Putative ABC transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ABC transport system ATP-binding protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HA37_LEIBR

TriTrypDb:

LbrM.19.1110 , LBRM2903_190017200

Length:

616

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HA37

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HA37

Function

Biological processes
Term	Name	Level	Count
GO:0044087	regulation of cellular component biogenesis	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1
GO:0090069	regulation of ribosome biogenesis	5	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11
GO:0003824	catalytic activity	1	1
GO:0016787	hydrolase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	194	198	PF00656	0.257
CLV_C14_Caspase3-7	28	32	PF00656	0.635
CLV_C14_Caspase3-7	546	550	PF00656	0.323
CLV_NRD_NRD_1	220	222	PF00675	0.416
CLV_PCSK_KEX2_1	191	193	PF00082	0.249
CLV_PCSK_KEX2_1	220	222	PF00082	0.416
CLV_PCSK_KEX2_1	529	531	PF00082	0.382
CLV_PCSK_KEX2_1	588	590	PF00082	0.479
CLV_PCSK_PC1ET2_1	191	193	PF00082	0.249
CLV_PCSK_PC1ET2_1	529	531	PF00082	0.373
CLV_PCSK_PC1ET2_1	588	590	PF00082	0.479
CLV_PCSK_SKI1_1	207	211	PF00082	0.258
CLV_PCSK_SKI1_1	273	277	PF00082	0.285
CLV_PCSK_SKI1_1	333	337	PF00082	0.214
CLV_PCSK_SKI1_1	493	497	PF00082	0.249
CLV_PCSK_SKI1_1	5	9	PF00082	0.508
CLV_PCSK_SKI1_1	520	524	PF00082	0.249
DEG_MDM2_SWIB_1	226	234	PF02201	0.249
DOC_CKS1_1	506	511	PF01111	0.249
DOC_CYCLIN_RxL_1	270	279	PF00134	0.299
DOC_MAPK_FxFP_2	380	383	PF00069	0.327
DOC_MAPK_FxFP_2	400	403	PF00069	0.226
DOC_MAPK_gen_1	204	214	PF00069	0.243
DOC_MAPK_gen_1	529	536	PF00069	0.382
DOC_PP1_RVXF_1	205	211	PF00149	0.249
DOC_PP1_RVXF_1	375	381	PF00149	0.381
DOC_PP1_RVXF_1	394	401	PF00149	0.467
DOC_PP1_RVXF_1	518	524	PF00149	0.249
DOC_PP2B_LxvP_1	388	391	PF13499	0.363
DOC_PP4_FxxP_1	241	244	PF00568	0.249
DOC_PP4_FxxP_1	380	383	PF00568	0.327
DOC_PP4_FxxP_1	400	403	PF00568	0.226
DOC_PP4_FxxP_1	67	70	PF00568	0.394
DOC_SPAK_OSR1_1	498	502	PF12202	0.249
DOC_USP7_MATH_1	130	134	PF00917	0.382
