Kinesin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Flagellum attachment zone protein 7 (fragment)

Species:

Leishmania braziliensis

UniProt:

A4HA40_LEIBR

TriTrypDb:

LbrM.19.1150 , LBRM2903_190017600

Length:

820

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 40

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0005874	microtubule	6	5
GO:0099080	supramolecular complex	2	5
GO:0099081	supramolecular polymer	3	5
GO:0099512	supramolecular fiber	4	5
GO:0099513	polymeric cytoskeletal fiber	5	5
GO:0110165	cellular anatomical entity	1	5
GO:0005856	cytoskeleton	5	2
GO:0005871	kinesin complex	3	2
GO:0005875	microtubule associated complex	2	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2

Expansion

Sequence features

A4HA40

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HA40

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	17
GO:0007018	microtubule-based movement	3	17
GO:0009987	cellular process	1	17

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	16
GO:0003774	cytoskeletal motor activity	1	17
GO:0003777	microtubule motor activity	2	17
GO:0003824	catalytic activity	1	10
GO:0005488	binding	1	16
GO:0005515	protein binding	2	16
GO:0005524	ATP binding	5	16
GO:0008017	microtubule binding	5	16
GO:0008092	cytoskeletal protein binding	3	16
GO:0015631	tubulin binding	4	16
GO:0016787	hydrolase activity	2	10
GO:0017076	purine nucleotide binding	4	16
GO:0030554	adenyl nucleotide binding	5	16
GO:0032553	ribonucleotide binding	3	16
GO:0032555	purine ribonucleotide binding	4	16
GO:0032559	adenyl ribonucleotide binding	5	16
GO:0035639	purine ribonucleoside triphosphate binding	4	16
GO:0036094	small molecule binding	2	16
GO:0043167	ion binding	2	16
GO:0043168	anion binding	3	16
GO:0097159	organic cyclic compound binding	2	16
GO:0097367	carbohydrate derivative binding	2	16
GO:0140657	ATP-dependent activity	1	17
GO:1901265	nucleoside phosphate binding	3	16
GO:1901363	heterocyclic compound binding	2	16
GO:0016462	pyrophosphatase activity	5	2
GO:0016817	hydrolase activity, acting on acid anhydrides	3	2
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	2
GO:0016887	ATP hydrolysis activity	7	2
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	127	131	PF00656	0.451
CLV_NRD_NRD_1	248	250	PF00675	0.692
CLV_NRD_NRD_1	358	360	PF00675	0.706
CLV_NRD_NRD_1	541	543	PF00675	0.592
CLV_NRD_NRD_1	611	613	PF00675	0.594
CLV_NRD_NRD_1	631	633	PF00675	0.627
CLV_NRD_NRD_1	655	657	PF00675	0.641
CLV_NRD_NRD_1	738	740	PF00675	0.661
CLV_NRD_NRD_1	768	770	PF00675	0.711
CLV_NRD_NRD_1	772	774	PF00675	0.730
CLV_NRD_NRD_1	92	94	PF00675	0.436
CLV_PCSK_FUR_1	25	29	PF00082	0.512
CLV_PCSK_FUR_1	514	518	PF00082	0.735
CLV_PCSK_KEX2_1	248	250	PF00082	0.692
CLV_PCSK_KEX2_1	27	29	PF00082	0.475
CLV_PCSK_KEX2_1	290	292	PF00082	0.549
CLV_PCSK_KEX2_1	358	360	PF00082	0.646
CLV_PCSK_KEX2_1	516	518	PF00082	0.722
CLV_PCSK_KEX2_1	540	542	PF00082	0.619
