Putative ATG8/AUT7/APG8/PAZ2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATG8/AUT7/APG8/PAZ2, putative

Species:

Leishmania braziliensis

UniProt:

A4HA43_LEIBR

TriTrypDb:

LbrM.19.1170 , LBRM2903_190017500

Length:

118

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 45
NetGPI	no	yes: 0, no: 45

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	46
GO:0110165	cellular anatomical entity	1	46

Expansion

Sequence features

A4HA43

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HA43

Function

Biological processes
Term	Name	Level	Count
GO:0006914	autophagy	3	14
GO:0008152	metabolic process	1	14
GO:0009056	catabolic process	2	14
GO:0009987	cellular process	1	26
GO:0044237	cellular metabolic process	2	14
GO:0044248	cellular catabolic process	3	14
GO:0061919	process utilizing autophagic mechanism	2	14
GO:0006950	response to stress	2	14
GO:0006995	cellular response to nitrogen starvation	5	14
GO:0007154	cell communication	2	14
GO:0009267	cellular response to starvation	4	14
GO:0009605	response to external stimulus	2	14
GO:0009991	response to extracellular stimulus	3	14
GO:0031667	response to nutrient levels	4	14
GO:0031668	cellular response to extracellular stimulus	3	14
GO:0031669	cellular response to nutrient levels	4	14
GO:0033554	cellular response to stress	3	14
GO:0042594	response to starvation	3	14
GO:0043562	cellular response to nitrogen levels	5	14
GO:0050896	response to stimulus	1	14
GO:0051716	cellular response to stimulus	2	14
GO:0071496	cellular response to external stimulus	3	14

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	86	90	PF00656	0.338
CLV_NRD_NRD_1	13	15	PF00675	0.379
CLV_PCSK_KEX2_1	13	15	PF00082	0.379
CLV_PCSK_SKI1_1	47	51	PF00082	0.376
CLV_PCSK_SKI1_1	59	63	PF00082	0.395
DOC_AGCK_PIF_3	115	118	PF00069	0.388
DOC_MAPK_gen_1	36	45	PF00069	0.194
DOC_PP2B_LxvP_1	43	46	PF13499	0.371
DOC_USP7_MATH_1	3	7	PF00917	0.454
DOC_USP7_MATH_1	34	38	PF00917	0.212
DOC_WW_Pin1_4	74	79	PF00397	0.408
LIG_BIR_II_1	1	5	PF00653	0.614
LIG_BRCT_BRCA1_1	111	115	PF00533	0.399
LIG_FHA_1	68	74	PF00498	0.323
LIG_FHA_1	79	85	PF00498	0.292
LIG_FHA_2	48	54	PF00498	0.376
LIG_IRF3_LxIS_1	58	65	PF10401	0.203
LIG_LIR_Gen_1	95	102	PF02991	0.278
LIG_LIR_Nem_3	112	118	PF02991	0.445
LIG_LIR_Nem_3	95	100	PF02991	0.276
LIG_Pex14_2	111	115	PF04695	0.405
LIG_SH2_PTP2	99	102	PF00017	0.361
LIG_SH2_STAT5	99	102	PF00017	0.331
LIG_SUMO_SIM_par_1	69	74	PF11976	0.355
MOD_CK1_1	6	12	PF00069	0.312
MOD_CK2_1	47	53	PF00069	0.362
MOD_GlcNHglycan	1	4	PF01048	0.598
MOD_GlcNHglycan	64	67	PF01048	0.365
MOD_GSK3_1	74	81	PF00069	0.416
MOD_NEK2_1	62	67	PF00069	0.283
MOD_NEK2_1	98	103	PF00069	0.347
MOD_Plk_1	47	53	PF00069	0.410
MOD_ProDKin_1	74	80	PF00069	0.408
TRG_ENDOCYTIC_2	99	102	PF00928	0.361

