Putative transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

transporter, putative

Species:

Leishmania braziliensis

UniProt:

A4HA33_LEIBR

TriTrypDb:

LbrM.19.1070 , LBRM2903_190016800

Length:

506

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	18
GO:0110165	cellular anatomical entity	1	18
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A4HA33

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HA33

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	18
GO:0009914	hormone transport	4	18
GO:0009987	cellular process	1	18
GO:0010817	regulation of hormone levels	3	18
GO:0051179	localization	1	18
GO:0051234	establishment of localization	2	18
GO:0055085	transmembrane transport	2	18
GO:0060918	auxin transport	5	18
GO:0065007	biological regulation	1	18
GO:0065008	regulation of biological quality	2	18
GO:0080162	endoplasmic reticulum to cytosol auxin transport	3	18

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	352	356	PF00656	0.455
CLV_NRD_NRD_1	166	168	PF00675	0.245
CLV_NRD_NRD_1	180	182	PF00675	0.317
CLV_NRD_NRD_1	199	201	PF00675	0.306
CLV_PCSK_FUR_1	281	285	PF00082	0.381
CLV_PCSK_KEX2_1	166	168	PF00082	0.223
CLV_PCSK_KEX2_1	179	181	PF00082	0.341
CLV_PCSK_KEX2_1	199	201	PF00082	0.277
CLV_PCSK_KEX2_1	283	285	PF00082	0.356
CLV_PCSK_PC1ET2_1	166	168	PF00082	0.214
CLV_PCSK_PC1ET2_1	283	285	PF00082	0.381
CLV_PCSK_SKI1_1	18	22	PF00082	0.347
CLV_PCSK_SKI1_1	251	255	PF00082	0.373
CLV_PCSK_SKI1_1	291	295	PF00082	0.308
CLV_PCSK_SKI1_1	401	405	PF00082	0.236
CLV_PCSK_SKI1_1	446	450	PF00082	0.509
CLV_PCSK_SKI1_1	480	484	PF00082	0.268
CLV_PCSK_SKI1_1	94	98	PF00082	0.303
DEG_APCC_DBOX_1	283	291	PF00400	0.542
DEG_SPOP_SBC_1	357	361	PF00917	0.464
DOC_CKS1_1	252	257	PF01111	0.414
DOC_CKS1_1	33	38	PF01111	0.380
DOC_CYCLIN_yCln2_LP_2	115	121	PF00134	0.450
DOC_MAPK_DCC_7	421	430	PF00069	0.273
DOC_MAPK_gen_1	166	172	PF00069	0.380
DOC_MAPK_gen_1	281	290	PF00069	0.564
DOC_MAPK_gen_1	291	299	PF00069	0.446
DOC_MAPK_gen_1	99	107	PF00069	0.560
DOC_MAPK_HePTP_8	331	343	PF00069	0.405
DOC_MAPK_HePTP_8	418	430	PF00069	0.329
DOC_MAPK_JIP1_4	446	452	PF00069	0.309
DOC_MAPK_MEF2A_6	257	264	PF00069	0.559
DOC_MAPK_MEF2A_6	334	343	PF00069	0.405
DOC_MAPK_MEF2A_6	406	413	PF00069	0.492
DOC_MAPK_MEF2A_6	421	430	PF00069	0.244
DOC_MAPK_MEF2A_6	49	57	PF00069	0.368
DOC_MAPK_NFAT4_5	334	342	PF00069	0.405
DOC_PP1_RVXF_1	124	131	PF00149	0.290
DOC_PP1_RVXF_1	166	173	PF00149	0.380
DOC_PP2B_LxvP_1	309	312	PF13499	0.306
DOC_PP4_FxxP_1	201	204	PF00568	0.506
DOC_PP4_FxxP_1	33	36	PF00568	0.490
DOC_SPAK_OSR1_1	102	106	PF12202	0.380
DOC_USP7_MATH_1	193	197	PF00917	0.531
DOC_USP7_MATH_1	289	293	PF00917	0.471