CLV_PCSK_KEX2_1	570	572	PF00082	0.595
CLV_PCSK_KEX2_1	613	615	PF00082	0.630
CLV_PCSK_KEX2_1	655	657	PF00082	0.706
CLV_PCSK_KEX2_1	738	740	PF00082	0.730
CLV_PCSK_KEX2_1	772	774	PF00082	0.682
CLV_PCSK_PC1ET2_1	27	29	PF00082	0.475
CLV_PCSK_PC1ET2_1	290	292	PF00082	0.590
CLV_PCSK_PC1ET2_1	516	518	PF00082	0.722
CLV_PCSK_PC1ET2_1	540	542	PF00082	0.601
CLV_PCSK_PC1ET2_1	570	572	PF00082	0.595
CLV_PCSK_PC1ET2_1	613	615	PF00082	0.660
CLV_PCSK_PC7_1	286	292	PF00082	0.538
CLV_PCSK_SKI1_1	27	31	PF00082	0.533
CLV_PCSK_SKI1_1	290	294	PF00082	0.547
CLV_PCSK_SKI1_1	380	384	PF00082	0.597
CLV_PCSK_SKI1_1	557	561	PF00082	0.394
CLV_PCSK_SKI1_1	677	681	PF00082	0.674
CLV_Separin_Metazoa	374	378	PF03568	0.457
DEG_APCC_DBOX_1	135	143	PF00400	0.538
DEG_APCC_DBOX_1	482	490	PF00400	0.694
DEG_Nend_UBRbox_1	1	3	PF02207	0.503
DEG_SPOP_SBC_1	577	581	PF00917	0.493
DOC_CYCLIN_RxL_1	377	386	PF00134	0.533
DOC_CYCLIN_yClb5_NLxxxL_5	196	204	PF00134	0.429
DOC_MAPK_gen_1	109	119	PF00069	0.428
DOC_MAPK_gen_1	136	144	PF00069	0.457
DOC_MAPK_gen_1	387	395	PF00069	0.494
DOC_MAPK_gen_1	55	64	PF00069	0.442
DOC_MAPK_gen_1	583	590	PF00069	0.473
DOC_MAPK_gen_1	653	661	PF00069	0.718
DOC_MAPK_gen_1	724	732	PF00069	0.607
DOC_PP1_RVXF_1	291	298	PF00149	0.632
DOC_PP2B_LxvP_1	191	194	PF13499	0.351
DOC_PP4_FxxP_1	732	735	PF00568	0.648
DOC_USP7_MATH_1	275	279	PF00917	0.699
DOC_USP7_MATH_1	29	33	PF00917	0.436
DOC_USP7_MATH_1	713	717	PF00917	0.507
DOC_USP7_MATH_1	740	744	PF00917	0.709
DOC_USP7_UBL2_3	403	407	PF12436	0.650
DOC_WW_Pin1_4	218	223	PF00397	0.399
DOC_WW_Pin1_4	64	69	PF00397	0.501
LIG_14-3-3_CanoR_1	109	119	PF00244	0.407
LIG_14-3-3_CanoR_1	304	313	PF00244	0.641
LIG_14-3-3_CanoR_1	412	416	PF00244	0.669
LIG_14-3-3_CanoR_1	431	438	PF00244	0.513
LIG_14-3-3_CanoR_1	58	64	PF00244	0.501
LIG_14-3-3_CanoR_1	585	591	PF00244	0.614
LIG_14-3-3_CanoR_1	670	680	PF00244	0.709
LIG_14-3-3_CanoR_1	712	720	PF00244	0.658
LIG_14-3-3_CanoR_1	739	745	PF00244	0.672
LIG_14-3-3_CanoR_1	99	106	PF00244	0.436
LIG_Actin_WH2_2	258	275	PF00022	0.565
LIG_Actin_WH2_2	460	478	PF00022	0.737
LIG_BRCT_BRCA1_1	223	227	PF00533	0.403
LIG_BRCT_BRCA1_1	69	73	PF00533	0.501
LIG_BRCT_BRCA1_1	792	796	PF00533	0.750
LIG_FHA_1	116	122	PF00498	0.446
LIG_FHA_1	199	205	PF00498	0.429
LIG_FHA_1	212	218	PF00498	0.429
LIG_FHA_1	33	39	PF00498	0.556
LIG_FHA_1	432	438	PF00498	0.620
LIG_FHA_1	476	482	PF00498	0.754
LIG_FHA_1	689	695	PF00498	0.572
LIG_FHA_2	412	418	PF00498	0.437
LIG_FHA_2	577	583	PF00498	0.623
LIG_FHA_2	636	642	PF00498	0.544
LIG_FHA_2	645	651	PF00498	0.793
LIG_FHA_2	769	775	PF00498	0.713
LIG_GBD_Chelix_1	88	96	PF00786	0.393
LIG_LIR_Apic_2	729	735	PF02991	0.728
LIG_LIR_Gen_1	118	126	PF02991	0.514
LIG_LIR_Gen_1	224	235	PF02991	0.498
LIG_LIR_Gen_1	48	56	PF02991	0.419
LIG_LIR_Gen_1	717	727	PF02991	0.630
LIG_LIR_Nem_3	118	122	PF02991	0.514
LIG_LIR_Nem_3	19	24	PF02991	0.420
LIG_LIR_Nem_3	39	45	PF02991	0.422
