Putative kinesin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative kinesin

Gene product:

kinesin, putative (fragment)

Species:

Leishmania braziliensis

UniProt:

A4HA41_LEIBR

TriTrypDb:

LbrM.19.1160 , LBRM2903_190015700

Length:

267

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HA41

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HA41

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	2
GO:0007018	microtubule-based movement	3	2
GO:0009987	cellular process	1	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	2
GO:0003774	cytoskeletal motor activity	1	2
GO:0003777	microtubule motor activity	2	2
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0005524	ATP binding	5	2
GO:0008017	microtubule binding	5	2
GO:0008092	cytoskeletal protein binding	3	2
GO:0015631	tubulin binding	4	2
GO:0017076	purine nucleotide binding	4	2
GO:0030554	adenyl nucleotide binding	5	2
GO:0032553	ribonucleotide binding	3	2
GO:0032555	purine ribonucleotide binding	4	2
GO:0032559	adenyl ribonucleotide binding	5	2
GO:0035639	purine ribonucleoside triphosphate binding	4	2
GO:0036094	small molecule binding	2	2
GO:0043167	ion binding	2	2
GO:0043168	anion binding	3	2
GO:0097159	organic cyclic compound binding	2	2
GO:0097367	carbohydrate derivative binding	2	2
GO:0140657	ATP-dependent activity	1	2
GO:1901265	nucleoside phosphate binding	3	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	12	14	PF00675	0.829
CLV_NRD_NRD_1	171	173	PF00675	0.784
CLV_NRD_NRD_1	189	191	PF00675	0.516
CLV_NRD_NRD_1	23	25	PF00675	0.654
CLV_PCSK_KEX2_1	12	14	PF00082	0.829
CLV_PCSK_KEX2_1	171	173	PF00082	0.784
CLV_PCSK_KEX2_1	189	191	PF00082	0.516
CLV_PCSK_KEX2_1	23	25	PF00082	0.654
CLV_PCSK_PC7_1	8	14	PF00082	0.825
CLV_PCSK_SKI1_1	189	193	PF00082	0.711
DEG_APCC_DBOX_1	32	40	PF00400	0.841
DEG_Kelch_actinfilin_1	218	222	PF01344	0.810
DEG_Nend_Nbox_1	1	3	PF02207	0.840
DEG_SCF_FBW7_1	100	105	PF00400	0.601
DEG_SPOP_SBC_1	7	11	PF00917	0.821
DOC_MAPK_gen_1	171	181	PF00069	0.680
DOC_MAPK_gen_1	189	200	PF00069	0.508
DOC_MAPK_MEF2A_6	193	200	PF00069	0.723
DOC_MAPK_MEF2A_6	78	86	PF00069	0.706
DOC_MAPK_NFAT4_5	193	201	PF00069	0.725
DOC_USP7_MATH_1	170	174	PF00917	0.784
DOC_USP7_MATH_1	191	195	PF00917	0.710
DOC_USP7_MATH_1	224	228	PF00917	0.732
DOC_USP7_MATH_1	25	29	PF00917	0.720
DOC_WW_Pin1_4	206	211	PF00397	0.722
DOC_WW_Pin1_4	48	53	PF00397	0.818
DOC_WW_Pin1_4	70	75	PF00397	0.787
DOC_WW_Pin1_4	98	103	PF00397	0.629
LIG_14-3-3_CanoR_1	126	133	PF00244	0.645
LIG_14-3-3_CanoR_1	174	179	PF00244	0.797
LIG_14-3-3_CanoR_1	24	34	PF00244	0.564
LIG_14-3-3_CanoR_1	8	16	PF00244	0.825
LIG_14-3-3_CanoR_1	89	96	PF00244	0.682
LIG_APCC_ABBA_1	88	93	PF00400	0.664
LIG_DLG_GKlike_1	12	20	PF00625	0.714
LIG_DLG_GKlike_1	174	181	PF00625	0.801
LIG_FHA_1	103	109	PF00498	0.663
LIG_FHA_2	115	121	PF00498	0.640
LIG_FHA_2	203	209	PF00498	0.840