DOC_USP7_MATH_1	350	354	PF00917	0.559
DOC_USP7_MATH_1	357	361	PF00917	0.563
DOC_USP7_MATH_1	36	40	PF00917	0.411
DOC_USP7_MATH_1	390	394	PF00917	0.392
DOC_USP7_MATH_1	461	465	PF00917	0.394
DOC_WW_Pin1_4	251	256	PF00397	0.544
DOC_WW_Pin1_4	292	297	PF00397	0.533
DOC_WW_Pin1_4	307	312	PF00397	0.366
DOC_WW_Pin1_4	316	321	PF00397	0.249
DOC_WW_Pin1_4	32	37	PF00397	0.555
DOC_WW_Pin1_4	367	372	PF00397	0.509
DOC_WW_Pin1_4	455	460	PF00397	0.399
LIG_14-3-3_CanoR_1	231	240	PF00244	0.491
LIG_14-3-3_CanoR_1	31	36	PF00244	0.470
LIG_14-3-3_CanoR_1	401	409	PF00244	0.553
LIG_ActinCP_TwfCPI_2	201	208	PF01115	0.380
LIG_BRCT_BRCA1_1	113	117	PF00533	0.357
LIG_EH1_1	429	437	PF00400	0.354
LIG_eIF4E_1	5	11	PF01652	0.360
LIG_FHA_1	114	120	PF00498	0.364
LIG_FHA_1	308	314	PF00498	0.425
LIG_FHA_1	402	408	PF00498	0.525
LIG_FHA_1	418	424	PF00498	0.223
LIG_FHA_1	499	505	PF00498	0.405
LIG_FHA_2	233	239	PF00498	0.496
LIG_FHA_2	33	39	PF00498	0.536
LIG_FHA_2	382	388	PF00498	0.570
LIG_LIR_Apic_2	198	204	PF02991	0.512
LIG_LIR_Apic_2	30	36	PF02991	0.497
LIG_LIR_Apic_2	70	76	PF02991	0.328
LIG_LIR_Gen_1	100	111	PF02991	0.502
LIG_LIR_Gen_1	141	149	PF02991	0.336
LIG_LIR_Gen_1	4	13	PF02991	0.207
LIG_LIR_Gen_1	414	423	PF02991	0.254
LIG_LIR_Gen_1	477	486	PF02991	0.494
LIG_LIR_Gen_1	494	504	PF02991	0.198
LIG_LIR_Gen_1	63	73	PF02991	0.283
LIG_LIR_Nem_3	141	145	PF02991	0.336
LIG_LIR_Nem_3	4	8	PF02991	0.325
LIG_LIR_Nem_3	414	418	PF02991	0.289
LIG_LIR_Nem_3	494	499	PF02991	0.217
LIG_LIR_Nem_3	63	69	PF02991	0.275
LIG_LIR_Nem_3	98	104	PF02991	0.481
LIG_Pex14_1	415	419	PF04695	0.198
LIG_Pex14_1	496	500	PF04695	0.197
LIG_Pex14_1	74	78	PF04695	0.409
LIG_SH2_CRK	101	105	PF00017	0.520
LIG_SH2_CRK	146	150	PF00017	0.347
LIG_SH2_PTP2	142	145	PF00017	0.352
LIG_SH2_STAP1	478	482	PF00017	0.478
LIG_SH2_STAP1	5	9	PF00017	0.239
LIG_SH2_STAT5	142	145	PF00017	0.326
LIG_SH2_STAT5	32	35	PF00017	0.496
LIG_SH2_STAT5	399	402	PF00017	0.449
LIG_SH2_STAT5	486	489	PF00017	0.336
LIG_SH2_STAT5	5	8	PF00017	0.420
LIG_SH2_STAT5	503	506	PF00017	0.296
LIG_SH3_1	249	255	PF00018	0.380
LIG_SH3_2	252	257	PF14604	0.380
LIG_SH3_3	201	207	PF00018	0.446
LIG_SH3_3	249	255	PF00018	0.531
LIG_SH3_3	314	320	PF00018	0.334
LIG_SH3_3	420	426	PF00018	0.399
LIG_SH3_3	47	53	PF00018	0.422
LIG_SUMO_SIM_anti_2	420	426	PF11976	0.405
LIG_SUMO_SIM_anti_2	6	12	PF11976	0.305
LIG_SUMO_SIM_par_1	295	301	PF11976	0.320
LIG_SUMO_SIM_par_1	305	310	PF11976	0.373
LIG_SUMO_SIM_par_1	384	389	PF11976	0.380
LIG_TRAF2_1	35	38	PF00917	0.506
LIG_UBA3_1	121	126	PF00899	0.368
LIG_UBA3_1	287	294	PF00899	0.380
LIG_Vh1_VBS_1	9	27	PF01044	0.198
LIG_WW_3	254	258	PF00397	0.380
MOD_CDK_SPxK_1	251	257	PF00069	0.380
MOD_CDK_SPxxK_3	307	314	PF00069	0.352