DOC_USP7_MATH_1	554	558	PF00917	0.350
DOC_USP7_MATH_1	58	62	PF00917	0.425
DOC_USP7_MATH_1	63	67	PF00917	0.383
DOC_USP7_UBL2_3	358	362	PF12436	0.509
DOC_USP7_UBL2_3	5	9	PF12436	0.490
DOC_USP7_UBL2_3	584	588	PF12436	0.452
DOC_WW_Pin1_4	471	476	PF00397	0.249
DOC_WW_Pin1_4	505	510	PF00397	0.249
LIG_14-3-3_CanoR_1	231	237	PF00244	0.292
LIG_14-3-3_CanoR_1	365	373	PF00244	0.457
LIG_14-3-3_CanoR_1	607	613	PF00244	0.467
LIG_BRCT_BRCA1_1	280	284	PF00533	0.311
LIG_FHA_1	243	249	PF00498	0.278
LIG_FHA_1	251	257	PF00498	0.301
LIG_FHA_1	367	373	PF00498	0.381
LIG_FHA_1	445	451	PF00498	0.211
LIG_FHA_1	538	544	PF00498	0.292
LIG_FHA_1	96	102	PF00498	0.249
LIG_FHA_2	310	316	PF00498	0.422
LIG_FHA_2	39	45	PF00498	0.581
LIG_FHA_2	472	478	PF00498	0.259
LIG_LIR_Apic_2	397	403	PF02991	0.343
LIG_LIR_Apic_2	66	70	PF02991	0.472
LIG_LIR_Gen_1	407	416	PF02991	0.295
LIG_LIR_Nem_3	187	193	PF02991	0.249
LIG_LIR_Nem_3	304	310	PF02991	0.448
LIG_LIR_Nem_3	407	412	PF02991	0.364
LIG_LIR_Nem_3	482	486	PF02991	0.243
LIG_LYPXL_yS_3	483	486	PF13949	0.268
LIG_MAD2	122	130	PF02301	0.249
LIG_PCNA_yPIPBox_3	598	609	PF02747	0.419
LIG_Pex14_1	263	267	PF04695	0.293
LIG_Pex14_2	210	214	PF04695	0.249
LIG_Pex14_2	226	230	PF04695	0.249
LIG_Pex14_2	461	465	PF04695	0.249
LIG_Rb_LxCxE_1	119	141	PF01857	0.327
LIG_Rb_LxCxE_1	433	447	PF01857	0.249
LIG_SH2_CRK	107	111	PF00017	0.369
LIG_SH2_CRK	528	532	PF00017	0.314
LIG_SH2_STAP1	612	616	PF00017	0.504
LIG_SH2_STAT3	139	142	PF00017	0.314
LIG_SH2_STAT5	139	142	PF00017	0.253
LIG_SH2_STAT5	267	270	PF00017	0.309
LIG_SH2_STAT5	310	313	PF00017	0.428
LIG_SH2_STAT5	338	341	PF00017	0.414
LIG_SH2_STAT5	449	452	PF00017	0.249
LIG_SH2_STAT5	6	9	PF00017	0.484
LIG_SH3_3	384	390	PF00018	0.372
LIG_SH3_3	400	406	PF00018	0.327
LIG_SH3_3	483	489	PF00018	0.268
LIG_SUMO_SIM_anti_2	245	251	PF11976	0.249
LIG_SUMO_SIM_par_1	153	159	PF11976	0.249
LIG_SUMO_SIM_par_1	244	251	PF11976	0.250
LIG_SUMO_SIM_par_1	561	566	PF11976	0.271
LIG_TRAF2_1	313	316	PF00917	0.509
LIG_UBA3_1	208	216	PF00899	0.382
LIG_WRC_WIRS_1	555	560	PF05994	0.358