LIG_LIR_Apic_2	69	74	PF02991	0.790
LIG_LIR_Gen_1	235	246	PF02991	0.549
LIG_LIR_Nem_3	235	241	PF02991	0.549
LIG_Pex14_2	133	137	PF04695	0.593
LIG_PTB_Apo_2	131	138	PF02174	0.605
LIG_PTB_Apo_2	65	72	PF02174	0.697
LIG_PTB_Phospho_1	65	71	PF10480	0.699
LIG_SH2_NCK_1	238	242	PF00017	0.433
LIG_SH2_NCK_1	71	75	PF00017	0.784
LIG_SH2_PTP2	85	88	PF00017	0.640
LIG_SH2_SRC	238	241	PF00017	0.433
LIG_SH2_STAT3	231	234	PF00017	0.549
LIG_SH2_STAT5	85	88	PF00017	0.640
LIG_SH3_3	223	229	PF00018	0.731
LIG_SH3_3	238	244	PF00018	0.287
LIG_SUMO_SIM_par_1	114	120	PF11976	0.630
LIG_SUMO_SIM_par_1	217	223	PF11976	0.811
LIG_WRC_WIRS_1	159	164	PF05994	0.736
MOD_CDK_SPxK_1	48	54	PF00069	0.819
MOD_CK1_1	206	212	PF00069	0.722
MOD_CK1_1	28	34	PF00069	0.846
MOD_CK1_1	42	48	PF00069	0.580
MOD_CK1_1	57	63	PF00069	0.553
MOD_CK1_1	6	12	PF00069	0.824
MOD_CK1_1	73	79	PF00069	0.501
MOD_CK2_1	114	120	PF00069	0.630
MOD_CK2_1	12	18	PF00069	0.831
MOD_CK2_1	136	142	PF00069	0.608
MOD_CK2_1	202	208	PF00069	0.842
MOD_CK2_1	89	95	PF00069	0.679
MOD_GlcNHglycan	168	171	PF01048	0.773
MOD_GlcNHglycan	186	189	PF01048	0.509
MOD_GlcNHglycan	193	196	PF01048	0.638
MOD_GlcNHglycan	20	23	PF01048	0.576
MOD_GlcNHglycan	204	208	PF01048	0.561
MOD_GlcNHglycan	216	219	PF01048	0.677
MOD_GlcNHglycan	264	267	PF01048	0.549
MOD_GlcNHglycan	27	30	PF01048	0.719
MOD_GlcNHglycan	5	8	PF01048	0.832
MOD_GlcNHglycan	58	62	PF01048	0.759
MOD_GSK3_1	12	19	PF00069	0.666
MOD_GSK3_1	166	173	PF00069	0.775
MOD_GSK3_1	180	187	PF00069	0.579
MOD_GSK3_1	202	209	PF00069	0.723
MOD_GSK3_1	24	31	PF00069	0.668
MOD_GSK3_1	3	10	PF00069	0.816
MOD_GSK3_1	35	42	PF00069	0.610
MOD_GSK3_1	44	51	PF00069	0.537
MOD_GSK3_1	70	77	PF00069	0.783
MOD_GSK3_1	98	105	PF00069	0.613
MOD_N-GLC_1	179	184	PF02516	0.704
MOD_N-GLC_1	224	229	PF02516	0.717
MOD_N-GLC_2	134	136	PF02516	0.591
MOD_N-GLC_2	254	256	PF02516	0.549
MOD_NEK2_1	16	21	PF00069	0.718
MOD_NEK2_1	179	184	PF00069	0.704
MOD_NEK2_2	102	107	PF00069	0.681
MOD_NEK2_2	136	141	PF00069	0.594
MOD_PIKK_1	39	45	PF00454	0.827
MOD_PK_1	44	50	PF00069	0.826
MOD_PKA_1	12	18	PF00069	0.831
MOD_PKA_1	189	195	PF00069	0.829
MOD_PKA_1	23	29	PF00069	0.648
MOD_PKA_2	170	176	PF00069	0.783
MOD_PKA_2	189	195	PF00069	0.496
MOD_PKA_2	23	29	PF00069	0.561
MOD_PKA_2	7	13	PF00069	0.824
MOD_PKB_1	172	180	PF00069	0.794
MOD_PKB_1	87	95	PF00069	0.671
MOD_Plk_1	179	185	PF00069	0.702
MOD_Plk_4	158	164	PF00069	0.736
MOD_Plk_4	174	180	PF00069	0.520
MOD_ProDKin_1	206	212	PF00069	0.722
MOD_ProDKin_1	48	54	PF00069	0.819
MOD_ProDKin_1	70	76	PF00069	0.784
MOD_ProDKin_1	98	104	PF00069	0.618
TRG_ENDOCYTIC_2	238	241	PF00928	0.549
TRG_ENDOCYTIC_2	85	88	PF00928	0.640
TRG_ER_diArg_1	171	174	PF00400	0.789
TRG_ER_diArg_1	86	89	PF00400	0.640
TRG_Pf-PMV_PEXEL_1	64	69	PF00026	0.710
TRG_Pf-PMV_PEXEL_1	94	98	PF00026	0.712

Homologs


Protein	Taxonomy	Sequence identity	Coverage
Q6ZMV9	HUMAN	56%	33%