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9V5	Leptomonas seymouri	77%	98%
A0A0N1PD53	Leptomonas seymouri	29%	99%
A0A0S4JA79	Bodo saltans	27%	95%
A0A1X0P492	Trypanosomatidae	40%	84%
A0A1X0P5E7	Trypanosomatidae	38%	84%
A0A381MAT2	Leishmania infantum	47%	88%
A0A381MBG2	Leishmania infantum	47%	95%
A0A381MCF0	Leishmania infantum	47%	95%
A0A381MFR9	Leishmania infantum	80%	94%
A0A3Q8IB99	Leishmania donovani	80%	98%
A0A3Q8IK22	Leishmania donovani	57%	87%
A0A3S5H6B2	Leishmania donovani	47%	88%
A0A3S5H6B3	Leishmania donovani	47%	95%
A0A3S5H761	Leishmania donovani	79%	94%
A0A3S5H762	Leishmania donovani	79%	98%
A0A3S7WQH8	Leishmania donovani	47%	95%
A0A3S7WQJ1	Leishmania donovani	47%	97%
A0A3S7WVM4	Leishmania donovani	77%	98%
A0A3S7WVQ8	Leishmania donovani	30%	94%
A0A422NM46	Trypanosoma rangeli	27%	97%
A0A422NM79	Trypanosoma rangeli	29%	96%
A1CQS1	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	27%	100%
A1D3N4	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	27%	100%
A2QPN1	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	27%	100%
A2XXR7	Oryza sativa subsp. indica	30%	99%
A2YS06	Oryza sativa subsp. indica	31%	98%
A4H5J2	Leishmania braziliensis	50%	100%
A4H5J3	Leishmania braziliensis	49%	100%
A4HA39	Leishmania braziliensis	56%	100%
A4HA42	Leishmania braziliensis	99%	100%
A4HAB2	Leishmania braziliensis	30%	98%
A4HTT6	Leishmania infantum	47%	97%
A4HYA4	Leishmania infantum	78%	94%
A4HYA5	Leishmania infantum	81%	74%
A4HYJ2	Leishmania infantum	30%	94%
A4LA70	Colletotrichum lindemuthianum	27%	98%
A6RPU4	Botryotinia fuckeliana (strain B05.10)	28%	96%
A7E8H4	Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)	28%	96%
A7KAL9	Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255)	27%	100%
C4B4E4	Glomerella lagenarium	27%	98%
C9ZTR3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	98%
E9AGS4	Leishmania infantum	57%	87%
E9AML6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	95%
E9AS34	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	98%
E9AS37	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	94%
E9AS38	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	98%
E9AS40	Leishmania mexicana (strain MHOM/GT/2001/U1103)	55%	87%
E9AS41	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	98%
E9ASB6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	94%
I1S1W5	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	27%	100%
J4UTT5	Beauveria bassiana (strain ARSEF 2860)	27%	100%
M1C146	Solanum tuberosum	32%	99%
M2SQA5	Cochliobolus heterostrophus (strain C5 / ATCC 48332 / race O)	27%	99%
N4X184	Cochliobolus heterostrophus (strain C4 / ATCC 48331 / race T)	27%	99%
O94272	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	98%
P0CO54	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	27%	94%
P0CO55	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	27%	94%
P60519	Bos taurus	29%	100%
P60520	Homo sapiens	29%	100%
P60521	Mus musculus	29%	100%
P60522	Rattus norvegicus	29%	100%
Q09490	Caenorhabditis elegans	28%	96%
Q0C804	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	27%	100%
Q0V3Y9	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	27%	99%
Q1E4K5	Coccidioides immitis (strain RS)	27%	100%
Q2GVL1	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	27%	98%
Q2UBH5	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	27%	100%
Q2XPP5	Oryza sativa subsp. indica	28%	99%
Q4P2U6	Ustilago maydis (strain 521 / FGSC 9021)	30%	100%
Q4QD46	Leishmania major	30%	100%
Q4QDC5	Leishmania major	80%	100%
Q4QDC8	Leishmania major	80%	100%
Q4QDD0	Leishmania major	79%	100%
Q4QDD1	Leishmania major	56%	100%
Q4QDD3	Leishmania major	77%	100%
Q4QDD4	Leishmania major	57%	100%
Q4QDD6	Leishmania major	76%	100%
Q4QI08	Leishmania major	46%	100%
Q4QI09	Leishmania major	46%	100%
Q4QI11	Leishmania major	47%	100%
Q4QI13	Leishmania major	45%	100%
Q4QI15	Leishmania major	47%	100%
Q4QI18	Leishmania major	46%	100%
Q4QI19	Leishmania major	46%	100%
Q4WJ27	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	27%	100%
Q51MW4	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	27%	96%
Q5B2U9	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	28%	100%
Q69RC4	Oryza sativa subsp. japonica	28%	99%
Q6C794	Yarrowia lipolytica (strain CLIB 122 / E 150)	27%	95%
Q6Z1D5	Oryza sativa subsp. japonica	31%	98%
Q755X2	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	29%	98%
Q7XPR1	Oryza sativa subsp. japonica	30%	99%
Q86CR8	Dictyostelium discoideum	28%	97%
Q8H715	Phytophthora infestans	28%	100%
Q8J282	Podospora anserina	27%	98%
Q8LEM4	Arabidopsis thaliana	32%	97%
Q8S926	Arabidopsis thaliana	31%	97%
Q8S927	Arabidopsis thaliana	31%	99%
Q8VYK7	Arabidopsis thaliana	34%	98%
Q8WZY7	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	27%	98%
Q9LZZ9	Arabidopsis thaliana	30%	98%
Q9SL04	Arabidopsis thaliana	33%	98%
Q9XEB5	Arabidopsis thaliana	32%	97%