LIG_WRC_WIRS_1	64	69	PF05994	0.478
MOD_CDK_SPxK_1	505	511	PF00069	0.382
MOD_CK1_1	39	45	PF00069	0.710
MOD_CK2_1	309	315	PF00069	0.415
MOD_CK2_1	38	44	PF00069	0.615
MOD_CK2_1	471	477	PF00069	0.249
MOD_GlcNHglycan	102	105	PF01048	0.382
MOD_GlcNHglycan	226	229	PF01048	0.249
MOD_GlcNHglycan	345	348	PF01048	0.214
MOD_GlcNHglycan	493	496	PF01048	0.249
MOD_GlcNHglycan	501	504	PF01048	0.249
MOD_GlcNHglycan	60	63	PF01048	0.408
MOD_GSK3_1	220	227	PF00069	0.274
MOD_GSK3_1	29	36	PF00069	0.678
MOD_GSK3_1	352	359	PF00069	0.414
MOD_GSK3_1	608	615	PF00069	0.371
MOD_N-GLC_1	29	34	PF02516	0.782
MOD_N-GLC_1	36	41	PF02516	0.751
MOD_N-GLC_1	95	100	PF02516	0.249
MOD_N-GLC_2	113	115	PF02516	0.249
MOD_N-GLC_2	287	289	PF02516	0.319
MOD_NEK2_1	232	237	PF00069	0.264
MOD_NEK2_1	271	276	PF00069	0.318
MOD_NEK2_1	29	34	PF00069	0.572
MOD_NEK2_1	499	504	PF00069	0.249
MOD_NEK2_1	608	613	PF00069	0.364
MOD_PIKK_1	138	144	PF00454	0.314
MOD_PIKK_1	278	284	PF00454	0.303
MOD_PIKK_1	484	490	PF00454	0.264
MOD_PKA_1	220	226	PF00069	0.382
MOD_PKA_2	220	226	PF00069	0.249
MOD_PKA_2	232	238	PF00069	0.249
MOD_PKA_2	404	410	PF00069	0.446
MOD_Plk_1	30	36	PF00069	0.775
MOD_Plk_1	356	362	PF00069	0.414
MOD_Plk_1	396	402	PF00069	0.358
MOD_Plk_1	84	90	PF00069	0.349
MOD_Plk_1	95	101	PF00069	0.249
MOD_Plk_2-3	18	24	PF00069	0.476
MOD_Plk_2-3	544	550	PF00069	0.322
MOD_Plk_4	116	122	PF00069	0.259
MOD_Plk_4	242	248	PF00069	0.291
MOD_Plk_4	271	277	PF00069	0.422
MOD_Plk_4	404	410	PF00069	0.446
MOD_ProDKin_1	471	477	PF00069	0.249
MOD_ProDKin_1	505	511	PF00069	0.249
MOD_SUMO_rev_2	583	590	PF00179	0.408
TRG_DiLeu_BaLyEn_6	567	572	PF01217	0.295
TRG_ENDOCYTIC_2	107	110	PF00928	0.369
TRG_ENDOCYTIC_2	190	193	PF00928	0.249
TRG_ENDOCYTIC_2	483	486	PF00928	0.249
TRG_ER_diArg_1	220	222	PF00400	0.341
TRG_ER_diArg_1	230	233	PF00400	0.248
TRG_NES_CRM1_1	148	161	PF08389	0.279
TRG_NES_CRM1_1	163	178	PF08389	0.196
TRG_NES_CRM1_1	553	568	PF08389	0.429
TRG_NLS_MonoExtN_4	5	12	PF00514	0.554
TRG_Pf-PMV_PEXEL_1	191	195	PF00026	0.249
TRG_Pf-PMV_PEXEL_1	570	574	PF00026	0.306

