Kinesin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Flagellum attachment zone protein 7 (fragment)

Species:

Leishmania braziliensis

UniProt:

A4HA40_LEIBR

TriTrypDb:

LbrM.19.1150 , LBRM2903_190017600

Length:

820

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 40

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

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Cellular components
Term	Name	Level	Count
GO:0005856	cytoskeleton	5	2
GO:0005871	kinesin complex	3	2
GO:0005874	microtubule	6	5
GO:0005875	microtubule associated complex	2	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0099080	supramolecular complex	2	5

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Expansion

Sequence features

A4HA40

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HA40

Function

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Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	17
GO:0007018	microtubule-based movement	3	17
GO:0009987	cellular process	1	17

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	16
GO:0003774	cytoskeletal motor activity	1	17
GO:0003777	microtubule motor activity	2	17
GO:0003824	catalytic activity	1	10
GO:0005488	binding	1	16
GO:0005515	protein binding	2	16
GO:0005524	ATP binding	5	16
GO:0008017	microtubule binding	5	16
GO:0008092	cytoskeletal protein binding	3	16
GO:0015631	tubulin binding	4	16

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	127	131	PF00656	0.451
CLV_NRD_NRD_1	248	250	PF00675	0.692
CLV_NRD_NRD_1	358	360	PF00675	0.706
CLV_NRD_NRD_1	541	543	PF00675	0.592
CLV_NRD_NRD_1	611	613	PF00675	0.594
CLV_NRD_NRD_1	631	633	PF00675	0.627
CLV_NRD_NRD_1	655	657	PF00675	0.641
CLV_NRD_NRD_1	738	740	PF00675	0.661
CLV_NRD_NRD_1	768	770	PF00675	0.711
CLV_NRD_NRD_1	772	774	PF00675	0.730

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2P7	Leptomonas seymouri	61%	100%
A0A0N1PB89	Leptomonas seymouri	32%	100%
A0A1X0P696	Trypanosomatidae	40%	71%
A0A3Q8IBD8	Leishmania donovani	47%	79%
A0A3R7KHX7	Trypanosoma rangeli	36%	100%
A0A3R7L3H0	Trypanosoma rangeli	38%	70%
A0A3S5H759	Leishmania donovani	86%	77%
A4HA26	Leishmania braziliensis	53%	100%
A4HY89	Leishmania infantum	48%	75%
A4HYA2	Leishmania infantum	86%	73%

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