LIG_LIR_Nem_3	435	441	PF02991	0.583
LIG_LIR_Nem_3	48	54	PF02991	0.422
LIG_LIR_Nem_3	717	723	PF02991	0.630
LIG_LIR_Nem_3	78	82	PF02991	0.510
LIG_PCNA_yPIPBox_3	47	58	PF02747	0.442
LIG_PCNA_yPIPBox_3	666	680	PF02747	0.721
LIG_PCNA_yPIPBox_3	682	690	PF02747	0.703
LIG_Pex14_1	432	436	PF04695	0.558
LIG_SH2_GRB2like	280	283	PF00017	0.687
LIG_SH2_STAP1	236	240	PF00017	0.393
LIG_SH2_STAP1	554	558	PF00017	0.576
LIG_SH2_STAT5	280	283	PF00017	0.633
LIG_SH2_STAT5	436	439	PF00017	0.683
LIG_SH2_STAT5	462	465	PF00017	0.541
LIG_SUMO_SIM_anti_2	169	174	PF11976	0.515
LIG_SUMO_SIM_par_1	684	692	PF11976	0.585
LIG_TRAF2_1	553	556	PF00917	0.480
LIG_TRAF2_1	589	592	PF00917	0.583
LIG_TRAF2_1	647	650	PF00917	0.620
LIG_TRAF2_1	798	801	PF00917	0.527
LIG_TRAF2_1	83	86	PF00917	0.510
LIG_TYR_ITIM	40	45	PF00017	0.422
LIG_UBA3_1	20	27	PF00899	0.445
LIG_WRC_WIRS_1	116	121	PF05994	0.514
MOD_CK1_1	110	116	PF00069	0.426
MOD_CK1_1	147	153	PF00069	0.426
MOD_CK1_1	198	204	PF00069	0.429
MOD_CK1_1	212	218	PF00069	0.429
MOD_CK1_1	221	227	PF00069	0.429
MOD_CK1_1	278	284	PF00069	0.677
MOD_CK1_1	32	38	PF00069	0.512
MOD_CK1_1	353	359	PF00069	0.728
MOD_CK1_1	366	372	PF00069	0.551
MOD_CK1_1	385	391	PF00069	0.708
MOD_CK1_1	490	496	PF00069	0.675
MOD_CK1_1	522	528	PF00069	0.736
MOD_CK1_1	575	581	PF00069	0.605
MOD_CK1_1	67	73	PF00069	0.501
MOD_CK2_1	38	44	PF00069	0.514
MOD_CK2_1	465	471	PF00069	0.669
MOD_CK2_1	520	526	PF00069	0.662
MOD_CK2_1	550	556	PF00069	0.504
MOD_CK2_1	586	592	PF00069	0.455
MOD_CK2_1	628	634	PF00069	0.477
MOD_CK2_1	644	650	PF00069	0.792
MOD_CK2_1	746	752	PF00069	0.815
MOD_CK2_1	760	766	PF00069	0.538
MOD_CK2_1	80	86	PF00069	0.501
MOD_Cter_Amidation	815	818	PF01082	0.569
MOD_GlcNHglycan	314	317	PF01048	0.659
MOD_GlcNHglycan	327	330	PF01048	0.612
MOD_GlcNHglycan	341	344	PF01048	0.676
MOD_GlcNHglycan	352	355	PF01048	0.649
MOD_GlcNHglycan	369	372	PF01048	0.648
MOD_GlcNHglycan	389	392	PF01048	0.721
MOD_GlcNHglycan	488	492	PF01048	0.526
MOD_GlcNHglycan	69	72	PF01048	0.472
MOD_GlcNHglycan	740	743	PF01048	0.790
MOD_GlcNHglycan	762	765	PF01048	0.596
MOD_GSK3_1	122	129	PF00069	0.504
MOD_GSK3_1	198	205	PF00069	0.500
MOD_GSK3_1	212	219	PF00069	0.314
MOD_GSK3_1	348	355	PF00069	0.778
MOD_GSK3_1	363	370	PF00069	0.569
MOD_GSK3_1	465	472	PF00069	0.660
MOD_GSK3_1	520	527	PF00069	0.546
MOD_GSK3_1	572	579	PF00069	0.586
MOD_GSK3_1	624	631	PF00069	0.444
MOD_GSK3_1	635	642	PF00069	0.451
MOD_GSK3_1	734	741	PF00069	0.782
MOD_LATS_1	429	435	PF00433	0.445
MOD_N-GLC_1	166	171	PF02516	0.429
MOD_N-GLC_1	198	203	PF02516	0.429
MOD_N-GLC_1	278	283	PF02516	0.702
MOD_NEK2_1	204	209	PF00069	0.421
MOD_NEK2_1	216	221	PF00069	0.387
MOD_NEK2_1	230	235	PF00069	0.410
MOD_NEK2_1	410	415	PF00069	0.498
MOD_NEK2_1	475	480	PF00069	0.692
MOD_NEK2_1	572	577	PF00069	0.675
MOD_NEK2_1	768	773	PF00069	0.630
MOD_NEK2_1	790	795	PF00069	0.658
MOD_NEK2_2	411	416	PF00069	0.562
MOD_NEK2_2	740	745	PF00069	0.546
MOD_PIKK_1	181	187	PF00454	0.480
