Signal recognition particle subunit SRP72

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

signal recognition particle protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HA36_LEIBR

TriTrypDb:

LbrM.19.1100 , LBRM2903_190017100

Length:

745

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	12
GO:0005786	signal recognition particle, endoplasmic reticulum targeting	4	12
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0048500	signal recognition particle	3	12
GO:0110165	cellular anatomical entity	1	12
GO:1990904	ribonucleoprotein complex	2	12
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4HA36

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HA36

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	12
GO:0006612	protein targeting to membrane	5	12
GO:0006613	cotranslational protein targeting to membrane	6	12
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	7	12
GO:0006810	transport	3	12
GO:0006886	intracellular protein transport	4	12
GO:0008104	protein localization	4	12
GO:0009987	cellular process	1	12
GO:0015031	protein transport	4	12
GO:0033036	macromolecule localization	2	12
GO:0033365	protein localization to organelle	5	12
GO:0045047	protein targeting to ER	6	12
GO:0045184	establishment of protein localization	3	12
GO:0046907	intracellular transport	3	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	12
GO:0051649	establishment of localization in cell	3	12
GO:0051668	localization within membrane	3	12
GO:0070727	cellular macromolecule localization	3	12
GO:0070972	protein localization to endoplasmic reticulum	6	12
GO:0071702	organic substance transport	4	12
GO:0071705	nitrogen compound transport	4	12
GO:0072594	establishment of protein localization to organelle	4	12
GO:0072599	establishment of protein localization to endoplasmic reticulum	5	12
GO:0072657	protein localization to membrane	4	12
GO:0090150	establishment of protein localization to membrane	4	12

