Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HA35_LEIBR

TriTrypDb:

LbrM.19.1090 , LBRM2903_190017000

Length:

252

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0016020	membrane	2	8
GO:0020023	kinetoplast	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A4HA35

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HA35

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	127	129	PF00675	0.579
CLV_NRD_NRD_1	148	150	PF00675	0.626
CLV_NRD_NRD_1	209	211	PF00675	0.399
CLV_NRD_NRD_1	224	226	PF00675	0.485
CLV_PCSK_FUR_1	146	150	PF00082	0.641
CLV_PCSK_KEX2_1	127	129	PF00082	0.598
CLV_PCSK_KEX2_1	148	150	PF00082	0.628
CLV_PCSK_KEX2_1	209	211	PF00082	0.363
CLV_PCSK_KEX2_1	224	226	PF00082	0.477
CLV_PCSK_SKI1_1	138	142	PF00082	0.615
CLV_PCSK_SKI1_1	64	68	PF00082	0.609
DEG_APCC_DBOX_1	68	76	PF00400	0.334
DEG_Nend_UBRbox_2	1	3	PF02207	0.756
DOC_MAPK_gen_1	133	141	PF00069	0.394
DOC_MAPK_gen_1	214	223	PF00069	0.668
DOC_MAPK_MEF2A_6	69	77	PF00069	0.226
DOC_USP7_MATH_1	131	135	PF00917	0.432
DOC_WW_Pin1_4	209	214	PF00397	0.571
LIG_14-3-3_CanoR_1	22	28	PF00244	0.597
LIG_14-3-3_CanoR_1	56	63	PF00244	0.486
LIG_14-3-3_CanoR_1	69	73	PF00244	0.232
LIG_BRCT_BRCA1_1	38	42	PF00533	0.424
LIG_CSL_BTD_1	154	157	PF09270	0.504
LIG_deltaCOP1_diTrp_1	166	174	PF00928	0.391
LIG_deltaCOP1_diTrp_1	245	252	PF00928	0.737
LIG_FHA_1	162	168	PF00498	0.385
LIG_FHA_1	173	179	PF00498	0.327
LIG_FHA_1	81	87	PF00498	0.364
LIG_LIR_Gen_1	168	178	PF02991	0.296
LIG_LIR_Gen_1	41	52	PF02991	0.349
LIG_LIR_Nem_3	14	19	PF02991	0.667
LIG_LIR_Nem_3	158	163	PF02991	0.428
LIG_LIR_Nem_3	166	172	PF02991	0.391
LIG_LIR_Nem_3	177	182	PF02991	0.355
LIG_LIR_Nem_3	217	221	PF02991	0.623
LIG_LIR_Nem_3	41	47	PF02991	0.349
LIG_NRBOX	177	183	PF00104	0.480
LIG_PTB_Apo_2	201	208	PF02174	0.693
LIG_PTB_Phospho_1	201	207	PF10480	0.699
LIG_SH2_SRC	129	132	PF00017	0.462
LIG_SH2_STAP1	198	202	PF00017	0.591
LIG_SH2_STAT5	129	132	PF00017	0.462
LIG_SH3_2	12	17	PF14604	0.574
LIG_SH3_3	151	157	PF00018	0.524
LIG_SH3_3	6	12	PF00018	0.723
LIG_SH3_5	15	19	PF00018	0.635
MOD_CDK_SPK_2	209	214	PF00069	0.571
MOD_CDK_SPxxK_3	209	216	PF00069	0.575
MOD_CK1_1	107	113	PF00069	0.312
MOD_CK1_1	91	97	PF00069	0.614
MOD_CMANNOS	215	218	PF00535	0.395
MOD_GlcNHglycan	38	41	PF01048	0.363
MOD_GSK3_1	116	123	PF00069	0.263
MOD_GSK3_1	205	212	PF00069	0.586
MOD_GSK3_1	34	41	PF00069	0.441
MOD_N-GLC_1	110	115	PF02516	0.426
MOD_NEK2_1	121	126	PF00069	0.403
MOD_NEK2_1	3	8	PF00069	0.755
MOD_NEK2_1	36	41	PF00069	0.376
MOD_NEK2_1	42	47	PF00069	0.343
MOD_NEK2_1	88	93	PF00069	0.579
MOD_NEK2_2	174	179	PF00069	0.378
MOD_PIKK_1	102	108	PF00454	0.626
MOD_PIKK_1	3	9	PF00454	0.760
MOD_PKA_2	161	167	PF00069	0.420
MOD_PKA_2	55	61	PF00069	0.485
MOD_PKA_2	68	74	PF00069	0.232
MOD_Plk_1	110	116	PF00069	0.426
MOD_Plk_4	110	116	PF00069	0.409
MOD_Plk_4	155	161	PF00069	0.468
MOD_Plk_4	174	180	PF00069	0.342
MOD_Plk_4	184	190	PF00069	0.368
MOD_Plk_4	237	243	PF00069	0.681
MOD_Plk_4	68	74	PF00069	0.390
MOD_Plk_4	88	94	PF00069	0.561
MOD_ProDKin_1	209	215	PF00069	0.575
TRG_ENDOCYTIC_2	170	173	PF00928	0.370
TRG_ENDOCYTIC_2	179	182	PF00928	0.353
TRG_ENDOCYTIC_2	198	201	PF00928	0.445
TRG_ER_diArg_1	127	129	PF00400	0.433
TRG_ER_diArg_1	146	149	PF00400	0.286
TRG_ER_diArg_1	223	225	PF00400	0.679
TRG_ER_diArg_1	247	250	PF00400	0.711

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8R5	Leptomonas seymouri	25%	95%
A0A0N1PBN8	Leptomonas seymouri	77%	100%
A0A0S4IWK7	Bodo saltans	40%	82%
A0A1X0P7P1	Trypanosomatidae	57%	100%
A0A3Q8IA89	Leishmania donovani	88%	100%
A4HY98	Leishmania infantum	88%	100%
D0A0N4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
E9AS30	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QDE3	Leishmania major	89%	100%