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0H2VBH0	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	38%	97%
A0A0H2VFI8	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	27%	100%
A0A0N0P4L2	Leptomonas seymouri	41%	85%
A0A0N1I593	Leptomonas seymouri	40%	92%
A0A0N1PAH6	Leptomonas seymouri	87%	100%
A0A0S4IYK6	Bodo saltans	34%	100%
A0A0S4JRN6	Bodo saltans	40%	90%
A0A0S4JUD9	Bodo saltans	39%	100%
A0A1X0P0L3	Trypanosomatidae	41%	92%
A0A1X0P688	Trypanosomatidae	78%	100%
A0A1X0P8V9	Trypanosomatidae	43%	85%
A0A3Q8IHB5	Leishmania donovani	41%	92%
A0A3R7LWT1	Trypanosoma rangeli	81%	100%
A0A3S5H525	Leishmania donovani	42%	85%
A0A3S7WVI6	Leishmania donovani	94%	100%
A0A422N7J4	Trypanosoma rangeli	42%	85%
A0A422NHP3	Trypanosoma rangeli	41%	92%
A4H3I8	Leishmania braziliensis	41%	100%
A4HL68	Leishmania braziliensis	40%	93%
A4HRS7	Leishmania infantum	42%	85%
A4HYA0	Leishmania infantum	93%	100%
A4I8P8	Leishmania infantum	41%	92%
D0A0N6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	82%	100%
D0A223	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	85%
D0A4N3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	90%
E9ACG3	Leishmania major	42%	100%
E9AJQ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	85%
E9AS32	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9B3L1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	92%
O05519	Bacillus subtilis (strain 168)	28%	96%
O06476	Bacillus subtilis (strain 168)	28%	98%
O31716	Bacillus subtilis (strain 168)	30%	100%
O34362	Bacillus subtilis (strain 168)	23%	100%
O34512	Bacillus subtilis (strain 168)	28%	100%
O42943	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	44%	100%
O59672	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	42%	84%
P0A9U3	Escherichia coli (strain K12)	31%	100%
P0A9U4	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	31%	100%
P0A9U5	Escherichia coli O157:H7	31%	100%
P0A9W3	Escherichia coli (strain K12)	27%	100%
P0A9W4	Escherichia coli O157:H7	27%	100%
P0A9W5	Shigella flexneri	27%	100%
P25256	Streptomyces fradiae	27%	100%
P39115	Bacillus subtilis (strain 168)	24%	100%
P40024	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	47%	100%
P43535	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	41%	82%
P43672	Escherichia coli (strain K12)	31%	97%
P44808	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	37%	97%
P45127	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	29%	100%
P63389	Escherichia coli (strain K12)	38%	97%
P63390	Escherichia coli O157:H7	38%	97%
P9WQK2	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	28%	100%
P9WQK3	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	28%	100%
Q2KJA2	Bos taurus	54%	99%
Q45978	Caulobacter vibrioides (strain ATCC 19089 / CB15)	26%	100%
Q4Q4I8	Leishmania major	41%	100%
Q4QDE1	Leishmania major	93%	99%
Q57242	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	29%	95%
Q5R9Z5	Pongo abelii	39%	87%
Q66H39	Rattus norvegicus	38%	87%
Q6MG08	Rattus norvegicus	41%	73%
Q6P542	Mus musculus	41%	74%
Q6YRJ4	Onion yellows phytoplasma (strain OY-M)	22%	100%
Q73P93	Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)	22%	100%
Q73R11	Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)	22%	100%
Q74I62	Lactobacillus johnsonii (strain CNCM I-12250 / La1 / NCC 533)	22%	100%
Q767L0	Sus scrofa	42%	76%
Q7MFH3	Vibrio vulnificus (strain YJ016)	23%	100%
Q7YR37	Pan troglodytes	41%	76%
Q832R5	Enterococcus faecalis (strain ATCC 700802 / V583)	22%	100%
Q88ZZ2	Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)	23%	100%
Q8D3Z9	Vibrio vulnificus (strain CMCP6)	22%	100%
Q8G838	Bifidobacterium longum (strain NCC 2705)	25%	79%
Q8H0V6	Arabidopsis thaliana	44%	86%
Q8K268	Mus musculus	38%	87%
Q8K9I3	Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)	25%	100%
Q8NE71	Homo sapiens	42%	73%
Q8PSR0	Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)	24%	100%
Q8PUE7	Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)	23%	100%
Q8R9L8	Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4)	24%	100%
Q8SRV5	Encephalitozoon cuniculi (strain GB-M1)	37%	100%
Q8T6B7	Dictyostelium discoideum	45%	100%
Q8TQ05	Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)	24%	100%
Q8TQW9	Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)	24%	100%
Q99LE6	Mus musculus	54%	98%
Q9FIB4	Arabidopsis thaliana	31%	91%
Q9FJH6	Arabidopsis thaliana	58%	100%
Q9LV93	Arabidopsis thaliana	32%	89%
Q9M1H3	Arabidopsis thaliana	43%	85%
Q9NUQ8	Homo sapiens	39%	87%
Q9UG63	Homo sapiens	54%	99%
Q9USH9	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	43%	75%
V5AVV7	Trypanosoma cruzi	41%	100%
V5BD93	Trypanosoma cruzi	43%	96%
V5DFD4	Trypanosoma cruzi	77%	100%