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0005488	binding	1	12
GO:0008312	7S RNA binding	5	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	11	13	PF00675	0.582
CLV_NRD_NRD_1	289	291	PF00675	0.559
CLV_NRD_NRD_1	326	328	PF00675	0.446
CLV_NRD_NRD_1	436	438	PF00675	0.628
CLV_NRD_NRD_1	54	56	PF00675	0.227
CLV_NRD_NRD_1	633	635	PF00675	0.677
CLV_NRD_NRD_1	661	663	PF00675	0.306
CLV_NRD_NRD_1	665	667	PF00675	0.302
CLV_NRD_NRD_1	695	697	PF00675	0.560
CLV_NRD_NRD_1	712	714	PF00675	0.573
CLV_NRD_NRD_1	724	726	PF00675	0.617
CLV_PCSK_FUR_1	659	663	PF00082	0.330
CLV_PCSK_KEX2_1	289	291	PF00082	0.559
CLV_PCSK_KEX2_1	436	438	PF00082	0.644
CLV_PCSK_KEX2_1	449	451	PF00082	0.614
CLV_PCSK_KEX2_1	54	56	PF00082	0.227
CLV_PCSK_KEX2_1	584	586	PF00082	0.632
CLV_PCSK_KEX2_1	633	635	PF00082	0.664
CLV_PCSK_KEX2_1	659	661	PF00082	0.312
CLV_PCSK_KEX2_1	665	667	PF00082	0.306
CLV_PCSK_KEX2_1	695	697	PF00082	0.560
CLV_PCSK_KEX2_1	701	703	PF00082	0.588
CLV_PCSK_KEX2_1	711	713	PF00082	0.573
CLV_PCSK_PC1ET2_1	449	451	PF00082	0.624
CLV_PCSK_PC1ET2_1	584	586	PF00082	0.632
CLV_PCSK_PC1ET2_1	701	703	PF00082	0.559
CLV_PCSK_PC1ET2_1	711	713	PF00082	0.624
CLV_PCSK_PC7_1	661	667	PF00082	0.344
CLV_PCSK_SKI1_1	109	113	PF00082	0.345
CLV_PCSK_SKI1_1	116	120	PF00082	0.356
CLV_PCSK_SKI1_1	262	266	PF00082	0.404
CLV_PCSK_SKI1_1	327	331	PF00082	0.464
CLV_PCSK_SKI1_1	387	391	PF00082	0.456
CLV_PCSK_SKI1_1	393	397	PF00082	0.492
CLV_PCSK_SKI1_1	414	418	PF00082	0.692
CLV_PCSK_SKI1_1	527	531	PF00082	0.427
CLV_PCSK_SKI1_1	54	58	PF00082	0.227
CLV_PCSK_SKI1_1	565	569	PF00082	0.479
CLV_PCSK_SKI1_1	633	637	PF00082	0.720
CLV_PCSK_SKI1_1	666	670	PF00082	0.364
CLV_PCSK_SKI1_1	698	702	PF00082	0.451
CLV_Separin_Metazoa	234	238	PF03568	0.484
CLV_Separin_Metazoa	433	437	PF03568	0.417
DEG_APCC_DBOX_1	115	123	PF00400	0.564
DEG_SPOP_SBC_1	245	249	PF00917	0.490
DOC_CKS1_1	69	74	PF01111	0.427
DOC_CYCLIN_RxL_1	28	36	PF00134	0.288
DOC_CYCLIN_yCln2_LP_2	240	246	PF00134	0.612
DOC_MAPK_gen_1	289	296	PF00069	0.499
DOC_MAPK_gen_1	327	337	PF00069	0.574
DOC_MAPK_gen_1	449	456	PF00069	0.611
DOC_MAPK_gen_1	54	62	PF00069	0.427
DOC_MAPK_gen_1	563	572	PF00069	0.497
DOC_MAPK_MEF2A_6	237	244	PF00069	0.503
DOC_MAPK_MEF2A_6	289	296	PF00069	0.455
DOC_MAPK_RevD_3	386	399	PF00069	0.595
DOC_PP2B_LxvP_1	240	243	PF13499	0.585
DOC_USP7_MATH_1	218	222	PF00917	0.525
DOC_USP7_MATH_1	230	234	PF00917	0.606
DOC_USP7_MATH_1	246	250	PF00917	0.691
DOC_USP7_MATH_1	303	307	PF00917	0.432
DOC_USP7_MATH_1	405	409	PF00917	0.732
DOC_USP7_MATH_1	416	420	PF00917	0.671
DOC_USP7_MATH_1	596	600	PF00917	0.615
DOC_USP7_MATH_1	601	605	PF00917	0.627
DOC_USP7_MATH_1	607	611	PF00917	0.637
DOC_USP7_MATH_1	718	722	PF00917	0.670
DOC_USP7_MATH_2	735	741	PF00917	0.579
DOC_USP7_UBL2_3	697	701	PF12436	0.439
DOC_USP7_UBL2_3	9	13	PF12436	0.588
DOC_WW_Pin1_4	179	184	PF00397	0.591
DOC_WW_Pin1_4	256	261	PF00397	0.512
DOC_WW_Pin1_4	408	413	PF00397	0.749
DOC_WW_Pin1_4	68	73	PF00397	0.614
LIG_14-3-3_CanoR_1	12	20	PF00244	0.615
LIG_14-3-3_CanoR_1	24	33	PF00244	0.563
LIG_14-3-3_CanoR_1	340	347	PF00244	0.473
LIG_14-3-3_CanoR_1	365	371	PF00244	0.532