MOD_PIKK_1	209	215	PF00454	0.538
MOD_PIKK_1	304	310	PF00454	0.611
MOD_PIKK_1	639	645	PF00454	0.477
MOD_PIKK_1	810	816	PF00454	0.709
MOD_PKA_1	738	744	PF00069	0.774
MOD_PKA_2	108	114	PF00069	0.436
MOD_PKA_2	195	201	PF00069	0.429
MOD_PKA_2	230	236	PF00069	0.429
MOD_PKA_2	357	363	PF00069	0.712
MOD_PKA_2	411	417	PF00069	0.675
MOD_PKA_2	430	436	PF00069	0.419
MOD_PKA_2	475	481	PF00069	0.709
MOD_PKA_2	532	538	PF00069	0.668
MOD_PKA_2	57	63	PF00069	0.501
MOD_PKA_2	572	578	PF00069	0.668
MOD_PKA_2	639	645	PF00069	0.639
MOD_PKA_2	738	744	PF00069	0.729
MOD_PKA_2	768	774	PF00069	0.697
MOD_PKA_2	98	104	PF00069	0.431
MOD_Plk_1	166	172	PF00069	0.414
MOD_Plk_1	198	204	PF00069	0.429
MOD_Plk_1	32	38	PF00069	0.526
MOD_Plk_1	397	403	PF00069	0.667
MOD_Plk_1	487	493	PF00069	0.675
MOD_Plk_4	168	174	PF00069	0.486
MOD_Plk_4	198	204	PF00069	0.429
MOD_Plk_4	212	218	PF00069	0.429
MOD_Plk_4	230	236	PF00069	0.429
MOD_Plk_4	319	325	PF00069	0.681
MOD_Plk_4	38	44	PF00069	0.526
MOD_Plk_4	689	695	PF00069	0.673
MOD_ProDKin_1	218	224	PF00069	0.399
MOD_ProDKin_1	64	70	PF00069	0.501
MOD_SUMO_for_1	503	506	PF00179	0.666
MOD_SUMO_for_1	681	684	PF00179	0.664
MOD_SUMO_rev_2	553	559	PF00179	0.600
MOD_SUMO_rev_2	564	572	PF00179	0.550
MOD_SUMO_rev_2	595	604	PF00179	0.725
MOD_SUMO_rev_2	669	679	PF00179	0.689
TRG_AP2beta_CARGO_1	19	28	PF09066	0.445
TRG_DiLeu_BaEn_1	675	680	PF01217	0.675
TRG_DiLeu_BaEn_4	649	655	PF01217	0.616
TRG_ENDOCYTIC_2	42	45	PF00928	0.416
TRG_ENDOCYTIC_2	720	723	PF00928	0.587
TRG_ENDOCYTIC_2	787	790	PF00928	0.729
TRG_ER_diArg_1	357	359	PF00400	0.714
TRG_ER_diArg_1	541	543	PF00400	0.620
TRG_ER_diArg_1	62	65	PF00400	0.472
TRG_ER_diArg_1	654	656	PF00400	0.694
TRG_ER_diArg_1	738	740	PF00400	0.582
TRG_ER_diLys_1	817	820	PF00400	0.582
TRG_NES_CRM1_1	134	148	PF08389	0.538
TRG_NES_CRM1_1	260	274	PF08389	0.587
TRG_NES_CRM1_1	435	451	PF08389	0.534
TRG_NES_CRM1_1	671	684	PF08389	0.675
TRG_NLS_Bipartite_1	504	520	PF00514	0.482
TRG_NLS_MonoExtC_3	768	773	PF00514	0.606
TRG_NLS_MonoExtN_4	514	520	PF00514	0.504
TRG_Pf-PMV_PEXEL_1	259	264	PF00026	0.563
TRG_Pf-PMV_PEXEL_1	304	308	PF00026	0.554
TRG_Pf-PMV_PEXEL_1	380	384	PF00026	0.455
TRG_Pf-PMV_PEXEL_1	570	574	PF00026	0.606
TRG_Pf-PMV_PEXEL_1	670	675	PF00026	0.732

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2P7	Leptomonas seymouri	61%	100%
A0A0N1PB89	Leptomonas seymouri	32%	100%
A0A1X0P696	Trypanosomatidae	40%	71%
A0A3Q8IBD8	Leishmania donovani	47%	79%
A0A3R7KHX7	Trypanosoma rangeli	36%	100%
A0A3R7L3H0	Trypanosoma rangeli	38%	70%
A0A3S5H759	Leishmania donovani	86%	77%
A4HA26	Leishmania braziliensis	53%	100%
A4HY89	Leishmania infantum	48%	75%
A4HYA2	Leishmania infantum	86%	73%
E9AS20	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	73%
E9AS21	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	79%
Q4QDF2	Leishmania major	50%	100%
Q4QDF3	Leishmania major	86%	100%
V5C1V7	Trypanosoma cruzi	40%	70%