GSK3_1	160	167	PF00069	0.397
MOD_GSK3_1	20	27	PF00069	0.503
MOD_GSK3_1	225	232	PF00069	0.678
MOD_GSK3_1	256	263	PF00069	0.585
MOD_GSK3_1	265	272	PF00069	0.515
MOD_GSK3_1	273	280	PF00069	0.505
MOD_GSK3_1	302	309	PF00069	0.491
MOD_GSK3_1	32	39	PF00069	0.489
MOD_GSK3_1	327	334	PF00069	0.390
MOD_GSK3_1	338	345	PF00069	0.451
MOD_GSK3_1	402	409	PF00069	0.400
MOD_GSK3_1	426	433	PF00069	0.442
MOD_GSK3_1	443	450	PF00069	0.539
MOD_GSK3_1	463	470	PF00069	0.485
MOD_GSK3_1	483	490	PF00069	0.452
MOD_GSK3_1	569	576	PF00069	0.579
MOD_GSK3_1	580	587	PF00069	0.559
MOD_GSK3_1	602	609	PF00069	0.594
MOD_GSK3_1	612	619	PF00069	0.535
MOD_GSK3_1	634	641	PF00069	0.559
MOD_GSK3_1	647	654	PF00069	0.518
MOD_GSK3_1	7	14	PF00069	0.486
MOD_GSK3_1	700	707	PF00069	0.521
MOD_GSK3_1	721	728	PF00069	0.737
MOD_GSK3_1	75	82	PF00069	0.486
MOD_GSK3_1	88	95	PF00069	0.518
MOD_N-GLC_1	24	29	PF02516	0.510
MOD_N-GLC_1	483	488	PF02516	0.464
MOD_N-GLC_1	607	612	PF02516	0.623
MOD_N-GLC_1	627	632	PF02516	0.527
MOD_N-GLC_1	725	730	PF02516	0.505
MOD_NEK2_1	160	165	PF00069	0.409
MOD_NEK2_1	172	177	PF00069	0.536
MOD_NEK2_1	258	263	PF00069	0.518
MOD_NEK2_1	271	276	PF00069	0.524
MOD_NEK2_1	331	336	PF00069	0.348
MOD_NEK2_1	36	41	PF00069	0.517
MOD_NEK2_1	381	386	PF00069	0.442
MOD_NEK2_1	402	407	PF00069	0.427
MOD_NEK2_1	443	448	PF00069	0.495
MOD_NEK2_1	45	50	PF00069	0.481
MOD_NEK2_1	482	487	PF00069	0.426
MOD_NEK2_1	671	676	PF00069	0.459
MOD_NEK2_1	734	739	PF00069	0.480
MOD_NEK2_1	777	782	PF00069	0.421
MOD_NEK2_1	816	821	PF00069	0.543
MOD_NEK2_2	94	99	PF00069	0.442
MOD_PIKK_1	275	281	PF00454	0.499
MOD_PKA_1	338	344	PF00069	0.411
MOD_PKA_1	419	425	PF00069	0.472
MOD_PKA_2	237	243	PF00069	0.455
MOD_PKA_2	338	344	PF00069	0.419
MOD_PKA_2	350	356	PF00069	0.390
MOD_PKA_2	36	42	PF00069	0.480
MOD_PKA_2	381	387	PF00069	0.465
MOD_PKA_2	419	425	PF00069	0.500
MOD_PKA_2	427	433	PF00069	0.569
MOD_PKA_2	443	449	PF00069	0.385
MOD_PKA_2	463	469	PF00069	0.487
MOD_PKA_2	504	510	PF00069	0.473
MOD_PKA_2	584	590	PF00069	0.567
MOD_PKA_2	638	644	PF00069	0.545
MOD_PKA_2	703	709	PF00069	0.611
MOD_PKB_1	336	344	PF00069	0.435
MOD_PKB_1	445	453	PF00069	0.415
MOD_PKB_1	857	865	PF00069	0.455
MOD_Plk_1	203	209	PF00069	0.419
MOD_Plk_1	483	489	PF00069	0.467
MOD_Plk_1	62	68	PF00069	0.476
MOD_Plk_1	627	633	PF00069	0.514
MOD_Plk_1	725	731	PF00069	0.513
MOD_Plk_1	816	822	PF00069	0.551
MOD_Plk_2-3	472	478	PF00069	0.456
MOD_Plk_2-3	651	657	PF00069	0.530
MOD_Plk_4	203	209	PF00069	0.415
MOD_Plk_4	237	243	PF00069	0.411
MOD_Plk_4	327	333	PF00069	0.366
MOD_Plk_4	527	533	PF00069	0.530
MOD_Plk_4	616	622	PF00069	0.545
MOD_Plk_4	677	683	PF00069	0.458
MOD_Plk_4	834	840	PF00069	0.430
MOD_Plk_4	874	880	PF00069	0.494
MOD_ProDKin_1	11	17	PF00069	0.472
MOD_ProDKin_1	112	118	PF00069	0.474
MOD_ProDKin_1	310	316	PF00069	0.544
MOD_ProDKin_1	342	348	PF00069	0.504
MOD_ProDKin_1	457	463	PF00069	0.479
MOD_ProDKin_1	532	538	PF00069	0.555
MOD_ProDKin_1	56	62	PF00069	0.474
MOD_ProDKin_1	575	581	PF00069	0.578
MOD_ProDKin_1	593	599	PF00069	0.517
MOD_ProDKin_1	711	717	PF00069	0.529
MOD_ProDKin_1	735	741	PF00069	0.510
MOD_ProDKin_1	792	798	PF00069	0.479
MOD_ProDKin_1	88	94	PF00069	0.509
MOD_SUMO_rev_2	414	421	PF00179	0.507
TRG_DiLeu_BaEn_1	327	332	PF01217	0.369
TRG_DiLeu_BaEn_4	684	690	PF01217	0.466
TRG_DiLeu_BaLyEn_6	176	181	PF01217	0.367
TRG_ENDOCYTIC_2	210	213	PF00928	0.400
TRG_ENDOCYTIC_2	356	359	PF00928	0.368
TRG_ENDOCYTIC_2	620	623	PF00928	0.528
TRG_ENDOCYTIC_2	678	681	PF00928	0.454
TRG_ENDOCYTIC_2	875	878	PF00928	0.507
TRG_ER_diArg_1	110	113	PF00400	0.483
TRG_ER_diArg_1	236	239	PF00400	0.449
TRG_ER_diArg_1	289	292	PF00400	0.428
TRG_ER_diArg_1	335	338	PF00400	0.390
TRG_ER_diArg_1	443	445	PF00400	0.432
TRG_ER_diArg_1	522	525	PF00400	0.520
TRG_ER_diArg_1	686	688	PF00400	0.462
TRG_ER_diArg_1	689	692	PF00400	0.466
TRG_ER_diArg_1	787	789	PF00400	0.489
TRG_ER_diArg_1	857	860	PF00400	0.443
TRG_NES_CRM1_1	743	755	PF08389	0.435
TRG_Pf-PMV_PEXEL_1	179	183	PF00026	0.369
TRG_Pf-PMV_PEXEL_1	404	408	PF00026	0.466

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P316	Leptomonas seymouri	35%	100%
A0A3S7WVF4	Leishmania donovani	66%	97%
A4HYB0	Leishmania infantum	66%	97%
E9AS43	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	88%
Q4QDC3	Leishmania major	67%	100%