LIG_14-3-3_CanoR_1	414	423	PF00244	0.701
LIG_14-3-3_CanoR_1	486	491	PF00244	0.542
LIG_14-3-3_CanoR_1	513	521	PF00244	0.574
LIG_14-3-3_CanoR_1	54	63	PF00244	0.427
LIG_14-3-3_CanoR_1	74	80	PF00244	0.524
LIG_Actin_WH2_2	536	554	PF00022	0.514
LIG_BIR_II_1	1	5	PF00653	0.473
LIG_BRCT_BRCA1_1	75	79	PF00533	0.608
LIG_eIF4E_1	85	91	PF01652	0.564
LIG_FHA_1	157	163	PF00498	0.467
LIG_FHA_1	180	186	PF00498	0.514
LIG_FHA_1	189	195	PF00498	0.288
LIG_FHA_1	303	309	PF00498	0.445
LIG_FHA_1	351	357	PF00498	0.420
LIG_FHA_1	381	387	PF00498	0.445
LIG_FHA_1	456	462	PF00498	0.578
LIG_FHA_1	55	61	PF00498	0.561
LIG_FHA_1	566	572	PF00498	0.567
LIG_FHA_2	13	19	PF00498	0.610
LIG_FHA_2	634	640	PF00498	0.715
LIG_GBD_Chelix_1	308	316	PF00786	0.511
LIG_LIR_Nem_3	629	635	PF02991	0.688
LIG_LIR_Nem_3	678	683	PF02991	0.524
LIG_NRBOX	6	12	PF00104	0.441
LIG_SH2_CRK	136	140	PF00017	0.574
LIG_SH2_CRK	313	317	PF00017	0.510
LIG_SH2_CRK	544	548	PF00017	0.552
LIG_SH2_CRK	632	636	PF00017	0.617
LIG_SH2_NCK_1	129	133	PF00017	0.564
LIG_SH2_NCK_1	544	548	PF00017	0.525
LIG_SH2_SRC	129	132	PF00017	0.589
LIG_SH2_SRC	93	96	PF00017	0.427
LIG_SH2_STAP1	129	133	PF00017	0.519
LIG_SH2_STAP1	136	140	PF00017	0.484
LIG_SH2_STAP1	158	162	PF00017	0.519
LIG_SH2_STAP1	384	388	PF00017	0.340
LIG_SH2_STAP1	430	434	PF00017	0.611
LIG_SH2_STAP1	521	525	PF00017	0.582
LIG_SH2_STAT3	41	44	PF00017	0.585
LIG_SH2_STAT5	158	161	PF00017	0.486
LIG_SH2_STAT5	277	280	PF00017	0.416
LIG_SH2_STAT5	313	316	PF00017	0.443
LIG_SH2_STAT5	688	691	PF00017	0.514
LIG_SH2_STAT5	85	88	PF00017	0.503
LIG_SH3_1	399	405	PF00018	0.516
LIG_SH3_3	399	405	PF00018	0.516
LIG_SH3_3	724	730	PF00018	0.550
LIG_Sin3_3	202	209	PF02671	0.302
LIG_Sin3_3	569	576	PF02671	0.542
LIG_SUMO_SIM_anti_2	47	53	PF11976	0.590
LIG_SUMO_SIM_anti_2	568	574	PF11976	0.507
LIG_SUMO_SIM_par_1	30	36	PF11976	0.524
LIG_SUMO_SIM_par_1	388	394	PF11976	0.562
LIG_TYR_ITIM	311	316	PF00017	0.541
LIG_TYR_ITIM	630	635	PF00017	0.638
MOD_CDC14_SPxK_1	259	262	PF00782	0.465
MOD_CDC14_SPxK_1	411	414	PF00782	0.532
MOD_CDK_SPxK_1	256	262	PF00069	0.510
MOD_CDK_SPxK_1	408	414	PF00069	0.532
MOD_CDK_SPxK_1	68	74	PF00069	0.463
MOD_CK1_1	221	227	PF00069	0.406
MOD_CK1_1	302	308	PF00069	0.420
MOD_CK1_1	339	345	PF00069	0.543
MOD_CK1_1	380	386	PF00069	0.450
MOD_CK1_1	407	413	PF00069	0.707
MOD_CK1_1	684	690	PF00069	0.390
MOD_CK2_1	24	30	PF00069	0.507
MOD_CK2_1	251	257	PF00069	0.677
MOD_CK2_1	440	446	PF00069	0.639
MOD_CK2_1	58	64	PF00069	0.476
MOD_GlcNHglycan	142	145	PF01048	0.403
MOD_GlcNHglycan	162	165	PF01048	0.473
MOD_GlcNHglycan	301	304	PF01048	0.452
MOD_GlcNHglycan	305	308	PF01048	0.434
MOD_GlcNHglycan	358	361	PF01048	0.573
MOD_GlcNHglycan	407	410	PF01048	0.728
MOD_GlcNHglycan	418	421	PF01048	0.662
MOD_GlcNHglycan	479	483	PF01048	0.427
MOD_GlcNHglycan	521	524	PF01048	0.429
MOD_GlcNHglycan	598	601	PF01048	0.696
MOD_GlcNHglycan	603	606	PF01048	0.682
MOD_GlcNHglycan	641	644	PF01048	0.678
MOD_GlcNHglycan	651	654	PF01048	0.824
MOD_GlcNHglycan	739	742	PF01048	0.787
MOD_GlcNHglycan	75	78	PF01048	0.478
MOD_GSK3_1	156	163	PF00069	0.451
MOD_GSK3_1	20	27	PF00069	0.561
MOD_GSK3_1	213	220	PF00069	0.434