MOD_CK1_1	222	228	PF00069	0.506
MOD_CK1_1	292	298	PF00069	0.560
MOD_CK1_1	393	399	PF00069	0.545
MOD_CK1_1	489	495	PF00069	0.405
MOD_CK2_1	1	7	PF00069	0.273
MOD_CK2_1	31	37	PF00069	0.465
MOD_CK2_1	357	363	PF00069	0.476
MOD_GlcNHglycan	387	391	PF01048	0.339
MOD_GSK3_1	107	114	PF00069	0.394
MOD_GSK3_1	27	34	PF00069	0.441
MOD_GSK3_1	367	374	PF00069	0.521
MOD_GSK3_1	386	393	PF00069	0.530
MOD_GSK3_1	453	460	PF00069	0.316
MOD_GSK3_1	485	492	PF00069	0.316
MOD_GSK3_1	56	63	PF00069	0.452
MOD_N-GLC_1	462	467	PF02516	0.351
MOD_NEK2_1	1	6	PF00069	0.401
MOD_NEK2_1	107	112	PF00069	0.317
MOD_NEK2_1	131	136	PF00069	0.240
MOD_NEK2_1	27	32	PF00069	0.217
MOD_NEK2_1	344	349	PF00069	0.410
MOD_NEK2_1	386	391	PF00069	0.471
MOD_NEK2_1	448	453	PF00069	0.288
MOD_NEK2_1	485	490	PF00069	0.278
MOD_NEK2_1	498	503	PF00069	0.305
MOD_NEK2_1	55	60	PF00069	0.235
MOD_NEK2_1	9	14	PF00069	0.351
MOD_NEK2_2	289	294	PF00069	0.380
MOD_PIKK_1	388	394	PF00454	0.565
MOD_PKA_1	199	205	PF00069	0.380
MOD_PKA_2	199	205	PF00069	0.506
MOD_Plk_1	219	225	PF00069	0.573
MOD_Plk_1	36	42	PF00069	0.394
MOD_Plk_1	462	468	PF00069	0.347
MOD_Plk_4	117	123	PF00069	0.348
MOD_Plk_4	298	304	PF00069	0.269
MOD_Plk_4	344	350	PF00069	0.327
MOD_Plk_4	36	42	PF00069	0.533
MOD_Plk_4	381	387	PF00069	0.528
MOD_Plk_4	395	401	PF00069	0.475
MOD_Plk_4	414	420	PF00069	0.220
MOD_Plk_4	448	454	PF00069	0.362
MOD_Plk_4	462	468	PF00069	0.251
MOD_Plk_4	486	492	PF00069	0.394
MOD_ProDKin_1	251	257	PF00069	0.544
MOD_ProDKin_1	292	298	PF00069	0.533
MOD_ProDKin_1	307	313	PF00069	0.366
MOD_ProDKin_1	316	322	PF00069	0.249
MOD_ProDKin_1	32	38	PF00069	0.555
MOD_ProDKin_1	367	373	PF00069	0.509
MOD_ProDKin_1	455	461	PF00069	0.399
TRG_DiLeu_BaEn_1	445	450	PF01217	0.360
TRG_ENDOCYTIC_2	101	104	PF00928	0.508
TRG_ENDOCYTIC_2	142	145	PF00928	0.315
TRG_ENDOCYTIC_2	146	149	PF00928	0.299
TRG_ENDOCYTIC_2	478	481	PF00928	0.486
TRG_ENDOCYTIC_2	5	8	PF00928	0.420
TRG_ER_diArg_1	179	181	PF00400	0.534
TRG_ER_diArg_1	199	201	PF00400	0.506

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3A2	Leptomonas seymouri	54%	98%
A0A0S4IZH0	Bodo saltans	20%	91%
A0A0S4J2X2	Bodo saltans	23%	100%
A0A0S4J5Y3	Bodo saltans	23%	100%
A0A1X0P681	Trypanosomatidae	29%	100%
A0A1X0P6F8	Trypanosomatidae	36%	98%
A0A3Q8IEH9	Leishmania donovani	61%	100%
A0A422NMT2	Trypanosoma rangeli	37%	100%
A0A422NN55	Trypanosoma rangeli	30%	100%
A4H8K4	Leishmania braziliensis	22%	67%
A4HY96	Leishmania infantum	61%	100%
D0A0N1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9AS28	Leishmania mexicana (strain MHOM/GT/2001/U1103)	58%	100%
Q4QDE5	Leishmania major	58%	96%
V5B7J7	Trypanosoma cruzi	29%	100%
V5BC60	Trypanosoma cruzi	38%	100%