MOD_GSK3_1	252	259	PF00069	0.628
MOD_GSK3_1	294	301	PF00069	0.517
MOD_GSK3_1	336	343	PF00069	0.552
MOD_GSK3_1	373	380	PF00069	0.463
MOD_GSK3_1	403	410	PF00069	0.683
MOD_GSK3_1	485	492	PF00069	0.581
MOD_GSK3_1	50	57	PF00069	0.246
MOD_GSK3_1	639	646	PF00069	0.524
MOD_LATS_1	334	340	PF00433	0.594
MOD_LATS_1	52	58	PF00433	0.250
MOD_N-GLC_1	156	161	PF02516	0.453
MOD_NEK2_1	244	249	PF00069	0.599
MOD_NEK2_1	294	299	PF00069	0.529
MOD_NEK2_1	322	327	PF00069	0.463
MOD_NEK2_1	356	361	PF00069	0.451
MOD_NEK2_1	373	378	PF00069	0.465
MOD_NEK2_1	382	387	PF00069	0.474
MOD_NEK2_1	478	483	PF00069	0.545
MOD_NEK2_1	50	55	PF00069	0.519
MOD_NEK2_1	514	519	PF00069	0.530
MOD_NEK2_1	551	556	PF00069	0.317
MOD_NEK2_1	73	78	PF00069	0.447
MOD_NEK2_2	218	223	PF00069	0.523
MOD_PIKK_1	551	557	PF00454	0.460
MOD_PIKK_1	718	724	PF00454	0.522
MOD_PKA_1	12	18	PF00069	0.594
MOD_PKA_1	54	60	PF00069	0.250
MOD_PKA_1	633	639	PF00069	0.713
MOD_PKA_2	339	345	PF00069	0.456
MOD_PKA_2	485	491	PF00069	0.608
MOD_PKA_2	512	518	PF00069	0.573
MOD_PKA_2	54	60	PF00069	0.250
MOD_PKA_2	633	639	PF00069	0.638
MOD_PKA_2	73	79	PF00069	0.408
MOD_Plk_1	20	26	PF00069	0.622
MOD_Plk_1	380	386	PF00069	0.514
MOD_Plk_1	478	484	PF00069	0.569
MOD_Plk_1	565	571	PF00069	0.473
MOD_Plk_4	486	492	PF00069	0.466
MOD_Plk_4	58	64	PF00069	0.390
MOD_ProDKin_1	179	185	PF00069	0.582
MOD_ProDKin_1	256	262	PF00069	0.501
MOD_ProDKin_1	408	414	PF00069	0.746
MOD_ProDKin_1	68	74	PF00069	0.511
MOD_SUMO_for_1	5	8	PF00179	0.525
MOD_SUMO_for_1	96	99	PF00179	0.288
MOD_SUMO_rev_2	176	183	PF00179	0.512
MOD_SUMO_rev_2	694	703	PF00179	0.448
TRG_DiLeu_BaEn_1	150	155	PF01217	0.490
TRG_DiLeu_BaEn_1	566	571	PF01217	0.456
TRG_ENDOCYTIC_2	136	139	PF00928	0.355
TRG_ENDOCYTIC_2	277	280	PF00928	0.521
TRG_ENDOCYTIC_2	313	316	PF00928	0.501
TRG_ENDOCYTIC_2	544	547	PF00928	0.530
TRG_ENDOCYTIC_2	632	635	PF00928	0.623
TRG_ENDOCYTIC_2	88	91	PF00928	0.372
TRG_ER_diArg_1	289	291	PF00400	0.446
TRG_ER_diArg_1	435	437	PF00400	0.625
TRG_ER_diArg_1	450	453	PF00400	0.518
TRG_ER_diArg_1	54	56	PF00400	0.249
TRG_ER_diArg_1	632	634	PF00400	0.708
TRG_ER_diArg_1	659	662	PF00400	0.357
TRG_ER_diArg_1	664	666	PF00400	0.355
TRG_NES_CRM1_1	381	394	PF08389	0.466
TRG_NES_CRM1_1	499	512	PF08389	0.587
TRG_NLS_Bipartite_1	436	453	PF00514	0.436
TRG_NLS_Bipartite_1	695	715	PF00514	0.632
TRG_NLS_MonoCore_2	395	400	PF00514	0.553
TRG_NLS_MonoExtN_4	393	400	PF00514	0.540
TRG_NLS_MonoExtN_4	698	705	PF00514	0.451
TRG_Pf-PMV_PEXEL_1	116	121	PF00026	0.440
TRG_Pf-PMV_PEXEL_1	31	36	PF00026	0.431
TRG_Pf-PMV_PEXEL_1	690	694	PF00026	0.566
TRG_Pf-PMV_PEXEL_1	704	708	PF00026	0.574

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I027	Leptomonas seymouri	64%	100%
A0A0S4J0A8	Bodo saltans	33%	100%
A0A1X0P6G4	Trypanosomatidae	41%	100%
A0A3Q8IDA7	Leishmania donovani	83%	100%
A0A422NHC6	Trypanosoma rangeli	42%	100%
A4HY99	Leishmania infantum	82%	100%
D0A0N5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AS31	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
O76094	Homo sapiens	23%	100%
P33731	Canis lupus familiaris	23%	100%
Q4QDE2	Leishmania major	83%	99%
V5BJ44	Trypanosoma cruzi	43%	100%